BG60530B2 - Дехидрохолекалцифероли - Google Patents

Дехидрохолекалцифероли Download PDF

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Publication number
BG60530B2
BG60530B2 BG98544A BG9854494A BG60530B2 BG 60530 B2 BG60530 B2 BG 60530B2 BG 98544 A BG98544 A BG 98544A BG 9854494 A BG9854494 A BG 9854494A BG 60530 B2 BG60530 B2 BG 60530B2
Authority
BG
Bulgaria
Prior art keywords
formula
compound
treatment
mixture
solution
Prior art date
Application number
BG98544A
Other languages
Bulgarian (bg)
English (en)
Inventor
Enrico Baggiolini
Bernard Hennessy
Shian-Jan Shiuey
Gary Truitt
Milan Uskokovic
Original Assignee
F. Hoffmann- La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann- La Roche Ag filed Critical F. Hoffmann- La Roche Ag
Publication of BG60530B2 publication Critical patent/BG60530B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG98544A 1988-01-20 1994-02-24 Дехидрохолекалцифероли BG60530B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20

Publications (1)

Publication Number Publication Date
BG60530B2 true BG60530B2 (bg) 1995-07-28

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98544A BG60530B2 (bg) 1988-01-20 1994-02-24 Дехидрохолекалцифероли

Country Status (23)

Country Link
EP (1) EP0325279B1 (fr)
JP (1) JPH0764806B2 (fr)
KR (1) KR960009119B1 (fr)
AR (1) AR247551A1 (fr)
AT (1) ATE74350T1 (fr)
AU (1) AU622139B2 (fr)
BG (1) BG60530B2 (fr)
CA (1) CA1337529C (fr)
DE (1) DE58901056D1 (fr)
DK (1) DK169945B1 (fr)
ES (1) ES2033467T3 (fr)
FI (1) FI90764C (fr)
GR (1) GR3004786T3 (fr)
HU (1) HU201007B (fr)
IE (1) IE60921B1 (fr)
IL (1) IL88989A (fr)
MC (1) MC1998A1 (fr)
NO (1) NO175429C (fr)
NZ (1) NZ227641A (fr)
PH (1) PH25605A (fr)
PT (1) PT89486B (fr)
YU (1) YU47298B (fr)
ZA (1) ZA8923B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DK0398217T3 (da) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferolderivater
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
DE69304279T2 (de) * 1992-05-20 1997-02-20 Hoffmann La Roche Fluorierte Analoge Vitamins D3
CA2096105A1 (fr) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Analogues fluores de vitamine d3
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
TW267161B (fr) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
ES2196476T3 (es) * 1997-05-02 2003-12-16 Duphar Int Res Un metodo de preparar compuestos de 16-deshidro-vitamina d.
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US9221753B2 (en) * 2004-02-03 2015-12-29 Chugai Seiyaku Kabushiki Kaisha Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
EP1883626B1 (fr) * 2005-04-25 2017-10-11 OPKO Ireland Global Holdings, Ltd. Analogues d'oxime 16,23-diene 25 a calcemie basse de 1alpha,25-dihydroxy-vitamine d3
JP2009508813A (ja) * 2005-08-18 2009-03-05 ビオクセル エッセ ピ ア １α−フルオロー２５−ヒドロキシ−１６−２３Ｅ−ジエン−２６，２７−ビスホモ−２０−エピ−コレカルシフェロールの合成

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7803154A (nl) * 1977-03-24 1978-09-26 Wisconsin Alumni Res Found Vitamine d-antagonisten, werkwijze voor de be- reiding daarvan, en preparaten die ze bevatten.
NL7903929A (nl) * 1978-05-19 1979-11-21 Wisconsin Alumni Res Found Verbindingen met anti-vitamine d activiteit, farmaceutisch preparaat, dat een dergelijke verbinding bevat, alsmede werkwijze voor de toepassing van dergelijke verbindingen.
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DK0398217T3 (da) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferolderivater

Also Published As

Publication number Publication date
NO175429B (no) 1994-07-04
DK169945B1 (da) 1995-04-10
AR247551A1 (es) 1995-01-31
GR3004786T3 (fr) 1993-04-28
JPH0764806B2 (ja) 1995-07-12
MC1998A1 (fr) 1990-01-26
KR960009119B1 (en) 1996-07-13
PT89486A (pt) 1989-10-04
YU47298B (sh) 1995-01-31
DE58901056D1 (de) 1992-05-07
FI90764C (fi) 1994-03-25
NO890239D0 (no) 1989-01-19
NO890239L (no) 1989-07-21
KR890011838A (ko) 1989-08-22
EP0325279B1 (fr) 1992-04-01
CA1337529C (fr) 1995-11-07
YU11789A (en) 1991-04-30
ES2033467T3 (es) 1993-03-16
ZA8923B (en) 1989-09-27
PH25605A (en) 1991-08-08
FI890283A0 (fi) 1989-01-19
IL88989A (en) 1993-08-18
IE890157L (en) 1989-07-20
JPH029861A (ja) 1990-01-12
ATE74350T1 (de) 1992-04-15
HU201007B (en) 1990-09-28
IL88989A0 (en) 1989-08-15
AU2864489A (en) 1989-07-20
EP0325279A1 (fr) 1989-07-26
FI890283A (fi) 1989-07-21
NO175429C (no) 1994-10-12
IE60921B1 (en) 1994-09-07
DK19789D0 (da) 1989-01-17
DK19789A (da) 1989-07-21
HUT49317A (en) 1989-09-28
NZ227641A (en) 1991-06-25
AU622139B2 (en) 1992-04-02
FI90764B (fi) 1993-12-15
PT89486B (pt) 1993-12-31

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