DK167825B1 - Fremgangsmaade og reagenssystem til immunobestemmelse af glycoprotein-analyten hb alc. - Google Patents

Fremgangsmaade og reagenssystem til immunobestemmelse af glycoprotein-analyten hb alc. Download PDF

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Publication number
DK167825B1
DK167825B1 DK494085A DK494085A DK167825B1 DK 167825 B1 DK167825 B1 DK 167825B1 DK 494085 A DK494085 A DK 494085A DK 494085 A DK494085 A DK 494085A DK 167825 B1 DK167825 B1 DK 167825B1
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DK
Denmark
Prior art keywords
antibody
hemoglobin
alc
protein
epitope
Prior art date
Application number
DK494085A
Other languages
Danish (da)
English (en)
Other versions
DK494085D0 (da
DK494085A (da
Inventor
William Knowles
Vincent Marchesi
Wallace Haigh
Original Assignee
Molecular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27505324&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK167825(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/763,193 external-priority patent/US4647654A/en
Priority claimed from US06/779,730 external-priority patent/US4658022A/en
Priority claimed from US06/779,731 external-priority patent/US4727036A/en
Application filed by Molecular Diagnostics Inc filed Critical Molecular Diagnostics Inc
Publication of DK494085D0 publication Critical patent/DK494085D0/da
Publication of DK494085A publication Critical patent/DK494085A/da
Application granted granted Critical
Publication of DK167825B1 publication Critical patent/DK167825B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK494085A 1984-10-29 1985-10-28 Fremgangsmaade og reagenssystem til immunobestemmelse af glycoprotein-analyten hb alc. DK167825B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US66581184A 1984-10-29 1984-10-29
US66581184 1984-10-29
US76319385 1985-08-08
US06/763,193 US4647654A (en) 1984-10-29 1985-08-08 Peptides useful in preparing hemoglobin A1c immunogens
US77973085 1985-09-27
US06/779,730 US4658022A (en) 1985-08-08 1985-09-27 Binding of antibody reagents to denatured protein analytes
US77973185 1985-09-27
US06/779,731 US4727036A (en) 1985-08-08 1985-09-27 Antibodies for use in determining hemoglobin A1c

Publications (3)

Publication Number Publication Date
DK494085D0 DK494085D0 (da) 1985-10-28
DK494085A DK494085A (da) 1986-04-30
DK167825B1 true DK167825B1 (da) 1993-12-20

Family

ID=27505324

Family Applications (2)

Application Number Title Priority Date Filing Date
DK494085A DK167825B1 (da) 1984-10-29 1985-10-28 Fremgangsmaade og reagenssystem til immunobestemmelse af glycoprotein-analyten hb alc.
DK199101307A DK165327C (da) 1984-10-29 1991-07-04 Monoklonale antistoffer for Hb Alc og hybridomaer til brug ved fremstilling af antistofferne

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK199101307A DK165327C (da) 1984-10-29 1991-07-04 Monoklonale antistoffer for Hb Alc og hybridomaer til brug ved fremstilling af antistofferne

Country Status (12)

Country Link
EP (2) EP0316306B1 (de)
JP (2) JPH0723891B2 (de)
AT (2) ATE80951T1 (de)
AU (1) AU594651B2 (de)
CA (1) CA1339952C (de)
DE (2) DE3586679T3 (de)
DK (2) DK167825B1 (de)
ES (2) ES8705633A1 (de)
FI (1) FI84107C (de)
IE (1) IE63731B1 (de)
IL (1) IL76827A (de)
NZ (1) NZ213959A (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse
US5206144A (en) * 1985-03-29 1993-04-27 Novo Industri A/S Determination of glycated (glycosylated) hemoglobin in blood
US4797473A (en) * 1986-06-25 1989-01-10 Regents Of The University Of Minnesota Monoclonal antibodies to unreduced, nonenzymatically-glycated proteins
US5173422A (en) * 1986-08-22 1992-12-22 Miles Inc. Monoclonal antibodies specific for human glycoalbumin
US4822747A (en) * 1986-12-09 1989-04-18 Miles Inc. Polyacrylamide gel particles having hapten moieties bound thereto as immunoassay reagent
JPS63273472A (ja) * 1987-04-30 1988-11-10 Asahi Breweries Ltd 新規抗体とそれを用いたヒトヘモグロビンの検出
US4970171A (en) * 1987-11-09 1990-11-13 Miles Inc. Denaturant reagents for convenient determination of hemoglobin derivatives in blood
US4847209A (en) * 1987-11-09 1989-07-11 Miles Inc. Latex agglutination immunoassay in the presence of hemoglobin
DE3806198A1 (de) * 1988-02-04 1989-08-17 Boehringer Mannheim Gmbh Immunogen und seine verwendung zur gewinnung von antikoerpern gegen hba(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)c(pfeil abwaerts)
IL94724A (en) * 1989-07-13 1994-02-27 Miles Inc Decomposition of red blood cells and denaturation of hemoglobin by the use of lithium salts
US5484735A (en) * 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
DE4206932A1 (de) * 1992-03-05 1993-09-09 Boehringer Mannheim Gmbh Immunologische methode zur bestimmung eines haemoglobinderivates
JP2596322B2 (ja) * 1992-06-10 1997-04-02 富士レビオ株式会社 総ヘモグロビンに対する糖化ヘモグロビンの割合の測定方法
AU661207B2 (en) * 1992-11-17 1995-07-13 Boehringer Mannheim Gmbh Simultaneous determination of HbA1c and haemoglobin variants with a glycation analogus to HbA1c
JP2703116B2 (ja) * 1993-07-28 1998-01-26 ベーリンガー マンハイム ゲーエムベーハー コラーゲンまたはコラーゲン断片を検出するためのイムノアッセイ
JP3269765B2 (ja) 1995-12-14 2002-04-02 富士写真フイルム株式会社 ヘモグロビン誘導体の免疫学的測定方法及びその方法に用いる処理試薬
AU753701B2 (en) 1997-04-21 2002-10-24 Glycozyme, Inc. Determination of recombinant glycosylated proteins and peptides in biological fluids
JPH10332693A (ja) * 1997-05-29 1998-12-18 Tokuyama Corp 被検体の前処理方法
WO1999013907A2 (en) * 1997-09-19 1999-03-25 Serex, Inc. Methods to improve immunogenicity of antigens and specificity of antibodies
WO1999021015A2 (en) * 1997-10-21 1999-04-29 Cranfield University Affinity ligands, their production and use
JPH11258238A (ja) * 1998-03-10 1999-09-24 Tokuyama Corp 免疫学的凝集測定用試薬キット
US6428704B1 (en) * 1998-08-07 2002-08-06 Sekisui Chemical Co., Ltd. Method for determination of hemoglobins
JP2002005936A (ja) * 2000-06-26 2002-01-09 Shino Test Corp 酵素免疫測定法による測定試薬及び測定方法
US7109309B2 (en) 2000-07-14 2006-09-19 Matsushita Electric Industrial Co., Ltd. Peptide fructose and protein conjugate with the same
EP1414860B1 (de) * 2001-04-26 2009-12-30 Dako Denmark A/S Pan-spezifischer monoklonaler antikörper der gegen glycosiliertes hämoglobin gerichtet ist
EP1816460B1 (de) 2006-02-03 2009-07-22 MTM Laboratories AG Verfahren zur Durchführung eines Denaturierungs-Immunoassays
ES2690319T3 (es) * 2006-06-06 2018-11-20 F. Hoffmann-La Roche Ag Hemólisis diferencial de una muestra de sangre completa
US8936791B2 (en) * 2006-10-18 2015-01-20 Biomerieux Method for in vitro diagnosis of PVL-producing Staphylococcus aureus
ES2352335T3 (es) * 2007-06-06 2011-02-17 Roche Diagnostics Gmbh Detección de un analito en una muestra de sangre entera hemolizada.
JP5574977B2 (ja) * 2008-12-11 2014-08-20 積水メディカル株式会社 糖化ヘモグロビン含有試料の前処理法
JP5743550B2 (ja) * 2008-12-11 2015-07-01 積水メディカル株式会社 ヘモグロビンβ鎖のＮ末端領域に対する抗体
WO2017096373A1 (en) * 2015-12-04 2017-06-08 Polymer Technology Systems, Inc. Systems and methods for interference correction from hemoglobin variants
JP6811581B2 (ja) * 2016-10-25 2021-01-13 福井県 人血検査方法及び人血検査用キット
TW202020453A (zh) 2018-09-28 2020-06-01 日商積水醫療股份有限公司 糖化血紅素(%)之測定方法
US20200284807A1 (en) * 2019-03-05 2020-09-10 Victor Manneh Saturation binding ratiometric assay

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247533A (en) * 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
GB1580318A (en) * 1978-05-06 1980-12-03 Univ Rockefeller Antibodies active against human hemoglobin a1c
JPS5610254A (en) * 1979-07-07 1981-02-02 Wako Pure Chem Ind Ltd New rheumatism factor measuring reagent
US4478744A (en) * 1982-01-25 1984-10-23 Sherwood Medical Company Method of obtaining antibodies
JPS58205854A (ja) * 1982-05-25 1983-11-30 Mihama Hisaharu 潜血反応検査用の固定化抗体
US4629692A (en) * 1982-12-06 1986-12-16 Miles Laboratories, Inc. Immunoassay for nonenzymatically glucosylated proteins and protein fragments an index of glycemia
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse

Also Published As

Publication number Publication date
IE852655L (en) 1986-04-29
EP0185870A3 (en) 1986-08-27
ES548270A0 (es) 1987-05-01
EP0316306A2 (de) 1989-05-17
JPS61172064A (ja) 1986-08-02
DE3587687D1 (de) 1994-01-27
EP0316306A3 (en) 1989-10-11
FI854187L (fi) 1986-04-30
FI854187A0 (fi) 1985-10-25
ATE98776T1 (de) 1994-01-15
JPH0723891B2 (ja) 1995-03-15
AU4926085A (en) 1986-05-08
DK165327B (da) 1992-11-09
DE3586679T2 (de) 1993-02-18
IE63731B1 (en) 1995-06-14
ES8705633A1 (es) 1987-05-01
EP0316306B1 (de) 1993-12-15
DE3586679T3 (de) 1998-10-15
FI84107C (fi) 1996-04-11
DK165327C (da) 2000-09-11
DE3586679D1 (de) 1992-10-29
DK494085D0 (da) 1985-10-28
ES556865A0 (es) 1987-10-16
EP0185870B1 (de) 1992-09-23
FI84107B (fi) 1991-06-28
AU594651B2 (en) 1990-03-15
DE3587687T2 (de) 1994-04-07
IL76827A0 (en) 1986-02-28
EP0185870A2 (de) 1986-07-02
CA1339952C (en) 1998-07-14
JP2858534B2 (ja) 1999-02-17
NZ213959A (en) 1990-03-27
DK494085A (da) 1986-04-30
DK130791A (da) 1991-07-04
ATE80951T1 (de) 1992-10-15
ES8800435A1 (es) 1987-10-16
DK130791D0 (da) 1991-07-04
IL76827A (en) 1990-11-29
JPH0751087A (ja) 1995-02-28
EP0185870B2 (de) 1998-06-17

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Date Code Title Description
B1 Patent granted (law 1993)
PPF Opposition filed
PUG Patent revoked
PBP Patent lapsed

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