ES8705633A1 - Un metodo de inmunoensayo - Google Patents

Un metodo de inmunoensayo

Info

Publication number
ES8705633A1
ES8705633A1 ES548270A ES548270A ES8705633A1 ES 8705633 A1 ES8705633 A1 ES 8705633A1 ES 548270 A ES548270 A ES 548270A ES 548270 A ES548270 A ES 548270A ES 8705633 A1 ES8705633 A1 ES 8705633A1
Authority
ES
Spain
Prior art keywords
protein
alc
binding
monoclonal antibodies
antibody reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548270A
Other languages
English (en)
Other versions
ES548270A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Diagnostics Inc
Original Assignee
Molecular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27505324&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8705633(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/763,193 external-priority patent/US4647654A/en
Priority claimed from US06/779,731 external-priority patent/US4727036A/en
Priority claimed from US06/779,730 external-priority patent/US4658022A/en
Application filed by Molecular Diagnostics Inc filed Critical Molecular Diagnostics Inc
Publication of ES8705633A1 publication Critical patent/ES8705633A1/es
Publication of ES548270A0 publication Critical patent/ES548270A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

METODO DE INMUNOENSAYO PARA DETERMINAR HBALC EN UNA MUESTRA DE SANGRE. CONSISTE EN PONER EN CONTACTO LA MUESTRA DE SANGRE CON UN REACTIVO ANTICUERPO CAPAZ DE UNIRSE AL HBALC Y DETERMINAR LA UNION DE DICHO REACTIVO ANTICUERPO AL HBALC EN LA MUESTRA DE SANGRE, DONDE EL REACTIVO ANTICUERPO ES UN ANTICUERPO MONOCLONAL, O UN FRAGMENTO DEL MISMO QUE COMPRENDE UN SITIO DE COMBINACION DEL ANTICUERPO, QUE SE UNE ESPECIFICAMENTE A LA SECUENCIA PEPTIDICA N-TERMINAL GLUCOSIDICA DE LA SUBUNIDAD BETA DE LA HEMOGLOBINA HUMANA O A UN PEPTIDO GLUCOSILADO DE FORMULA GLYCO-(NH)VAL-HIS-AA-. TIENE UTILIDAD PARA LA DETERMINACION DE PROTEINAS DE IMPORTANCIA ANALITICA.
ES548270A 1984-10-29 1985-10-28 Un metodo de inmunoensayo Expired ES8705633A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66581184A 1984-10-29 1984-10-29
US06/763,193 US4647654A (en) 1984-10-29 1985-08-08 Peptides useful in preparing hemoglobin A1c immunogens
US06/779,731 US4727036A (en) 1985-08-08 1985-09-27 Antibodies for use in determining hemoglobin A1c
US06/779,730 US4658022A (en) 1985-08-08 1985-09-27 Binding of antibody reagents to denatured protein analytes

Publications (2)

Publication Number Publication Date
ES8705633A1 true ES8705633A1 (es) 1987-05-01
ES548270A0 ES548270A0 (es) 1987-05-01

Family

ID=27505324

Family Applications (2)

Application Number Title Priority Date Filing Date
ES548270A Expired ES8705633A1 (es) 1984-10-29 1985-10-28 Un metodo de inmunoensayo
ES556865A Expired ES8800435A1 (es) 1984-10-29 1986-07-01 Un metodo de inmunoensayo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES556865A Expired ES8800435A1 (es) 1984-10-29 1986-07-01 Un metodo de inmunoensayo.

Country Status (12)

Country Link
EP (2) EP0316306B1 (es)
JP (2) JPH0723891B2 (es)
AT (2) ATE80951T1 (es)
AU (1) AU594651B2 (es)
CA (1) CA1339952C (es)
DE (2) DE3587687T2 (es)
DK (2) DK167825B1 (es)
ES (2) ES8705633A1 (es)
FI (1) FI84107C (es)
IE (1) IE63731B1 (es)
IL (1) IL76827A (es)
NZ (1) NZ213959A (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206144A (en) * 1985-03-29 1993-04-27 Novo Industri A/S Determination of glycated (glycosylated) hemoglobin in blood
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse
US4797473A (en) * 1986-06-25 1989-01-10 Regents Of The University Of Minnesota Monoclonal antibodies to unreduced, nonenzymatically-glycated proteins
US5173422A (en) * 1986-08-22 1992-12-22 Miles Inc. Monoclonal antibodies specific for human glycoalbumin
US4822747A (en) * 1986-12-09 1989-04-18 Miles Inc. Polyacrylamide gel particles having hapten moieties bound thereto as immunoassay reagent
JPS63273472A (ja) * 1987-04-30 1988-11-10 Asahi Breweries Ltd 新規抗体とそれを用いたヒトヘモグロビンの検出
US4970171A (en) * 1987-11-09 1990-11-13 Miles Inc. Denaturant reagents for convenient determination of hemoglobin derivatives in blood
US4847209A (en) * 1987-11-09 1989-07-11 Miles Inc. Latex agglutination immunoassay in the presence of hemoglobin
DE3806198A1 (de) * 1988-02-04 1989-08-17 Boehringer Mannheim Gmbh Immunogen und seine verwendung zur gewinnung von antikoerpern gegen hba(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)c(pfeil abwaerts)
IL94724A (en) * 1989-07-13 1994-02-27 Miles Inc Decomposition of red blood cells and denaturation of hemoglobin by the use of lithium salts
US5484735A (en) * 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
DE4206932A1 (de) * 1992-03-05 1993-09-09 Boehringer Mannheim Gmbh Immunologische methode zur bestimmung eines haemoglobinderivates
JP2596322B2 (ja) * 1992-06-10 1997-04-02 富士レビオ株式会社 総ヘモグロビンに対する糖化ヘモグロビンの割合の測定方法
AU661207B2 (en) * 1992-11-17 1995-07-13 Boehringer Mannheim Gmbh Simultaneous determination of HbA1c and haemoglobin variants with a glycation analogus to HbA1c
DK0711415T3 (da) * 1993-07-28 1999-04-26 Roche Diagnostics Gmbh Immunoanalyse til påvisning af collagen eller collagenfragmenter
JP3269765B2 (ja) * 1995-12-14 2002-04-02 富士写真フイルム株式会社 ヘモグロビン誘導体の免疫学的測定方法及びその方法に用いる処理試薬
AU753701B2 (en) * 1997-04-21 2002-10-24 Glycozyme, Inc. Determination of recombinant glycosylated proteins and peptides in biological fluids
JPH10332693A (ja) * 1997-05-29 1998-12-18 Tokuyama Corp 被検体の前処理方法
US6455047B1 (en) 1997-09-19 2002-09-24 Serex, Inc. Methods to improve immunogenicity of antigens and specificity of antibodies
AU9549798A (en) * 1997-10-21 1999-05-10 Cranfield University Affinity ligands, their production and use
JPH11258238A (ja) * 1998-03-10 1999-09-24 Tokuyama Corp 免疫学的凝集測定用試薬キット
ES2563162T3 (es) * 1998-08-07 2016-03-11 Sekisui Chemical Co., Ltd. Método para determinar hemoglobinas
JP2002005936A (ja) * 2000-06-26 2002-01-09 Shino Test Corp 酵素免疫測定法による測定試薬及び測定方法
WO2002006310A1 (fr) * 2000-07-14 2002-01-24 Matsushita Electric Industrial Co., Ltd. Fructose peptidique et complexe de ce dernier associe a une proteine de liaison
ATE453668T1 (de) * 2001-04-26 2010-01-15 Dako Denmark As Pan-spezifischer monoklonaler antikörper der gegen glycosiliertes hämoglobin gerichtet ist
EP1816460B1 (en) 2006-02-03 2009-07-22 MTM Laboratories AG Method of performing a denaturing immunassay
CA2649633C (en) * 2006-06-06 2012-11-27 F. Hoffmann-La Roche Ag Differential hemolysis of a whole blood sample
AU2007310738B2 (en) * 2006-10-18 2013-07-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for in vitro diagnosis of PVL-producing Staphylococcus aureus
CN101680885B (zh) * 2007-06-06 2017-03-15 霍夫曼-拉罗奇有限公司 已溶血的全血样品中待分析物的检测
US9169320B2 (en) 2008-12-11 2015-10-27 Sekisui Medical Co., Ltd. Antibody to N-terminal region of hemoglobin β-chain
JP5574977B2 (ja) * 2008-12-11 2014-08-20 積水メディカル株式会社 糖化ヘモグロビン含有試料の前処理法
WO2017096373A1 (en) * 2015-12-04 2017-06-08 Polymer Technology Systems, Inc. Systems and methods for interference correction from hemoglobin variants
JP6811581B2 (ja) * 2016-10-25 2021-01-13 福井県 人血検査方法及び人血検査用キット
KR20210068048A (ko) 2018-09-28 2021-06-08 세키스이 메디칼 가부시키가이샤 당화 헤모글로빈(％)의 측정 방법
US20200284807A1 (en) 2019-03-05 2020-09-10 Victor Manneh Saturation binding ratiometric assay

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247533A (en) * 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
GB1580318A (en) * 1978-05-06 1980-12-03 Univ Rockefeller Antibodies active against human hemoglobin a1c
JPS5610254A (en) * 1979-07-07 1981-02-02 Wako Pure Chem Ind Ltd New rheumatism factor measuring reagent
US4478744A (en) * 1982-01-25 1984-10-23 Sherwood Medical Company Method of obtaining antibodies
JPS58205854A (ja) * 1982-05-25 1983-11-30 Mihama Hisaharu 潜血反応検査用の固定化抗体
US4629692A (en) * 1982-12-06 1986-12-16 Miles Laboratories, Inc. Immunoassay for nonenzymatically glucosylated proteins and protein fragments an index of glycemia
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse

Also Published As

Publication number Publication date
DK130791D0 (da) 1991-07-04
FI84107C (fi) 1996-04-11
ATE80951T1 (de) 1992-10-15
ES556865A0 (es) 1987-10-16
NZ213959A (en) 1990-03-27
ATE98776T1 (de) 1994-01-15
CA1339952C (en) 1998-07-14
EP0185870A2 (en) 1986-07-02
EP0185870A3 (en) 1986-08-27
FI854187A0 (fi) 1985-10-25
DK130791A (da) 1991-07-04
EP0316306B1 (en) 1993-12-15
IE852655L (en) 1986-04-29
DE3586679T2 (de) 1993-02-18
IE63731B1 (en) 1995-06-14
EP0316306A3 (en) 1989-10-11
JPH0751087A (ja) 1995-02-28
EP0185870B1 (en) 1992-09-23
EP0316306A2 (en) 1989-05-17
DK494085A (da) 1986-04-30
DE3587687T2 (de) 1994-04-07
ES8800435A1 (es) 1987-10-16
ES548270A0 (es) 1987-05-01
FI84107B (fi) 1991-06-28
DE3586679D1 (de) 1992-10-29
DE3587687D1 (de) 1994-01-27
EP0185870B2 (en) 1998-06-17
DE3586679T3 (de) 1998-10-15
DK165327B (da) 1992-11-09
JPS61172064A (ja) 1986-08-02
DK167825B1 (da) 1993-12-20
DK494085D0 (da) 1985-10-28
JP2858534B2 (ja) 1999-02-17
IL76827A (en) 1990-11-29
FI854187L (fi) 1986-04-30
AU594651B2 (en) 1990-03-15
DK165327C (da) 2000-09-11
IL76827A0 (en) 1986-02-28
JPH0723891B2 (ja) 1995-03-15
AU4926085A (en) 1986-05-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070120