DE3587687D1 - Monoklonale Antikörper für HbA1c. - Google Patents

Monoklonale Antikörper für HbA1c.

Info

Publication number
DE3587687D1
DE3587687D1 DE89100369T DE3587687T DE3587687D1 DE 3587687 D1 DE3587687 D1 DE 3587687D1 DE 89100369 T DE89100369 T DE 89100369T DE 3587687 T DE3587687 T DE 3587687T DE 3587687 D1 DE3587687 D1 DE 3587687D1
Authority
DE
Germany
Prior art keywords
binding
antibody reagent
protein
monoclonal antibodies
denaturation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89100369T
Other languages
English (en)
Other versions
DE3587687T2 (de
Inventor
William Knowles
Vincent Marchesi
Wallace Haigh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27505324&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3587687(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/763,193 external-priority patent/US4647654A/en
Priority claimed from US06/779,730 external-priority patent/US4658022A/en
Priority claimed from US06/779,731 external-priority patent/US4727036A/en
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of DE3587687D1 publication Critical patent/DE3587687D1/de
Publication of DE3587687T2 publication Critical patent/DE3587687T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
DE89100369T 1984-10-29 1985-10-17 Monoklonale Antikörper für HbA1c. Expired - Lifetime DE3587687T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66581184A 1984-10-29 1984-10-29
US06/763,193 US4647654A (en) 1984-10-29 1985-08-08 Peptides useful in preparing hemoglobin A1c immunogens
US06/779,730 US4658022A (en) 1985-08-08 1985-09-27 Binding of antibody reagents to denatured protein analytes
US06/779,731 US4727036A (en) 1985-08-08 1985-09-27 Antibodies for use in determining hemoglobin A1c

Publications (2)

Publication Number Publication Date
DE3587687D1 true DE3587687D1 (de) 1994-01-27
DE3587687T2 DE3587687T2 (de) 1994-04-07

Family

ID=27505324

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3586679T Expired - Lifetime DE3586679T3 (de) 1984-10-29 1985-10-17 Immunoassays für denaturierte Proteinanalyte, insbesondere HbAlC und monoklonale Antikörper dafür.
DE89100369T Expired - Lifetime DE3587687T2 (de) 1984-10-29 1985-10-17 Monoklonale Antikörper für HbA1c.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3586679T Expired - Lifetime DE3586679T3 (de) 1984-10-29 1985-10-17 Immunoassays für denaturierte Proteinanalyte, insbesondere HbAlC und monoklonale Antikörper dafür.

Country Status (12)

Country Link
EP (2) EP0185870B2 (de)
JP (2) JPH0723891B2 (de)
AT (2) ATE80951T1 (de)
AU (1) AU594651B2 (de)
CA (1) CA1339952C (de)
DE (2) DE3586679T3 (de)
DK (2) DK167825B1 (de)
ES (2) ES8705633A1 (de)
FI (1) FI84107C (de)
IE (1) IE63731B1 (de)
IL (1) IL76827A (de)
NZ (1) NZ213959A (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206144A (en) * 1985-03-29 1993-04-27 Novo Industri A/S Determination of glycated (glycosylated) hemoglobin in blood
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse
US4797473A (en) * 1986-06-25 1989-01-10 Regents Of The University Of Minnesota Monoclonal antibodies to unreduced, nonenzymatically-glycated proteins
US5173422A (en) * 1986-08-22 1992-12-22 Miles Inc. Monoclonal antibodies specific for human glycoalbumin
US4822747A (en) * 1986-12-09 1989-04-18 Miles Inc. Polyacrylamide gel particles having hapten moieties bound thereto as immunoassay reagent
JPS63273472A (ja) * 1987-04-30 1988-11-10 Asahi Breweries Ltd 新規抗体とそれを用いたヒトヘモグロビンの検出
US4847209A (en) * 1987-11-09 1989-07-11 Miles Inc. Latex agglutination immunoassay in the presence of hemoglobin
US4970171A (en) * 1987-11-09 1990-11-13 Miles Inc. Denaturant reagents for convenient determination of hemoglobin derivatives in blood
DE3806198A1 (de) * 1988-02-04 1989-08-17 Boehringer Mannheim Gmbh Immunogen und seine verwendung zur gewinnung von antikoerpern gegen hba(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)c(pfeil abwaerts)
IL94724A (en) * 1989-07-13 1994-02-27 Miles Inc Decomposition of red blood cells and denaturation of hemoglobin by the use of lithium salts
US5484735A (en) * 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
DE4206932A1 (de) * 1992-03-05 1993-09-09 Boehringer Mannheim Gmbh Immunologische methode zur bestimmung eines haemoglobinderivates
JP2596322B2 (ja) * 1992-06-10 1997-04-02 富士レビオ株式会社 総ヘモグロビンに対する糖化ヘモグロビンの割合の測定方法
AU661207B2 (en) * 1992-11-17 1995-07-13 Boehringer Mannheim Gmbh Simultaneous determination of HbA1c and haemoglobin variants with a glycation analogus to HbA1c
ATE168779T1 (de) * 1993-07-28 1998-08-15 Boehringer Mannheim Gmbh Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon
JP3269765B2 (ja) * 1995-12-14 2002-04-02 富士写真フイルム株式会社 ヘモグロビン誘導体の免疫学的測定方法及びその方法に用いる処理試薬
WO1998047922A2 (en) * 1997-04-21 1998-10-29 Glycozyme, Inc. Determination of recombinant glycosylated proteins and peptides in biological fluids
JPH10332693A (ja) * 1997-05-29 1998-12-18 Tokuyama Corp 被検体の前処理方法
US6455047B1 (en) 1997-09-19 2002-09-24 Serex, Inc. Methods to improve immunogenicity of antigens and specificity of antibodies
AU9549798A (en) * 1997-10-21 1999-05-10 Cranfield University Affinity ligands, their production and use
JPH11258238A (ja) * 1998-03-10 1999-09-24 Tokuyama Corp 免疫学的凝集測定用試薬キット
WO2000008460A1 (fr) * 1998-08-07 2000-02-17 Sekisui Chemical Co., Ltd. Procede de determination d'hemoglobines
JP2002005936A (ja) * 2000-06-26 2002-01-09 Shino Test Corp 酵素免疫測定法による測定試薬及び測定方法
EP1302477B1 (de) * 2000-07-14 2006-09-13 Matsushita Electric Industrial Co., Ltd. Peptid-fruktose und ein komplex davon mit bindendem protein
WO2002088185A2 (en) * 2001-04-26 2002-11-07 Dakocytomation Denmark A/S Pan-specific monoclonal antibody
DE602006007942D1 (de) 2006-02-03 2009-09-03 Mtm Lab Ag Verfahren zur Durchführung eines Denaturierungs-Immunoassays
WO2007140961A1 (en) * 2006-06-06 2007-12-13 Roche Diagnostics Gmbh Differential hemolysis of a whole blood sample
ES2398412T3 (es) * 2006-10-18 2013-03-19 Biomerieux Procedimiento de diagnóstico in vitro de cepas de Staphylococcus aureus productoras de PVL
ATE483974T1 (de) * 2007-06-06 2010-10-15 Hoffmann La Roche Detektion eines analyten in einer hämolysierten vollblutprobe
EP2357199A4 (de) 2008-12-11 2013-02-20 Sekisui Medical Co Ltd ANTIKÖRPER GEGEN N-TERMINUS DER ß-KETTE VON HÄMOGLOBIN
WO2010067612A1 (ja) 2008-12-11 2010-06-17 積水メディカル株式会社 糖化ヘモグロビン含有試料の前処理法
US10670615B2 (en) 2015-12-04 2020-06-02 Polymer Technology Systems, Inc. Systems and methods for interference correction from hemoglobin variants
JP6811581B2 (ja) * 2016-10-25 2021-01-13 福井県 人血検査方法及び人血検査用キット
SG11202103027UA (en) 2018-09-28 2021-04-29 Sekisui Medical Co Ltd Glycated hemoglobin (%) assay method
US20200284807A1 (en) 2019-03-05 2020-09-10 Victor Manneh Saturation binding ratiometric assay

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247533A (en) * 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
GB1580318A (en) * 1978-05-06 1980-12-03 Univ Rockefeller Antibodies active against human hemoglobin a1c
JPS5610254A (en) * 1979-07-07 1981-02-02 Wako Pure Chem Ind Ltd New rheumatism factor measuring reagent
US4478744A (en) * 1982-01-25 1984-10-23 Sherwood Medical Company Method of obtaining antibodies
JPS58205854A (ja) * 1982-05-25 1983-11-30 Mihama Hisaharu 潜血反応検査用の固定化抗体
US4629692A (en) * 1982-12-06 1986-12-16 Miles Laboratories, Inc. Immunoassay for nonenzymatically glucosylated proteins and protein fragments an index of glycemia
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse

Also Published As

Publication number Publication date
DK130791A (da) 1991-07-04
ES8705633A1 (es) 1987-05-01
JPS61172064A (ja) 1986-08-02
ATE98776T1 (de) 1994-01-15
DE3586679D1 (de) 1992-10-29
DE3587687T2 (de) 1994-04-07
JPH0723891B2 (ja) 1995-03-15
CA1339952C (en) 1998-07-14
IL76827A (en) 1990-11-29
EP0185870B2 (de) 1998-06-17
EP0185870A2 (de) 1986-07-02
FI854187L (fi) 1986-04-30
FI84107C (fi) 1996-04-11
EP0316306B1 (de) 1993-12-15
FI84107B (fi) 1991-06-28
DK167825B1 (da) 1993-12-20
DK494085D0 (da) 1985-10-28
DE3586679T3 (de) 1998-10-15
JP2858534B2 (ja) 1999-02-17
NZ213959A (en) 1990-03-27
DK165327B (da) 1992-11-09
AU594651B2 (en) 1990-03-15
ES8800435A1 (es) 1987-10-16
IE63731B1 (en) 1995-06-14
ES556865A0 (es) 1987-10-16
JPH0751087A (ja) 1995-02-28
EP0185870B1 (de) 1992-09-23
EP0316306A3 (en) 1989-10-11
IL76827A0 (en) 1986-02-28
DK130791D0 (da) 1991-07-04
DK494085A (da) 1986-04-30
DE3586679T2 (de) 1993-02-18
ES548270A0 (es) 1987-05-01
AU4926085A (en) 1986-05-08
EP0185870A3 (en) 1986-08-27
FI854187A0 (fi) 1985-10-25
EP0316306A2 (de) 1989-05-17
DK165327C (da) 2000-09-11
IE852655L (en) 1986-04-29
ATE80951T1 (de) 1992-10-15

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: BAYER CORP., PITTSBURGH, PA., US

8328 Change in the person/name/address of the agent

Free format text: MUELLER, ZOBEL, STEILING, 51373 LEVERKUSEN

8365 Fully valid after opposition proceedings