DK1509537T3 - Cellulær akkumulering af phosphonatanaloger af HIV-protease-inhibitorforbindelser og forbindelserne som sådanne - Google Patents
Cellulær akkumulering af phosphonatanaloger af HIV-protease-inhibitorforbindelser og forbindelserne som sådanneInfo
- Publication number
- DK1509537T3 DK1509537T3 DK03747326T DK03747326T DK1509537T3 DK 1509537 T3 DK1509537 T3 DK 1509537T3 DK 03747326 T DK03747326 T DK 03747326T DK 03747326 T DK03747326 T DK 03747326T DK 1509537 T3 DK1509537 T3 DK 1509537T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- hiv protease
- protease inhibitor
- cellular accumulation
- phosphonate analogues
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940122440 HIV protease inhibitor Drugs 0.000 title 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- 230000035567 cellular accumulation Effects 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 108010010369 HIV Protease Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical group [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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US37562202P | 2002-04-26 | 2002-04-26 | |
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US37566502P | 2002-04-26 | 2002-04-26 | |
US37583402P | 2002-04-26 | 2002-04-26 | |
PCT/US2003/012901 WO2003090690A2 (en) | 2002-04-26 | 2003-04-25 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds and the compounds as such |
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DK1509537T3 true DK1509537T3 (da) | 2007-11-12 |
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DK03747326T DK1509537T3 (da) | 2002-04-26 | 2003-04-25 | Cellulær akkumulering af phosphonatanaloger af HIV-protease-inhibitorforbindelser og forbindelserne som sådanne |
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EP (4) | EP1509537B9 (ro) |
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KR (2) | KR100987815B1 (ro) |
CN (4) | CN1656109A (ro) |
AT (1) | ATE367394T1 (ro) |
AU (4) | AU2003231766A1 (ro) |
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