DK0834576T3 - Påvisning af nukleinsyresekvenser - Google Patents
Påvisning af nukleinsyresekvenserInfo
- Publication number
- DK0834576T3 DK0834576T3 DK97116548T DK97116548T DK0834576T3 DK 0834576 T3 DK0834576 T3 DK 0834576T3 DK 97116548 T DK97116548 T DK 97116548T DK 97116548 T DK97116548 T DK 97116548T DK 0834576 T3 DK0834576 T3 DK 0834576T3
- Authority
- DK
- Denmark
- Prior art keywords
- detection
- nucleic acid
- acid sequences
- sequences
- nucleic
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 title 1
Classifications
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
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- G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
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- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
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DK97116541T DK0834575T3 (da) | 1990-12-06 | 1991-12-06 | Identifikation af nucleinsyrer i prøver |
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Families Citing this family (422)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US6040138A (en) * | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US5871928A (en) * | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
US5925525A (en) * | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5547839A (en) * | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
EP0562047A4 (en) * | 1990-12-06 | 1995-11-02 | Affymax Tech Nv | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
ATE262374T1 (de) | 1991-11-22 | 2004-04-15 | Affymetrix Inc | Kombinatorische strategien für polymersynthese |
US6943034B1 (en) | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
US5721099A (en) * | 1992-10-01 | 1998-02-24 | Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US6503759B1 (en) | 1992-10-01 | 2003-01-07 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5795714A (en) * | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
US7258977B1 (en) | 1992-11-27 | 2007-08-21 | Innogenetics N.V. | Process for typing of HCV isolates |
DE69334357D1 (de) | 1992-11-27 | 2011-06-09 | Innogenetics Nv | Nachweis und Typisierung das Hepatitis C Virus (HCV) mittels 5'UTR und NS5 Nukleinsäuresequenzen |
US7001722B1 (en) | 1993-06-22 | 2006-02-21 | Baylor College Of Medicine | Parallel primer extension approach to nucleic acid sequence analysis |
SE501439C2 (sv) * | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
US6153379A (en) * | 1993-06-22 | 2000-11-28 | Baylor College Of Medicine | Parallel primer extension approach to nucleic acid sequence analysis |
US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
WO1995000530A1 (en) | 1993-06-25 | 1995-01-05 | Affymax Technologies N.V. | Hybridization and sequencing of nucleic acids |
US7115364B1 (en) | 1993-10-26 | 2006-10-03 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5650274A (en) * | 1993-06-25 | 1997-07-22 | Hitachi, Ltd. | DNA analyzing method |
US6027880A (en) * | 1995-08-02 | 2000-02-22 | Affymetrix, Inc. | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis |
US5861242A (en) * | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
JPH09508003A (ja) | 1993-07-23 | 1997-08-19 | ハイセック,インコーポレイション | 未知の生物をスクリーニングするための方法 |
CN1525171A (zh) * | 1993-10-01 | 2004-09-01 | ŦԼ�и��ױ��Ǵ�ѧ���� | 用标示物编码的多元组合化学库 |
DE69432424T2 (de) * | 1993-10-21 | 2004-03-18 | Abbott Laboratories, Abbott Park | Vorrichtung und verfahren zum nachweis von zielliganden |
US6045996A (en) * | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
AU8126694A (en) * | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
US6309823B1 (en) | 1993-10-26 | 2001-10-30 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same |
US20060229824A1 (en) | 1993-10-26 | 2006-10-12 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes |
ZA95260B (en) * | 1994-01-13 | 1995-09-28 | Univ Columbia | Synthetic receptors libraries and uses thereof |
US6015880A (en) * | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
US6936477B2 (en) | 1994-04-13 | 2005-08-30 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
WO1995030774A1 (en) * | 1994-05-05 | 1995-11-16 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
US5571639A (en) * | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US6287850B1 (en) | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6558633B1 (en) | 1994-09-21 | 2003-05-06 | Isis Pharmaceuticals, Inc. | Chemical reaction apparatus and methods |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
US6280935B1 (en) | 1994-10-13 | 2001-08-28 | Lynx Therapeutics, Inc. | Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags |
US5604097A (en) * | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
US6974666B1 (en) * | 1994-10-21 | 2005-12-13 | Appymetric, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
US6600996B2 (en) | 1994-10-21 | 2003-07-29 | Affymetrix, Inc. | Computer-aided techniques for analyzing biological sequences |
US5747248A (en) * | 1994-12-05 | 1998-05-05 | Chiron Corporation | Discontinuous probe design using hybritope mapping |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5908926A (en) * | 1995-03-16 | 1999-06-01 | Duke University | 5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group |
US6312894B1 (en) | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
US5753439A (en) * | 1995-05-19 | 1998-05-19 | Trustees Of Boston University | Nucleic acid detection methods |
US5614386A (en) * | 1995-06-23 | 1997-03-25 | Baylor College Of Medicine | Alternative dye-labeled primers for automated DNA sequencing |
US5968740A (en) * | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
US5633724A (en) * | 1995-08-29 | 1997-05-27 | Hewlett-Packard Company | Evanescent scanning of biochemical array |
US5733729A (en) * | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
US6300063B1 (en) | 1995-11-29 | 2001-10-09 | Affymetrix, Inc. | Polymorphism detection |
US6953663B1 (en) | 1995-11-29 | 2005-10-11 | Affymetrix, Inc. | Polymorphism detection |
US7423143B2 (en) | 1996-01-23 | 2008-09-09 | Affymetrix. Inc. | Nucleic acid labeling compounds |
US7291463B2 (en) | 1996-01-23 | 2007-11-06 | Affymetrix, Inc. | Nucleic acid labeling compounds |
US6965020B2 (en) | 1996-01-23 | 2005-11-15 | Affymetrix, Inc. | Nucleic acid labeling compounds |
US7468243B2 (en) | 2001-03-12 | 2008-12-23 | Affymetrix, Inc. | 2-aminopyrimidin-4-one nucleic acid labeling compounds |
US20010018514A1 (en) | 1998-07-31 | 2001-08-30 | Mcgall Glenn H. | Nucleic acid labeling compounds |
US7282327B2 (en) | 1996-01-23 | 2007-10-16 | Affymetrix, Inc. | Nucleic acid labeling compounds |
US6864059B2 (en) | 1996-01-23 | 2005-03-08 | Affymetrix, Inc. | Biotin containing C-glycoside nucleic acid labeling compounds |
US6924094B1 (en) | 1996-02-08 | 2005-08-02 | Affymetrix, Inc. | Chip-based species identification and phenotypic characterization of microorganisms |
JP2000504575A (ja) * | 1996-02-08 | 2000-04-18 | アフィメトリックス,インコーポレイテッド | 微生物のチップベースの種分化および表現型特徴付け |
EP1728875A3 (en) * | 1996-02-08 | 2007-05-09 | Affymetrix, Inc. | Chip-based speciation and phenotypic characterization of microorganisms |
US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
EP2332958B1 (en) | 1996-02-09 | 2016-04-20 | Cornell Research Foundation, Inc. | Detection of nucleic and sequence differences using the ligase detection reaction with addressable arrays |
US6361937B1 (en) | 1996-03-19 | 2002-03-26 | Affymetrix, Incorporated | Computer-aided nucleic acid sequencing |
US5958342A (en) * | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
CA2255774C (en) | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
US6391550B1 (en) | 1996-09-19 | 2002-05-21 | Affymetrix, Inc. | Identification of molecular sequence signatures and methods involving the same |
FR2754344B1 (fr) * | 1996-10-04 | 1998-11-20 | Bio Merieux | Procede et dispositif de traitement par complexation d'un milieu liquide |
US6303301B1 (en) * | 1997-01-13 | 2001-10-16 | Affymetrix, Inc. | Expression monitoring for gene function identification |
US6297006B1 (en) | 1997-01-16 | 2001-10-02 | Hyseq, Inc. | Methods for sequencing repetitive sequences and for determining the order of sequence subfragments |
US20020042048A1 (en) | 1997-01-16 | 2002-04-11 | Radoje Drmanac | Methods and compositions for detection or quantification of nucleic acid species |
US6309824B1 (en) | 1997-01-16 | 2001-10-30 | Hyseq, Inc. | Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes |
US5837475A (en) * | 1997-01-30 | 1998-11-17 | Hewlett-Packard Co. | Apparatus and method for scanning a chemical array |
US5812272A (en) * | 1997-01-30 | 1998-09-22 | Hewlett-Packard Company | Apparatus and method with tiled light source array for integrated assay sensing |
CA2281205A1 (en) | 1997-02-12 | 1998-08-13 | Eugene Y. Chan | Methods and products for analyzing polymers |
US6419883B1 (en) | 1998-01-16 | 2002-07-16 | University Of Washington | Chemical synthesis using solvent microdroplets |
CA2284211A1 (en) | 1997-03-20 | 1998-09-24 | University Of Washington | Solvent for biopolymer synthesis, solvent microdroplets and methods of use |
US6028189A (en) * | 1997-03-20 | 2000-02-22 | University Of Washington | Solvent for oligonucleotide synthesis and methods of use |
US6826296B2 (en) | 1997-07-25 | 2004-11-30 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
US7068830B2 (en) | 1997-07-25 | 2006-06-27 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
US6420108B2 (en) | 1998-02-09 | 2002-07-16 | Affymetrix, Inc. | Computer-aided display for comparative gene expression |
DE69823206T2 (de) | 1997-07-25 | 2004-08-19 | Affymetrix, Inc. (a Delaware Corp.), Santa Clara | Verfahren zur herstellung einer bio-informatik-datenbank |
US6365731B1 (en) | 1997-08-06 | 2002-04-02 | Ambion, Inc. | Stripping nucleic acids with iodine and sodium thiosulfate |
EP1003914A1 (en) * | 1997-08-05 | 2000-05-31 | Ambion, Inc. | Methods and compositions for stripping nucleic acids |
CN1273609A (zh) * | 1997-08-15 | 2000-11-15 | 希斯克有限公司 | 检测或量化核酸物类的方法和组合物 |
US6607878B2 (en) | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
WO1999037816A1 (en) * | 1998-01-26 | 1999-07-29 | Genzyme Corporation | Methods for identifying therapeutic targets |
CA2318175A1 (en) | 1998-02-04 | 1999-08-12 | Invitrogen Corporation | Microarrays and uses therefor |
US6187535B1 (en) | 1998-02-18 | 2001-02-13 | Institut Pasteur | Fast and exhaustive method for selecting a prey polypeptide interacting with a bait polypeptide of interest: application to the construction of maps of interactors polypeptides |
US6127121A (en) | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
US6683173B2 (en) | 1998-04-03 | 2004-01-27 | Epoch Biosciences, Inc. | Tm leveling methods |
US7045610B2 (en) | 1998-04-03 | 2006-05-16 | Epoch Biosciences, Inc. | Modified oligonucleotides for mismatch discrimination |
WO1999051773A1 (en) * | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
US6949367B1 (en) | 1998-04-03 | 2005-09-27 | Epoch Pharmaceuticals, Inc. | Modified oligonucleotides for mismatch discrimination |
US7715989B2 (en) | 1998-04-03 | 2010-05-11 | Elitech Holding B.V. | Systems and methods for predicting oligonucleotide melting temperature (TmS) |
US6355419B1 (en) | 1998-04-27 | 2002-03-12 | Hyseq, Inc. | Preparation of pools of nucleic acids based on representation in a sample |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6699659B2 (en) | 1998-06-01 | 2004-03-02 | Affymetrix, Inc. | Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions |
US6383744B1 (en) * | 1998-07-10 | 2002-05-07 | Incyte Genomics, Inc. | Human checkpoint kinase |
US20030138973A1 (en) * | 1998-07-14 | 2003-07-24 | Peter Wagner | Microdevices for screening biomolecules |
US20020119579A1 (en) * | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
US6780582B1 (en) * | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
US6576478B1 (en) * | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6185561B1 (en) | 1998-09-17 | 2001-02-06 | Affymetrix, Inc. | Method and apparatus for providing and expression data mining database |
US7071324B2 (en) | 1998-10-13 | 2006-07-04 | Brown University Research Foundation | Systems and methods for sequencing by hybridization |
US7034143B1 (en) * | 1998-10-13 | 2006-04-25 | Brown University Research Foundation | Systems and methods for sequencing by hybridization |
US6489096B1 (en) | 1998-10-15 | 2002-12-03 | Princeton University | Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays |
ES2198835T3 (es) * | 1998-11-03 | 2004-02-01 | METASYSTEMS HARD & SOFTWARE GMBH | Procedimiento para la aplicacion selectiva de reactivos sobre material biologico inmovilizado. |
US6861218B2 (en) | 1998-11-03 | 2005-03-01 | Metasystems Hard And Software Gmbh | Method for the targeted application of reagents onto immobilized biological material |
MXPA01005745A (es) | 1998-12-09 | 2003-07-14 | Vistagen Inc | Tipificacion de la toxicidad utilizando cuerpos embrioides. |
US7005256B1 (en) | 1999-03-10 | 2006-02-28 | Cold Spring Harbor Laboratory | Gene chip technology for determining memory genes |
AU782926B2 (en) * | 1999-03-10 | 2005-09-08 | Cold Spring Harbor Laboratory | Gene chip technology for determining memory genes |
US6506594B1 (en) | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US7014994B1 (en) | 1999-03-19 | 2006-03-21 | Cornell Research Foundation,Inc. | Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process |
US20060275782A1 (en) * | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US20030215821A1 (en) * | 1999-04-20 | 2003-11-20 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
WO2000070093A1 (en) * | 1999-05-13 | 2000-11-23 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
BR0011603A (pt) | 1999-05-19 | 2002-03-12 | Advanced Array Technologies S | Método para a identificação e/ou quantificação de um composto alvo obtido a partir de uma amostra biológica sobre chips |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6346423B1 (en) | 1999-07-16 | 2002-02-12 | Agilent Technologies, Inc. | Methods and compositions for producing biopolymeric arrays |
US6339147B1 (en) | 1999-07-29 | 2002-01-15 | Epoch Biosciences, Inc. | Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids |
EP1212599A2 (en) | 1999-08-30 | 2002-06-12 | Illumina, Inc. | Methods for improving signal detection from an array |
US6607885B1 (en) | 1999-10-15 | 2003-08-19 | E. I. Du Pont De Nemours And Company | Method for high-density microarray medicated gene expression profiling |
CA2390305A1 (en) * | 1999-11-03 | 2001-05-10 | Oncotech, Inc. | Methods for cancer prognosis and diagnosis |
US6660845B1 (en) | 1999-11-23 | 2003-12-09 | Epoch Biosciences, Inc. | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
US20040081959A9 (en) | 1999-12-08 | 2004-04-29 | Epoch Biosciences, Inc. | Fluorescent quenching detection reagents and methods |
US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
US8076063B2 (en) * | 2000-02-07 | 2011-12-13 | Illumina, Inc. | Multiplexed methylation detection methods |
US20050214825A1 (en) * | 2000-02-07 | 2005-09-29 | John Stuelpnagel | Multiplex sample analysis on universal arrays |
US7955794B2 (en) * | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
US6770441B2 (en) * | 2000-02-10 | 2004-08-03 | Illumina, Inc. | Array compositions and methods of making same |
EP1944310A3 (en) | 2000-03-01 | 2008-08-06 | Epoch Biosciences, Inc. | Modified oligonucleotides for mismatch discrimination |
DE60142828D1 (de) | 2000-03-01 | 2010-09-30 | Epoch Biosciences Inc | Modifizierte oligonukleotide zur unterscheidung von fehlpaarungen |
WO2001079548A2 (en) | 2000-04-14 | 2001-10-25 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
AU2001259512B2 (en) | 2000-05-04 | 2007-03-01 | Yale University | High density protein arrays for screening of protein activity |
ATE445158T1 (de) | 2000-06-14 | 2009-10-15 | Vistagen Inc | Toxizitätstypisierung unter verwendung von leberstammzellen |
DE10036174B4 (de) | 2000-07-25 | 2006-12-07 | Axaron Bioscience Ag | Verfahren und Vorrichtung zum Analysieren von chemischen oder biologischen Proben |
US6954253B2 (en) * | 2000-07-25 | 2005-10-11 | Scientific Solutions, Inc. | Optical multiplexer and cross-switch using etched liquid crystal fabry-perot etalons |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US6629038B1 (en) * | 2000-09-05 | 2003-09-30 | Yeda Research And Development Co. Ltd. | Method and system for identifying commercially distributed organisms |
AU2002227156A1 (en) | 2000-12-01 | 2002-06-11 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
DE10105339B4 (de) * | 2001-02-05 | 2004-05-13 | november Aktiengesellschaft Gesellschaft für Molekulare Medizin | Verfahren zur fälschungssicheren Markierung, fälschungssichere Markierung und Kit |
EP1360336A2 (en) * | 2001-02-15 | 2003-11-12 | Bayer Corporation | Innate immunity markers for rapid diagnosis of infectious diseases |
JP2004523243A (ja) * | 2001-03-12 | 2004-08-05 | カリフォルニア インスティチュート オブ テクノロジー | 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置 |
WO2002090599A1 (en) | 2001-05-09 | 2002-11-14 | Genetic Id, Inc. | Universal microarray system |
US7196183B2 (en) | 2001-08-31 | 2007-03-27 | Innogenetics N.V. | Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent |
WO2004013290A2 (en) * | 2002-08-05 | 2004-02-12 | Invitrogen Corporation | Compositions and methods for molecular biology |
US20040053315A1 (en) * | 2002-08-12 | 2004-03-18 | Caliper Technologies Corp. | Methods and systems for monitoring molecular interactions |
US20050233473A1 (en) * | 2002-08-16 | 2005-10-20 | Zyomyx, Inc. | Methods and reagents for surface functionalization |
AU2003265583C1 (en) * | 2002-08-20 | 2009-05-21 | Cyvera Corporation | Diffraction grating-based optical identification element |
US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
US7441703B2 (en) * | 2002-08-20 | 2008-10-28 | Illumina, Inc. | Optical reader for diffraction grating-based encoded optical identification elements |
US7164533B2 (en) * | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
WO2004025563A1 (en) * | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
EP1540592A1 (en) * | 2002-09-12 | 2005-06-15 | Cyvera Corporation | Method and apparatus for labeling using diffraction grating-based encoded optical identification elements |
US20100255603A9 (en) | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
US7498176B2 (en) * | 2002-09-27 | 2009-03-03 | Roche Nimblegen, Inc. | Microarray with hydrophobic barriers |
US20040110212A1 (en) * | 2002-09-30 | 2004-06-10 | Mccormick Mark | Microarrays with visual alignment marks |
GB2409454B (en) * | 2002-10-01 | 2007-05-23 | Nimblegen Systems Inc | Microarrays having multiple oligonucleotides in single array features |
US20040259105A1 (en) * | 2002-10-03 | 2004-12-23 | Jian-Bing Fan | Multiplex nucleic acid analysis using archived or fixed samples |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
AU2002952696A0 (en) | 2002-11-14 | 2002-11-28 | Genomics Research Partners Pty Ltd | Status determination |
EP1579005A4 (en) * | 2002-11-15 | 2007-07-25 | Sangamo Biosciences Inc | METHOD AND COMPOSITIONS FOR THE ANALYSIS OF REGULATORY SEQUENCES |
US7250289B2 (en) | 2002-11-20 | 2007-07-31 | Affymetrix, Inc. | Methods of genetic analysis of mouse |
US7314750B2 (en) | 2002-11-20 | 2008-01-01 | Affymetrix, Inc. | Addressable oligonucleotide array of the rat genome |
US7541152B2 (en) | 2002-12-24 | 2009-06-02 | Agilent Technologies, Inc. | Integrated light source for diagnostic arrays |
CA2458085A1 (en) | 2003-03-21 | 2004-09-21 | F. Hoffmann-La Roche Ag | Transcriptional activity assay |
US7833714B1 (en) * | 2003-04-11 | 2010-11-16 | Affymetrix, Inc. | Combinatorial affinity selection |
US20040248323A1 (en) * | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
US20050064462A1 (en) * | 2003-06-17 | 2005-03-24 | Bernd Stein | Methods, compositions, and kits for predicting the effect of compounds on hot flash symptoms |
US7642064B2 (en) | 2003-06-24 | 2010-01-05 | Ventana Medical Systems, Inc. | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest |
ES2596753T3 (es) | 2003-08-29 | 2017-01-11 | Fujirebio Europe N.V. | Nuevo clado del virus de la hepatitis C y secuencias prototipo del mismo |
US8131475B2 (en) | 2003-09-03 | 2012-03-06 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for identifying, diagnosing, and predicting survival of lymphomas |
AU2004271192B2 (en) | 2003-09-03 | 2011-11-17 | Government Of The United States Of America, As Represented By Secretary, Department Of Health And Human Services | Methods for identifying, diagnosing, and predicting survival of lymphomas |
US7365179B2 (en) * | 2003-09-09 | 2008-04-29 | Compass Genetics, Llc | Multiplexed analytical platform |
WO2005029040A2 (en) * | 2003-09-18 | 2005-03-31 | Parallele Biosciences, Inc. | System and methods for enhancing signal-to-noise ratios of microarray-based measurements |
EP1678701A2 (en) * | 2003-10-01 | 2006-07-12 | Board Of Regents The University Of Texas System | Compositions, methods and systems for making and using electronic paper |
US20080297878A1 (en) * | 2003-10-01 | 2008-12-04 | Board Of Regents, The University Of Texas System | Compositions, methods and systems for making and using electronic paper |
US20050227251A1 (en) | 2003-10-23 | 2005-10-13 | Robert Darnell | Method of purifying RNA binding protein-RNA complexes |
WO2005044086A2 (en) * | 2003-10-30 | 2005-05-19 | Tufts-New England Medical Center | Prenatal diagnosis using cell-free fetal dna in amniotic fluid |
JP2007512811A (ja) * | 2003-11-10 | 2007-05-24 | インベスチゲン, インコーポレイテッド | 検出のための核酸を調製する方法 |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
US7439341B2 (en) | 2003-11-14 | 2008-10-21 | Integrated Dna Technologies, Inc. | Fluorescence quenching azo dyes, their methods of preparation and use |
EP1697534B1 (en) | 2003-12-01 | 2010-06-02 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
US8017321B2 (en) | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
US7217522B2 (en) * | 2004-02-12 | 2007-05-15 | Campass Genetics Llc | Genetic analysis by sequence-specific sorting |
US7433123B2 (en) | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
WO2005080605A2 (en) | 2004-02-19 | 2005-09-01 | Helicos Biosciences Corporation | Methods and kits for analyzing polynucleotide sequences |
WO2005111242A2 (en) * | 2004-05-10 | 2005-11-24 | Parallele Bioscience, Inc. | Digital profiling of polynucleotide populations |
US20080090233A1 (en) | 2004-05-27 | 2008-04-17 | The Regents Of The University Of Colorado | Methods for Prediction of Clinical Outcome to Epidermal Growth Factor Receptor Inhibitors by Cancer Patients |
WO2006020363A2 (en) | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
AU2005269527B2 (en) | 2004-07-26 | 2011-12-01 | Pfenex Inc. | Process for improved protein expression by strain engineering |
WO2006014869A1 (en) * | 2004-07-26 | 2006-02-09 | Parallele Bioscience, Inc. | Simultaneous analysis of multiple genomes |
DE102004038163A1 (de) * | 2004-08-06 | 2006-03-16 | Diacdem Chip Technologies Gmbh | Fluoreszenz-basierte Assays zur schnellen, quantitativen Analyse von Biomolekülen (Proteine und Nukleinsäuren) durch Anreicherung auf Zellen oder Beads |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
KR20070053205A (ko) | 2004-09-17 | 2007-05-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 의약 조성물 |
US20060073506A1 (en) | 2004-09-17 | 2006-04-06 | Affymetrix, Inc. | Methods for identifying biological samples |
AU2005296200B2 (en) | 2004-09-17 | 2011-07-14 | Pacific Biosciences Of California, Inc. | Apparatus and method for analysis of molecules |
EP2194485B1 (en) | 2004-11-16 | 2012-10-17 | Illumina, Inc. | Method and apparatus for reading coded microbeads |
US20060183893A1 (en) * | 2005-01-25 | 2006-08-17 | North Don A | Nucleic acids for apoptosis of cancer cells |
WO2006081008A2 (en) * | 2005-01-25 | 2006-08-03 | Sky Genetics, Inc. | Nucleic acids for apoptosis of cancer cells |
US7407757B2 (en) * | 2005-02-10 | 2008-08-05 | Population Genetics Technologies | Genetic analysis by sequence-specific sorting |
US8178291B2 (en) | 2005-02-18 | 2012-05-15 | Monogram Biosciences, Inc. | Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors |
EP2522757A1 (en) | 2005-02-18 | 2012-11-14 | Monogram BioSciences, Inc. | Methods and compositions for determining anti-HIV drug susceptibility and replication capacity of HIV |
WO2006099604A2 (en) * | 2005-03-16 | 2006-09-21 | Compass Genetics, Llc | Methods and compositions for assay readouts on multiple analytical platforms |
US20070020650A1 (en) * | 2005-04-01 | 2007-01-25 | Avak Kahvejian | Methods for detecting proteins |
WO2006127507A2 (en) | 2005-05-20 | 2006-11-30 | Integrated Dna Technologies, Inc. | Compounds and methods for labeling oligonucleotides |
EP2458019A3 (en) | 2005-05-27 | 2012-07-25 | Monogram BioSciences, Inc. | Methods and compositions for determining resistance of HIV-1 to protease inhibitors |
WO2006133266A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods for determining resistance or susceptibility to hiv entry inhibitors |
US8071284B2 (en) * | 2005-06-06 | 2011-12-06 | Monogram Biosciences, Inc. | Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs |
EP1925676A4 (en) | 2005-08-02 | 2010-11-10 | Eisai R&D Man Co Ltd | TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR |
WO2007022335A1 (en) | 2005-08-16 | 2007-02-22 | Merlogen, Llc | Methods for identification of merle gene |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
CN102716490A (zh) * | 2005-09-01 | 2012-10-10 | 卫材R&D管理有限公司 | 药物组合物的崩解性的改善方法 |
WO2007081410A2 (en) * | 2005-09-13 | 2007-07-19 | True Materials Incorporated | Encoded microparticles |
US8178278B2 (en) * | 2005-09-13 | 2012-05-15 | Affymetrix, Inc. | Miniaturized microparticles |
EP1951900B1 (en) | 2005-10-07 | 2016-06-15 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
AU2006309551B2 (en) | 2005-11-07 | 2012-04-19 | Eisai R & D Management Co., Ltd. | Use of combination of anti-angiogenic substance and c-kit kinase inhibitor |
US7889347B2 (en) * | 2005-11-21 | 2011-02-15 | Plexera Llc | Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism |
US7623624B2 (en) * | 2005-11-22 | 2009-11-24 | Illumina, Inc. | Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction |
US7463358B2 (en) | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
US7932037B2 (en) * | 2007-12-05 | 2011-04-26 | Perkinelmer Health Sciences, Inc. | DNA assays using amplicon probes on encoded particles |
US20100009373A1 (en) * | 2005-12-23 | 2010-01-14 | Perkinelmer Health Sciences, Inc. | Methods and compositions relating to multiplex genomic gain and loss assays |
US20090104613A1 (en) * | 2005-12-23 | 2009-04-23 | Perkinelmer Las, Inc. | Methods and compositions relating to multiplexed genomic gain and loss assays |
US7537897B2 (en) * | 2006-01-23 | 2009-05-26 | Population Genetics Technologies, Ltd. | Molecular counting |
US9445025B2 (en) | 2006-01-27 | 2016-09-13 | Affymetrix, Inc. | System, method, and product for imaging probe arrays with small feature sizes |
US20080045471A1 (en) * | 2006-03-27 | 2008-02-21 | North Don A | Nucleic Acids For Apoptosis Of Cancer Cells |
US7285388B1 (en) | 2006-04-07 | 2007-10-23 | Merlogen, Llc | Methods for identification of alport syndrome |
US7888044B2 (en) | 2006-04-10 | 2011-02-15 | Trustees Of Boston University | Melanoma biomarker and methods of uses |
US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
EP2036557B1 (en) * | 2006-05-18 | 2015-10-21 | Eisai R&D Management Co., Ltd. | Antitumor agent for thyroid cancer |
WO2008016562A2 (en) * | 2006-07-31 | 2008-02-07 | Wanli Bi | Nucleic acid amplification using a reversibly modified oligonucleotide |
WO2008026748A1 (fr) * | 2006-08-28 | 2008-03-06 | Eisai R & D Management Co., Ltd. | Agent antitumoral pour cancer gastrique non différencié |
US8962655B2 (en) * | 2007-01-29 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
US9581595B2 (en) | 2007-02-26 | 2017-02-28 | Laboratory Corporation Of America Holdings | Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy |
JP5444553B2 (ja) | 2007-04-27 | 2014-03-19 | フェネックス インコーポレイテッド | 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および/または質が改善されている特定の株を同定する方法 |
US9580719B2 (en) * | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2008136769A1 (en) * | 2007-05-03 | 2008-11-13 | Nanyang Technological University | Online contaminant detection and removal system |
MX2009013410A (es) | 2007-06-08 | 2010-03-22 | Biogen Idec Inc | Biomarcadores para predecir capacidad de respuesta anti-tnf o sin capacidad de respuesta. |
EP2190448B1 (en) | 2007-06-22 | 2016-04-20 | Children's Medical Center Corporation | Methods and uses thereof of a fragment of saposin a |
US20090060786A1 (en) * | 2007-08-29 | 2009-03-05 | Gibum Kim | Microfluidic apparatus for wide area microarrays |
AU2008325608B2 (en) * | 2007-11-09 | 2013-03-14 | Eisai R & D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
US20090299644A1 (en) * | 2008-02-01 | 2009-12-03 | Life Technologies Corporation | System and method for selecting samples from an antibody analysis for display of complete specificity analysis data |
WO2009098485A1 (en) * | 2008-02-07 | 2009-08-13 | Forensic Sciences Service Ltd | Improvements in and relating to analysis |
BRPI0909212A2 (pt) | 2008-03-28 | 2015-08-18 | Pacific Biosciences California | Composições e método para sequeciamento de ácido nucléico |
WO2009137369A1 (en) * | 2008-05-03 | 2009-11-12 | Tufts Medical Center, Inc. | Neonatal salivary genomics |
JP2009268665A (ja) * | 2008-05-07 | 2009-11-19 | Canon Inc | 吸入装置 |
EP2297347B1 (en) | 2008-05-14 | 2017-03-08 | Millennium Pharmaceuticals, Inc. | Methods and kits for monitoring the effects of immunomodulators on adaptive immunity |
TWI460602B (zh) * | 2008-05-16 | 2014-11-11 | Counsyl Inc | 廣用的懷孕前篩檢裝置 |
US20110195064A1 (en) | 2008-06-06 | 2011-08-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Survival predictor for diffuse large b cell lymphoma |
WO2010028366A2 (en) * | 2008-09-05 | 2010-03-11 | Life Technologies Corporation | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
BRPI0919882A8 (pt) | 2008-10-30 | 2017-09-19 | Caris Life Sciences Luxembourg Holdings | Métodos para avaliar padrões de rna |
WO2010091414A2 (en) * | 2009-02-09 | 2010-08-12 | Forensic Science Service Limited | Improvements in and relating to components |
GB2472371B (en) * | 2009-04-24 | 2011-10-26 | Selectamark Security Systems Plc | Synthetic nucleotide containing compositions for use in security marking of property and/or for marking a thief or attacker |
EP2248914A1 (en) | 2009-05-05 | 2010-11-10 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | The use of class IIB restriction endonucleases in 2nd generation sequencing applications |
US20120277112A1 (en) | 2009-10-19 | 2012-11-01 | Stichting Het Nederlands Kanker Instituut | Predicting response to anti-cancer therapy via array comparative genomic hybridization |
US20120316080A1 (en) | 2009-10-19 | 2012-12-13 | Stichting Het Nederlands Kanker Instiuut | Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization |
US20120322677A1 (en) | 2009-10-19 | 2012-12-20 | Stichting Het Nederlands Kanker Instituut | Predicting benefit of anti-cancer therapy via array comparative genomic hybridization |
EP2507220B1 (en) | 2009-12-04 | 2016-10-05 | Biotium Inc. | Heterocycle-substituted xanthene dyes |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
EP3925670A1 (en) | 2009-12-17 | 2021-12-22 | Children's Medical Center, Corp. | Saposin-a derived peptides and uses thereof |
WO2011103467A2 (en) | 2010-02-19 | 2011-08-25 | Life Technologies Corporation | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
EP2553123B1 (en) | 2010-03-26 | 2016-08-24 | Integrated DNA Technologies, Inc. | Methods for enhancing nucleic acid hybridization |
ES2573515T3 (es) | 2010-06-25 | 2016-06-08 | Eisai R&D Management Co., Ltd. | Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados |
JP6053684B2 (ja) | 2010-09-07 | 2016-12-27 | インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド | アンチセンス化合物の修飾 |
JP2013545439A (ja) | 2010-09-17 | 2013-12-26 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 多能性幹細胞の有用性および安全性の特徴決定を行うための機能的ゲノミクスアッセイ |
US20140018251A1 (en) | 2010-09-20 | 2014-01-16 | Stichting Het Nederlands Kanker Instituut | Methods for Predicting Response to Anti-Cancer Therapy in Cancer Patients |
ES2690753T3 (es) | 2010-09-21 | 2018-11-22 | Agilent Technologies, Inc. | Aumento de la confianza en las identificaciones de alelos con el recuento molecular |
US9085800B2 (en) | 2011-03-23 | 2015-07-21 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
US8969003B2 (en) | 2011-03-23 | 2015-03-03 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
RU2580609C2 (ru) | 2011-04-18 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое терапевтическое средство |
EP2714939B1 (en) | 2011-05-24 | 2015-04-15 | Elitech Holding B.V. | Detection of methicillin-resistant staphylococcus aureus |
ES2705950T3 (es) | 2011-06-03 | 2019-03-27 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
EP2723865B1 (en) | 2011-06-21 | 2019-03-27 | Alnylam Pharmaceuticals, Inc. | METHODS FOR DETERMINING ACTIVITY OF RNAi IN A SUBJECT |
EP2724156B1 (en) | 2011-06-27 | 2017-08-16 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
WO2013055911A1 (en) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Znf365/zfp365 biomarker predictive of anti-cancer response |
WO2013063481A1 (en) | 2011-10-28 | 2013-05-02 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to nae inhibitors |
JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
CA2855356A1 (en) | 2011-11-11 | 2013-05-16 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
MX354547B (es) | 2011-11-14 | 2018-03-09 | Alfasigma Spa | Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión. |
AU2012358269B2 (en) | 2011-12-22 | 2017-11-02 | Children's Medical Center Corporation | Saposin-A derived peptides and uses thereof |
ES2663234T3 (es) | 2012-02-27 | 2018-04-11 | Cellular Research, Inc | Composiciones y kits para recuento molecular |
US11177020B2 (en) | 2012-02-27 | 2021-11-16 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
WO2013128281A1 (en) | 2012-02-28 | 2013-09-06 | Population Genetics Technologies Ltd | Method for attaching a counter sequence to a nucleic acid sample |
WO2013149258A2 (en) | 2012-03-30 | 2013-10-03 | Charles Drew University of Medicine and Science | Compositions and methods for treating or preventing metabolic syndrome disorders |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
ES2906714T3 (es) | 2012-09-04 | 2022-04-20 | Guardant Health Inc | Métodos para detectar mutaciones raras y variación en el número de copias |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
WO2014055543A2 (en) | 2012-10-01 | 2014-04-10 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods to predict response to inhibitors and uses thereof |
EP2937337A4 (en) | 2012-12-21 | 2016-06-22 | Eisai R&D Man Co Ltd | AMORPHIC FORM OF CHINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
EP2971086A1 (en) | 2013-03-14 | 2016-01-20 | ELITechGroup B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
US20140274747A1 (en) | 2013-03-15 | 2014-09-18 | Illumina, Inc. | Super resolution imaging |
US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
NZ714049A (en) | 2013-05-14 | 2020-05-29 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
EP3008229B1 (en) | 2013-06-10 | 2020-05-27 | President and Fellows of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
KR102291045B1 (ko) | 2013-08-05 | 2021-08-19 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
AU2014312208B2 (en) | 2013-08-28 | 2019-07-25 | Becton, Dickinson And Company | Massively parallel single cell analysis |
US9501796B2 (en) * | 2013-09-18 | 2016-11-22 | Chicago Mercantile Exchange Inc. | Dataset intersection determination |
EP3055676A1 (en) | 2013-10-07 | 2016-08-17 | Cellular Research, Inc. | Methods and systems for digitally counting features on arrays |
US10607717B2 (en) | 2013-11-06 | 2020-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for subtyping lymphoma types by means of expression profiling |
ES2822125T3 (es) | 2013-12-28 | 2021-04-29 | Guardant Health Inc | Métodos y sistemas para detectar variantes genéticas |
EP3134546A4 (en) | 2014-04-24 | 2017-12-06 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
JP6684230B2 (ja) | 2014-06-19 | 2020-04-22 | メモリアル スローン ケタリング キャンサー センター | Ezh2阻害剤への応答についてのバイオマーカー |
EP3169691B1 (en) | 2014-07-17 | 2020-09-02 | The Trustees Of The University Of Pennsylvania | Methods for using exosomes to monitor transplanted organ status |
TWI721954B (zh) | 2014-08-28 | 2021-03-21 | 日商衛材R&D企管股份有限公司 | 高純度喹啉衍生物及其生產方法 |
CA2963091A1 (en) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
JP6941561B2 (ja) | 2014-10-09 | 2021-09-29 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 免疫障害を処置するための複数の可変il−2用量レジメン |
SI3224376T2 (sl) * | 2014-11-28 | 2023-07-31 | Uniqure Ip B.V. | DNA nečistoče v sestavku, ki obsega parvovirusni virion |
TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
EP3250588A1 (en) | 2015-01-29 | 2017-12-06 | Board of Trustees of Michigan State University | Cryptic polypeptides and uses thereof |
CA2975855A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
ES2824700T3 (es) | 2015-02-19 | 2021-05-13 | Becton Dickinson Co | Análisis unicelular de alto rendimiento que combina información proteómica y genómica |
RU2017128583A (ru) | 2015-02-25 | 2019-03-25 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способ ослабления горечи хинолинового производного |
US9727810B2 (en) | 2015-02-27 | 2017-08-08 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
CA2978226A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharpe & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
AU2016229238B2 (en) | 2015-03-06 | 2022-06-02 | Dana-Farber Cancer Institute, Inc. | PD-L2 biomarkers predictive of PD-1 pathway inhibitor responses in esophagogastric cancers |
CN107406888A (zh) | 2015-03-30 | 2017-11-28 | 赛卢拉研究公司 | 用于组合条形编码的方法和组合物 |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
CN107580632B (zh) | 2015-04-23 | 2021-12-28 | 贝克顿迪金森公司 | 用于全转录组扩增的方法和组合物 |
US11124823B2 (en) | 2015-06-01 | 2021-09-21 | Becton, Dickinson And Company | Methods for RNA quantification |
AU2016279474B2 (en) | 2015-06-16 | 2021-09-09 | Eisai R&D Management Co., Ltd. | Anticancer agent |
JP6940484B2 (ja) | 2015-09-11 | 2021-09-29 | セルラー リサーチ, インコーポレイテッド | ライブラリー正規化のための方法および組成物 |
US10844373B2 (en) | 2015-09-18 | 2020-11-24 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
JP7075896B2 (ja) | 2016-04-20 | 2022-05-26 | アメリカ合衆国 | マントル細胞リンパ腫の評価及びそれに関連する方法 |
ES2956757T3 (es) | 2016-05-02 | 2023-12-27 | Becton Dickinson Co | Codificación con códigos de barras moleculares precisa |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
EP3465502B1 (en) | 2016-05-26 | 2024-04-10 | Becton, Dickinson and Company | Molecular label counting adjustment methods |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
GB2568444A (en) | 2016-08-22 | 2019-05-15 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
AU2017332721B2 (en) | 2016-09-20 | 2023-11-09 | Sara BUHRLAGE | Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators |
US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
KR102522023B1 (ko) | 2016-09-26 | 2023-04-17 | 셀룰러 리서치, 인크. | 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정 |
JP7232180B2 (ja) | 2016-11-08 | 2023-03-02 | ベクトン・ディキンソン・アンド・カンパニー | 発現プロファイル分類の方法 |
WO2018089377A1 (en) | 2016-11-08 | 2018-05-17 | Cellular Research, Inc. | Methods for cell label classification |
CA3047128A1 (en) | 2016-12-16 | 2018-06-21 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
ES2961580T3 (es) | 2017-01-13 | 2024-03-12 | Cellular Res Inc | Revestimiento hidrófilo de canales de fluidos |
US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
CA3054303A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
WO2018226293A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
US11820822B2 (en) | 2017-06-06 | 2023-11-21 | Dana-Farber Cancer Institute, Inc. | Methods for sensitizing cancer cells to T cell-mediated killing by modulating molecular pathways |
WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
EP3638814B8 (en) | 2017-06-14 | 2023-06-21 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Method for determining lymphoma type |
JP2020536504A (ja) | 2017-09-11 | 2020-12-17 | ツイスト バイオサイエンス コーポレーション | Gpcr結合タンパク質およびその合成 |
PL3681884T3 (pl) | 2017-09-11 | 2022-11-14 | Cyteir Therapeutics, Inc. | Inhibitory RAD51 |
WO2019079769A1 (en) | 2017-10-20 | 2019-04-25 | Twist Bioscience Corporation | HEATED NANOWELLS FOR THE SYNTHESIS OF POLYNUCLEOTIDES |
MX2020004507A (es) | 2017-11-09 | 2020-08-13 | Alnylam Pharmaceuticals Inc | Ensayos y métodos para determinar la expresión del gen de quimiotaxina 2 derivada de leucocitos (lect2). |
WO2019094798A1 (en) | 2017-11-10 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for promoting or inducing hair growth |
WO2019109016A1 (en) | 2017-12-01 | 2019-06-06 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods for treatment with nae inhibitors |
US11946095B2 (en) | 2017-12-19 | 2024-04-02 | Becton, Dickinson And Company | Particles associated with oligonucleotides |
AU2019205269A1 (en) | 2018-01-04 | 2020-07-30 | Twist Bioscience Corporation | DNA-based digital information storage |
CN112567246A (zh) | 2018-01-25 | 2021-03-26 | 比奥根Ma公司 | 治疗脊髓性肌萎缩症的方法 |
CN112272710A (zh) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | 高通量多组学样品分析 |
EP3788170A1 (en) | 2018-05-03 | 2021-03-10 | Becton, Dickinson and Company | Molecular barcoding on opposite transcript ends |
SG11202011467RA (en) | 2018-05-18 | 2020-12-30 | Twist Bioscience Corp | Polynucleotides, reagents, and methods for nucleic acid hybridization |
CN112805389A (zh) | 2018-10-01 | 2021-05-14 | 贝克顿迪金森公司 | 确定5’转录物序列 |
WO2020071457A1 (en) | 2018-10-05 | 2020-04-09 | Eisai R&D Management Co., Ltd. | Biomarkers for a combination therapy comprising lenvatinib and everolimus |
US20210333281A1 (en) | 2018-10-05 | 2021-10-28 | Eisai R&D Management Co., Ltd. | Biomarkers for a therapy comprising a sorafenib compound |
CN112969789A (zh) | 2018-11-08 | 2021-06-15 | 贝克顿迪金森公司 | 使用随机引发的单细胞全转录组分析 |
WO2020123384A1 (en) | 2018-12-13 | 2020-06-18 | Cellular Research, Inc. | Selective extension in single cell whole transcriptome analysis |
US11371076B2 (en) | 2019-01-16 | 2022-06-28 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
CN113574178A (zh) | 2019-01-23 | 2021-10-29 | 贝克顿迪金森公司 | 与抗体关联的寡核苷酸 |
US20220128578A1 (en) | 2019-02-12 | 2022-04-28 | Biogen Ma Inc. | Biomarkers of progressive multifocal leukoencephalopathy |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
CN113766930A (zh) | 2019-02-26 | 2021-12-07 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
EP3938358A4 (en) | 2019-03-12 | 2022-12-21 | Cyteir Therapeutics, Inc. | RAD51 INHIBITORS |
TW202102215A (zh) | 2019-03-25 | 2021-01-16 | 美商賽堤爾醫療公司 | Rad51及parp抑制劑之組合 |
US11965208B2 (en) | 2019-04-19 | 2024-04-23 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
US20220289854A1 (en) | 2019-04-30 | 2022-09-15 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents |
CN114514023A (zh) | 2019-06-21 | 2022-05-17 | 赛泰尔治疗公司 | 使用rad51抑制剂治疗胰腺癌的方法 |
EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | BARCODE-BASED NUCLEIC ACID SEQUENCE ARRANGEMENT |
CN114051534A (zh) | 2019-07-22 | 2022-02-15 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
EP4029020A4 (en) | 2019-09-13 | 2023-09-20 | 23Andme, Inc. | METHODS AND SYSTEMS FOR DETERMINING AND DISPLAYING PEDIGREES |
EP4055160B1 (en) | 2019-11-08 | 2024-04-10 | Becton Dickinson and Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
EP4090763A1 (en) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
AU2021231802A1 (en) | 2020-03-03 | 2022-10-06 | Cyteir Therapeutics, Inc. | The RAD51 inhibitor Compound 67A (2301085-06-1) at a specific dosage for treating cancer |
US20230235379A1 (en) | 2020-04-30 | 2023-07-27 | Dimensiongen | Devices and methods for macromolecular manipulation |
CN115605614A (zh) | 2020-05-14 | 2023-01-13 | 贝克顿迪金森公司(Us) | 用于免疫组库谱分析的引物 |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
WO2022035729A1 (en) | 2020-08-10 | 2022-02-17 | Dimensiongen | Devices and methods for multi-dimensional genome analysis |
US20240024377A1 (en) | 2020-10-29 | 2024-01-25 | Evelo Biosciences, Inc. | Compositions comprising spirulina components |
WO2022109343A1 (en) | 2020-11-20 | 2022-05-27 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
CN117425674A (zh) | 2021-03-02 | 2024-01-19 | 丹娜法伯癌症研究院 | 治疗红细胞疾患的方法 |
EP4074820A1 (en) | 2021-04-16 | 2022-10-19 | The Trustees of The University of Pennsylvania | Micro-engineered models of the human eye and methods of use |
WO2022251166A2 (en) | 2021-05-25 | 2022-12-01 | Evelo Biosciences, Inc. | Bacterial compositions comprising soy hemoglobin |
WO2022261183A2 (en) | 2021-06-08 | 2022-12-15 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating and/or identifying an agent for treating intestinal cancers |
WO2023097119A2 (en) | 2021-11-29 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to modulate riok2 |
GB202208171D0 (en) | 2022-06-01 | 2022-07-13 | Institute Of Cancer Res | Method |
Family Cites Families (356)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US559720A (en) * | 1896-05-05 | Island | ||
US3077780A (en) * | 1961-11-21 | 1963-02-19 | Metrimpex Magyar Mueszeripari | Volumetric liquid-transfer device |
US3862056A (en) | 1967-12-15 | 1975-01-21 | Allied Chem | Semiconductor polymer compositions comprising a grafted block copolymer of synthetic rubber and polyolefin and carbon black |
US3861886A (en) * | 1968-11-13 | 1975-01-21 | Melpar Inc | Material identification coding methods and systems |
US3646346A (en) * | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
IL33640A (en) * | 1969-01-16 | 1973-05-31 | Kabi Ab | Test strip packaged-unit |
US3730884A (en) * | 1971-04-02 | 1973-05-01 | B Burns | Method and apparatus for conveying sewage |
US3730844A (en) * | 1971-08-27 | 1973-05-01 | Purdue Research Foundation | Polynucleotide analysis |
DE2150691C2 (de) | 1971-10-12 | 1982-09-09 | Basf Ag, 6700 Ludwigshafen | Lichtempfindliches Gemisch und Verwendung eines lichtempfindlichen Gemisches zur Herstellung einer Flachdruckplatte |
DE2242394A1 (de) | 1972-08-29 | 1974-03-14 | Basf Ag | Unter lichteinwirkung haertbare stoffgemische |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
JPS6112373B2 (xx) * | 1974-09-04 | 1986-04-08 | Hitachi Ltd | |
US4001583A (en) * | 1974-10-04 | 1977-01-04 | Barrett M James | Covalently bound biological substances to plastic materials and use in radioassay |
SE407115B (sv) | 1975-10-06 | 1979-03-12 | Kabi Ab | Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner |
US4238757A (en) | 1976-03-19 | 1980-12-09 | General Electric Company | Field effect transistor for detection of biological reactions |
US4259223A (en) * | 1976-03-29 | 1981-03-31 | California Institute Of Technology | Cross-linked polyvinyl pyridine coated glass particle catalyst support and aqueous composition or polyvinyl pyridine adducted microspheres |
US4145406A (en) * | 1977-04-11 | 1979-03-20 | Miles Laboratories, Inc. | Specific binding - adsorbent assay method and test means |
US4086254A (en) * | 1977-04-13 | 1978-04-25 | The Upjohn Company | Photocleavable steroids |
US4121222A (en) * | 1977-09-06 | 1978-10-17 | A. B. Dick Company | Drop counter ink replenishing system |
US4180739A (en) | 1977-12-23 | 1979-12-25 | Varian Associates, Inc. | Thermostatable flow cell for fluorescence measurements |
US4267234A (en) * | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
US4448534A (en) | 1978-03-30 | 1984-05-15 | American Hospital Corporation | Antibiotic susceptibility testing |
US4204929A (en) * | 1978-04-18 | 1980-05-27 | University Patents, Inc. | Isoelectric focusing method |
US4269933A (en) | 1978-06-08 | 1981-05-26 | E. I. Du Pont De Nemours And Company | Methods of developing photopolymerizable compositions containing an 0-nitroaromatic compound as photoinhibitor |
US4216245A (en) * | 1978-07-25 | 1980-08-05 | Miles Laboratories, Inc. | Method of making printed reagent test devices |
US4258001A (en) * | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
US4427415A (en) * | 1979-01-05 | 1984-01-24 | Cleveland Patrick H | Manifold vacuum biochemical test method and device |
US4314821A (en) | 1979-04-09 | 1982-02-09 | Minnesota Mining And Manufacturing Company | Sandwich immunoassay using piezoelectric oscillator |
US4263504A (en) * | 1979-08-01 | 1981-04-21 | Ncr Corporation | High density matrix code |
US4342905A (en) | 1979-08-31 | 1982-08-03 | Nippon Kogaku K.K. | Automatic focusing device of a microscope |
US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4327073A (en) | 1980-04-07 | 1982-04-27 | Huang Henry V | Automated method for quantitative analysis of biological fluids |
US4444892A (en) | 1980-10-20 | 1984-04-24 | Malmros Mark K | Analytical device having semiconductive organic polymeric element associated with analyte-binding substance |
US4325913A (en) * | 1980-10-20 | 1982-04-20 | Coulter Electronics, Inc. | Reagent probe and method for fabrication thereof |
IL61351A (en) | 1980-10-27 | 1983-12-30 | Yeda Res & Dev | Organometallic polymers,their preparation and compositions of co-ordination compounds containing them |
US4378333A (en) * | 1980-12-11 | 1983-03-29 | Laipply Thomas C | Device for preparing blood smears on glass slides and method therefor |
US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
AR231590A1 (es) | 1981-04-29 | 1984-12-28 | Ciba Geigy Ag | Dispositivo de analisis inmunologico y procedimiento para obtenerlo |
US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
US4339528A (en) | 1981-05-19 | 1982-07-13 | Rca Corporation | Etching method using a hardened PVA stencil |
JPS57192856A (en) * | 1981-05-25 | 1982-11-27 | Ngk Insulators Ltd | Oxygen concentration detector |
US4732847A (en) * | 1981-06-09 | 1988-03-22 | University Of Hawaii | Monoclonal antibodies for DNA-RNA hybrid complexes and their uses |
US4430299A (en) * | 1981-06-18 | 1984-02-07 | Coulter Electronics, Inc. | Apparatus for monitoring chemical reactions |
US4498774A (en) * | 1981-07-22 | 1985-02-12 | Iowa State University Research Foundation, Inc. | Micro-polarimeter for high performance liquid chromatography |
US5087558A (en) * | 1981-09-25 | 1992-02-11 | Webster John A Jr | Method for identifying and characterizing organisms |
FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
US4444878A (en) | 1981-12-21 | 1984-04-24 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
JPS58189558A (ja) | 1982-04-28 | 1983-11-05 | Mochida Pharmaceut Co Ltd | 免疫学的測定用容器 |
US4500919A (en) * | 1982-05-04 | 1985-02-19 | Massachusetts Institute Of Technology | Color reproduction system |
US4483920A (en) | 1982-05-17 | 1984-11-20 | Hahnemann University | Immobilization of message RNA directly from cells onto filter material |
US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
US4624915A (en) | 1982-07-29 | 1986-11-25 | Board Of Trustees Of Michigan State University | Positive selection sorting of cells |
JPS5927900A (ja) * | 1982-08-09 | 1984-02-14 | Wakunaga Seiyaku Kk | 固定化オリゴヌクレオチド |
US5599720A (en) * | 1982-08-27 | 1997-02-04 | Multilyte Limited | Measurement of analyte concentration |
US4722906A (en) | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
US4845027B1 (en) * | 1982-10-13 | 1994-05-10 | Biowhittaker Inc | Fluorometric assay of allergic reactions |
US4588682A (en) * | 1982-12-13 | 1986-05-13 | Integrated Genetics, Inc. | Binding nucleic acid to a support |
CA1237645A (en) * | 1982-12-21 | 1988-06-07 | John H. Fisher | Assay technique |
US4516833A (en) | 1982-12-27 | 1985-05-14 | University Of Dayton | Production of high performance optical spatial filters |
US4487839A (en) * | 1983-01-05 | 1984-12-11 | Ortho Diagnostic Systems Inc. | Immunoassay methods employing patterns for the detection of soluble and cell surface antigens |
DE3301833A1 (de) | 1983-01-20 | 1984-07-26 | Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig | Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US4575433A (en) * | 1983-01-31 | 1986-03-11 | Iowa State University Research Foundation, Inc. | Method of generating chemiluminescent light |
US4634574A (en) * | 1983-01-31 | 1987-01-06 | Iowa State Research Foundation, Inc. | Apparatus for use in sulfide chemiluminescence detection |
US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
US4537861A (en) | 1983-02-03 | 1985-08-27 | Elings Virgil B | Apparatus and method for homogeneous immunoassay |
US4584277A (en) | 1983-04-05 | 1986-04-22 | Syntex (U.S.A.) Inc. | Fluorescent multiparameter particle analysis |
GB8311018D0 (en) * | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
US4652533A (en) * | 1983-04-28 | 1987-03-24 | Pandex Laboratories, Inc. | Method of solid phase immunoassay incorporating a luminescent label |
US4533682A (en) * | 1983-04-29 | 1985-08-06 | Desoto, Inc. | Imidazolidine-blocked amine polymers |
GB8314523D0 (en) | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
US4517338A (en) | 1983-06-20 | 1985-05-14 | Chiron Corporation | Multiple reactor system and method for polynucleotide synthesis |
US4987065A (en) | 1983-07-05 | 1991-01-22 | Enzo Biochem, Inc. | In vivo labelling of polynucleotide sequences |
US4542102A (en) | 1983-07-05 | 1985-09-17 | Molecular Diagnostics, Inc. | Coupling of nucleic acids to solid support by photochemical methods |
US4713326A (en) | 1983-07-05 | 1987-12-15 | Molecular Diagnostics, Inc. | Coupling of nucleic acids to solid support by photochemical methods |
US4626684A (en) | 1983-07-13 | 1986-12-02 | Landa Isaac J | Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples |
US4737454A (en) * | 1983-07-14 | 1988-04-12 | Molecular Diagnostics, Inc. | Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays |
US5200313A (en) * | 1983-08-05 | 1993-04-06 | Miles Inc. | Nucleic acid hybridization assay employing detectable anti-hybrid antibodies |
US4677054A (en) | 1983-08-08 | 1987-06-30 | Sloan-Kettering Institute For Cancer Research | Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization |
US4719615A (en) | 1983-08-22 | 1988-01-12 | Optical Data, Inc. | Erasable optical data storage medium |
US4598049A (en) * | 1983-08-31 | 1986-07-01 | Systec Inc. | General purpose gene synthesizer |
US4746490A (en) * | 1983-09-22 | 1988-05-24 | Saneii Hossain H | Solid phase peptide synthesizer |
US4569967A (en) | 1983-10-24 | 1986-02-11 | The Salk Institute For Biological Studies | Synthesis of N-substituted peptide amides |
US4580895A (en) | 1983-10-28 | 1986-04-08 | Dynatech Laboratories, Incorporated | Sample-scanning photometer |
US4849513A (en) | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
US5821058A (en) * | 1984-01-16 | 1998-10-13 | California Institute Of Technology | Automated DNA sequencing technique |
US4613566A (en) | 1984-01-23 | 1986-09-23 | President And Fellows Of Harvard College | Hybridization assay and kit therefor |
JPS60155942A (ja) * | 1984-01-25 | 1985-08-16 | Fuji Photo Film Co Ltd | 液体試料点着装置 |
FI71768C (fi) | 1984-02-17 | 1987-02-09 | Orion Yhtymae Oy | Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning. |
GB8405437D0 (en) * | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
US4668476A (en) * | 1984-03-23 | 1987-05-26 | Applied Biosystems, Inc. | Automated polypeptide synthesis apparatus |
US4704353A (en) | 1984-04-27 | 1987-11-03 | Molecular Devices Corporation | Photoresponsive redox detection and discrimination |
DE3565986D1 (en) | 1984-05-02 | 1988-12-08 | Brendan James Hamill | An apparatus for the chemical synthesis of oligonucleotides |
US4766062A (en) * | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
US4670380A (en) * | 1984-05-23 | 1987-06-02 | Molecular Diagnostics, Inc. | Assays utilizing labeled nucleic acid probes |
US4555490A (en) | 1984-06-08 | 1985-11-26 | The United States Of America As Represented By The Department Of Health And Human Services | Rapid visualization system for gel electrophoresis |
US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
US4738669A (en) * | 1984-08-24 | 1988-04-19 | Vlock D G | Fluid dispenser using capillary action |
US4755458A (en) | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
US4563417A (en) * | 1984-08-31 | 1986-01-07 | Miles Laboratories, Inc. | Nucleic acid hybridization assay employing antibodies to intercalation complexes |
US4681859A (en) | 1984-09-21 | 1987-07-21 | Ortho Diagnostic Systems Inc. | Fluorescence polarization immunoassay for heavy antigens |
FR2571147B1 (fr) * | 1984-10-01 | 1986-11-14 | Commissariat Energie Atomique | Automate programmable pour effectuer le depot en position precise sur un support d'analyse d'une infime quantite precise de liquide |
US5258506A (en) | 1984-10-16 | 1993-11-02 | Chiron Corporation | Photolabile reagents for incorporation into oligonucleotide chains |
US4586546A (en) * | 1984-10-23 | 1986-05-06 | Cetus Corporation | Liquid handling device and method |
DE3440141A1 (de) | 1984-11-02 | 1986-05-07 | Heiner Dipl.-Chem. Dr. 8000 München Eckert | Verwendung von kohlensaeure-bis-trichlormethylester als proreagens fuer phosgen |
US4820630A (en) | 1984-11-23 | 1989-04-11 | Digene Diagnostics, Incorporated | Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels |
US4719179A (en) * | 1984-11-30 | 1988-01-12 | Pharmacia P-L Biochemicals, Inc. | Six base oligonucleotide linkers and methods for their use |
US5064754A (en) * | 1984-12-14 | 1991-11-12 | Mills Randell L | Genomic sequencing method |
US5026840A (en) | 1985-01-10 | 1991-06-25 | Molecular Diagnostics, Inc. | Photochemical nucleic acid-labeling reagent having a polyalklamine spacer |
US4713347A (en) | 1985-01-14 | 1987-12-15 | Sensor Diagnostics, Inc. | Measurement of ligand/anti-ligand interactions using bulk conductance |
US4767700A (en) * | 1985-02-15 | 1988-08-30 | Beckman Research Institute Of The City Of Hope | Detection of particular nucleotide sequences |
US5096807A (en) * | 1985-03-06 | 1992-03-17 | Murex Corporation | Imaging immunoassay detection system with background compensation and its use |
US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US6040166A (en) * | 1985-03-28 | 2000-03-21 | Roche Molecular Systems, Inc. | Kits for amplifying and detecting nucleic acid sequences, including a probe |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
DE3513168A1 (de) | 1985-04-12 | 1986-10-16 | Thomas 8000 München Dandekar | Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren) |
US4654165A (en) * | 1985-04-16 | 1987-03-31 | Micro Tracers, Inc. | Microingredient containing tracer |
DE3684030D1 (de) * | 1985-04-19 | 1992-04-09 | Fuji Photo Film Co Ltd | Signalverarbeitungsverfahren um die reihenfolge der basen von nukleinsaeure festzustellen. |
NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
US4797355A (en) * | 1985-06-13 | 1989-01-10 | Amgen Inc. | Methods for attaching polynucleotides to supports |
FR2583772B1 (fr) | 1985-06-20 | 1987-08-28 | Roussel Uclaf | Nouveaux supports, la preparation de ces supports, les intermediaires nouveaux obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus |
FR2584090B1 (fr) | 1985-06-27 | 1987-08-28 | Roussel Uclaf | Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus |
US4719087A (en) * | 1985-07-01 | 1988-01-12 | Baxter Travenol Laboratories, Inc. | Tray for analyzing system |
FR2584498B1 (fr) * | 1985-07-02 | 1987-10-16 | Centre Nat Rech Scient | Dispositif pour detecter sur une feuille de nitrocellulose la presence de complexes macromoleculaires, tels que antigenes/anticorps et procede de mise en oeuvre. |
EP0212807A3 (en) | 1985-07-15 | 1988-01-07 | Imperial Chemical Industries Plc | Coloured compound containing a cationic group and a reactive group |
DD254998A1 (de) | 1985-07-26 | 1988-03-16 | Zeiss Jena Veb Carl | Anordnung zur bildlichen darstellung und analyse von fluoreszenzsignalen |
US5164598A (en) * | 1985-08-05 | 1992-11-17 | Biotrack | Capillary flow device |
JPS63500400A (ja) | 1985-08-05 | 1988-02-12 | レエイクスニフエルシテイト レイデン | 標識高分子、その製法および免疫学または免疫細胞化学検定に対する使用 |
JPS6242057A (ja) * | 1985-08-19 | 1987-02-24 | Fuji Photo Film Co Ltd | 核酸の塩基配列決定のための信号処理方法 |
EP0213825A3 (en) * | 1985-08-22 | 1989-04-26 | Molecular Devices Corporation | Multiple chemically modulated capacitance |
US4806312A (en) * | 1985-08-28 | 1989-02-21 | Miles Inc. | Multizone analytical element having detectable signal concentrating zone |
US4731335A (en) * | 1985-09-13 | 1988-03-15 | Fisher Scientific Company | Method for treating thin samples on a surface employing capillary flow |
US4725536A (en) * | 1985-09-19 | 1988-02-16 | Genetics Institute, Inc. | Reagent polynucleotide complex with multiple target binding regions, and kit and methods |
US4725537A (en) * | 1985-09-19 | 1988-02-16 | Allied Corporation | Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage |
US4806631A (en) * | 1985-09-30 | 1989-02-21 | Miles Inc. | Immobilization of nucleic acids on solvolyzed nylon supports |
US4806546A (en) * | 1985-09-30 | 1989-02-21 | Miles Inc. | Immobilization of nucleic acids on derivatized nylon supports |
TW203120B (xx) * | 1985-10-04 | 1993-04-01 | Abbott Lab | |
IT1206532B (it) * | 1985-10-15 | 1989-04-27 | Marcucci Francesco | Metodo allergodiagnostico mucosale e relativo dispositivo per il rilievo in vivo delle ige specifiche e totali |
SE450171B (sv) * | 1985-10-18 | 1987-06-09 | Carl Urban Ungerstedt | Anordning for automatisk uppsamling av sma vetskevolymer |
US4888278A (en) | 1985-10-22 | 1989-12-19 | University Of Massachusetts Medical Center | In-situ hybridization to detect nucleic acid sequences in morphologically intact cells |
US4741043B1 (en) * | 1985-11-04 | 1994-08-09 | Cell Analysis Systems Inc | Method of and apparatus for image analyses of biological specimens |
US4822566A (en) | 1985-11-19 | 1989-04-18 | The Johns Hopkins University | Optimized capacitive sensor for chemical analysis and measurement |
US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
US4637861A (en) | 1985-12-16 | 1987-01-20 | Allied Corporation | Stabilized, lipid membrane-based device and method of analysis |
US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
EP0235526A3 (de) * | 1986-01-29 | 1988-03-23 | Leipziger Arzneimittelwerk GmbH | Aktivierte Polymerfestkörper und Verfahren zu ihrer Herstellung |
US4855225A (en) | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
JPH0685387B2 (ja) | 1986-02-14 | 1994-10-26 | 株式会社東芝 | 位置合わせ方法 |
US4916056A (en) * | 1986-02-18 | 1990-04-10 | Abbott Laboratories | Solid-phase analytical device and method for using same |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
US5348855A (en) | 1986-03-05 | 1994-09-20 | Miles Inc. | Assay for nucleic acid sequences in an unpurified sample |
EP0240729A3 (en) * | 1986-03-05 | 1988-08-24 | Fuji Photo Film Co., Ltd. | Method of analyzing autoradiograph for determining base sequence of nucleic acid |
US4925785A (en) | 1986-03-07 | 1990-05-15 | Biotechnica Diagnostics, Inc. | Nucleic acid hybridization assays |
US4728591A (en) | 1986-03-07 | 1988-03-01 | Trustees Of Boston University | Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures |
US5310893A (en) | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
US5567809A (en) | 1986-03-13 | 1996-10-22 | Hoffmann-La Roche Inc. | Methods and reagents for HLA DRbeta DNA typing |
US5604099A (en) * | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
US4894796A (en) * | 1986-03-17 | 1990-01-16 | Westinghouse Electric Corp. | Automatic transfer switch with programmable display |
JPH0833320B2 (ja) * | 1986-03-20 | 1996-03-29 | 株式会社東芝 | 自動化学分析装置 |
US4906439A (en) * | 1986-03-25 | 1990-03-06 | Pb Diagnostic Systems, Inc. | Biological diagnostic device and method of use |
US5256549A (en) | 1986-03-28 | 1993-10-26 | Chiron Corporation | Purification of synthetic oligomers |
US5153319A (en) | 1986-03-31 | 1992-10-06 | University Patents, Inc. | Process for preparing polynucleotides |
US4981783A (en) | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
US4846552A (en) | 1986-04-16 | 1989-07-11 | The United States Of America As Represented By The Secretary Of The Air Force | Method of fabricating high efficiency binary planar optical elements |
US4811218A (en) * | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
US4808508A (en) | 1986-07-01 | 1989-02-28 | Hoechst Celanese Corporation | Negative working color proofing process comprising diazo compound and polyvinyl acetal/polyvinyl alcohol/polyvinyl acetate resin |
CA1340806C (en) * | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
US4786684A (en) | 1986-08-21 | 1988-11-22 | The Mount Sinai School Of Medicine Of The City University Of New York | Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis |
GB8621337D0 (en) * | 1986-09-04 | 1986-10-15 | Agricultural Genetics Co | Non-radioactive nucleic acid hybridization probes |
US5021550A (en) | 1986-10-07 | 1991-06-04 | Thomas Jefferson University | Method for preventing deletion sequences in solid phase synthesis |
GB8624637D0 (en) | 1986-10-14 | 1986-11-19 | Emi Plc Thorn | Electrical device |
US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
US4877745A (en) * | 1986-11-17 | 1989-10-31 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
US5028525A (en) | 1986-11-24 | 1991-07-02 | Regents Of The University Of California | Method of preparing and applying single stranded DNA probes to double stranded target DNAs in situ |
JPS63167313A (ja) | 1986-12-27 | 1988-07-11 | Hitachi Ltd | 自動焦点制御方法 |
JPH0664057B2 (ja) * | 1987-01-06 | 1994-08-22 | 富士写真フイルム株式会社 | オ−トラジオグラフ解析のための信号処理方法 |
US4762881A (en) | 1987-01-09 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Photoreactive benzoylphenylalanines and related peptides |
US5077085A (en) * | 1987-03-06 | 1991-12-31 | Schnur Joel M | High resolution metal patterning of ultra-thin films on solid substrates |
US5079600A (en) | 1987-03-06 | 1992-01-07 | Schnur Joel M | High resolution patterning on solid substrates |
US4794150A (en) | 1987-03-11 | 1988-12-27 | Samuel Steel | Synthesis of peptide analogs |
US5026773A (en) | 1987-03-11 | 1991-06-25 | Samuel Steel | Apparatus for a solid phase synthesis of peptide analogs |
US5037882A (en) * | 1987-03-11 | 1991-08-06 | Steel Samuel L | Synthesis of oligonucleotide analogs |
US4829010A (en) * | 1987-03-13 | 1989-05-09 | Tanox Biosystems, Inc. | Immunoassay device enclosing matrixes of antibody spots for cell determinations |
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US5202231A (en) * | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US5100777A (en) * | 1987-04-27 | 1992-03-31 | Tanox Biosystems, Inc. | Antibody matrix device and method for evaluating immune status |
US4997521A (en) * | 1987-05-20 | 1991-03-05 | Massachusetts Institute Of Technology | Electrostatic micromotor |
SE458968B (sv) * | 1987-06-16 | 1989-05-22 | Wallac Oy | Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser |
US4880750A (en) * | 1987-07-09 | 1989-11-14 | Miragen, Inc. | Individual-specific antibody identification methods |
DE3722958A1 (de) * | 1987-07-11 | 1989-01-19 | Heinrich Dr Klefenz | Verfahren zur identifizierung und/oder isolierung spezifischer molekuele bzw. molekuelpopulationen |
US4874500A (en) | 1987-07-15 | 1989-10-17 | Sri International | Microelectrochemical sensor and sensor array |
US4921805A (en) * | 1987-07-29 | 1990-05-01 | Life Technologies, Inc. | Nucleic acid capture method |
GB8803000D0 (en) * | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
US5149625A (en) * | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
CA1321488C (en) * | 1987-08-22 | 1993-08-24 | Martin Francis Finlan | Biological sensors |
US4923901A (en) | 1987-09-04 | 1990-05-08 | Millipore Corporation | Membranes with bound oligonucleotides and peptides |
US5011770A (en) * | 1987-09-04 | 1991-04-30 | Molecular Devices, Inc. | DNA detection method |
US5089000A (en) * | 1987-09-18 | 1992-02-18 | John M. Agee | Surgical method and instrument therefor |
US5006464A (en) * | 1987-10-01 | 1991-04-09 | E-Y Laboratories, Inc. | Directed flow diagnostic device and method |
US4981985A (en) | 1987-10-20 | 1991-01-01 | Trustees Of The University Of Pennsylvania | Synthesis of photolabile chelators for multivalent cations |
US4886741A (en) | 1987-12-09 | 1989-12-12 | Microprobe Corporation | Use of volume exclusion agents for the enhancement of in situ hybridization |
US5306510A (en) * | 1988-01-14 | 1994-04-26 | Cyberlab, Inc. | Automated pipetting system |
US4844617A (en) | 1988-01-20 | 1989-07-04 | Tencor Instruments | Confocal measuring microscope with automatic focusing |
US5093245A (en) * | 1988-01-26 | 1992-03-03 | Applied Biosystems | Labeling by simultaneous ligation and restriction |
US5082830A (en) | 1988-02-26 | 1992-01-21 | Enzo Biochem, Inc. | End labeled nucleotide probe |
GB8810400D0 (en) * | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US4946942A (en) | 1988-03-11 | 1990-08-07 | Bioresearch, Inc. | Urethane-protected amino acid-N-carboxyanhydrides |
US4986942A (en) * | 1988-03-22 | 1991-01-22 | Outboard Marine Corporation | Method for forming ported cylinder sleeve liner foam pattern |
US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
US4996646A (en) * | 1988-03-31 | 1991-02-26 | Square D Company | Microprocessor-controlled circuit breaker and system |
IL89964A0 (en) * | 1988-04-15 | 1989-12-15 | Montefiore Med Center | Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same |
US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
US5013669A (en) * | 1988-06-01 | 1991-05-07 | Smithkline Diagnostics, Inc. | Mass producible biologically active solid phase devices |
US5204268A (en) * | 1988-06-02 | 1993-04-20 | Fuji Photo Film Co., Ltd. | Method and apparatus for applying liquid samples |
US5047321A (en) * | 1988-06-15 | 1991-09-10 | Becton Dickinson & Co. | Method for analysis of cellular components of a fluid |
DE3923165A1 (de) | 1988-07-15 | 1990-01-18 | Hitachi Ltd | Magnetplattenvorrichtung |
US5094939A (en) * | 1988-07-19 | 1992-03-10 | Fujirebio, Inc. | Chemiluminescence assays using stabilized dioxetane derivatives |
US5281540A (en) * | 1988-08-02 | 1994-01-25 | Abbott Laboratories | Test array for performing assays |
US5075077A (en) | 1988-08-02 | 1991-12-24 | Abbott Laboratories | Test card for performing assays |
US5188963A (en) * | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
US4992383A (en) | 1988-08-05 | 1991-02-12 | Porton Instruments, Inc. | Method for protein and peptide sequencing using derivatized glass supports |
US5206137A (en) | 1988-09-08 | 1993-04-27 | Lifecodes Corporation | Compositions and methods useful for genetic analysis |
GB8822228D0 (en) * | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
FR2638848B1 (fr) * | 1988-11-04 | 1993-01-22 | Chemunex Sa | Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination |
SE8804074D0 (sv) * | 1988-11-10 | 1988-11-10 | Pharmacia Ab | Sensorenhet och dess anvaendning i biosensorsystem |
US5200051A (en) | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5869237A (en) * | 1988-11-15 | 1999-02-09 | Yale University | Amplification karyotyping |
US5215889A (en) | 1988-11-18 | 1993-06-01 | The Regents Of The University Of California | Catalytic and reactive polypeptides and methods for their preparation and use |
US5489507A (en) | 1988-11-30 | 1996-02-06 | Perkin-Elmer Corporation | DNA detection by color complementation |
US5047524A (en) | 1988-12-21 | 1991-09-10 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
US5077210A (en) | 1989-01-13 | 1991-12-31 | Eigler Frances S | Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent |
US4984857A (en) * | 1989-01-17 | 1991-01-15 | Iowa State University Research Foundation, Inc. | Linearization of scan velocity of resonant vibrating-mirror beam deflectors |
CA2047191A1 (en) | 1989-02-17 | 1990-08-18 | Hendrik M. Geysen | Method for the use and synthesis of peptides |
US5081584A (en) | 1989-03-13 | 1992-01-14 | United States Of America | Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide |
JPH02299598A (ja) * | 1989-04-14 | 1990-12-11 | Ro Inst For Molecular Genetics & Geneteic Res | 微視的サイズの別個の粒子と結合している核酸試料中のごく短い配列の全部または一部のオリゴヌクレチドプローブとのハイブリダイゼーションによる決定法 |
US5112962A (en) | 1989-04-19 | 1992-05-12 | Northwestern University | Labile anchors for solid phase polynucleotide synthesis |
DK0477220T3 (da) | 1989-05-22 | 1996-10-21 | Hoffmann La Roche | Fremgangsmåde til mærkning og sporing af materialer med nukleinsyrer |
US5219726A (en) * | 1989-06-02 | 1993-06-15 | The Salk Institute For Biological Studies | Physical mapping of complex genomes |
US5871928A (en) * | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
US6309822B1 (en) * | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
US6919211B1 (en) * | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5547839A (en) * | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US6955915B2 (en) * | 1989-06-07 | 2005-10-18 | Affymetrix, Inc. | Apparatus comprising polymers |
US6379895B1 (en) * | 1989-06-07 | 2002-04-30 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5279558A (en) * | 1989-06-16 | 1994-01-18 | Science Incorporated | Fluid delivery apparatus with an additive |
FR2649518B1 (fr) * | 1989-07-07 | 1991-10-18 | Bioprobe Systems Sa | Procede et dispositif de marquage crypte de haute securite pour la protection d'objets de valeur |
GB2233654A (en) | 1989-07-07 | 1991-01-16 | Nat Res Dev | Immobilised polynucleotides |
DE3924454A1 (de) | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
US5141813A (en) | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
US5196305A (en) * | 1989-09-12 | 1993-03-23 | Eastman Kodak Company | Diagnostic and amplification methods using primers having thymine at 3' end to overcome primer-target mismatch at the 3' end |
US5232829A (en) | 1989-09-29 | 1993-08-03 | Hoffmann-La Roche Inc. | Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes |
US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
US5297288A (en) * | 1989-11-28 | 1994-03-22 | United States Biochemical Corporation | System for use with a high resolution scanner for scheduling a sequence of software tools for determining the presence of bands in DNA sequencing samples |
US5215882A (en) | 1989-11-30 | 1993-06-01 | Ortho Diagnostic Systems, Inc. | Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays |
US5282490A (en) * | 1989-12-18 | 1994-02-01 | Higgs Robert E | Flow metering injection controller |
US5091652A (en) | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
US5192407A (en) * | 1990-01-30 | 1993-03-09 | Iowa State University Research Foundation, Inc. | Means and method of detection in chemical separation procedures |
US6506558B1 (en) * | 1990-03-07 | 2003-01-14 | Affymetrix Inc. | Very large scale immobilized polymer synthesis |
US5094594A (en) * | 1990-04-23 | 1992-03-10 | Genomyx, Incorporated | Piezoelectric pumping device |
US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
US5494810A (en) * | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
DK0455905T3 (da) * | 1990-05-11 | 1998-12-07 | Microprobe Corp | Dipsticks til nukleinsyrehybridiseringsassays og fremgangsmåde til kovalent immobilisering af oligonukleotider |
US5100626A (en) * | 1990-05-24 | 1992-03-31 | Levin Andrew E | Binding assay device with removable cassette and manifold |
US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
GB9014263D0 (en) | 1990-06-27 | 1990-08-15 | Dixon Arthur E | Apparatus and method for spatially- and spectrally- resolvedmeasurements |
US5306641A (en) | 1990-07-27 | 1994-04-26 | Saccocio Edward J | Apparatus and method for determining gel rate of polymerizable compositions |
DE4024544A1 (de) * | 1990-08-02 | 1992-02-06 | Boehringer Mannheim Gmbh | Analyseelement und verfahren zu seiner herstellung |
US5235028A (en) | 1990-08-31 | 1993-08-10 | University Of Minnesota | Polyethylene glycol derivatives for solid-phase applications |
US5491224A (en) * | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
US5384262A (en) * | 1990-11-30 | 1995-01-24 | Quantix Systems, L.P. | Quantitative immunoassay for volatile organic compounds |
EP0562047A4 (en) * | 1990-12-06 | 1995-11-02 | Affymax Tech Nv | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
RU1794088C (ru) | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени |
US5380489A (en) * | 1992-02-18 | 1995-01-10 | Eastman Kodak Company | Element and method for nucleic acid amplification and detection using adhered probes |
US5491570A (en) * | 1991-07-26 | 1996-02-13 | Accuwave Corporation | Methods and devices for using photorefractive materials at infrared wavelengths |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
EP0773227A1 (en) * | 1991-09-18 | 1997-05-14 | Affymax Technologies N.V. | Diverse collections of oligomers in use to prepare drugs, diagnostic reagents, pesticides or herbicides |
US5291763A (en) * | 1991-09-18 | 1994-03-08 | Cuisinot Charles P | Universal lock for quick release mechanism |
US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
US5733731A (en) * | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
US5556961A (en) | 1991-11-15 | 1996-09-17 | Foote; Robert S. | Nucleosides with 5'-O-photolabile protecting groups |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
ATE262374T1 (de) * | 1991-11-22 | 2004-04-15 | Affymetrix Inc | Kombinatorische strategien für polymersynthese |
US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
US6864101B1 (en) * | 1991-11-22 | 2005-03-08 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
US6943034B1 (en) * | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5382514A (en) * | 1992-03-31 | 1995-01-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | In vivo angiogenesis assay |
US5667667A (en) | 1992-04-24 | 1997-09-16 | Isis Innovation Limited | Electrochemical treatment of surfaces |
US5728802A (en) * | 1992-05-06 | 1998-03-17 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) |
US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
GB9218131D0 (en) * | 1992-08-26 | 1992-10-14 | Slater James H | A method of marking a liquid |
US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5807683A (en) | 1992-11-19 | 1998-09-15 | Combichem, Inc. | Combinatorial libraries and methods for their use |
US5491074A (en) * | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
US6864048B2 (en) * | 1993-04-28 | 2005-03-08 | Affymetrix, Inc. | Factorial chemical libraries |
WO1995000530A1 (en) * | 1993-06-25 | 1995-01-05 | Affymax Technologies N.V. | Hybridization and sequencing of nucleic acids |
GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
DE69434520T3 (de) * | 1993-07-30 | 2009-10-15 | Affymax, Inc., Palo Alto | Biotinylierung von proteinen |
US5382512A (en) * | 1993-08-23 | 1995-01-17 | Chiron Corporation | Assay device with captured particle reagent |
CA2174140C (en) | 1993-10-28 | 2004-04-06 | Kenneth L. Beattie | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
US5503805A (en) * | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US5591578A (en) * | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
ZA95260B (en) | 1994-01-13 | 1995-09-28 | Univ Columbia | Synthetic receptors libraries and uses thereof |
US5880096A (en) * | 1994-02-02 | 1999-03-09 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5608035A (en) * | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5861476A (en) * | 1994-02-02 | 1999-01-19 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5727098A (en) * | 1994-09-07 | 1998-03-10 | Jacobson; Joseph M. | Oscillating fiber optic display and imager |
US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US6974666B1 (en) | 1994-10-21 | 2005-12-13 | Appymetric, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5776737A (en) * | 1994-12-22 | 1998-07-07 | Visible Genetics Inc. | Method and composition for internal identification of samples |
US5599695A (en) * | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
US6673533B1 (en) * | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
US5690894A (en) | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5707806A (en) | 1995-06-07 | 1998-01-13 | Genzyme Corporation | Direct sequence identification of mutations by cleavage- and ligation-associated mutation-specific sequencing |
US5777888A (en) | 1995-08-09 | 1998-07-07 | Regents Of The University Of California | Systems for generating and analyzing stimulus-response output signal matrices |
US5698393A (en) | 1995-08-18 | 1997-12-16 | Abbott Laboratories | Method for elimination of rheumatoid factor interference in diagnostic assays |
US5871697A (en) | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
US5861071A (en) * | 1995-11-21 | 1999-01-19 | Alconex Specialty Products, Inc. | Electrically insulated magnet wire and method of making the same |
US5641634A (en) | 1995-11-30 | 1997-06-24 | Mandecki; Wlodek | Electronically-indexed solid-phase assay for biomolecules |
US5846839A (en) * | 1995-12-22 | 1998-12-08 | Glaxo Group Limited | Methods for hard-tagging an encoded synthetic library |
US6060240A (en) | 1996-12-13 | 2000-05-09 | Arcaris, Inc. | Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom |
US5896047A (en) * | 1997-02-05 | 1999-04-20 | Xilinx, Inc. | Balanced truth-and-complement circuit |
US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
US6306643B1 (en) * | 1998-08-24 | 2001-10-23 | Affymetrix, Inc. | Methods of using an array of pooled probes in genetic analysis |
US6346423B1 (en) * | 1999-07-16 | 2002-02-12 | Agilent Technologies, Inc. | Methods and compositions for producing biopolymeric arrays |
US6171797B1 (en) * | 1999-10-20 | 2001-01-09 | Agilent Technologies Inc. | Methods of making polymeric arrays |
EP1299722A1 (en) * | 2000-07-03 | 2003-04-09 | Merck & Co., Inc. | Methods for encoding combinatorial libraries |
US7492462B2 (en) * | 2006-01-17 | 2009-02-17 | Honeywell International, Inc. | Optochemical sensor |
-
1991
- 1991-12-06 EP EP92904971A patent/EP0562047A4/en not_active Withdrawn
- 1991-12-06 AU AU12482/92A patent/AU1248292A/en not_active Abandoned
- 1991-12-06 EP EP97116548A patent/EP0834576B1/en not_active Revoked
- 1991-12-06 WO PCT/US1991/009226 patent/WO1992010588A1/en not_active Application Discontinuation
- 1991-12-06 EP EP01204634A patent/EP1231282A3/en not_active Ceased
- 1991-12-06 DK DK97116548T patent/DK0834576T3/da active
- 1991-12-06 DK DK97116541T patent/DK0834575T3/da active
- 1991-12-06 DE DE69132905T patent/DE69132905T2/de not_active Expired - Fee Related
- 1991-12-06 DE DE69132843T patent/DE69132843T2/de not_active Revoked
- 1991-12-06 EP EP97116541A patent/EP0834575B1/en not_active Revoked
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1998
- 1998-10-08 HK HK98111142A patent/HK1010218A1/xx not_active IP Right Cessation
- 1998-10-08 HK HK98111143A patent/HK1010219A1/xx not_active IP Right Cessation
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2000
- 2000-06-02 US US09/585,556 patent/US6544739B1/en not_active Expired - Fee Related
- 2000-09-27 US US09/670,563 patent/US6451536B1/en not_active Expired - Fee Related
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2001
- 2001-01-25 US US09/768,626 patent/US6576424B2/en not_active Expired - Fee Related
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2002
- 2002-03-18 US US10/098,484 patent/US20030119011A1/en not_active Abandoned
- 2002-03-18 US US10/098,485 patent/US20030104411A1/en not_active Abandoned
- 2002-03-22 US US10/102,915 patent/US20050170340A9/en not_active Abandoned
- 2002-03-22 US US10/102,774 patent/US20050009014A9/en not_active Abandoned
- 2002-04-19 US US10/125,460 patent/US20020155492A1/en not_active Abandoned
- 2002-04-19 US US10/125,530 patent/US20050053928A9/en not_active Abandoned
- 2002-04-19 US US10/125,428 patent/US20020155491A1/en not_active Abandoned
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2003
- 2003-10-28 US US10/694,536 patent/US20040248147A1/en not_active Abandoned
- 2003-10-28 US US10/694,541 patent/US20040067521A1/en not_active Abandoned
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2004
- 2004-11-22 US US10/992,782 patent/US20050158743A1/en not_active Abandoned
- 2004-11-22 US US10/993,432 patent/US20050112676A1/en not_active Abandoned
- 2004-11-22 US US10/992,772 patent/US20050164249A1/en not_active Abandoned
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