US5466823A
(en)
*
|
1993-11-30 |
1995-11-14 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides
|
US6492411B1
(en)
|
1993-11-30 |
2002-12-10 |
G. D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
|
US6716991B1
(en)
*
|
1993-11-30 |
2004-04-06 |
G. D. Searle & Co. |
Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
|
JPH10509140A
(ja)
*
|
1994-11-08 |
1998-09-08 |
エーザイ株式会社 |
ピラゾール誘導体
|
US6429221B1
(en)
*
|
1994-12-30 |
2002-08-06 |
Celgene Corporation |
Substituted imides
|
EP0828717B1
(en)
*
|
1995-05-25 |
2002-09-04 |
G.D. SEARLE & CO. |
Method of preparing 3-haloalkyl-1h-pyrazoles
|
EP0828718A1
(en)
|
1995-06-02 |
1998-03-18 |
G.D. SEARLE & CO. |
Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
|
WO1996041645A1
(en)
*
|
1995-06-12 |
1996-12-27 |
G.D. Searle & Co. |
Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations
|
US5700816A
(en)
*
|
1995-06-12 |
1997-12-23 |
Isakson; Peter C. |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
|
US6136839A
(en)
*
|
1995-06-12 |
2000-10-24 |
G. D. Searle & Co. |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
|
US5968974A
(en)
|
1995-07-19 |
1999-10-19 |
Merck & Co., Inc. |
Method of treating colonic adenomas
|
US6593361B2
(en)
|
1995-07-19 |
2003-07-15 |
Merck & Co Inc |
Method of treating colonic adenomas
|
US5756529A
(en)
*
|
1995-09-29 |
1998-05-26 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
|
GB9520584D0
(en)
*
|
1995-10-09 |
1995-12-13 |
Fujisawa Pharmaceutical Co |
Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
|
CA2234633A1
(en)
*
|
1995-10-17 |
1997-04-24 |
G.D. Searle & Co. |
Method of detecting cyclooxygenase-2
|
DE69709069T2
(de)
|
1996-02-13 |
2002-07-04 |
Searle & Co |
Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten
|
PT880362E
(pt)
*
|
1996-02-13 |
2005-10-31 |
Searle & Co |
Composicoes compreendendo um inibidor do cicloxigenase tipo 2 e um antagonista do receptor do leucotrieno b4
|
DK0880363T3
(da)
|
1996-02-13 |
2003-01-20 |
Searle & Co |
Kombinationer der omfatter en cyclooxygenase-2 hæmmer samt en leukotrien A4 hydrolasehæmmer, som har immunsuppressive virkninger
|
US5908858A
(en)
*
|
1996-04-05 |
1999-06-01 |
Sankyo Company, Limited |
1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
|
EP0892791B1
(en)
|
1996-04-12 |
2003-03-05 |
G.D. Searle & Co. |
N-[[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL]PHENYL]SULFONYLPROPYLAMIDE and its SODIUMSALT AS PRODRUGS OF COX-2 INHIBITORS
|
US5677318A
(en)
*
|
1996-07-11 |
1997-10-14 |
Merck Frosst Canada, Inc. |
Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
|
TWI235060B
(en)
*
|
1996-10-15 |
2005-07-01 |
Searle & Co |
Pharmaceutical compositions comprising substituted pyrazolyl benzenesulfonamide derivatives for use in treating or preventing an epithelial cell-derived neoplasia
|
IT1287174B1
(it)
*
|
1996-11-15 |
1998-08-04 |
Angelini Ricerche Spa |
Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono
|
TR199901703T2
(xx)
*
|
1996-11-19 |
2000-07-21 |
G.D. Searle & Co. |
Siklooksijenaz-2 inhibit�rlerini anti-anjiyojenik ajanlar olarak kullanma y�ntemi.
|
EP0971714B1
(en)
*
|
1997-04-03 |
2002-10-09 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia
|
IL132163A0
(en)
*
|
1997-04-18 |
2001-03-19 |
Searle & Co |
Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders
|
US20040072889A1
(en)
*
|
1997-04-21 |
2004-04-15 |
Pharmacia Corporation |
Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
|
AUPO941497A0
(en)
*
|
1997-09-24 |
1997-10-16 |
Fujisawa Pharmaceutical Co., Ltd. |
Novel compounds
|
AU750356B2
(en)
*
|
1997-09-24 |
2002-07-18 |
Fujisawa Pharmaceutical Co., Ltd. |
1,5-diphenylpyrazole derivatives
|
FR2769311B1
(fr)
*
|
1997-10-07 |
1999-12-24 |
Union Pharma Scient Appl |
Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique
|
US5972986A
(en)
*
|
1997-10-14 |
1999-10-26 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
|
AUPP042397A0
(en)
*
|
1997-11-18 |
1997-12-11 |
Fujisawa Pharmaceutical Co., Ltd. |
5-arylpyrazole compounds
|
US6025353A
(en)
*
|
1997-11-19 |
2000-02-15 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
|
NZ333399A
(en)
|
1997-12-24 |
2000-05-26 |
Sankyo Co |
Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
|
AU3387999A
(en)
*
|
1998-04-08 |
1999-10-25 |
Abbott Laboratories |
Pyrazole inhibitors of cytokine production
|
US6727238B2
(en)
*
|
1998-06-11 |
2004-04-27 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
US6294558B1
(en)
|
1999-05-31 |
2001-09-25 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
USRE39708E1
(en)
|
1998-08-07 |
2007-06-26 |
Chiron Corporation |
Estrogen receptor modulators
|
ES2234324T3
(es)
*
|
1998-11-02 |
2005-06-16 |
MERCK & CO., INC. |
Combinaciones de un agonista 5ht1b/1d y un inhibidor selectivo de cox-2 para el tratamiento de la migraña.
|
SA99191255B1
(ar)
*
|
1998-11-30 |
2006-11-25 |
جي دي سيرل اند كو |
مركبات سيليكوكسيب celecoxib
|
US6858598B1
(en)
|
1998-12-23 |
2005-02-22 |
G. D. Searle & Co. |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
US6833373B1
(en)
|
1998-12-23 |
2004-12-21 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
US6649645B1
(en)
|
1998-12-23 |
2003-11-18 |
Pharmacia Corporation |
Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
|
US20040122011A1
(en)
*
|
1998-12-23 |
2004-06-24 |
Pharmacia Corporation |
Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
|
US20010024664A1
(en)
*
|
1999-03-19 |
2001-09-27 |
Obukowicz Mark G. |
Selective COX-2 inhibition from edible plant extracts
|
AU4308300A
(en)
*
|
1999-05-03 |
2000-11-17 |
Dr. Reddy's Research Foundation |
Pyrazoles having antiinflammatory activity
|
IL136025A0
(en)
*
|
1999-05-14 |
2001-05-20 |
Pfizer Prod Inc |
Combination therapy for the treatment of migraine
|
JP2002544229A
(ja)
*
|
1999-05-17 |
2002-12-24 |
アイレックス オンコロジー, インコーポレイテッド |
癌の化学的予防および治療のために組み合わせたdfmoおよびセレコキシブ
|
CO5190664A1
(es)
|
1999-06-30 |
2002-08-29 |
Pfizer Prod Inc |
Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2
|
DE60001623T2
(de)
|
1999-12-03 |
2003-12-18 |
Pfizer Prod Inc |
Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
|
CA2392931A1
(en)
|
1999-12-03 |
2001-06-07 |
Pfizer Products Inc. |
Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
|
ES2208227T3
(es)
|
1999-12-03 |
2004-06-16 |
Pfizer Products Inc. |
Compuestos de heteroarilfenilpirazol como agentes antiinflamatorios/analgesicos.
|
DK1104758T3
(da)
|
1999-12-03 |
2003-10-20 |
Pfizer Prod Inc |
Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler
|
CN1376146B
(zh)
*
|
1999-12-08 |
2011-04-06 |
法马西亚公司 |
提高了生物利用率的雪列柯西的固态形式
|
UA74539C2
(en)
*
|
1999-12-08 |
2006-01-16 |
Pharmacia Corp |
Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
|
CZ20012875A3
(cs)
*
|
1999-12-08 |
2002-02-13 |
Pharmacia Corporation |
Polymorfní krystalické formy celecoxibu
|
KR100793668B1
(ko)
*
|
1999-12-08 |
2008-01-10 |
파마시아 코포레이션 |
강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브
|
WO2001045703A1
(en)
|
1999-12-23 |
2001-06-28 |
Nitromed, Inc. |
Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
|
EP1268486A2
(en)
*
|
2000-03-31 |
2003-01-02 |
Takeda Chemical Industries, Ltd. |
Fused heterocyclic derivatives, their production and use
|
WO2001081332A2
(en)
*
|
2000-04-25 |
2001-11-01 |
Pharmacia Corporation |
2-fluorobenzenesulfonyl compounds for the treatment of inflammation
|
US6403629B2
(en)
*
|
2000-05-02 |
2002-06-11 |
J.B. Chemical And Pharmaceuticals Limited |
Heterocyclic compounds for therapeutic use
|
AR035642A1
(es)
|
2000-05-26 |
2004-06-23 |
Pharmacia Corp |
Uso de una composicion de celecoxib para el alivio rapido del dolor
|
CA2411960C
(en)
*
|
2000-06-13 |
2010-10-12 |
Wyeth |
Analgesic and anti-inflammatory compositions containing cox-2 inhibitors
|
TR200001872A3
(tr)
*
|
2000-06-26 |
2002-01-21 |
Fako Ilaclari A.S |
4-[5-(4-Metilfenil-3-(triflorometil)-1H-pirazol-1-il] benzensulfonamit' in yeni kristal biçimi "Biçim I" ve bu ürünün üretilmesine iliskin yöntem.
|
WO2002005848A2
(en)
*
|
2000-07-13 |
2002-01-24 |
Pharmacia Corporation |
Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
|
PE20020146A1
(es)
*
|
2000-07-13 |
2002-03-31 |
Upjohn Co |
Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
|
PT1303265E
(pt)
|
2000-07-20 |
2007-10-09 |
Lauras As |
''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida''
|
US6716829B2
(en)
|
2000-07-27 |
2004-04-06 |
Pharmacia Corporation |
Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
|
GB0021494D0
(en)
*
|
2000-09-01 |
2000-10-18 |
Glaxo Group Ltd |
Chemical comkpounds
|
US20030219461A1
(en)
*
|
2000-09-12 |
2003-11-27 |
Britten Nancy J. |
Parenteral combination therapy for infective conditions
|
WO2002047707A2
(en)
*
|
2000-12-15 |
2002-06-20 |
Pharmacia Corporation |
Selective cox-2 inhibition from non-edible plant extracts
|
EP1401460A2
(en)
*
|
2000-12-15 |
2004-03-31 |
Pharmacia Corporation |
Selective cox-2 inhibition from plant extracts
|
US7115565B2
(en)
*
|
2001-01-18 |
2006-10-03 |
Pharmacia & Upjohn Company |
Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
|
CA2435350A1
(en)
*
|
2001-02-02 |
2002-08-15 |
Pharmacia Corporation |
Method of using a cyclooxygenase-2 inhibitor and sex steroids as a combination therapy for the treatment and prevention of dismenorrhea
|
ITMI20010733A1
(it)
|
2001-04-05 |
2002-10-05 |
Recordati Chem Pharm |
Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
|
US20030105141A1
(en)
*
|
2001-04-17 |
2003-06-05 |
Ping Gao |
Finely self-emulsifiable pharmaceutical composition
|
US20030105144A1
(en)
|
2001-04-17 |
2003-06-05 |
Ping Gao |
Stabilized oral pharmaceutical composition
|
US6673818B2
(en)
|
2001-04-20 |
2004-01-06 |
Pharmacia Corporation |
Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
|
GB0112802D0
(en)
*
|
2001-05-25 |
2001-07-18 |
Glaxo Group Ltd |
Pyrimidine derivatives
|
GB0112810D0
(en)
*
|
2001-05-25 |
2001-07-18 |
Glaxo Group Ltd |
Pyrimidine derivatives
|
US20060167074A1
(en)
*
|
2001-06-19 |
2006-07-27 |
Norbert Muller |
Methods and compositions for the treatment of psychiatric disorders
|
DE10129320A1
(de)
*
|
2001-06-19 |
2003-04-10 |
Norbert Mueller |
Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen
|
ES2241964T3
(es)
|
2001-07-05 |
2005-11-01 |
Pfizer Products Inc. |
Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos.
|
DE10135027A1
(de)
*
|
2001-07-18 |
2003-02-06 |
Solvay Pharm Gmbh |
Verwendung Trifluoracetylalkyl-substituierter Phenyl-, Phenol- und Benzoylderivate in der Behandlung und/oder Prophylaxe von Obestias und deren Begleit- und/oder Folgeerkrankungen
|
UA80682C2
(en)
*
|
2001-08-06 |
2007-10-25 |
Pharmacia Corp |
Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
|
GB0119477D0
(en)
*
|
2001-08-09 |
2001-10-03 |
Glaxo Group Ltd |
Pyrimidine derivatives
|
US20030220376A1
(en)
*
|
2001-08-10 |
2003-11-27 |
Pharmacia Corporation |
Methods for treating carbonic anhydrase mediated disorders
|
US20030100594A1
(en)
*
|
2001-08-10 |
2003-05-29 |
Pharmacia Corporation |
Carbonic anhydrase inhibitor
|
WO2003013655A2
(en)
*
|
2001-08-10 |
2003-02-20 |
Pharmacia Corporation |
Carbonic anhydrase inhibitors
|
US20040067992A1
(en)
*
|
2001-08-10 |
2004-04-08 |
Pharmacia Corporation |
Compositions of a cyclooxygenase-2 selective inhibitor and a carbonic anhydrase inhibitor for the treatment of neoplasia
|
US20050101563A1
(en)
*
|
2001-08-14 |
2005-05-12 |
Pharmacia Corporation |
Method and compositions for the treatment and prevention of pain and inflammation
|
US20030114418A1
(en)
*
|
2001-08-14 |
2003-06-19 |
Pharmacia Corporation |
Method for the treatment and prevention of pain and inflammation with glucosamine and a cyclooxygenase-2 selective inhibitor and compositions therefor
|
US20030114416A1
(en)
*
|
2001-08-14 |
2003-06-19 |
Pharmacia Corporation |
Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate
|
AR038957A1
(es)
|
2001-08-15 |
2005-02-02 |
Pharmacia Corp |
Terapia de combinacion para el tratamiento del cancer
|
JP2005506983A
(ja)
*
|
2001-09-19 |
2005-03-10 |
ファルマシア・コーポレーション |
炎症の治療のための置換ピラゾリル化合物
|
AR036608A1
(es)
*
|
2001-09-24 |
2004-09-22 |
Bayer Corp |
Derivados de imidazol, composiciones farmaceuticas y el uso de dichos derivados para la fabricacion de un medicamento para el tratamiento de la obesidad
|
GT200200183A
(es)
|
2001-09-28 |
2003-05-23 |
|
Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
|
WO2003037336A1
(en)
|
2001-11-02 |
2003-05-08 |
Pfizer Products Inc. |
1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
|
DE10162121A1
(de)
*
|
2001-12-12 |
2003-06-18 |
Berolina Drug Dev Ab Svedala |
Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel
|
US20040126438A1
(en)
*
|
2001-12-13 |
2004-07-01 |
Obukowicz Mark G. |
Selective cox-2 inhibition from plant extracts
|
US20040062823A1
(en)
*
|
2001-12-13 |
2004-04-01 |
Obukowicz Mark G. |
Selective cox-2 inhibition from non-edible plant extracts
|
US20030212138A1
(en)
*
|
2002-01-14 |
2003-11-13 |
Pharmacia Corporation |
Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
|
US20030220374A1
(en)
*
|
2002-01-14 |
2003-11-27 |
Pharmacia Corporation |
Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
|
US7927613B2
(en)
*
|
2002-02-15 |
2011-04-19 |
University Of South Florida |
Pharmaceutical co-crystal compositions
|
US20050025791A1
(en)
*
|
2002-06-21 |
2005-02-03 |
Julius Remenar |
Pharmaceutical compositions with improved dissolution
|
US7790905B2
(en)
*
|
2002-02-15 |
2010-09-07 |
Mcneil-Ppc, Inc. |
Pharmaceutical propylene glycol solvate compositions
|
US20100311701A1
(en)
*
|
2002-02-15 |
2010-12-09 |
Transform Pharmaceuticals, Inc |
Pharmaceutical Co-Crystal Compositions
|
US20090088443A1
(en)
*
|
2002-02-15 |
2009-04-02 |
Julius Remenar |
Novel crystalline forms of conazoles and methods of making and using the same
|
JP4906233B2
(ja)
*
|
2002-03-01 |
2012-03-28 |
ユニバーシティー オブ サウス フロリダ |
少なくとも1種の有効薬剤成分を含有する多構成要素固相
|
TW562937B
(en)
*
|
2002-03-26 |
2003-11-21 |
Nanya Technology Corp |
Method for fast determining defect type of word line
|
EP1499597A4
(en)
*
|
2002-04-08 |
2006-01-25 |
Univ Ohio State Res Found |
COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATION CELLS
|
US20040034083A1
(en)
*
|
2002-04-18 |
2004-02-19 |
Stephenson Diane T. |
Combination therapy for the treatment of Parkinson's disease with cyclooxygenase-2 (COX2) inhibitor(s)
|
CA2482510A1
(en)
*
|
2002-04-18 |
2003-10-30 |
Pharmacia Corporation |
Monotherapy for the treatment of parkinson`s disease with cyclooxygenase-2 (cox 2) inhibitor(s)
|
AU2003220483A1
(en)
*
|
2002-05-09 |
2003-11-11 |
Pharmacia Corporation |
Substituted pyrazolyl compounds for the treatment of inflammation
|
JP2005532333A
(ja)
*
|
2002-05-24 |
2005-10-27 |
ファルマシア・コーポレーション |
ジアリールピラゾールの合成
|
WO2004002409A2
(en)
|
2002-06-27 |
2004-01-08 |
Nitromed, Inc. |
Cyclooxygenase-2 selective inhibitors, compositions and methods of use
|
EP1539679A4
(en)
*
|
2002-06-28 |
2007-07-04 |
Nitromed Inc |
OXIM- AND / OR HYDRAZO-CONTAINING, NITROSED AND / OR NITROSYLATED CYCLOOXIGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND USE METHODS
|
KR100467668B1
(ko)
*
|
2002-08-07 |
2005-01-24 |
씨제이 주식회사 |
1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
|
ATE325115T1
(de)
*
|
2002-08-19 |
2006-06-15 |
Glaxo Group Ltd |
Pyrimidinderivate als selektive cox-2-inhibitoren
|
GB0221443D0
(en)
|
2002-09-16 |
2002-10-23 |
Glaxo Group Ltd |
Pyridine derivates
|
AU2003267231A1
(en)
*
|
2002-09-20 |
2004-04-08 |
Transform Pharmaceuticals, Inc. |
Pharmaceutical compositions with improved dissolution
|
US20040087558A1
(en)
*
|
2002-10-24 |
2004-05-06 |
Zeldis Jerome B. |
Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
|
US20050203142A1
(en)
*
|
2002-10-24 |
2005-09-15 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
|
GB0227443D0
(en)
*
|
2002-11-25 |
2002-12-31 |
Glaxo Group Ltd |
Pyrimidine derivatives
|
US20060148877A1
(en)
*
|
2002-11-26 |
2006-07-06 |
Transform Pharmaceuticals, Inc. |
Pharmaceutical formulations of celcoxib
|
CA2509605C
(en)
|
2002-12-13 |
2010-10-05 |
Warner-Lambert Company Llc |
Alpha-2-delta ligand to treat lower urinary tract symptoms
|
US20040235925A1
(en)
*
|
2002-12-17 |
2004-11-25 |
Pharmacia Corporation |
Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
|
US20040204411A1
(en)
*
|
2002-12-17 |
2004-10-14 |
Pharmacia Corporation |
Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
|
US20080153894A1
(en)
*
|
2002-12-19 |
2008-06-26 |
Pharmacia Corporation |
Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
|
ES2215474B1
(es)
|
2002-12-24 |
2005-12-16 |
J. URIACH & CIA S.A. |
Nuevos derivados de fosforamida.
|
US8183290B2
(en)
|
2002-12-30 |
2012-05-22 |
Mcneil-Ppc, Inc. |
Pharmaceutically acceptable propylene glycol solvate of naproxen
|
EP2339328A3
(en)
|
2002-12-30 |
2011-07-13 |
Transform Pharmaceuticals, Inc. |
Pharmaceutical co-crystal compositions of celecoxib
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
EP1601353A4
(en)
*
|
2003-01-29 |
2008-08-13 |
Childrens Medical Center |
PREVENT OPERATIONAL ADVANCES WITH SELECTIVE COX-2 INHIBITORS
|
US20040220155A1
(en)
*
|
2003-03-28 |
2004-11-04 |
Pharmacia Corporation |
Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
|
US20060142368A1
(en)
*
|
2003-04-08 |
2006-06-29 |
Ching-Shih Chen |
Compounds and methods for inducing apoptosis in proliferating cells
|
EP2266584B1
(en)
*
|
2003-05-07 |
2012-09-05 |
Osteologix A/S |
Composition with strontium and vitamin D for the prophylaxis and/or treatment of cartilage and/or bone conditions
|
EP1534305B9
(en)
*
|
2003-05-07 |
2007-03-07 |
Osteologix A/S |
Treating cartilage / bone conditions with water-soluble strontium salts
|
CN1309717C
(zh)
*
|
2003-06-03 |
2007-04-11 |
李小虎 |
4-芳基-5h-噻吩-2-酮衍生物、其制法和用途
|
GB0319037D0
(en)
*
|
2003-08-13 |
2003-09-17 |
Glaxo Group Ltd |
7-Azaindole Derivatives
|
US20050119262A1
(en)
*
|
2003-08-21 |
2005-06-02 |
Pharmacia Corporation |
Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
|
US20050107350A1
(en)
*
|
2003-08-22 |
2005-05-19 |
Pharmacia Corporation |
Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
|
US20050131028A1
(en)
*
|
2003-09-11 |
2005-06-16 |
Pharmacia Corporation |
Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders
|
US20060079566A1
(en)
*
|
2003-10-03 |
2006-04-13 |
Ching-Shih Chen |
PDK-1/Akt signaling inhibitors
|
DK1696907T3
(da)
*
|
2003-10-03 |
2013-06-24 |
Univ Ohio State Res Found |
PDK-1/AKT Signalinhibitorer
|
WO2005054204A2
(en)
*
|
2003-11-26 |
2005-06-16 |
Synchrony Biosciences, Inc. |
Pharmaceutical compounds that regenerate in vivo
|
US7659426B2
(en)
|
2003-12-01 |
2010-02-09 |
Reverse Proteomics Research Institute Co., Ltd. |
Target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto
|
US7067159B2
(en)
|
2003-12-05 |
2006-06-27 |
New Chapter, Inc. |
Methods for treating prostate cancer with herbal compositions
|
US7070816B2
(en)
|
2003-12-05 |
2006-07-04 |
New Chapter, Inc. |
Methods for treating prostatic intraepithelial neoplasia with herbal compositions
|
TW200526641A
(en)
*
|
2003-12-26 |
2005-08-16 |
Daiichi Seiyaku Co |
Amidopyrazole derivatives
|
JP4718453B2
(ja)
*
|
2004-04-12 |
2011-07-06 |
武田薬品工業株式会社 |
Gタンパク質共役型レセプタータンパク質の新規リガンドとその用途
|
ITMI20041032A1
(it)
|
2004-05-24 |
2004-08-24 |
Neuroscienze S C A R L |
Compositi farmaceutici
|
WO2006041855A2
(en)
|
2004-10-04 |
2006-04-20 |
Nitromed, Inc. |
Compositions and methods using apocynin compounds and nitric oxide donors
|
AU2005302523A1
(en)
*
|
2004-10-28 |
2006-05-11 |
Celgene Corporation |
Methods and compositions using PDE4 modulators for treatment and management of central nervous system injury
|
US20070298102A1
(en)
|
2004-11-23 |
2007-12-27 |
Aleksandra Dumicic |
Extended Release Pharmaceutical Composition of Celecoxib
|
CA2594477C
(en)
|
2005-01-21 |
2016-07-12 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
US7521435B2
(en)
|
2005-02-18 |
2009-04-21 |
Pharma Diagnostics, N.V. |
Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
|
US7923465B2
(en)
|
2005-06-02 |
2011-04-12 |
Glenmark Pharmaceuticals S.A. |
Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
|
EP1928859A1
(en)
*
|
2005-06-17 |
2008-06-11 |
Carex SA |
Pyrazole derivates as cannabinoid receptor modulators
|
BRPI0612287A8
(pt)
*
|
2005-06-27 |
2019-01-22 |
Exelixis Inc |
composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear
|
HUP0500730A2
(en)
*
|
2005-07-29 |
2007-02-28 |
Richter Gedeon Vegyuszeti Gyar |
1,2-diaryl-heterocyclic compounds, their preparation, pharmaceutical compositions comprising thereof and their use
|
EP1915157A4
(en)
|
2005-08-02 |
2010-09-01 |
Nicox Sa |
NICKEL OXYGENIZING ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND USE PROCESSES
|
EP1954685A4
(en)
|
2005-11-16 |
2009-11-11 |
Nitromed Inc |
FUROXANE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
|
EP1965774A2
(en)
*
|
2005-12-30 |
2008-09-10 |
Cogentus Pharmaceuticals, Inc. |
Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
|
EP2007705A4
(en)
|
2006-03-29 |
2011-09-07 |
Nicox Sa |
NITROGEN MONOXIDE REINFORCING PROSTAGLANDIN COMPOUNDS, COMPOSITION AND APPLICATION PROCESS
|
US8128460B2
(en)
*
|
2006-09-14 |
2012-03-06 |
The Material Works, Ltd. |
Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell
|
US8916552B2
(en)
|
2006-10-12 |
2014-12-23 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
EP2073807A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
EP2121621B1
(en)
|
2006-12-08 |
2014-05-07 |
Exelixis Patent Company LLC |
Lxr and fxr modulators
|
EA017171B1
(ru)
|
2006-12-22 |
2012-10-30 |
Рекордати Айерленд Лимитед |
КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП)
|
FR2911136B1
(fr)
*
|
2007-01-05 |
2009-02-20 |
Sanofi Aventis Sa |
Derives de n-(4-cyano-1h-pyrazol-3-yl)methylamine substitues leur preparation et leur application en therapeutique.
|
CA2676413A1
(en)
*
|
2007-01-19 |
2008-07-31 |
Mallinckrodt Inc. |
Diagnostic and therapeutic cyclooxygenase-2 binding ligands
|
CN101679244B
(zh)
|
2007-04-11 |
2014-01-01 |
橘生药品工业株式会社 |
5元杂环衍生物及其医药用途
|
US8039502B2
(en)
|
2007-07-24 |
2011-10-18 |
The Ohio State University Research Foundation |
Anti-infective agents against intracellular pathogens
|
US20090062364A1
(en)
*
|
2007-08-29 |
2009-03-05 |
Protia, Llc |
Deuterium-enriched celecoxib
|
WO2009152647A1
(zh)
|
2008-06-20 |
2009-12-23 |
江苏恩华药业股份有限公司 |
芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用
|
CN103965200B
(zh)
|
2008-09-22 |
2016-06-08 |
阵列生物制药公司 |
作为trk激酶抑制剂的取代的咪唑并[1,2-b]哒嗪化合物
|
EP2177215A1
(en)
|
2008-10-17 |
2010-04-21 |
Laboratorios Del. Dr. Esteve, S.A. |
Co-crystals of tramadol and NSAIDs
|
RS57221B2
(sr)
|
2008-10-22 |
2020-08-31 |
Array Biopharma Inc |
Jedinjenja supstituisanog pirazolo[1,5-]pirimidina kao inhibitori trk kinaze
|
US8686017B2
(en)
*
|
2008-10-31 |
2014-04-01 |
Loyola University Chicago |
Methods of using proteinacious channels to identify pharmaceutical treatments and risks, and treatments resulting therefrom
|
US8785466B2
(en)
*
|
2008-10-31 |
2014-07-22 |
Loyola University Chicago |
Methods of using proteinacious channels to identify pharmaceutical treatments and risks, and treatments resulting therefrom
|
US20120108823A1
(en)
|
2009-04-22 |
2012-05-03 |
The Ohio State University Research Foundation |
Anti-francisella agents
|
WO2010150144A2
(en)
|
2009-06-25 |
2010-12-29 |
Wockhardt Research Centre |
Low dose pharmaceutical compositions of celecoxib
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
WO2011050944A1
(en)
|
2009-10-28 |
2011-05-05 |
Ratiopharm Gmbh |
Formulations containing celecoxib
|
WO2011055233A2
(en)
|
2009-11-03 |
2011-05-12 |
Actavis Group Ptc Ehf |
Improved process for preparing celecoxib polymorph
|
EP2560966B1
(en)
|
2010-03-30 |
2021-01-06 |
Verseon International Corporation |
Multisubstituted aromatic compounds as inhibitors of thrombin
|
RU2735545C2
(ru)
|
2010-05-20 |
2020-11-03 |
Эррэй Биофарма Инк. |
Макроциклические соединения в качестве ингибиторов киназы trk
|
EP2635274B1
(en)
*
|
2010-11-01 |
2017-12-06 |
The Ohio State University Research Foundation |
Anti-staphylococcal celecoxib derivatives
|
CN102746231A
(zh)
*
|
2011-04-20 |
2012-10-24 |
天津药物研究院 |
塞来昔布制备工艺
|
AR086745A1
(es)
|
2011-06-27 |
2014-01-22 |
Parion Sciences Inc |
3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
|
PT3176170T
(pt)
|
2012-06-13 |
2019-02-05 |
Incyte Holdings Corp |
Compostos tricíclicos substituídos como inibidores de fgfr
|
US9732038B2
(en)
|
2012-06-14 |
2017-08-15 |
Mayo Foundation For Medical Education And Research |
Pyrazole derivatives as inhibitors of STAT3
|
CN102746232A
(zh)
*
|
2012-07-03 |
2012-10-24 |
石药集团中诺药业(石家庄)有限公司 |
一种塞来昔布杂质的制备方法
|
WO2014012074A2
(en)
*
|
2012-07-12 |
2014-01-16 |
Euclises Pharmaceuticals, Inc. |
No-releasing nonoate (nitrogen-bound) sulfonamide-linked-coxib anti-cancer agents
|
US9044464B2
(en)
|
2012-07-12 |
2015-06-02 |
Euclises Pharmaceuticals, Inc. |
No-releasing guanidine-coxib anti-cancer agents
|
US9505765B2
(en)
|
2012-07-26 |
2016-11-29 |
Confluence Life Sciences Inc. |
4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as TAK1 inhibitors in disease treatment
|
AU2013370491B2
(en)
|
2012-12-28 |
2016-10-06 |
Corteva Agriscience Llc |
Synergistic fungicidal mixtures for fungal control in cereals
|
US9107947B2
(en)
|
2013-01-31 |
2015-08-18 |
The Penn State Research Foundation |
Anti-cancer compositions and methods
|
WO2014138616A2
(en)
*
|
2013-03-08 |
2014-09-12 |
Translational Drug Development, Llc |
Pyrazole compounds and methods of use thereof
|
EP2970141B1
(en)
|
2013-03-15 |
2020-02-26 |
Verseon Corporation |
Halogenopyrazoles as inhibitors of thrombin
|
LT2968297T
(lt)
|
2013-03-15 |
2019-01-10 |
Verseon Corporation |
Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai
|
SG10201708520YA
(en)
|
2013-04-19 |
2017-12-28 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
US9453002B2
(en)
|
2013-08-16 |
2016-09-27 |
Janssen Pharmaceutica Nv |
Substituted imidazoles as N-type calcium channel blockers
|
CN104974091B
(zh)
*
|
2014-04-10 |
2018-01-02 |
沈阳药科大学 |
3‑甲基‑1,5‑二芳基吡唑类化合物及其制备方法和用途
|
CA2960790A1
(en)
|
2014-09-17 |
2016-03-24 |
Verseon Corporation |
Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
|
SG11201703962XA
(en)
|
2014-11-16 |
2017-06-29 |
Array Biopharma Inc |
Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
|
JP6777637B2
(ja)
|
2014-12-30 |
2020-10-28 |
ダウ アグロサイエンシィズ エルエルシー |
殺真菌剤としてのピコリンアミド
|
BR112017013105A2
(pt)
|
2014-12-30 |
2017-12-26 |
Dow Agrosciences Llc |
picolinamidas com atividade fungicida
|
KR20170100550A
(ko)
|
2014-12-30 |
2017-09-04 |
다우 아그로사이언시즈 엘엘씨 |
살진균 활성을 갖는 피콜린아미드 화합물
|
CN113173838A
(zh)
|
2014-12-30 |
2021-07-27 |
美国陶氏益农公司 |
具有杀真菌活性的吡啶酰胺化合物
|
BR112017013645A2
(pt)
|
2014-12-30 |
2018-03-06 |
Dow Agrosciences Llc |
uso de compostos de picolinamida com atividade fungicida
|
MX2017009571A
(es)
|
2015-01-23 |
2018-09-27 |
Aclaris Therapeutics Inc |
Inhibidores heterociclicos de itk para el tratamiento de la inflamacion y cancer.
|
TWI712601B
(zh)
|
2015-02-20 |
2020-12-11 |
美商英塞特公司 |
作為fgfr抑制劑之雙環雜環
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
EP3261639B1
(en)
|
2015-02-27 |
2022-08-24 |
Verseon International Corporation |
Substituted pyrazole compounds as serine protease inhibitors
|
EP3292213A1
(en)
|
2015-05-04 |
2018-03-14 |
Academisch Medisch Centrum |
Biomarkers for the detection of aspirin insensitivity
|
CA2987272C
(en)
|
2015-05-28 |
2019-08-20 |
Dr. Reddy's Laboratories Ltd. |
Oral composition of celecoxib for treatment of pain
|
CN104945388A
(zh)
*
|
2015-07-09 |
2015-09-30 |
南京大学 |
4-(3-(3-(4-氯香豆素)-酰腙)-5-苯基-吡唑)苯磺酰胺类衍生物的制备方法及在抗癌药物中的应用
|
RU2744852C2
(ru)
|
2015-10-26 |
2021-03-16 |
Локсо Онколоджи, Инк. |
Точечные мутации в устойчивых к ингибитору trk злокачественных опухолях и связанные с ними способы
|
US20190038756A1
(en)
|
2016-02-10 |
2019-02-07 |
Cocoon Biotech Inc. |
Compositions including benzenesulfonamide-containing non-steroidal anti-inflammatory drugs, silk fibroin, and a gelling agent and uses thereof
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
KR102400423B1
(ko)
|
2016-04-04 |
2022-05-19 |
록쏘 온콜로지, 인코포레이티드 |
(s)-n-(5-((r)-2-(2,5-디플루오로페닐)-피롤리딘-1-일)-피라졸로[1,5-a]피리미딘-3-일)-3-하이드록시피롤리딘-1-카복사미드의 액체 제형
|
LT3800189T
(lt)
|
2016-05-18 |
2023-10-10 |
Loxo Oncology, Inc. |
(s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3- il)-3-hidroksipirolidin-1-karboksamido gavimas
|
RU2745196C2
(ru)
|
2016-05-27 |
2021-03-22 |
Др. Редди'С Лабораторис Лтд. |
Пероральная композиция целекоксиба для лечения боли
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
TW201842851A
(zh)
|
2017-05-02 |
2018-12-16 |
美商陶氏農業科學公司 |
用於穀類中的真菌防治之協同性混合物
|
TWI774761B
(zh)
|
2017-05-02 |
2022-08-21 |
美商科迪華農業科技有限責任公司 |
用於穀物中的真菌防治之協同性混合物
|
EP3618626A4
(en)
|
2017-05-02 |
2020-12-02 |
Dow Agrosciences LLC |
USE OF AN ACYCLIC PICOLINAMIDE COMPOUND AS A FUNGICIDE FOR FUNGAL GRASS INFESTATION
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
AU2018360059B2
(en)
|
2017-11-03 |
2023-07-13 |
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|
BR102019004480B1
(pt)
|
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|
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(fr)
|
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|
US11466004B2
(en)
|
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|
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(en)
|
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2020-02-13 |
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|
CN111039982A
(zh)
*
|
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2020-04-21 |
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|
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(ko)
|
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|
US11628162B2
(en)
|
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|
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(pt)
|
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|
US11591329B2
(en)
|
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|
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(en)
|
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|
US11566028B2
(en)
|
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|
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(ja)
|
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|
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(pt)
|
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|
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(ko)
|
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|
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|
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|
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(zh)
*
|
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|