CO5261541A1 - Terapia de combinacion para el tratamiento de la migrana - Google Patents
Terapia de combinacion para el tratamiento de la migranaInfo
- Publication number
- CO5261541A1 CO5261541A1 CO00032908A CO00032908A CO5261541A1 CO 5261541 A1 CO5261541 A1 CO 5261541A1 CO 00032908 A CO00032908 A CO 00032908A CO 00032908 A CO00032908 A CO 00032908A CO 5261541 A1 CO5261541 A1 CO 5261541A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- halo
- substituted
- alkoxy
- amino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición farmacéutica para el tratamiento de la migraña, que comprende un agonista del receptor 5HT1 o una sal farmacéuticamente aceptable del mismo, con (a) un compuesto de fórmula<EMI FILE="00032908_1" ID="1" IMF=JPEG >o las sales farmacéuticamente aceptables del mismo, en la que: R1 es hidrógeno o alquilo C1-C4; R2 es C(=LAND#39)R3 o SO2R4; Y es un enlace directo o alquileno C1-4; L y LAND#39 son independientemente oxígeno o azufre; Q se selecciona entre los siguientes: (Q-a) alquilo C1-6, (Q-b) alquilo C1-4 sustituido con halo, (Q-c) cicloalquilo C3-7, opcionalmente sustituido con uno o dos sustituyentes seleccionados independientemente entre alquilo C1-4, alquilo C1-4 sustituido con halo, alcoxi C1-4, hidroxi y halo, (Q-d) fenilo o naftilo, estando el fenilo y el naftilo opcionalmente sustituidos con uno, dos o tres sustituyentes seleccionados independientemente entre halo, alquilo C1-4, alquilo C1-4, sustituido con halo, hidroxi, alcoxi C1-4 nitro, alcoxi C1-4 sustituido con halo, S(O)mR5, SO2NH2, SO2N(alquilo C1-4)2, amino, alquil C1-4-amino, di-(alquil C1-4)amino, NR1C(O)R5, CN, alquil C1-4-OH y alquil C1-4-OR5, (Q-e) un grupo aromático monocíclico de 5 miembros que contiene un heteroátomo seleccionado entre O, S y N y que opcionalmente contiene uno, dos o tres átomos de nitrógeno además de dicho heteroátomo, estando dicho grupo aromático monocíclico opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados independientemente entre halo, alquilo C1-4, alquilo C1-4 sustituido con halo, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halo, amino, alquil C1-4,-amino, di(alquil C1-4)amino, alquil C1-4-OH y alquil C1-4-OR5, y (Q-f) un grupo aromático monocíclico de 6 miembros que contiene un átomo de nitrógeno y que contiene opcionalmente uno, dos o tres átomos de nitrógeno adicionales, estando dicho anillo aromático monocíclico opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados independientemente entre halo, alquilo C1-4 alquilo C1-4 sustituido con halo, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halo, amino, alquil C1-4-amino, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13431299P | 1999-05-14 | 1999-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261541A1 true CO5261541A1 (es) | 2003-03-31 |
Family
ID=22462780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00032908A CO5261541A1 (es) | 1999-05-14 | 2000-05-08 | Terapia de combinacion para el tratamiento de la migrana |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050101653A1 (es) |
| EP (1) | EP1051995A3 (es) |
| JP (1) | JP2000344667A (es) |
| KR (1) | KR20010029716A (es) |
| AU (1) | AU3406500A (es) |
| CA (1) | CA2308826A1 (es) |
| CO (1) | CO5261541A1 (es) |
| HU (1) | HUP0001891A3 (es) |
| IL (1) | IL136025A0 (es) |
| PE (1) | PE20010128A1 (es) |
| ZA (1) | ZA200002338B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| WO2000025779A1 (en) | 1998-11-02 | 2000-05-11 | Merck & Co., Inc. | Method of treating migraines and pharmaceutical compositions |
| GB9929039D0 (en) * | 1999-12-08 | 2000-02-02 | Glaxo Group Ltd | Medicaments |
| WO2004060355A1 (en) | 2002-12-26 | 2004-07-22 | Pozen Inc. | Multilayer Dosage Forms Containing NSAIDs and Triptans |
| JP2006522790A (ja) * | 2003-04-11 | 2006-10-05 | ファイザー・インク | エレトリプタンと重炭酸ナトリウムを含む医薬組み合わせ物 |
| US8618157B2 (en) | 2008-06-20 | 2013-12-31 | Alphapharm Pty. Ltd. | Pharmaceutical formulation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| US5286843A (en) * | 1992-05-22 | 1994-02-15 | Rohm And Haas Company | Process for improving water-whitening resistance of pressure sensitive adhesives |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| ATE212985T1 (de) * | 1993-11-30 | 2002-02-15 | Searle & Co | Tricyclische,substituierte pyrazolyl- benzolsulfonamide und ihre verwendung als cyclooxygenase ii inhibitoren |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5691374A (en) * | 1995-05-18 | 1997-11-25 | Merck Frosst Canada Inc. | Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors |
| US5861419A (en) * | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
-
2000
- 2000-05-08 CO CO00032908A patent/CO5261541A1/es not_active Application Discontinuation
- 2000-05-08 IL IL13602500A patent/IL136025A0/xx unknown
- 2000-05-10 PE PE2000000436A patent/PE20010128A1/es not_active Application Discontinuation
- 2000-05-10 EP EP00303914A patent/EP1051995A3/en not_active Withdrawn
- 2000-05-12 ZA ZA200002338A patent/ZA200002338B/xx unknown
- 2000-05-12 CA CA002308826A patent/CA2308826A1/en not_active Abandoned
- 2000-05-12 AU AU34065/00A patent/AU3406500A/en not_active Abandoned
- 2000-05-12 HU HU0001891A patent/HUP0001891A3/hu unknown
- 2000-05-13 KR KR1020000025586A patent/KR20010029716A/ko not_active Application Discontinuation
- 2000-05-15 JP JP2000141897A patent/JP2000344667A/ja not_active Abandoned
-
2004
- 2004-12-09 US US11/008,765 patent/US20050101653A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000344667A (ja) | 2000-12-12 |
| IL136025A0 (en) | 2001-05-20 |
| HUP0001891A3 (en) | 2003-07-28 |
| ZA200002338B (en) | 2001-11-12 |
| EP1051995A2 (en) | 2000-11-15 |
| HUP0001891A2 (en) | 2001-03-28 |
| EP1051995A3 (en) | 2003-01-08 |
| US20050101653A1 (en) | 2005-05-12 |
| CA2308826A1 (en) | 2000-11-14 |
| PE20010128A1 (es) | 2001-02-28 |
| HU0001891D0 (en) | 2000-07-28 |
| KR20010029716A (ko) | 2001-04-16 |
| AU3406500A (en) | 2000-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |