PE20010128A1 - Composicion de un agonista del receptor 5ht1 y un inhibidor de la cox-2 para el tratamiento de la migrana - Google Patents

Composicion de un agonista del receptor 5ht1 y un inhibidor de la cox-2 para el tratamiento de la migrana

Info

Publication number
PE20010128A1
PE20010128A1 PE2000000436A PE0004362000A PE20010128A1 PE 20010128 A1 PE20010128 A1 PE 20010128A1 PE 2000000436 A PE2000000436 A PE 2000000436A PE 0004362000 A PE0004362000 A PE 0004362000A PE 20010128 A1 PE20010128 A1 PE 20010128A1
Authority
PE
Peru
Prior art keywords
alkyl
halo
day
composition
migrana
Prior art date
Application number
PE2000000436A
Other languages
English (en)
Inventor
George Harry Sands
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20010128A1 publication Critical patent/PE20010128A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)UN AGONISTA DEL RECEPTOR 5HT1 TAL COMO ELETRIPTAN, RIZATRIPTAN, ZOLMITRIPTAN, SUMATRIPTAN, NARATRIPTAN, UTILIZANDOSE 0,05 mg/DIA A 100 mg/DIA; b)UN COMPUESTO DE FORMULA I, DONDE: R1 ES H, ALQUILO C1-C4; R2 ES C(=L`)R3, SO2R4; Y ES UN ENLACE, ALQUILENO C1-C4; L Y L' SON O, S; Q ES ALQUILO C1-C6, ENTRE OTROS; R3 ES OR6, NR7R8, R(OR1)R7, GRUPO a; Z ES UN ENLACE, O, S, NR5; R4 ES ALQUILO C1-C6, ALQUILO C1-C4 SUSTITUIDO CON HALO, ALQUIL C1-C4-OH, NR7R8, ENTRE OTROS; R5 ES ALQUILO C1-C4 SUSTITUIDO CON HALO; R6 ES ALQUILO C1-C4, CICLOALQUILO C3-C7, ENTRE OTROS; R7 Y R8 SON H, ALQUILO C1-C6, ENTRE OTROS; X ES HALO, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON HIDROXI, ALCOXI C1-C4, ENTRE OTROS, n ES 0-3 O UN COMPUESTO DE FORMULA XX, DONDE A ES UN ANILLO HETEROCICLO DE 5 MIEMBROS; R1 ES ARILO, HETEROARILO; R2 ES ALQUILO C1-C4; R3, R4 Y R5 SON H, HALO, ALQUILO C1-C4, ENTRE OTROS; R6 Y R7 SON H, HALO, ALQUILO, ENTRE OTROS; m Y n SON 1-4; CUANDO A CONTIENE O, S, UNO DE R3, R4, R5 ESTA AUSENTE; UN INHIBIDOR DE LA CICLOOXIGENASA-2 TAL COMO (2-BENZOIL-6-CLORO-1H-INDOL-3-IL)ACETATO DE ETILO, ACIDO [6-CLORO-2-(2-METILBENZOIL)-1H-INDOL-3-IL]ACETICO, ENTRE OTROS; UTILIZANDOSE 10 mg/DIA A 300mg/DIA. LA COMPOSICION ES UTIL PARA EL TRATAMIENTO DE LA MIGRANA
PE2000000436A 1999-05-14 2000-05-10 Composicion de un agonista del receptor 5ht1 y un inhibidor de la cox-2 para el tratamiento de la migrana PE20010128A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13431299P 1999-05-14 1999-05-14

Publications (1)

Publication Number Publication Date
PE20010128A1 true PE20010128A1 (es) 2001-02-28

Family

ID=22462780

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000436A PE20010128A1 (es) 1999-05-14 2000-05-10 Composicion de un agonista del receptor 5ht1 y un inhibidor de la cox-2 para el tratamiento de la migrana

Country Status (11)

Country Link
US (1) US20050101653A1 (es)
EP (1) EP1051995A3 (es)
JP (1) JP2000344667A (es)
KR (1) KR20010029716A (es)
AU (1) AU3406500A (es)
CA (1) CA2308826A1 (es)
CO (1) CO5261541A1 (es)
HU (1) HUP0001891A3 (es)
IL (1) IL136025A0 (es)
PE (1) PE20010128A1 (es)
ZA (1) ZA200002338B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
EP1126841B1 (en) 1998-11-02 2004-12-15 Merck & Co., Inc. Combinations of a 5ht1b/1d agonist and a selective cox-2 inhibitor for the treatment of migraine
GB9929039D0 (en) * 1999-12-08 2000-02-02 Glaxo Group Ltd Medicaments
US7332183B2 (en) 2002-12-26 2008-02-19 Pozen Inc. Multilayer dosage forms containing NSAIDs and triptans
WO2004089365A1 (en) * 2003-04-11 2004-10-21 Pfizer Limited Pharmaceutical combination comprising eletriptan and sodium bicarbonate
WO2009152551A1 (en) 2008-06-20 2009-12-23 Alphapharm Pty Ltd Pharmaceutical formulation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5286843A (en) * 1992-05-22 1994-02-15 Rohm And Haas Company Process for improving water-whitening resistance of pressure sensitive adhesives
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
NZ336428A (en) * 1993-11-30 2005-02-25 G use of substituted pyrazolyl benzosulphonamides to treat inflammation
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5691374A (en) * 1995-05-18 1997-11-25 Merck Frosst Canada Inc. Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
US5861419A (en) * 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US5994379A (en) * 1998-02-13 1999-11-30 Merck Frosst Canada, Inc. Bisaryl COX-2 inhibiting compounds, compositions and methods of use

Also Published As

Publication number Publication date
HUP0001891A3 (en) 2003-07-28
HU0001891D0 (en) 2000-07-28
EP1051995A2 (en) 2000-11-15
US20050101653A1 (en) 2005-05-12
IL136025A0 (en) 2001-05-20
ZA200002338B (en) 2001-11-12
EP1051995A3 (en) 2003-01-08
CO5261541A1 (es) 2003-03-31
KR20010029716A (ko) 2001-04-16
AU3406500A (en) 2000-11-16
JP2000344667A (ja) 2000-12-12
HUP0001891A2 (en) 2001-03-28
CA2308826A1 (en) 2000-11-14

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