ATE223383T1 - Verfahren zur herstellung von 3-haloalkyl-1h- pyrazole - Google Patents

Verfahren zur herstellung von 3-haloalkyl-1h- pyrazole

Info

Publication number
ATE223383T1
ATE223383T1 AT96920420T AT96920420T ATE223383T1 AT E223383 T1 ATE223383 T1 AT E223383T1 AT 96920420 T AT96920420 T AT 96920420T AT 96920420 T AT96920420 T AT 96920420T AT E223383 T1 ATE223383 T1 AT E223383T1
Authority
AT
Austria
Prior art keywords
pyrazoles
haloalkyl
producing
adoption
safe
Prior art date
Application number
AT96920420T
Other languages
English (en)
Inventor
Benxin Zhi
Murad Newaz
John J Talley
Stephen Bertenshaw
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE223383T1 publication Critical patent/ATE223383T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96920420T 1995-05-25 1996-05-23 Verfahren zur herstellung von 3-haloalkyl-1h- pyrazole ATE223383T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44997595A 1995-05-25 1995-05-25
PCT/US1996/007506 WO1996037476A1 (en) 1995-05-25 1996-05-23 Method of preparing 3-haloalkyl-1h-pyrazoles

Publications (1)

Publication Number Publication Date
ATE223383T1 true ATE223383T1 (de) 2002-09-15

Family

ID=23786237

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96920420T ATE223383T1 (de) 1995-05-25 1996-05-23 Verfahren zur herstellung von 3-haloalkyl-1h- pyrazole

Country Status (20)

Country Link
US (2) US5892053A (de)
EP (1) EP0828717B1 (de)
JP (1) JP3996638B2 (de)
KR (1) KR100444802B1 (de)
CN (1) CN1174970C (de)
AT (1) ATE223383T1 (de)
AU (1) AU708964B2 (de)
BR (1) BR9609043A (de)
CA (1) CA2222138C (de)
CZ (1) CZ292320B6 (de)
DE (1) DE69623460T2 (de)
DK (1) DK0828717T3 (de)
ES (1) ES2182991T3 (de)
NO (1) NO311130B1 (de)
NZ (1) NZ308875A (de)
PL (1) PL187410B1 (de)
PT (1) PT828717E (de)
RO (1) RO118200B1 (de)
RU (2) RU2251543C2 (de)
WO (1) WO1996037476A1 (de)

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US6492411B1 (en) * 1993-11-30 2002-12-10 G. D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
ES2137138B1 (es) * 1998-05-29 2000-09-16 Esteve Labor Dr Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
US6727238B2 (en) * 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6294558B1 (en) 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
WO2000042021A1 (en) * 1999-01-14 2000-07-20 Merck Frosst Canada & Co. Synthesis of 4-[(5-substituted or unsubstituted phenyl) -3-substituted -1h-pyrazol -1-yl] benzenesulfonamides
ES2299441T3 (es) * 1999-12-08 2008-06-01 Pharmacia Corporation Forma en estado solido de celecoxib con biodisponibilidad potenciada.
CO5261556A1 (es) * 1999-12-08 2003-03-31 Pharmacia Corp Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico
AR035642A1 (es) 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
TR200001872A2 (tr) 2000-06-26 2002-01-21 Fako �La�Lari A.� 4-[5-(4-Metilfenil-3-(triflorometil)-1H-pirazol-1-il] benzensulfonamit' in yeni kristal biçimi "Biçim I" ve bu ürünün üretilmesine ilişkin yöntem.
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
CA2414674A1 (en) * 2000-07-13 2002-01-24 Pharmacia Corporation Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
CA2448627A1 (en) * 2001-05-31 2002-12-05 Pharmacia Corporation Skin-permeable composition comprising a selective cyclooxygenase-2 inhibitor a monohydric alcohol
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AU2002251330A1 (en) * 2002-04-25 2003-11-10 Generics (Uk) Limited Celecoxib forms
EP1505987A2 (de) * 2002-05-13 2005-02-16 Pharmacia Corporation Stabile amorphe celecoxib komposite und verfahren deren
KR20050013553A (ko) * 2002-05-24 2005-02-04 파마시아 코포레이션 디아릴 피라졸의 합성
JP2004115436A (ja) * 2002-09-26 2004-04-15 Nippon Nohyaku Co Ltd ピラゾール誘導体の製造方法
US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
KR100717433B1 (ko) * 2003-03-20 2007-05-14 파마시아 코포레이션 소염제의 분산성 배합물
US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20050004098A1 (en) * 2003-03-20 2005-01-06 Britten Nancy Jean Dispersible formulation of an anti-inflammatory agent
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
WO2006056770A1 (en) 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Extended release pharmaceutical composition of celecoxib
WO2010095024A2 (en) 2009-02-20 2010-08-26 Aurobindo Pharma Limited An improved process for the preparation of celecoxib
WO2011055233A2 (en) 2009-11-03 2011-05-12 Actavis Group Ptc Ehf Improved process for preparing celecoxib polymorph
US20110213159A1 (en) * 2010-03-01 2011-09-01 Vamsee Krishna Muppidi Process for preparation of celecoxib crystalline form
US9238634B2 (en) 2010-08-19 2016-01-19 The University Of Tokyo Anti-inflammatory metabolite derived from omega-3-type fatty acid
CN102746231A (zh) * 2011-04-20 2012-10-24 天津药物研究院 塞来昔布制备工艺
CN103980201B (zh) * 2014-05-23 2016-02-10 苏州大学 一种含砜基的全取代吡唑的制备方法
CN110407683A (zh) * 2019-04-03 2019-11-05 湖南方盛制药股份有限公司 一种塞来昔布二酮中间体的制备方法
CN114292235B (zh) * 2021-12-29 2023-04-14 江苏天和制药有限公司 一种地拉考昔的制备和提纯方法

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US3946057A (en) * 1972-05-03 1976-03-23 Union Carbide Corporation Preparation of metal complexes of 1,3-diketones
DE2429674A1 (de) * 1974-06-20 1976-01-08 Hoechst Ag Verfahren zur herstellung aromatischer 1,3-diketone
IL91382A (en) * 1988-09-01 1995-06-29 Orion Yhtymae Oy Alkenyl or arylmethylene-substituted beta-diketones their preparation and pharmaceutical compositions containing them
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
KR0168056B1 (ko) * 1990-04-26 1999-03-20 베르너 발데크 선형 1,3-디케톤의 제조방법
US5344992A (en) * 1990-04-26 1994-09-06 Ciba-Geigy Corporation Process for the preparation of linear 1,3-diketones
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2701024B1 (fr) * 1993-02-01 1995-05-05 Rhone Poulenc Chimie Composant bétadicétonique pour additifs PVC, additif et PVC contenant ledit additif.
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
RU2139281C1 (ru) * 1993-11-30 1999-10-10 Джи Ди Сирл энд Компани Пиразолилзамещенный бензолсульфонамид или его фармацевтически приемлемая соль, фармацевтическая композиция, способ лечения от воспаления или связанного с воспалением заболевания

Also Published As

Publication number Publication date
CZ368997A3 (cs) 1998-03-18
NO975387L (no) 1997-12-17
PL187410B1 (pl) 2004-07-30
AU5873696A (en) 1996-12-11
JPH11505848A (ja) 1999-05-25
DE69623460T2 (de) 2003-02-27
MX9709065A (es) 1998-03-31
NO311130B1 (no) 2001-10-15
BR9609043A (pt) 1999-02-23
CZ292320B6 (cs) 2003-09-17
DE69623460D1 (de) 2002-10-10
DK0828717T3 (da) 2003-01-06
CN1174970C (zh) 2004-11-10
RU2251543C2 (ru) 2005-05-10
AU708964B2 (en) 1999-08-19
CN1190960A (zh) 1998-08-19
ES2182991T3 (es) 2003-03-16
RU2169143C2 (ru) 2001-06-20
EP0828717A1 (de) 1998-03-18
WO1996037476A1 (en) 1996-11-28
PT828717E (pt) 2002-12-31
KR19990021966A (ko) 1999-03-25
NO975387D0 (no) 1997-11-24
KR100444802B1 (ko) 2004-12-17
US5910597A (en) 1999-06-08
CA2222138A1 (en) 1996-11-28
RO118200B1 (ro) 2003-03-28
US5892053A (en) 1999-04-06
JP3996638B2 (ja) 2007-10-24
EP0828717B1 (de) 2002-09-04
NZ308875A (en) 1999-08-30
CA2222138C (en) 2008-10-14
PL323492A1 (en) 1998-03-30

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