BR9609043A - Método de preparar 3 haloalqui 1h pirazois - Google Patents

Método de preparar 3 haloalqui 1h pirazois

Info

Publication number
BR9609043A
BR9609043A BR9609043A BR9609043A BR9609043A BR 9609043 A BR9609043 A BR 9609043A BR 9609043 A BR9609043 A BR 9609043A BR 9609043 A BR9609043 A BR 9609043A BR 9609043 A BR9609043 A BR 9609043A
Authority
BR
Brazil
Prior art keywords
pyrazoles
preparing
halo
here
halo here
Prior art date
Application number
BR9609043A
Other languages
English (en)
Inventor
Murad Newaz
Benxin Zhi
Stephen Bertenshan
John J Talley
Stephen Bertenshaw
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BR9609043A publication Critical patent/BR9609043A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR9609043A 1995-05-25 1996-05-23 Método de preparar 3 haloalqui 1h pirazois BR9609043A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44997595A 1995-05-25 1995-05-25
PCT/US1996/007506 WO1996037476A1 (en) 1995-05-25 1996-05-23 Method of preparing 3-haloalkyl-1h-pyrazoles

Publications (1)

Publication Number Publication Date
BR9609043A true BR9609043A (pt) 1999-02-23

Family

ID=23786237

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9609043A BR9609043A (pt) 1995-05-25 1996-05-23 Método de preparar 3 haloalqui 1h pirazois

Country Status (20)

Country Link
US (2) US5892053A (pt)
EP (1) EP0828717B1 (pt)
JP (1) JP3996638B2 (pt)
KR (1) KR100444802B1 (pt)
CN (1) CN1174970C (pt)
AT (1) ATE223383T1 (pt)
AU (1) AU708964B2 (pt)
BR (1) BR9609043A (pt)
CA (1) CA2222138C (pt)
CZ (1) CZ292320B6 (pt)
DE (1) DE69623460T2 (pt)
DK (1) DK0828717T3 (pt)
ES (1) ES2182991T3 (pt)
NO (1) NO311130B1 (pt)
NZ (1) NZ308875A (pt)
PL (1) PL187410B1 (pt)
PT (1) PT828717E (pt)
RO (1) RO118200B1 (pt)
RU (2) RU2251543C2 (pt)
WO (1) WO1996037476A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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US6716991B1 (en) 1993-11-30 2004-04-06 G. D. Searle & Co. Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US6492411B1 (en) * 1993-11-30 2002-12-10 G. D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
ES2137138B1 (es) * 1998-05-29 2000-09-16 Esteve Labor Dr Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
US6727238B2 (en) * 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6294558B1 (en) 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
AU760888B2 (en) * 1999-01-14 2003-05-22 Merck Frosst Canada & Co. Synthesis of 4-((5-substituted or unsubstituted phenyl) -3-substituted -1H-pyrazol -1-yl) benzenesulfonamides
SK12682001A3 (sk) * 1999-12-08 2002-07-02 Pharmacia Corporation, Corporate Patent Department Celecoxib v tuhej forme so zvýšenou biologickou dostupnosťou
SK12672001A3 (sk) * 1999-12-08 2002-04-04 Pharmacia Corporation Zloženia inhibítora cyklooxygenázy-2 s rýchlym nástupom terapeutického účinku
MY120279A (en) 2000-05-26 2005-09-30 Pharmacia Corp Use of a celecoxib composition for fast pain relief
TR200001872A2 (tr) 2000-06-26 2002-01-21 Fako �La�Lari A.� 4-[5-(4-Metilfenil-3-(triflorometil)-1H-pirazol-1-il] benzensulfonamit' in yeni kristal biçimi "Biçim I" ve bu ürünün üretilmesine ilişkin yöntem.
US20020128267A1 (en) * 2000-07-13 2002-09-12 Rebanta Bandyopadhyay Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US7695736B2 (en) 2001-04-03 2010-04-13 Pfizer Inc. Reconstitutable parenteral composition
EP1404345A2 (en) * 2001-05-31 2004-04-07 Pharmacia Corporation Skin-permeable selective cyclooxygenase-2 inhibitor composition
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AU2002251330A1 (en) * 2002-04-25 2003-11-10 Generics (Uk) Limited Celecoxib forms
BR0309913A (pt) * 2002-05-13 2005-06-07 Pharmacia Corp Compósito estável de celecoxib amorfo e processo para fabricar o mesmo
WO2003099794A1 (en) * 2002-05-24 2003-12-04 Pharmacia Corporation Synthesis of diaryl pyrazoles
JP2004115436A (ja) * 2002-09-26 2004-04-15 Nippon Nohyaku Co Ltd ピラゾール誘導体の製造方法
US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US20050004098A1 (en) * 2003-03-20 2005-01-06 Britten Nancy Jean Dispersible formulation of an anti-inflammatory agent
US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
JP2006520779A (ja) * 2003-03-20 2006-09-14 ファルマシア コーポレイション 抗炎症薬の分散性処方物
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
EP1833476A1 (en) 2004-11-23 2007-09-19 PLIVA HRVATSKA d.o.o. Extended release pharmaceutical composition of celecoxib
WO2010095024A2 (en) 2009-02-20 2010-08-26 Aurobindo Pharma Limited An improved process for the preparation of celecoxib
WO2011055233A2 (en) 2009-11-03 2011-05-12 Actavis Group Ptc Ehf Improved process for preparing celecoxib polymorph
US20110213159A1 (en) 2010-03-01 2011-09-01 Vamsee Krishna Muppidi Process for preparation of celecoxib crystalline form
EP2607358A4 (en) 2010-08-19 2014-01-29 Univ Tokyo NEW ANTI-INFLAMMATORY METABOLITE DERIVED FROM OMEGA-3 TYPE FATTY ACID
CN102746231A (zh) * 2011-04-20 2012-10-24 天津药物研究院 塞来昔布制备工艺
CN103980201B (zh) * 2014-05-23 2016-02-10 苏州大学 一种含砜基的全取代吡唑的制备方法
CN110407683A (zh) * 2019-04-03 2019-11-05 湖南方盛制药股份有限公司 一种塞来昔布二酮中间体的制备方法
CN114292235B (zh) * 2021-12-29 2023-04-14 江苏天和制药有限公司 一种地拉考昔的制备和提纯方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA714221B (en) * 1970-07-10 1972-03-29 Astra Ab Insecticides
DE2429674A1 (de) * 1974-06-20 1976-01-08 Hoechst Ag Verfahren zur herstellung aromatischer 1,3-diketone
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
KR0168056B1 (ko) * 1990-04-26 1999-03-20 베르너 발데크 선형 1,3-디케톤의 제조방법
US5344992A (en) * 1990-04-26 1994-09-06 Ciba-Geigy Corporation Process for the preparation of linear 1,3-diketones
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
ATE212985T1 (de) * 1993-11-30 2002-02-15 Searle & Co Tricyclische,substituierte pyrazolyl- benzolsulfonamide und ihre verwendung als cyclooxygenase ii inhibitoren

Also Published As

Publication number Publication date
PL187410B1 (pl) 2004-07-30
PT828717E (pt) 2002-12-31
JPH11505848A (ja) 1999-05-25
CZ368997A3 (cs) 1998-03-18
NO975387L (no) 1997-12-17
CA2222138C (en) 2008-10-14
CN1174970C (zh) 2004-11-10
CZ292320B6 (cs) 2003-09-17
EP0828717B1 (en) 2002-09-04
EP0828717A1 (en) 1998-03-18
NO311130B1 (no) 2001-10-15
DK0828717T3 (da) 2003-01-06
CN1190960A (zh) 1998-08-19
CA2222138A1 (en) 1996-11-28
NZ308875A (en) 1999-08-30
RU2251543C2 (ru) 2005-05-10
US5892053A (en) 1999-04-06
JP3996638B2 (ja) 2007-10-24
DE69623460T2 (de) 2003-02-27
NO975387D0 (no) 1997-11-24
RO118200B1 (ro) 2003-03-28
AU5873696A (en) 1996-12-11
ATE223383T1 (de) 2002-09-15
DE69623460D1 (de) 2002-10-10
WO1996037476A1 (en) 1996-11-28
PL323492A1 (en) 1998-03-30
MX9709065A (es) 1998-03-31
US5910597A (en) 1999-06-08
ES2182991T3 (es) 2003-03-16
RU2169143C2 (ru) 2001-06-20
AU708964B2 (en) 1999-08-19
KR100444802B1 (ko) 2004-12-17
KR19990021966A (ko) 1999-03-25

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO COM BASE NO DISPOSTO NOS ARTIGOS 8O E 11O DA LEI 9.279 DE 14/05/1996 E NO ARTIGO 229-A DA LEI 10.196 DE 14/02/2001.

B12B Appeal against refusal [chapter 12.2 patent gazette]