DE69623460T2 - Verfahren zur herstellung von 3-haloalkyl-1h-pyrazole - Google Patents

Verfahren zur herstellung von 3-haloalkyl-1h-pyrazole

Info

Publication number
DE69623460T2
DE69623460T2 DE69623460T DE69623460T DE69623460T2 DE 69623460 T2 DE69623460 T2 DE 69623460T2 DE 69623460 T DE69623460 T DE 69623460T DE 69623460 T DE69623460 T DE 69623460T DE 69623460 T2 DE69623460 T2 DE 69623460T2
Authority
DE
Germany
Prior art keywords
haloalkyl
pyrazole
producing
pyrazoles
adoption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69623460T
Other languages
English (en)
Other versions
DE69623460D1 (de
Inventor
Benxin Zhi
Murad Newaz
J Talley
Stephen Bertenshaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69623460D1 publication Critical patent/DE69623460D1/de
Publication of DE69623460T2 publication Critical patent/DE69623460T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
DE69623460T 1995-05-25 1996-05-23 Verfahren zur herstellung von 3-haloalkyl-1h-pyrazole Expired - Lifetime DE69623460T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44997595A 1995-05-25 1995-05-25
PCT/US1996/007506 WO1996037476A1 (en) 1995-05-25 1996-05-23 Method of preparing 3-haloalkyl-1h-pyrazoles

Publications (2)

Publication Number Publication Date
DE69623460D1 DE69623460D1 (de) 2002-10-10
DE69623460T2 true DE69623460T2 (de) 2003-02-27

Family

ID=23786237

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69623460T Expired - Lifetime DE69623460T2 (de) 1995-05-25 1996-05-23 Verfahren zur herstellung von 3-haloalkyl-1h-pyrazole

Country Status (20)

Country Link
US (2) US5892053A (de)
EP (1) EP0828717B1 (de)
JP (1) JP3996638B2 (de)
KR (1) KR100444802B1 (de)
CN (1) CN1174970C (de)
AT (1) ATE223383T1 (de)
AU (1) AU708964B2 (de)
BR (1) BR9609043A (de)
CA (1) CA2222138C (de)
CZ (1) CZ292320B6 (de)
DE (1) DE69623460T2 (de)
DK (1) DK0828717T3 (de)
ES (1) ES2182991T3 (de)
NO (1) NO311130B1 (de)
NZ (1) NZ308875A (de)
PL (1) PL187410B1 (de)
PT (1) PT828717E (de)
RO (1) RO118200B1 (de)
RU (2) RU2251543C2 (de)
WO (1) WO1996037476A1 (de)

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US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US6492411B1 (en) * 1993-11-30 2002-12-10 G. D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
US6716991B1 (en) 1993-11-30 2004-04-06 G. D. Searle & Co. Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
ES2137138B1 (es) * 1998-05-29 2000-09-16 Esteve Labor Dr Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
US6294558B1 (en) 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6727238B2 (en) * 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
WO2000042021A1 (en) * 1999-01-14 2000-07-20 Merck Frosst Canada & Co. Synthesis of 4-[(5-substituted or unsubstituted phenyl) -3-substituted -1h-pyrazol -1-yl] benzenesulfonamides
EP1150959B1 (de) * 1999-12-08 2008-02-27 Pharmacia Corporation Celecoxib in festkörperform mit erhöhter bioverfügbarkeit
EP1525883A1 (de) * 1999-12-08 2005-04-27 Pharmacia Corporation Arzneizubereitungen mit schnellem Wirkungseintritt enthaltend einen Cyclooxygenase-2-Hemmer
AR035642A1 (es) 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
TR200001872A2 (tr) 2000-06-26 2002-01-21 Fako �La�Lari A.� 4-[5-(4-Metilfenil-3-(triflorometil)-1H-pirazol-1-il] benzensulfonamit' in yeni kristal biçimi "Biçim I" ve bu ürünün üretilmesine ilişkin yöntem.
WO2002005848A2 (en) * 2000-07-13 2002-01-24 Pharmacia Corporation Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
PE20021017A1 (es) 2001-04-03 2002-11-24 Pharmacia Corp Composicion parenteral reconstituible
WO2002096435A2 (en) * 2001-05-31 2002-12-05 Pharmacia Corporation Skin-permeable composition comprising a selective cyclooxygenase-2 inhibitor a monohydric alcohol
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AU2002251330A1 (en) * 2002-04-25 2003-11-10 Generics (Uk) Limited Celecoxib forms
CA2484943A1 (en) * 2002-05-13 2004-05-21 Pharmacia Corporation Stable amorphous celecoxib composite and process therefor
CN100348586C (zh) * 2002-05-24 2007-11-14 法玛西雅公司 二芳基吡唑的合成方法
JP2004115436A (ja) * 2002-09-26 2004-04-15 Nippon Nohyaku Co Ltd ピラゾール誘導体の製造方法
US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20050004098A1 (en) * 2003-03-20 2005-01-06 Britten Nancy Jean Dispersible formulation of an anti-inflammatory agent
ES2270361T3 (es) * 2003-03-20 2007-04-01 Pharmacia Corporation Formulacion dispersable de un agente antiinflamatorio.
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
EP1833476A1 (de) 2004-11-23 2007-09-19 PLIVA HRVATSKA d.o.o. Pharmazeutische zusammensetzung von celecoxib mit verlängerter freisetzung
WO2010095024A2 (en) 2009-02-20 2010-08-26 Aurobindo Pharma Limited An improved process for the preparation of celecoxib
WO2011055233A2 (en) 2009-11-03 2011-05-12 Actavis Group Ptc Ehf Improved process for preparing celecoxib polymorph
US20110213159A1 (en) 2010-03-01 2011-09-01 Vamsee Krishna Muppidi Process for preparation of celecoxib crystalline form
US9238634B2 (en) 2010-08-19 2016-01-19 The University Of Tokyo Anti-inflammatory metabolite derived from omega-3-type fatty acid
CN102746231A (zh) * 2011-04-20 2012-10-24 天津药物研究院 塞来昔布制备工艺
CN103980201B (zh) * 2014-05-23 2016-02-10 苏州大学 一种含砜基的全取代吡唑的制备方法
CN110407683A (zh) * 2019-04-03 2019-11-05 湖南方盛制药股份有限公司 一种塞来昔布二酮中间体的制备方法
CN114292235B (zh) * 2021-12-29 2023-04-14 江苏天和制药有限公司 一种地拉考昔的制备和提纯方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA714221B (en) * 1970-07-10 1972-03-29 Astra Ab Insecticides
DE2429674A1 (de) * 1974-06-20 1976-01-08 Hoechst Ag Verfahren zur herstellung aromatischer 1,3-diketone
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
US5344992A (en) * 1990-04-26 1994-09-06 Ciba-Geigy Corporation Process for the preparation of linear 1,3-diketones
KR0168056B1 (ko) * 1990-04-26 1999-03-20 베르너 발데크 선형 1,3-디케톤의 제조방법
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE69430930T2 (de) * 1993-11-30 2003-02-20 Searle & Co Substitutierte Pyrazolyl-Benzolsulfonamide zur Verwendung in der Behandlung von Entzündungen
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides

Also Published As

Publication number Publication date
KR100444802B1 (ko) 2004-12-17
NO311130B1 (no) 2001-10-15
US5910597A (en) 1999-06-08
JPH11505848A (ja) 1999-05-25
PT828717E (pt) 2002-12-31
AU5873696A (en) 1996-12-11
NO975387D0 (no) 1997-11-24
WO1996037476A1 (en) 1996-11-28
EP0828717A1 (de) 1998-03-18
RO118200B1 (ro) 2003-03-28
NO975387L (no) 1997-12-17
CZ292320B6 (cs) 2003-09-17
RU2251543C2 (ru) 2005-05-10
CN1174970C (zh) 2004-11-10
NZ308875A (en) 1999-08-30
CA2222138C (en) 2008-10-14
PL323492A1 (en) 1998-03-30
EP0828717B1 (de) 2002-09-04
MX9709065A (es) 1998-03-31
ATE223383T1 (de) 2002-09-15
PL187410B1 (pl) 2004-07-30
CA2222138A1 (en) 1996-11-28
CN1190960A (zh) 1998-08-19
ES2182991T3 (es) 2003-03-16
AU708964B2 (en) 1999-08-19
US5892053A (en) 1999-04-06
BR9609043A (pt) 1999-02-23
DK0828717T3 (da) 2003-01-06
CZ368997A3 (cs) 1998-03-18
JP3996638B2 (ja) 2007-10-24
KR19990021966A (ko) 1999-03-25
DE69623460D1 (de) 2002-10-10
RU2169143C2 (ru) 2001-06-20

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