ES2137138B1 - Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos. - Google Patents

Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2137138B1
ES2137138B1 ES009801129A ES9801129A ES2137138B1 ES 2137138 B1 ES2137138 B1 ES 2137138B1 ES 009801129 A ES009801129 A ES 009801129A ES 9801129 A ES9801129 A ES 9801129A ES 2137138 B1 ES2137138 B1 ES 2137138B1
Authority
ES
Spain
Prior art keywords
preparation
medicines
application
treatment
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES009801129A
Other languages
English (en)
Other versions
ES2137138A1 (es
Inventor
Maria Rosa Cuberes-Altisent
Romero Juana Maria Berrocal
Maria Montse Contijotch-Llobet
Jordi Frigola-Constansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ECUPHAR N.V.
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009801129A priority Critical patent/ES2137138B1/es
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to DK99922192T priority patent/DK1083171T3/da
Priority to EP99922192A priority patent/EP1083171B1/en
Priority to JP2000552096A priority patent/JP4633928B2/ja
Priority to TW88108709A priority patent/TW572898B/zh
Priority to GEAP19995706A priority patent/GEP20043237B/en
Priority to CNB998081116A priority patent/CN1189459C/zh
Priority to KR1020007013447A priority patent/KR100603666B1/ko
Priority to HU0102102A priority patent/HUP0102102A3/hu
Priority to US09/701,276 priority patent/US6353117B1/en
Priority to SI9920042A priority patent/SI20580B/sl
Priority to PCT/ES1999/000156 priority patent/WO1999062884A1/es
Priority to RU2000133231/04A priority patent/RU2233272C2/ru
Priority to PT99922192T priority patent/PT1083171E/pt
Priority to ES99922192T priority patent/ES2221382T3/es
Priority to US10/229,880 priority patent/USRE38963E1/en
Priority to CZ20004418A priority patent/CZ298391B6/cs
Priority to AT99922192T priority patent/ATE265437T1/de
Priority to CO99032824A priority patent/CO5031241A1/es
Priority to NZ508990A priority patent/NZ508990A/xx
Priority to CA002333475A priority patent/CA2333475C/en
Priority to AU39329/99A priority patent/AU752001B2/en
Priority to DE69916828T priority patent/DE69916828T2/de
Priority to SK1807-2000A priority patent/SK285550B6/sk
Priority to BR9910801-1A priority patent/BR9910801A/pt
Priority to PL99344412A priority patent/PL344412A1/xx
Priority to ARP990102513A priority patent/AR018402A1/es
Publication of ES2137138A1 publication Critical patent/ES2137138A1/es
Publication of ES2137138B1 publication Critical patent/ES2137138B1/es
Application granted granted Critical
Priority to LT2000108A priority patent/LT4879B/lt
Priority to IS5736A priority patent/IS2040B/is
Priority to NO20006029A priority patent/NO316600B1/no
Priority to BG105005A priority patent/BG64950B1/bg
Priority to ZA200007638A priority patent/ZA200007638B/xx
Priority to CU20000307A priority patent/CU22995A3/es
Priority to LVP-00-161A priority patent/LV12632B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Derivados de pirazolinas, su preparación y su aplicación como medicamentos. La presente invención se refiere a nuevos derivados de pirazolinas de fórmula general (I), así como a sus sales fisiológicamente aceptables, a los procedimientos para su preparación, a su aplicación como medicamentos en terapéutica humana y/o veterinaria y a las composiciones farmacéuticas que los contienen. Los nuevos compuestos objeto de la presente invención pueden ser utilizados en la industria farmacéutica como intermedios y para la preparación de medicamentos. En particular se pueden utilizar par la elaboración de medicamentos para el tratamiento de la inflamación y de otros trastornos asociados con la inflamación y otros procesos mediados por la ciclooxigenasa-2, por ejemplo, la artritis, el tratamiento del dolor o tratamiento de la fiebre.
ES009801129A 1998-05-29 1998-05-29 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos. Expired - Lifetime ES2137138B1 (es)

Priority Applications (34)

Application Number Priority Date Filing Date Title
ES009801129A ES2137138B1 (es) 1998-05-29 1998-05-29 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
US09/701,276 US6353117B1 (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation and application as medicaments
JP2000552096A JP4633928B2 (ja) 1998-05-29 1999-05-27 ピラゾリン誘導体、その調製及び薬剤としての適用
TW88108709A TW572898B (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation and their application as medicament
GEAP19995706A GEP20043237B (en) 1998-05-29 1999-05-27 Pyrazoline Derivatives, Method for Their Preparation and Compositions Containing Them for Treatment of Diseases Mediated by Cyclooxygenase-2
CNB998081116A CN1189459C (zh) 1998-05-29 1999-05-27 吡唑啉衍生物、它们的制备方法和作为药物的应用
KR1020007013447A KR100603666B1 (ko) 1998-05-29 1999-05-27 피라졸린 유도체, 그 제조방법 및 약으로서의 용도
HU0102102A HUP0102102A3 (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation, pharmaceutical compositions containing them and their use
NZ508990A NZ508990A (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation and application as medicaments
SI9920042A SI20580B (sl) 1998-05-29 1999-05-27 Derivati pirazolina, njihova priprava in njihova uporaba kot zdravila
PCT/ES1999/000156 WO1999062884A1 (es) 1998-05-29 1999-05-27 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos
RU2000133231/04A RU2233272C2 (ru) 1998-05-29 1999-05-27 Производные пиразолина, способы их получения и фармацевтическая композиция
PT99922192T PT1083171E (pt) 1998-05-29 1999-05-27 Derivados de pirazolina sua preparacao e aplicacao como medicamentos
ES99922192T ES2221382T3 (es) 1998-05-29 1999-05-27 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
US10/229,880 USRE38963E1 (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation and application as medicaments
CZ20004418A CZ298391B6 (cs) 1998-05-29 1999-05-27 Derivát pyrazolinu, zpusob jeho prípravy, jeho použití a farmaceutický prostredek, který ho obsahuje
AT99922192T ATE265437T1 (de) 1998-05-29 1999-05-27 Pyrazoline, ihre herstellung und verwendung als medikamente
CO99032824A CO5031241A1 (es) 1998-05-29 1999-05-27 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos
DK99922192T DK1083171T3 (da) 1998-05-29 1999-05-27 Pyrazolinderivater, deres fremstilling og anvendelse som medikamenter
CA002333475A CA2333475C (en) 1998-05-29 1999-05-27 Derivatives of pyrazolines, their preparation and their application as medicaments
ARP990102513A AR018402A1 (es) 1998-05-29 1999-05-27 DERIVADO DE PIRAZOLINA, PROCEDIMIENTO DE PREPARACIoN Y COMPOSICION FARMACEUTICA
DE69916828T DE69916828T2 (de) 1998-05-29 1999-05-27 Pyrazoline, ihre herstellung und verwendung als medikamente
EP99922192A EP1083171B1 (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation and application as medicaments
BR9910801-1A BR9910801A (pt) 1998-05-29 1999-05-27 Derivados da pirazolina, a preparação dos mesmose a aplicação dos mesmos como um medicamento
PL99344412A PL344412A1 (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation and application as medicaments
AU39329/99A AU752001B2 (en) 1998-05-29 1999-05-27 Pyrazoline derivatives, their preparation and application as medicaments
SK1807-2000A SK285550B6 (sk) 1998-05-29 1999-05-27 Derivát pyrazolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
NO20006029A NO316600B1 (no) 1998-05-29 2000-11-28 Pyrazolinderivater, deres fremstilling og anvendelse for fremstilling av legemidler
LT2000108A LT4879B (lt) 1998-05-29 2000-11-28 Pirazolino dariniai, jų gavimas ir jų panaudojimas vaistams
IS5736A IS2040B (is) 1998-05-29 2000-11-28 Pýrasólínafleiður, framleiðsla þeirra og notkun sem lyfja
BG105005A BG64950B1 (bg) 1998-05-29 2000-11-29 Пиразолинови производни, тяхното получаване и приложение като лекарствени средства
ZA200007638A ZA200007638B (en) 1998-05-29 2000-12-19 Pyrazoline derivatives, their preparation and application as medicaments.
CU20000307A CU22995A3 (es) 1998-05-29 2000-12-27 Derivados de pirazolinas, su preparación y su aplicación como medicamentos
LVP-00-161A LV12632B (en) 1998-05-29 2000-12-28 PIRAZOLINE DERIVATIVES, THEIR ACQUISITION AND USE OF MEDICINES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801129A ES2137138B1 (es) 1998-05-29 1998-05-29 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
ES2137138A1 ES2137138A1 (es) 1999-12-01
ES2137138B1 true ES2137138B1 (es) 2000-09-16

Family

ID=8303969

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801129A Expired - Lifetime ES2137138B1 (es) 1998-05-29 1998-05-29 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
ES99922192T Expired - Lifetime ES2221382T3 (es) 1998-05-29 1999-05-27 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99922192T Expired - Lifetime ES2221382T3 (es) 1998-05-29 1999-05-27 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.

Country Status (32)

Country Link
US (2) US6353117B1 (es)
EP (1) EP1083171B1 (es)
JP (1) JP4633928B2 (es)
KR (1) KR100603666B1 (es)
CN (1) CN1189459C (es)
AR (1) AR018402A1 (es)
AT (1) ATE265437T1 (es)
AU (1) AU752001B2 (es)
BG (1) BG64950B1 (es)
BR (1) BR9910801A (es)
CA (1) CA2333475C (es)
CO (1) CO5031241A1 (es)
CU (1) CU22995A3 (es)
CZ (1) CZ298391B6 (es)
DE (1) DE69916828T2 (es)
DK (1) DK1083171T3 (es)
ES (2) ES2137138B1 (es)
GE (1) GEP20043237B (es)
HU (1) HUP0102102A3 (es)
IS (1) IS2040B (es)
LT (1) LT4879B (es)
LV (1) LV12632B (es)
NO (1) NO316600B1 (es)
NZ (1) NZ508990A (es)
PL (1) PL344412A1 (es)
PT (1) PT1083171E (es)
RU (1) RU2233272C2 (es)
SI (1) SI20580B (es)
SK (1) SK285550B6 (es)
TW (1) TW572898B (es)
WO (1) WO1999062884A1 (es)
ZA (1) ZA200007638B (es)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
EP1191931B1 (en) * 1999-06-16 2007-05-09 Temple University of the Commonwealth System of Higher Education 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-aryl-2-pyrazolines as inhibitors of cyclooxygenase-2
ES2174757B1 (es) * 2001-04-06 2003-11-01 Esteve Labor Dr Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6878729B2 (en) * 2001-05-04 2005-04-12 The Procter & Gamble Company Medicinal uses of dihydropyrazoles
ES2183720B1 (es) * 2001-06-18 2004-01-16 Esteve Labor Dr Procedimiento para la preparacion de derivados de 1,5-diaril-3-trifluorometil-delta2-pirazolinas racemicas y enantiomericamente puras.
DE602004002832T2 (de) 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
ES2238923B1 (es) * 2004-02-16 2006-11-01 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados pirazolinicos sustituidos.
US7998996B2 (en) * 2004-02-17 2011-08-16 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
ES2278503B1 (es) * 2005-06-27 2008-06-16 Laboratorios Del Dr. Esteve, S.A. Epoxidacion de cetonas alfa, beta - insaturadas.
WO2007009706A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
WO2007009703A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. New formulations of substituted pyrazoline compounds
WO2007009699A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
WO2007009693A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A Combination of a substituted pyrazoline compound and a drug used in food-related disorders
WO2007009704A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
EP1757587A1 (en) * 2005-07-15 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
ES2336883B1 (es) * 2005-07-15 2011-03-22 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743643A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. New formulations of substituted pyrazoline compounds
EP1743638A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
EP1849784A1 (en) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Indoline-substituted pyrazoline compounds, their preparation and use as medicaments
WO2007009683A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
EP1743642A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
WO2007009698A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Combination of pyrazoline type cannabinoid receptor antagonist and statin
EP1749526A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
EP1760078A1 (en) * 2005-07-15 2007-03-07 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds; methods for their preparation
EP1745781A1 (en) * 2005-07-15 2007-01-24 Laboratorios Del Dr. Esteve, S.A. Combination of pyrazoline type cannabinoid receptor antagonist and statin
WO2007009710A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds: methods for their preparation
WO2007009692A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
EP1743636A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Combination of a substituted pyrazoline compound and a drug used in food-related disorders
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EP3009137A1 (en) * 2014-10-16 2016-04-20 Ecuphar N.V. Pyrazoline-derived compound and its use in a weekly dosage regime against inflammation and pain derived from degenerative joint disease in mammals
EP4029502A1 (en) 2021-01-15 2022-07-20 Ecuphar N.V. Pyrazoline-derived compound (enflicoxib) for use in the prevention and/or treatment of pain and inflammation associated to surgery in mammals
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

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JPS5818363A (ja) * 1981-07-13 1983-02-02 アメリカン・サイアナミド・カンパニ− 複素環式置換アミノピラゾリン類およびその薬としての用途
ATE57690T1 (de) * 1987-01-05 1990-11-15 Du Pont Pyrazolin mit insektizidischer aktivitaet.
AU708964B2 (en) * 1995-05-25 1999-08-19 G.D. Searle & Co. Method of preparing 3-haloalkyl-1h-pyrazoles
GB9520584D0 (en) * 1995-10-09 1995-12-13 Fujisawa Pharmaceutical Co Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
NO20006029L (no) 2001-01-26
USRE38963E1 (en) 2006-01-31
LT4879B (lt) 2002-01-25
IS2040B (is) 2005-08-15
JP2002516908A (ja) 2002-06-11
ATE265437T1 (de) 2004-05-15
PL344412A1 (en) 2001-11-05
NO20006029D0 (no) 2000-11-28
BG64950B1 (bg) 2006-10-31
EP1083171B1 (en) 2004-04-28
GEP20043237B (en) 2004-05-25
IS5736A (is) 2000-11-28
CA2333475C (en) 2009-12-08
CO5031241A1 (es) 2001-04-27
SK285550B6 (sk) 2007-03-01
HUP0102102A2 (hu) 2002-03-28
CN1189459C (zh) 2005-02-16
SI20580A (sl) 2001-12-31
BG105005A (en) 2001-08-31
RU2233272C2 (ru) 2004-07-27
ZA200007638B (en) 2001-11-13
CA2333475A1 (en) 1999-12-09
CZ20004418A3 (en) 2001-06-13
SK18072000A3 (sk) 2001-07-10
CU22995A3 (es) 2004-10-12
NO316600B1 (no) 2004-03-01
LV12632A (lv) 2001-03-20
DE69916828T2 (de) 2005-04-14
WO1999062884A1 (es) 1999-12-09
DK1083171T3 (da) 2004-08-09
AU752001B2 (en) 2002-09-05
AR018402A1 (es) 2001-11-14
NZ508990A (en) 2002-12-20
ES2221382T3 (es) 2004-12-16
CZ298391B6 (cs) 2007-09-19
AU3932999A (en) 1999-12-20
KR100603666B1 (ko) 2006-07-24
TW572898B (en) 2004-01-21
SI20580B (sl) 2007-10-31
ES2137138A1 (es) 1999-12-01
US6353117B1 (en) 2002-03-05
JP4633928B2 (ja) 2011-02-16
KR20010052437A (ko) 2001-06-25
LV12632B (en) 2001-07-20
PT1083171E (pt) 2004-09-30
DE69916828D1 (de) 2004-06-03
BR9910801A (pt) 2001-11-27
EP1083171A1 (en) 2001-03-14
LT2000108A (en) 2001-09-25
HUP0102102A3 (en) 2002-06-28
CN1307566A (zh) 2001-08-08

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