DE69502939T2 - Sublinguales oder bukkales arzneimittel - Google Patents

Sublinguales oder bukkales arzneimittel

Info

Publication number
DE69502939T2
DE69502939T2 DE69502939T DE69502939T DE69502939T2 DE 69502939 T2 DE69502939 T2 DE 69502939T2 DE 69502939 T DE69502939 T DE 69502939T DE 69502939 T DE69502939 T DE 69502939T DE 69502939 T2 DE69502939 T2 DE 69502939T2
Authority
DE
Germany
Prior art keywords
oxepino
dibenz
chloro
methyl
buccal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69502939T
Other languages
German (de)
English (en)
Other versions
DE69502939D1 (de
Inventor
Leonardus Delbressine
Johannes Wieringa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69502939(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE69502939D1 publication Critical patent/DE69502939D1/de
Application granted granted Critical
Publication of DE69502939T2 publication Critical patent/DE69502939T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69502939T 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel Expired - Lifetime DE69502939T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94200521 1994-03-02
PCT/EP1995/000765 WO1995023600A1 (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Publications (2)

Publication Number Publication Date
DE69502939D1 DE69502939D1 (de) 1998-07-16
DE69502939T2 true DE69502939T2 (de) 1998-10-22

Family

ID=8216678

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69502939T Expired - Lifetime DE69502939T2 (de) 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel
DE201012000050 Active DE122010000050I2 (de) 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE201012000050 Active DE122010000050I2 (de) 1994-03-02 1995-03-01 Sublinguales oder bukkales arzneimittel.

Country Status (23)

Country Link
US (1) US5763476A (OSRAM)
EP (1) EP0746317B1 (OSRAM)
JP (2) JP4099224B2 (OSRAM)
KR (1) KR100330942B1 (OSRAM)
CN (1) CN1079670C (OSRAM)
AT (1) ATE167057T1 (OSRAM)
AU (1) AU692530B2 (OSRAM)
BR (2) BR9506924A (OSRAM)
CA (1) CA2182981C (OSRAM)
CZ (1) CZ284633B6 (OSRAM)
DE (2) DE69502939T2 (OSRAM)
DK (1) DK0746317T3 (OSRAM)
ES (1) ES2118584T3 (OSRAM)
FI (1) FI117923B (OSRAM)
FR (1) FR10C0056I2 (OSRAM)
HK (1) HK1008417A1 (OSRAM)
HU (1) HU225051B1 (OSRAM)
LU (1) LU91751I2 (OSRAM)
NO (2) NO308772B1 (OSRAM)
NZ (1) NZ282394A (OSRAM)
PL (1) PL180465B1 (OSRAM)
RU (1) RU2139051C1 (OSRAM)
WO (1) WO1995023600A1 (OSRAM)

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MXPA06002766A (es) * 2003-09-22 2006-12-14 Baxter Int Esterilizacion a alta presion para esterilizar terminalmente preparaciones farmaceuticas y productos medicos.
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GB0416861D0 (en) * 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
RU2403039C2 (ru) * 2004-10-15 2010-11-10 H.B.Opганон Лечение биполярных расстройств и сопутствующих симптомов
ES2293626T3 (es) * 2005-04-07 2008-03-16 N.V. Organon Forma cristalina del maleato de asenapina.
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
AR063188A1 (es) 2005-04-07 2009-01-14 Organon Nv Compuestos intermediarios para la preparacion de trans -5-cloro-2-netil-2,3,3a,12b- tetrahidro-1h-dibenz (2,3:6,7)- oxepina (4,5c) pirrol
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
UY31531A1 (es) * 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
EP2321011A1 (en) * 2008-06-25 2011-05-18 Pfizer Inc. Diaryl compounds and uses thereof
WO2010127674A1 (en) * 2009-05-06 2010-11-11 Sunin K/S Transdermal compositions of asenapine for the treatment of psychiatric disorders
CA2766291C (en) 2009-06-24 2016-06-21 Msd Oss B.V. Injectable formulations containing asenapine and method of treatment using same
TW201118102A (en) 2009-07-29 2011-06-01 Organon Nv Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same
AU2011268335A1 (en) 2010-06-18 2013-01-10 Dr. Reddy's Laboratories Ltd. Asenapine maleate
KR101810717B1 (ko) 2010-07-29 2017-12-19 라보라토리오스 레스비, 에스.엘. 아세나핀을 제조하는 신규한 방법
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
DK2640391T3 (da) 2010-11-15 2016-02-15 Agenebio Inc Pyridazinderivater, sammensætninger og fremgangsmåder til behandling af kognitiv svækkelse
WO2012066565A2 (en) 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
EP2524919A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
US9533994B2 (en) 2011-05-18 2017-01-03 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
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JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
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Also Published As

Publication number Publication date
CA2182981C (en) 2006-10-17
EP0746317A1 (en) 1996-12-11
CZ254196A3 (en) 1997-10-15
WO1995023600A1 (en) 1995-09-08
NO963639D0 (no) 1996-08-30
FR10C0056I2 (OSRAM) 2011-11-25
DK0746317T3 (da) 1999-03-22
DE122010000050I2 (de) 2011-07-21
RU2139051C1 (ru) 1999-10-10
CA2182981A1 (en) 1995-09-08
NO963639L (no) 1996-10-30
CZ284633B6 (cs) 1999-01-13
JP4099224B2 (ja) 2008-06-11
FI963398L (fi) 1996-08-30
FR10C0056I1 (OSRAM) 2011-01-28
KR100330942B1 (ko) 2002-11-16
ES2118584T3 (es) 1998-09-16
AU1947895A (en) 1995-09-18
MX9603713A (es) 1997-12-31
NO2010024I2 (no) 2012-04-10
EP0746317B1 (en) 1998-06-10
FI963398A0 (fi) 1996-08-30
CN1079670C (zh) 2002-02-27
HU225051B1 (en) 2006-05-29
NO308772B1 (no) 2000-10-30
PL316080A1 (en) 1996-12-23
NZ282394A (en) 1997-12-19
CN1143320A (zh) 1997-02-19
BR1100625A (pt) 1999-12-28
ATE167057T1 (de) 1998-06-15
AU692530B2 (en) 1998-06-11
JP4616810B2 (ja) 2011-01-19
LU91751I2 (fr) 2011-01-04
DE69502939D1 (de) 1998-07-16
NO2010024I1 (no) 2011-01-03
HK1008417A1 (en) 1999-05-07
PL180465B1 (pl) 2001-02-28
JPH09509674A (ja) 1997-09-30
HU9602383D0 (en) 1996-10-28
HUT76319A (en) 1997-08-28
JP2006342178A (ja) 2006-12-21
BR9506924A (pt) 1997-09-30
US5763476A (en) 1998-06-09
DE122010000050I1 (de) 2011-05-05
FI117923B (fi) 2007-04-30

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