CA2182981C - Sublingual or buccal pharmaceutical composition - Google Patents

Sublingual or buccal pharmaceutical composition Download PDF

Info

Publication number
CA2182981C
CA2182981C CA002182981A CA2182981A CA2182981C CA 2182981 C CA2182981 C CA 2182981C CA 002182981 A CA002182981 A CA 002182981A CA 2182981 A CA2182981 A CA 2182981A CA 2182981 C CA2182981 C CA 2182981C
Authority
CA
Canada
Prior art keywords
sublingual
pharmaceutical composition
methyl
chloro
oxepino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002182981A
Other languages
English (en)
French (fr)
Other versions
CA2182981A1 (en
Inventor
Leonardus Petrus Carla Delbressine
Johannes Hubertus Wieringa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Organon Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2182981(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon Ireland Ltd filed Critical Organon Ireland Ltd
Publication of CA2182981A1 publication Critical patent/CA2182981A1/en
Application granted granted Critical
Publication of CA2182981C publication Critical patent/CA2182981C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002182981A 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition Expired - Lifetime CA2182981C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94200521.6 1994-03-02
EP94200521 1994-03-02
PCT/EP1995/000765 WO1995023600A1 (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Publications (2)

Publication Number Publication Date
CA2182981A1 CA2182981A1 (en) 1995-09-08
CA2182981C true CA2182981C (en) 2006-10-17

Family

ID=8216678

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002182981A Expired - Lifetime CA2182981C (en) 1994-03-02 1995-03-01 Sublingual or buccal pharmaceutical composition

Country Status (23)

Country Link
US (1) US5763476A (OSRAM)
EP (1) EP0746317B1 (OSRAM)
JP (2) JP4099224B2 (OSRAM)
KR (1) KR100330942B1 (OSRAM)
CN (1) CN1079670C (OSRAM)
AT (1) ATE167057T1 (OSRAM)
AU (1) AU692530B2 (OSRAM)
BR (2) BR9506924A (OSRAM)
CA (1) CA2182981C (OSRAM)
CZ (1) CZ284633B6 (OSRAM)
DE (2) DE69502939T2 (OSRAM)
DK (1) DK0746317T3 (OSRAM)
ES (1) ES2118584T3 (OSRAM)
FI (1) FI117923B (OSRAM)
FR (1) FR10C0056I2 (OSRAM)
HK (1) HK1008417A1 (OSRAM)
HU (1) HU225051B1 (OSRAM)
LU (1) LU91751I2 (OSRAM)
NO (2) NO308772B1 (OSRAM)
NZ (1) NZ282394A (OSRAM)
PL (1) PL180465B1 (OSRAM)
RU (1) RU2139051C1 (OSRAM)
WO (1) WO1995023600A1 (OSRAM)

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US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
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GB0416861D0 (en) * 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
RU2403039C2 (ru) * 2004-10-15 2010-11-10 H.B.Opганон Лечение биполярных расстройств и сопутствующих симптомов
ES2293626T3 (es) * 2005-04-07 2008-03-16 N.V. Organon Forma cristalina del maleato de asenapina.
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
AR063188A1 (es) 2005-04-07 2009-01-14 Organon Nv Compuestos intermediarios para la preparacion de trans -5-cloro-2-netil-2,3,3a,12b- tetrahidro-1h-dibenz (2,3:6,7)- oxepina (4,5c) pirrol
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US7750167B2 (en) 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
UY31531A1 (es) * 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
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WO2010127674A1 (en) * 2009-05-06 2010-11-11 Sunin K/S Transdermal compositions of asenapine for the treatment of psychiatric disorders
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AU2011268335A1 (en) 2010-06-18 2013-01-10 Dr. Reddy's Laboratories Ltd. Asenapine maleate
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WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
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JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
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Also Published As

Publication number Publication date
EP0746317A1 (en) 1996-12-11
CZ254196A3 (en) 1997-10-15
WO1995023600A1 (en) 1995-09-08
NO963639D0 (no) 1996-08-30
FR10C0056I2 (OSRAM) 2011-11-25
DK0746317T3 (da) 1999-03-22
DE122010000050I2 (de) 2011-07-21
RU2139051C1 (ru) 1999-10-10
CA2182981A1 (en) 1995-09-08
NO963639L (no) 1996-10-30
CZ284633B6 (cs) 1999-01-13
JP4099224B2 (ja) 2008-06-11
FI963398L (fi) 1996-08-30
FR10C0056I1 (OSRAM) 2011-01-28
KR100330942B1 (ko) 2002-11-16
ES2118584T3 (es) 1998-09-16
AU1947895A (en) 1995-09-18
MX9603713A (es) 1997-12-31
NO2010024I2 (no) 2012-04-10
EP0746317B1 (en) 1998-06-10
FI963398A0 (fi) 1996-08-30
CN1079670C (zh) 2002-02-27
HU225051B1 (en) 2006-05-29
NO308772B1 (no) 2000-10-30
PL316080A1 (en) 1996-12-23
NZ282394A (en) 1997-12-19
CN1143320A (zh) 1997-02-19
BR1100625A (pt) 1999-12-28
ATE167057T1 (de) 1998-06-15
AU692530B2 (en) 1998-06-11
JP4616810B2 (ja) 2011-01-19
LU91751I2 (fr) 2011-01-04
DE69502939D1 (de) 1998-07-16
DE69502939T2 (de) 1998-10-22
NO2010024I1 (no) 2011-01-03
HK1008417A1 (en) 1999-05-07
PL180465B1 (pl) 2001-02-28
JPH09509674A (ja) 1997-09-30
HU9602383D0 (en) 1996-10-28
HUT76319A (en) 1997-08-28
JP2006342178A (ja) 2006-12-21
BR9506924A (pt) 1997-09-30
US5763476A (en) 1998-06-09
DE122010000050I1 (de) 2011-05-05
FI117923B (fi) 2007-04-30

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