PT3407888T - Compostos de piridopirroloquinoxalina, suas composições e utilizações - Google Patents

Compostos de piridopirroloquinoxalina, suas composições e utilizações

Info

Publication number
PT3407888T
PT3407888T PT177449105T PT17744910T PT3407888T PT 3407888 T PT3407888 T PT 3407888T PT 177449105 T PT177449105 T PT 177449105T PT 17744910 T PT17744910 T PT 17744910T PT 3407888 T PT3407888 T PT 3407888T
Authority
PT
Portugal
Prior art keywords
organic compounds
compounds
organic
Prior art date
Application number
PT177449105T
Other languages
English (en)
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of PT3407888T publication Critical patent/PT3407888T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16Peri-condensed systems
PT177449105T 2016-01-26 2017-01-26 Compostos de piridopirroloquinoxalina, suas composições e utilizações PT3407888T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662287264P 2016-01-26 2016-01-26
US201662440130P 2016-12-29 2016-12-29

Publications (1)

Publication Number Publication Date
PT3407888T true PT3407888T (pt) 2021-03-19

Family

ID=59398657

Family Applications (2)

Application Number Title Priority Date Filing Date
PT177449105T PT3407888T (pt) 2016-01-26 2017-01-26 Compostos de piridopirroloquinoxalina, suas composições e utilizações
PT202157863T PT3838274T (pt) 2016-01-26 2017-01-26 Derivado de pirido[3',4':4,5]pirrolo[1,2,3-de]quinoxalina para utilização no tratamento de distúrbios do snc

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT202157863T PT3838274T (pt) 2016-01-26 2017-01-26 Derivado de pirido[3',4':4,5]pirrolo[1,2,3-de]quinoxalina para utilização no tratamento de distúrbios do snc

Country Status (17)

Country Link
US (3) US10245260B2 (pt)
EP (2) EP3838274B1 (pt)
JP (2) JP6995761B2 (pt)
KR (1) KR20180099905A (pt)
CN (2) CN108883111B (pt)
AU (1) AU2017211791B2 (pt)
BR (1) BR112018015283B1 (pt)
CA (1) CA3011983A1 (pt)
DK (2) DK3407888T3 (pt)
ES (1) ES2863471T3 (pt)
HU (1) HUE053737T2 (pt)
IL (3) IL296884B1 (pt)
MX (2) MX2018009158A (pt)
PL (2) PL3838274T3 (pt)
PT (2) PT3407888T (pt)
RU (1) RU2743513C2 (pt)
WO (1) WO2017132408A1 (pt)

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PL2968320T3 (pl) 2013-03-15 2021-05-17 Intra-Cellular Therapies, Inc. Związki organiczne
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DK3125893T3 (da) 2014-04-04 2023-11-20 Intra Cellular Therapies Inc Deutererede heterocyklus-fusionerede gamma-carboliner som antagonister af 5-ht2a-receptorer
DK3407888T3 (da) 2016-01-26 2021-04-06 Intra Cellular Therapies Inc Pyridopyrroloquinoxalinforbindelser, deres sammensætninger og anvendelser
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US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
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JP6987868B2 (ja) 2016-12-29 2022-01-05 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
US10961245B2 (en) * 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
BR112020001654A2 (pt) 2017-07-26 2020-07-21 Intra-Cellular Therapies, Inc. compostos orgânicos
US11376249B2 (en) 2017-07-26 2022-07-05 Intra-Cellular Therapies, Inc. Organic compounds
US20210009592A1 (en) * 2018-03-23 2021-01-14 Intra-Cellular Therapies, Inc. Organic compounds
MX2020009928A (es) * 2018-03-23 2021-01-08 Intra Cellular Therapies Inc Compuestos organicos.
CA3102948A1 (en) * 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Novel methods
CN110831941A (zh) 2018-06-11 2020-02-21 细胞内治疗公司 取代的杂环稠合的γ-咔啉类化合物合成
EP3843739A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS
WO2020131899A1 (en) * 2018-12-17 2020-06-25 Intra-Cellular Therapies, Inc. Organic compound
WO2020131911A1 (en) * 2018-12-17 2020-06-25 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
KR20210104833A (ko) * 2018-12-17 2021-08-25 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로사이클 융합 감마-카르볼린 합성
EP3897643B1 (en) * 2018-12-21 2023-11-15 Intra-Cellular Therapies, Inc. A pyridopyrroloquinoxaline compound and its medical use
JP2022515158A (ja) * 2018-12-21 2022-02-17 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
US20220088014A1 (en) * 2019-01-23 2022-03-24 Intra-Cellular Therapies, Inc. Methods of treating addiction
AU2020254812A1 (en) * 2019-04-04 2021-11-11 Intra-Cellular Therapies, Inc. Methods of treating neuropathic pain
JP2022549335A (ja) * 2019-09-25 2022-11-24 イントラ-セルラー・セラピーズ・インコーポレイテッド 新規方法
JP7261942B2 (ja) 2019-12-11 2023-04-20 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
IL301847A (en) * 2020-10-09 2023-06-01 Shujing Biopharma Co Ltd A modified heterocyclic γ-carboline derivative, a method of preparation thereof, its intermediate form and its use

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