MX2020009928A - Compuestos organicos. - Google Patents

Compuestos organicos.

Info

Publication number
MX2020009928A
MX2020009928A MX2020009928A MX2020009928A MX2020009928A MX 2020009928 A MX2020009928 A MX 2020009928A MX 2020009928 A MX2020009928 A MX 2020009928A MX 2020009928 A MX2020009928 A MX 2020009928A MX 2020009928 A MX2020009928 A MX 2020009928A
Authority
MX
Mexico
Prior art keywords
sub
receptor
organic compounds
involving
carbolines
Prior art date
Application number
MX2020009928A
Other languages
English (en)
Inventor
Peng Li
Qiang Zhang
Robert Davis
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of MX2020009928A publication Critical patent/MX2020009928A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a gamma-carbolinas fusionadas con heterociclo sustituido deuterado particulares, en forma libre, sólida, de sal farmacéuticamente aceptable o sustancialmente pura como se describe en la presente, composiciones farmacéuticas de las mismas y métodos de uso en el tratamiento de enfermedades que involucran el receptor 5-HT2A, el transportador de serotonina (SERT), rutas que involucran el sistema de señalización de dopamina D1 y D2, y/o el receptor de µ-opioide.
MX2020009928A 2018-03-23 2019-03-21 Compuestos organicos. MX2020009928A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862647488P 2018-03-23 2018-03-23
PCT/US2019/023350 WO2019183341A1 (en) 2018-03-23 2019-03-21 Organic compounds

Publications (1)

Publication Number Publication Date
MX2020009928A true MX2020009928A (es) 2021-01-08

Family

ID=67986376

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020009928A MX2020009928A (es) 2018-03-23 2019-03-21 Compuestos organicos.

Country Status (9)

Country Link
EP (1) EP3768254A4 (es)
JP (2) JP7462568B2 (es)
CN (1) CN112040940A (es)
AU (1) AU2019240226A1 (es)
BR (1) BR112020019119A2 (es)
CA (1) CA3094949A1 (es)
IL (1) IL277504A (es)
MX (1) MX2020009928A (es)
WO (1) WO2019183341A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022514263A (ja) * 2018-12-17 2022-02-10 イントラ－セルラー・セラピーズ・インコーポレイテッド 置換複素環縮合γ－カルボリンの合成
EP3898580A4 (en) * 2018-12-17 2022-08-10 Intra-Cellular Therapies, Inc. SYNTHESIS OF FUSED GAMMA-CARBOLINES WITH SUBSTITUTED HETEROCYCLES
EP3897643B1 (en) * 2018-12-21 2023-11-15 Intra-Cellular Therapies, Inc. A pyridopyrroloquinoxaline compound and its medical use

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Publication number Priority date Publication date Assignee Title
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
CH656884A5 (de) 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
US5538739A (en) 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
CN1074923C (zh) 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
CN1161101C (zh) 1998-12-17 2004-08-11 阿尔扎有限公司 用多层包衣将填充液体的明胶胶囊转变成控制释放的系统
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
US6552017B1 (en) 1999-06-15 2003-04-22 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
PT1539115E (pt) 2002-07-29 2008-01-14 Alza Corp Métodos e formas de dosagem para libertação controlada de paliperidona
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
JP5567349B2 (ja) 2007-03-12 2014-08-06 イントラ−セルラー・セラピーズ・インコーポレイテッド 置換ヘテロ環縮合ガンマ−カルボリンの合成
CN102046175B (zh) 2008-03-12 2015-08-12 细胞内治疗公司 取代的杂环稠合的γ-咔啉固体
AU2015218433B2 (en) * 2008-05-27 2017-07-27 Intra-Cellular Therapies, Inc. Methods and compositions for sleep disorders and other disorders
US8598119B2 (en) 2008-05-27 2013-12-03 Intra-Cellular Therapies, Inc. Methods and compositions for sleep disorders and other disorders
MX2016013046A (es) * 2014-04-04 2017-02-15 Intra-Cellular Therapies Inc Compuestos organicos.
WO2017117514A1 (en) 2015-12-31 2017-07-06 Tung Roger D Deuterated iti-007
BR112018015283B1 (pt) * 2016-01-26 2023-09-26 Intra-Cellular Therapies, Inc Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central
US10231974B2 (en) 2016-05-04 2019-03-19 Companion Therapeutics, LLC Pharmaceutical composition effective in preventing the adverse effects associated with the prolonged use of dihydrofolate reductase inhibitors
MX2020000968A (es) 2017-07-26 2020-09-28 Intra Cellular Therapies Inc Compuestos organicos.

Also Published As

Publication number Publication date
CN112040940A (zh) 2020-12-04
AU2019240226A1 (en) 2020-10-22
JP2021519267A (ja) 2021-08-10
EP3768254A4 (en) 2021-11-10
BR112020019119A2 (pt) 2021-01-12
EP3768254A1 (en) 2021-01-27
IL277504A (en) 2020-11-30
JP2024038336A (ja) 2024-03-19
CA3094949A1 (en) 2019-09-26
WO2019183341A1 (en) 2019-09-26
JP7462568B2 (ja) 2024-04-05

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