MX2012012277A - Compuestos organicos. - Google Patents
Compuestos organicos.Info
- Publication number
- MX2012012277A MX2012012277A MX2012012277A MX2012012277A MX2012012277A MX 2012012277 A MX2012012277 A MX 2012012277A MX 2012012277 A MX2012012277 A MX 2012012277A MX 2012012277 A MX2012012277 A MX 2012012277A MX 2012012277 A MX2012012277 A MX 2012012277A
- Authority
- MX
- Mexico
- Prior art keywords
- organic compounds
- receptor
- carbolines
- sert
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención se refiere a gamma-carbolinas particulares fusionadas substituidas con heterociclo, sus profármacos, en forma de sal libre, sólida, farmacéuticamente aceptable y/o substancialmente pura como se describe aquí, sus composiciones farmacéuticas, y métodos de uso en el tratamiento de enfermedades que involucran al receptor 5-HT2A, transportador de serotonina (SERT) y/o trayectorias que involucran sistemas de señalización del receptor de dopamina D2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32704910P | 2010-04-22 | 2010-04-22 | |
US36760910P | 2010-07-26 | 2010-07-26 | |
PCT/US2011/000719 WO2011133224A1 (en) | 2010-04-22 | 2011-04-22 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012012277A true MX2012012277A (es) | 2013-04-03 |
MX339805B MX339805B (es) | 2016-06-10 |
Family
ID=44834444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012012277A MX339805B (es) | 2010-04-22 | 2011-04-22 | Compuestos organicos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US8993572B2 (es) |
EP (1) | EP2560676B8 (es) |
JP (1) | JP5894574B2 (es) |
KR (1) | KR101868165B1 (es) |
CN (1) | CN103209704B (es) |
BR (1) | BR112012026881A2 (es) |
CA (1) | CA2796756A1 (es) |
ES (1) | ES2602503T3 (es) |
IL (2) | IL222571A (es) |
MX (1) | MX339805B (es) |
RU (1) | RU2591194C2 (es) |
WO (1) | WO2011133224A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103626766B (zh) | 2007-03-12 | 2017-06-09 | 细胞内治疗公司 | 与取代的杂环稠合的γ‑咔啉的合成 |
PL2262505T3 (pl) | 2008-03-12 | 2015-04-30 | Intra Cellular Therapies Inc | Podstawione heterocykliczne skondensowane gamma-karboliny w postaci stałej |
US8598119B2 (en) * | 2008-05-27 | 2013-12-03 | Intra-Cellular Therapies, Inc. | Methods and compositions for sleep disorders and other disorders |
JP2012526810A (ja) | 2009-05-13 | 2012-11-01 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
EP2560676B8 (en) * | 2010-04-22 | 2016-10-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
CA2870303A1 (en) * | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP6549040B2 (ja) | 2013-02-17 | 2019-07-24 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規使用 |
EP2968320B1 (en) | 2013-03-15 | 2020-11-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9545406B2 (en) | 2013-03-15 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Method of treating a CNS injury with a PDE1 inhibitor |
KR20230058736A (ko) * | 2013-12-03 | 2023-05-03 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
JP2017509677A (ja) * | 2014-04-04 | 2017-04-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
EP3125893B1 (en) | 2014-04-04 | 2023-09-20 | Intra-Cellular Therapies, Inc. | Deuterated heterocycle fused gamma-carbolines as antagonists of 5-ht2a receptors |
WO2015191554A1 (en) | 2014-06-09 | 2015-12-17 | Intra-Cellular Therapies, Inc. | Compounds and methods of use to treat schizophrenia |
ES2745819T3 (es) | 2014-08-07 | 2020-03-03 | Intra Cellular Therapies Inc | Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1 |
ES2857567T3 (es) | 2014-09-17 | 2021-09-29 | Intra Cellular Therapies Inc | Derivados de 7,8-dihidro-[2h]-imidazo-[1,2-a]pirazolo[4,3-e]pirimidin-4(5h)-ona como inhibidores de fosfodiesterasa 1 (PDE1) para tratar enfermedades, trastornos o lesiones del sistema nervioso central (SNC) |
CN104327066B (zh) * | 2014-09-30 | 2017-05-24 | 华东理工大学 | 快速高效提取卡柏林类生物碱的方法 |
KR101613245B1 (ko) | 2015-04-27 | 2016-04-18 | 주식회사 대웅제약 | 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
PT3407888T (pt) * | 2016-01-26 | 2021-03-19 | Intra Cellular Therapies Inc | Compostos de piridopirroloquinoxalina, suas composições e utilizações |
IL297676B2 (en) * | 2016-03-25 | 2023-12-01 | Intra Cellular Therapies Inc | A controlled or delayed release pharmaceutical preparation containing a deuterated compound |
EP3436083A4 (en) * | 2016-03-28 | 2019-11-27 | Intra-Cellular Therapies, Inc. | NEW COMPOSITIONS AND METHODS |
US10654854B2 (en) | 2016-03-28 | 2020-05-19 | Intra-Cellular Therapies, Inc. | Salts and crystals of ITI-007 |
JP6997718B2 (ja) * | 2016-03-28 | 2022-01-18 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規共結晶 |
WO2018071233A1 (en) | 2016-10-12 | 2018-04-19 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
WO2018106916A1 (en) * | 2016-12-07 | 2018-06-14 | Concert Pharmaceuticals, Inc. | Deuterated quinoxaline compounds |
US10906906B2 (en) | 2016-12-29 | 2021-02-02 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
IL304026A (en) * | 2017-03-24 | 2023-08-01 | Intra Cellular Therapies Inc | New preparations and methods |
CN111093664B (zh) | 2017-07-26 | 2023-06-02 | 细胞内治疗公司 | 有机化合物 |
IL272249B2 (en) | 2017-07-26 | 2023-11-01 | Intra Cellular Therapies Inc | organic compounds |
MX2020007271A (es) | 2017-09-26 | 2020-08-17 | Intra Cellular Therapies Inc | Sales y cristales novedosos. |
KR102089737B1 (ko) * | 2017-11-01 | 2020-03-16 | 한국화학연구원 | 에씨탈로프람을 함유한 미립구형 서방출 주사제 및 그의 제조방법 |
JP7401442B2 (ja) | 2018-01-31 | 2023-12-19 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
CA3094204A1 (en) | 2018-03-16 | 2019-09-19 | Intra-Cellular Therapies, Inc. | Novel methods |
WO2019237037A1 (en) * | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
AU2019287460B2 (en) | 2018-06-11 | 2024-02-15 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
EP3811371A1 (en) | 2018-06-21 | 2021-04-28 | Aquestive Therapeutics, Inc. | System and method for making personalized individual unit doses containing pharmaceutical actives |
BR112021003838A2 (pt) * | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
BR112021003655A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
EP3846778A1 (en) | 2018-09-07 | 2021-07-14 | Aquestive Therapeutics, Inc. | Oral film compositions and dosage forms having precise active dissolution profiles |
US11628171B2 (en) | 2019-03-13 | 2023-04-18 | Children's Medical Center Corporation | Method for treating brain or nerve injury |
JP2022539821A (ja) | 2019-07-07 | 2022-09-13 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
EP4051235A1 (en) | 2019-11-01 | 2022-09-07 | Aquestive Therapeutics, Inc. | Prodrug compositions and methods of treatment |
EP4058029A1 (en) | 2019-11-14 | 2022-09-21 | Aquestive Therapeutics, Inc. | Multimodal compositions and methods of treatment |
JP7261942B2 (ja) | 2019-12-11 | 2023-04-20 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
WO2022155544A1 (en) | 2021-01-15 | 2022-07-21 | Aquestive Therapeutics, Inc. | Prodrug compositions and methods of treatment |
EP4304554A1 (en) | 2021-03-09 | 2024-01-17 | Aquestive Therapeutics, Inc. | Dosage forms having equivalent biocomparable profiles |
US20230372336A1 (en) | 2022-05-18 | 2023-11-23 | Intra-Cellular Therapies, Inc. | Novel methods |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE41352B1 (en) | 1974-04-01 | 1979-12-19 | Pfizer | 5-aryl-1,2,3,4-tetrahydro- -carbolines |
AR206812A1 (es) * | 1974-04-01 | 1976-08-23 | Pfizer | Compuestos intermediarios de azaciclo(3,4-a)indoles 4- y 5-fenil substituidos desprovistos de actividad terapeutica |
US4001263A (en) * | 1974-04-01 | 1977-01-04 | Pfizer Inc. | 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
CH656884A5 (de) | 1983-08-26 | 1986-07-31 | Sandoz Ag | Polyolester, deren herstellung und verwendung. |
US5538739A (en) | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
IT1271352B (it) | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
KR100354270B1 (ko) * | 1993-11-19 | 2003-02-11 | 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii | 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸 |
WO1996038446A1 (fr) * | 1995-05-31 | 1996-12-05 | Eisai Co., Ltd. | Derives heterocycliques polycycliques fusionnes |
TWI242011B (en) | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
ATE260642T1 (de) | 1998-12-17 | 2004-03-15 | Alza Corp | Umwandlung von flüssigkeitsgefüllten gelatinkapseln in systeme mit gesteuerter wirkstoffabgabe durch mehrfache beschichtungen |
US6713471B1 (en) | 1999-06-15 | 2004-03-30 | Bristol-Myers Squibb Pharma Company | Substituted heterocycle fused gamma-carbolines |
US7071186B2 (en) | 1999-06-15 | 2006-07-04 | Bristol-Myers Squibb Pharma Co. | Substituted heterocycle fused gamma-carbolines |
AU5737900A (en) | 1999-06-15 | 2001-01-02 | Du Pont Pharmaceuticals Company | Substituted heterocycle fused gamma-carbolines |
BR0313139A (pt) * | 2002-07-29 | 2005-07-05 | Alza Corp | Métodos e formas de dosagem para fornecimento controlado de paliperidona |
US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
US20040142970A1 (en) | 2002-11-01 | 2004-07-22 | Kathryn Chung | Treatment of hyperkinetic movement disorder with donepezil |
PL377426A1 (pl) | 2002-12-19 | 2006-02-06 | Bristol-Myers Squibb Company | Podstawione tricykliczne gamma-karboliny jako agoniści i antagoniści receptora serotoninowego |
RU2258605C2 (ru) * | 2004-02-17 | 2005-08-20 | Общество с ограниченной ответственностью "Новые Строительные Технологии" | Устройство для приготовления и укладки строительных смесей |
US20080280941A1 (en) | 2004-03-05 | 2008-11-13 | Pierre Lourtie | 8-Phenoxy-Gamma Carboline Derivatives |
JP2008513432A (ja) | 2004-09-21 | 2008-05-01 | ファイザー・プロダクツ・インク | Cns状態の治療に有用なn−メチルヒドロキシエチルアミン |
US20080028094A1 (en) * | 2006-07-31 | 2008-01-31 | Widerthan Co., Ltd. | Method and system for servicing bgm request and for providing sound source information |
CN103626766B (zh) | 2007-03-12 | 2017-06-09 | 细胞内治疗公司 | 与取代的杂环稠合的γ‑咔啉的合成 |
EP2262502A4 (en) | 2008-02-05 | 2011-12-28 | Clera Inc | COMPOSITIONS AND METHODS FOR RELIEVING DEPRESSION OR ENHANCING COGNITIVE PROCESSES |
PL2262505T3 (pl) | 2008-03-12 | 2015-04-30 | Intra Cellular Therapies Inc | Podstawione heterocykliczne skondensowane gamma-karboliny w postaci stałej |
US8598119B2 (en) | 2008-05-27 | 2013-12-03 | Intra-Cellular Therapies, Inc. | Methods and compositions for sleep disorders and other disorders |
EP2560676B8 (en) * | 2010-04-22 | 2016-10-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
CA2870303A1 (en) | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
EP2968320B1 (en) | 2013-03-15 | 2020-11-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
KR20230058736A (ko) | 2013-12-03 | 2023-05-03 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
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2011
- 2011-04-22 EP EP11772360.1A patent/EP2560676B8/en active Active
- 2011-04-22 MX MX2012012277A patent/MX339805B/es active IP Right Grant
- 2011-04-22 BR BR112012026881A patent/BR112012026881A2/pt not_active IP Right Cessation
- 2011-04-22 ES ES11772360.1T patent/ES2602503T3/es active Active
- 2011-04-22 US US13/642,652 patent/US8993572B2/en active Active
- 2011-04-22 RU RU2012149633/04A patent/RU2591194C2/ru active
- 2011-04-22 KR KR1020127030238A patent/KR101868165B1/ko active IP Right Grant
- 2011-04-22 CN CN201180025403.6A patent/CN103209704B/zh active Active
- 2011-04-22 CA CA2796756A patent/CA2796756A1/en not_active Abandoned
- 2011-04-22 WO PCT/US2011/000719 patent/WO2011133224A1/en active Application Filing
- 2011-04-22 JP JP2013506138A patent/JP5894574B2/ja active Active
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2012
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IL222571A0 (en) | 2012-12-31 |
KR20130055610A (ko) | 2013-05-28 |
IL249578A (en) | 2017-12-31 |
MX339805B (es) | 2016-06-10 |
EP2560676A1 (en) | 2013-02-27 |
JP5894574B2 (ja) | 2016-03-30 |
CA2796756A1 (en) | 2011-10-27 |
KR101868165B1 (ko) | 2018-07-19 |
RU2012149633A (ru) | 2014-05-27 |
JP2013525352A (ja) | 2013-06-20 |
CN103209704A (zh) | 2013-07-17 |
EP2560676B8 (en) | 2016-10-12 |
CN103209704B (zh) | 2017-10-27 |
EP2560676B1 (en) | 2016-08-10 |
US20130202692A1 (en) | 2013-08-08 |
BR112012026881A2 (pt) | 2017-10-10 |
WO2011133224A1 (en) | 2011-10-27 |
IL222571A (en) | 2017-12-31 |
IL249578A0 (en) | 2017-02-28 |
US20150166540A1 (en) | 2015-06-18 |
US8993572B2 (en) | 2015-03-31 |
EP2560676A4 (en) | 2013-10-16 |
US9371324B2 (en) | 2016-06-21 |
ES2602503T3 (es) | 2017-02-21 |
RU2591194C2 (ru) | 2016-07-10 |
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