MX2020009929A - Compuestos organicos. - Google Patents
Compuestos organicos.Info
- Publication number
- MX2020009929A MX2020009929A MX2020009929A MX2020009929A MX2020009929A MX 2020009929 A MX2020009929 A MX 2020009929A MX 2020009929 A MX2020009929 A MX 2020009929A MX 2020009929 A MX2020009929 A MX 2020009929A MX 2020009929 A MX2020009929 A MX 2020009929A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- treatment
- organic compounds
- receptor
- carbolines
- Prior art date
Links
- 150000002894 organic compounds Chemical class 0.000 title 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 102000019208 Serotonin Plasma Membrane Transport Proteins Human genes 0.000 abstract 1
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención se refiere a gamma-carbolinas fusionadas con heterociclo deuterado sustituido particular, sus profármacos, en forma libre, sólida, sal farmacéuticamente aceptable y/o sustancialmente pura como se describe en este documento, composiciones farmacéuticas de las mismas y métodos de uso en el tratamiento de enfermedades que involucran receptor 5-HT2A, transportador de serotonina (SERT) y/o vías que involucran sistemas de señalización del receptor de dopamina D1/D2, y/o el tratamiento de síntomas residuales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862647482P | 2018-03-23 | 2018-03-23 | |
| PCT/US2019/023687 WO2019183546A1 (en) | 2018-03-23 | 2019-03-22 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020009929A true MX2020009929A (es) | 2021-01-08 |
Family
ID=67987581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009929A MX2020009929A (es) | 2018-03-23 | 2019-03-22 | Compuestos organicos. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20210009592A1 (es) |
| EP (1) | EP3768271A4 (es) |
| JP (1) | JP2021519271A (es) |
| CN (1) | CN112088004A (es) |
| AU (1) | AU2019236860A1 (es) |
| BR (1) | BR112020019181A2 (es) |
| CA (1) | CA3095101A1 (es) |
| IL (2) | IL303857B1 (es) |
| MX (1) | MX2020009929A (es) |
| WO (1) | WO2019183546A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL305990A (en) * | 2013-12-03 | 2023-11-01 | Intra Cellular Therapies Inc | Compressed gamma-carboline heterocyclic compounds are modified for use in the treatment of type I and/or type II bipolar disorders |
| JP7223742B2 (ja) | 2017-07-26 | 2023-02-16 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| WO2019237037A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
| EP3609891A4 (en) * | 2018-06-11 | 2021-04-14 | Intra-Cellular Therapies, Inc. | SYNTHESIS OF CONDENSED GAMMA CARBOLINE WITH SUBSTITUTED HETEROCYCLE |
| WO2021119334A1 (en) | 2019-12-11 | 2021-06-17 | Intra-Cellular Therapies, Inc. | Organic compound |
| WO2023225620A1 (en) | 2022-05-18 | 2023-11-23 | Intra-Cellular Therapies, Inc. | Novel methods |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104995191A (zh) * | 2012-09-14 | 2015-10-21 | 艾伯维德国有限责任两合公司 | 三环喹啉和喹喔啉衍生物 |
| ES2961843T3 (es) * | 2014-04-04 | 2024-03-14 | Intra Cellular Therapies Inc | Gamma-carbolinas condensadas con heterociclo deuteradas como antagonistas de los receptores de 5-HT2A |
| WO2015154030A1 (en) * | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2017117514A1 (en) * | 2015-12-31 | 2017-07-06 | Tung Roger D | Deuterated iti-007 |
| CN108883111B (zh) * | 2016-01-26 | 2021-10-08 | 细胞内治疗公司 | 有机化合物 |
| AU2017238842B2 (en) * | 2016-03-25 | 2019-06-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
-
2019
- 2019-03-21 US US17/040,892 patent/US20210009592A1/en active Pending
- 2019-03-22 IL IL303857A patent/IL303857B1/en unknown
- 2019-03-22 AU AU2019236860A patent/AU2019236860A1/en active Pending
- 2019-03-22 WO PCT/US2019/023687 patent/WO2019183546A1/en active Application Filing
- 2019-03-22 BR BR112020019181-7A patent/BR112020019181A2/pt unknown
- 2019-03-22 US US17/040,893 patent/US20210008065A1/en active Pending
- 2019-03-22 MX MX2020009929A patent/MX2020009929A/es unknown
- 2019-03-22 JP JP2020551349A patent/JP2021519271A/ja active Pending
- 2019-03-22 IL IL277509A patent/IL277509B2/en unknown
- 2019-03-22 EP EP19771617.8A patent/EP3768271A4/en active Pending
- 2019-03-22 CN CN201980028290.1A patent/CN112088004A/zh active Pending
- 2019-03-22 CA CA3095101A patent/CA3095101A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3768271A1 (en) | 2021-01-27 |
| IL277509B1 (en) | 2023-07-01 |
| EP3768271A4 (en) | 2021-11-17 |
| IL303857B1 (en) | 2024-04-01 |
| WO2019183546A1 (en) | 2019-09-26 |
| IL277509A (en) | 2020-11-30 |
| US20210008065A1 (en) | 2021-01-14 |
| AU2019236860A1 (en) | 2020-10-22 |
| IL303857A (en) | 2023-08-01 |
| US20210009592A1 (en) | 2021-01-14 |
| CA3095101A1 (en) | 2019-09-26 |
| IL277509B2 (en) | 2023-11-01 |
| CN112088004A (zh) | 2020-12-15 |
| BR112020019181A2 (pt) | 2021-01-05 |
| JP2021519271A (ja) | 2021-08-10 |
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