DE69434744D1 - Positive selektion auf mannose oder xylose basierend - Google Patents

Positive selektion auf mannose oder xylose basierend

Info

Publication number
DE69434744D1
DE69434744D1 DE69434744T DE69434744T DE69434744D1 DE 69434744 D1 DE69434744 D1 DE 69434744D1 DE 69434744 T DE69434744 T DE 69434744T DE 69434744 T DE69434744 T DE 69434744T DE 69434744 D1 DE69434744 D1 DE 69434744D1
Authority
DE
Germany
Prior art keywords
mannose
compound
cells
protein
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434744T
Other languages
English (en)
Other versions
DE69434744T2 (de
DE69434744T3 (de
Inventor
Kirsten Bojsen
Iain Donaldson
Anna Haldrup
Morten Joersboe
Dina Kreiberg
John Nielsen
Thyge Okkels
Guldager Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Syngenta Participations AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10731298&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69434744(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syngenta Participations AG filed Critical Syngenta Participations AG
Publication of DE69434744D1 publication Critical patent/DE69434744D1/de
Publication of DE69434744T2 publication Critical patent/DE69434744T2/de
Application granted granted Critical
Publication of DE69434744T3 publication Critical patent/DE69434744T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8209—Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01008—Mannose-6-phosphate isomerase (5.3.1.8)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Led Devices (AREA)
  • Semiconductor Lasers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Feedback Control In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69434744T 1993-03-02 1994-02-28 Positive selektion auf mannose oder xylose basierend Expired - Lifetime DE69434744T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9304200 1993-03-02
GB939304200A GB9304200D0 (en) 1993-03-02 1993-03-02 Improvements in or relating to organic compounds
EP94909084A EP0804599B2 (de) 1993-03-02 1994-02-28 Positive selektion auf mannose oder xylose basierend
PCT/EP1994/000575 WO1994020627A1 (en) 1993-03-02 1994-02-28 Mannose or xylose based positive selection

Publications (3)

Publication Number Publication Date
DE69434744D1 true DE69434744D1 (de) 2006-06-29
DE69434744T2 DE69434744T2 (de) 2007-05-03
DE69434744T3 DE69434744T3 (de) 2013-03-21

Family

ID=10731298

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434744T Expired - Lifetime DE69434744T3 (de) 1993-03-02 1994-02-28 Positive selektion auf mannose oder xylose basierend

Country Status (15)

Country Link
US (1) US5767378A (de)
EP (1) EP0804599B2 (de)
JP (3) JP3698722B2 (de)
AT (1) ATE327336T1 (de)
AU (1) AU682495B2 (de)
CA (1) CA2157470C (de)
DE (1) DE69434744T3 (de)
DK (1) DK0804599T3 (de)
ES (1) ES2265144T3 (de)
GB (1) GB9304200D0 (de)
HU (1) HU225771B1 (de)
SK (1) SK285107B6 (de)
UA (1) UA57696C2 (de)
WO (1) WO1994020627A1 (de)
ZA (1) ZA941467B (de)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9707666A (es) * 1995-04-06 1997-11-29 Seminis Vegetables Proceso de seleccion de celulas de planta transgenica.
GB9702592D0 (en) 1997-02-07 1997-03-26 Danisco Selection method
EP0870836A1 (de) * 1997-04-09 1998-10-14 IPK Gatersleben 2-Desoxyglucose-6-Phosphat (2-DOG-6-P) Phosphatase DNA-Sequenzen als Selektionsmarker in Pflanzen
US6075134A (en) * 1997-05-15 2000-06-13 The Regents Of The University Of California Glycoconjugates and methods
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US7087420B1 (en) 1997-07-17 2006-08-08 Cambia Microbial β-glucuronidase genes, gene products and uses thereof
US6391547B1 (en) * 1997-09-09 2002-05-21 Center For The Application Of Molecular Biology To International Agriculture Microbial β-glucuronidase genes, gene products and uses thereof
AU754803B2 (en) 1997-09-16 2002-11-28 Cropdesign N.V. Cyclin-dependent kinase inhibitors and uses thereof
AR020078A1 (es) 1998-05-26 2002-04-10 Syngenta Participations Ag Metodo para alterar la expresion de un gen objetivo en una celula de planta
GB9817465D0 (en) 1998-08-11 1998-10-07 Danisco Selection method
ATE542907T1 (de) 1998-11-12 2012-02-15 Max Planck Gesellschaft Chimäre promotoren, befähigt zur vermittlung der genexpression in pflanzen durch pathogeninfektion und deren anwendungen
DE19926216A1 (de) * 1999-06-09 2001-02-22 Metallgesellschaft Ag Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats
DE60140996D1 (de) 2000-02-11 2010-02-25 Metabolix Inc Intein enthaltende multigen-expressionskonstrukte
US7005561B2 (en) 2000-03-08 2006-02-28 University Of Georgia Research Foundation, Inc. Arabitol or ribitol as positive selectable markers
WO2001066779A2 (en) * 2000-03-08 2001-09-13 Univ. Of Georgia Research Foundation, Inc. Arabitol or ribitol as positive selectable markers
EP1780283A1 (de) * 2000-04-21 2007-05-02 Martek Biosciences Corporation Trophische Umwandlung von obligat phototropischen Algen durch metabolische Manipulation
EP1276885B1 (de) 2000-04-21 2007-09-12 Martek Biosciences Corporation Trophische umwandlung von obligat phototropischen algen durch metabolische manipulation
US7256050B2 (en) 2000-06-16 2007-08-14 Martek Biosciences Corp. High fluorescent intensity cross-linked allophycocyanin
DK1311696T3 (da) * 2000-08-11 2012-10-22 Syngenta Participations Ag Fremgangsmåder til stabil transformation af planter
WO2002018607A2 (en) * 2000-08-30 2002-03-07 North Carolina State University Transgenic plants containing molecular decoys that alter protein content therein
JP2004533807A (ja) * 2000-11-07 2004-11-11 ノース・キャロライナ・ステイト・ユニヴァーシティ プトレッシン−ｎ−メチルトランスフェラーゼプロモーター
JP4024676B2 (ja) * 2000-11-17 2007-12-19 メタボリックス，インコーポレイテッド 脂肪酸生合成経路からの中間鎖長のポリヒドロキシアルカノエートの産生
IL159213A0 (en) * 2001-06-08 2004-06-01 Vector Tobacco Ltd Modifying nicotine and nitrosamine levels in tobacco
US20060157072A1 (en) * 2001-06-08 2006-07-20 Anthony Albino Method of reducing the harmful effects of orally or transdermally delivered nicotine
EP1925672A1 (de) 2001-06-22 2008-05-28 Syngeta Participations AG Auf abiotischen Stress ansprechende Polynukleotide und Polypeptide
NL1019308C2 (nl) 2001-11-06 2003-05-07 Stichting Tech Wetenschapp Werkwijze voor het selecteren van genetisch getransformeerde cellen.
ATE495184T1 (de) 2001-11-07 2011-01-15 Syngenta Participations Ag Promotoren zur regulierung der genexpression in pflanzenwurzeln
US7534934B2 (en) 2002-02-20 2009-05-19 J.R. Simplot Company Precise breeding
NZ585399A (en) * 2002-02-20 2012-07-27 Simplot Co J R Recombinant plant comprising the insertion of a native genetic element without the insertion of border sequences or selectable markers
AU2003207323B2 (en) * 2002-02-26 2007-09-13 Syngenta Limited A method of selectively producing male or female sterile plants
EP1499188A4 (de) * 2002-04-09 2007-11-14 Vector Tobacco Ltd Tabak mit weniger nikotin und nitrosaminen
DE60230071D1 (de) 2002-06-14 2009-01-08 Monier Tadros Methode für die herstellung von protamin
EP2292768A1 (de) 2002-07-09 2011-03-09 BASF Plant Science GmbH Verwendung von mutierten AHAS Genen als Selektionsmarker bei der Kartoffeltransformation
CN101018864A (zh) 2002-12-26 2007-08-15 先正达合作有限公司 细胞增殖相关多肽及其应用
NZ546173A (en) 2003-10-16 2009-04-30 Micromet Ag Multispecific deimmunized CD3-binders
AU2004290051A1 (en) 2003-11-12 2005-05-26 E.I. Dupont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast
US20070003934A1 (en) 2003-12-02 2007-01-04 Basf Akiengesellschaft 2-Methyl-6-solanylbenzoquinone methyltransferase as target for herbicides
US20070169227A1 (en) 2003-12-16 2007-07-19 Pioneer Hi-Bred International Inc. Dominant Gene Suppression Transgenes and Methods of Using Same
PT1696721E (pt) 2003-12-16 2010-05-06 Pioneer Hi Bred Int Transgénicos com supressão de gene dominante e processos para a sua utilização
EP1723245A4 (de) 2004-03-08 2010-03-03 Syngenta Participations Ag Glutaminreiches maissamenprotein und promotor
CN102260668B (zh) 2004-03-25 2016-08-10 辛根塔参与股份公司 玉米事件mir604
EP1827095A4 (de) 2004-12-23 2013-01-16 Arthur M Nonomura Zusammensetzungen und verfahren für transpirationsschutz bei pflanzen
US7732680B2 (en) 2005-03-16 2010-06-08 Metabolix, Inc. Chemically inducible expression of biosynthetic pathways
BRPI0706368A2 (pt) * 2006-01-06 2011-03-22 Univ Georgia composição, vetor, método para fornecer resistência ao cisto nematódeo a uma planta, proteìna de fusão, método para inibir atividade biológica, ácido nucléico isolado
CA2636176A1 (en) 2006-01-12 2007-07-19 Avesthagen Limited Novel efficient transformation method for sunflower and oil seeds based on positive selection
AU2006337886A1 (en) * 2006-02-09 2007-08-16 Avestha Gengraine Technologies Pvt. Ltd. Method of selection and regeneration of transgenic Brassica jxmcea on Xylose
CN106222185B (zh) 2006-08-04 2021-12-03 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
EP2617814B1 (de) 2006-09-21 2015-11-18 BASF Enzymes LLC Phytasen, dafür kodierende Nukleinsäuren sowie Verfahren zu deren Herstellung und Verwendung
BRPI0719449A2 (pt) 2006-12-21 2017-06-20 Syngenta Participations Ag molécula de ácido nucléico isolada, sintética ou recombinante, polipeptídeo isolado, planta ou parte de planta, eículo de clonagem que compreende um ácido nucléico, cassete de expressão que compreende uma molécula de ácido nucléico e método para hidrolisar um polissacarídeo, oligossacarídeo ou amido
RS53008B2 (sr) 2007-04-03 2022-12-30 Amgen Res Munich Gmbh Interspecijski specifičan cd3-epsilon vezujući domen
PT2520590T (pt) 2007-04-03 2018-11-14 Amgen Res Munich Gmbh Domínio de ligação específico de espécies cruzadas
CA2584934A1 (en) 2007-04-17 2008-10-17 University Of Guelph Nitrogen-regulated sugar sensing gene and protein and modulation thereof
AU2008260555B2 (en) 2007-06-01 2012-07-26 Sapphire Energy, Inc. High throughput screening of genetically modified photosynthetic organisms
NZ583701A (en) 2007-09-11 2012-03-30 Sapphire Energy Inc Molecule production by photosynthetic organisms
US8314222B2 (en) 2007-10-05 2012-11-20 Sapphire Energy, Inc. System for capturing and modifying large pieces of genomic DNA and constructing organisms with chloroplasts
CN101883500A (zh) 2007-12-03 2010-11-10 先正达参股股份有限公司 工程化改造酶易感性蛋白质
US8487159B2 (en) * 2008-04-28 2013-07-16 Metabolix, Inc. Production of polyhydroxybutyrate in switchgrass
EP2294179B1 (de) 2008-06-27 2014-04-23 Sapphire Energy, Inc. Induktion von flockung bei fotosynthetischen organismen
EP2352765B1 (de) 2008-10-01 2018-01-03 Amgen Research (Munich) GmbH Bispezifischer einzelkettenantikörper mit kreuz-spezies-spezifischer einzeldomäne
CA2738565C (en) 2008-10-01 2023-10-10 Micromet Ag Cross-species-specific psmaxcd3 bispecific single chain antibody
MX2011006292A (es) 2008-12-16 2011-06-27 Syngenta Participations Ag Evento 5307 del maiz.
CN101768213B (zh) 2008-12-30 2012-05-30 中国科学院遗传与发育生物学研究所 一种与植物分蘖数目相关的蛋白及其编码基因与应用
US7868688B2 (en) * 2008-12-30 2011-01-11 Cosmic Circuits Private Limited Leakage independent very low bandwith current filter
ES2727575T3 (es) 2009-01-22 2019-10-17 Syngenta Participations Ag Polipéptidos de Hidroxifenilpiruvato Dioxigenasa mutantes, y Métodos de uso
AR075240A1 (es) 2009-02-06 2011-03-16 Syngenta Participations Ag Modificacion de enzima multidominio para la expresion en plantas
CN101817879A (zh) 2009-02-26 2010-09-01 中国科学院遗传与发育生物学研究所 金属硫蛋白及其编码基因与应用
WO2010102293A1 (en) 2009-03-06 2010-09-10 Metabolix, Inc. Method of positive plant selection using sorbitol dehydrogenase
AU2010249500B2 (en) 2009-05-21 2016-03-24 Basf Enzymes Llc Phytases, nucleic acids encoding them and methods for making and using them
CN102725402B (zh) 2009-07-10 2016-02-03 先正达参股股份有限公司 新颖的羟基苯丙酮酸双加氧酶多肽及其使用方法
BR112012005592A2 (pt) 2009-09-15 2017-05-02 Donald Danforth Plant Science Center geração de sementes oleaginosas produzindo alto poliidroxibutirato.
RU2613778C2 (ru) 2009-10-02 2017-03-21 Зингента Партисипейшнс Аг Инсектицидные белки
TWI653333B (zh) 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
UA111592C2 (uk) 2010-07-07 2016-05-25 Сінгента Партісіпейшнс Аг Спосіб контролю над твердокрилими комахами-шкідниками
WO2012008748A2 (ko) * 2010-07-14 2012-01-19 건국대학교 산학협력단 지오바실러스 써모디니트리피칸스 유래 만노스-6-인산 이성화효소의 변이체 및 이를 이용한 엘-리보스 생산방법
WO2012037324A2 (en) 2010-09-15 2012-03-22 Metabolix, Inc. Increasing carbon flow for polyhydroxybutyrate production in biomass crops
EP2431471A1 (de) 2010-09-17 2012-03-21 Université Catholique De Louvain Verfahren zur Steigerung der Größe von Pflanzen oder Pflanzenorganen
WO2012074868A2 (en) 2010-12-03 2012-06-07 Ms Technologies, Llc Optimized expression of glyphosate resistance encoding nucleic acid molecules in plant cells
AR083029A1 (es) 2010-12-09 2013-01-23 Syngenta Participations Ag Metodos y composiciones que utilizan arn interferente pequeño (arnip) para el control de nematodos en plantas
ES2461896B1 (es) 2010-12-21 2015-03-18 Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional Métodos para obtener plantas resistentes a sequía
AU2012242991B2 (en) 2011-04-11 2017-03-02 Targeted Growth, Inc. Identification and the use of KRP mutants in plants
US9121027B2 (en) 2011-04-26 2015-09-01 Syngenta Participations Ag Enhanced transformation of recalcitrant monocots
WO2012159891A1 (en) 2011-05-20 2012-11-29 Syngenta Participations Ag Endosperm-specific plant promoters and uses therefor
CA2841782A1 (en) 2011-07-15 2013-01-24 Syngenta Participations Ag Methods of increasing yield and stress tolerance in a plant
US9861105B2 (en) 2011-07-28 2018-01-09 Syngenta Participations Ag Methods and compositions for controlling nematode pests
US20140182011A1 (en) 2011-11-03 2014-06-26 The University Of Hong Kong Methods Using Acyl-Coenzyme A-Binding Proteins to Enchance Drought Tolerance in Genetically Modified Plants
CA2853490A1 (en) 2011-11-03 2013-05-10 Syngenta Participations Ag Polynucleotides, polypeptides and methods for enhancing photoassimilation in plants
ES2831653T3 (es) 2011-11-21 2021-06-09 Innovation Hammer Llc Procedimiento para el cultivo de plantas utilizando microperlas de silicato y fotofitoprotección mediante la utilización de glicopiranósidos exógenos
US9540654B2 (en) 2012-02-01 2017-01-10 Dow Agrosciences Llc Synthetic brassica-derived chloroplast transit peptides
JP6363021B2 (ja) 2012-02-03 2018-07-25 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 抗原をトランスフェクトされたｔ細胞を伴う二重特異性抗体分子及び医薬におけるそれらの使用
AU2013219927B2 (en) 2012-02-16 2018-11-08 Syngenta Participations Ag Engineered pesticidal proteins
WO2013134651A1 (en) 2012-03-09 2013-09-12 Board Of Trustees Of Michigan State University Method of enhancing plant drought tolerance by expression of ndr1
MX362917B (es) 2012-05-21 2019-02-26 Innovation Hammer Llc Metodos para hacer seguros complejos de coordinacion micelares para el tratamiento de plantas y formulaciones para los mismos.
WO2013184768A1 (en) 2012-06-05 2013-12-12 University Of Georgia Research Foundation, Inc. Compositions and methods of gene silencing in plants
CA2890235A1 (en) 2012-06-22 2013-12-27 Syngenta Participations Ag Biological control of coleopteran pests
US20150211019A1 (en) 2012-08-13 2015-07-30 University Of Georgia Research Foundation, Inc. Compositions and Methods for Increasing Pest Resistance in Plants
AU2013334670B2 (en) 2012-10-23 2017-02-16 Montana State University Production of high quality Durum wheat having increased amylose content
US20160000842A1 (en) 2013-03-05 2016-01-07 Baylor College Of Medicine Oncolytic virus
EP3447072A3 (de) 2013-03-05 2019-05-22 Baylor College of Medicine Engager-zellen, umfassend cd3-scfv und eine antigenerkennungsdomäne, die ein tumorantigen für die immunitätstherapie bindet
CA2904369A1 (en) 2013-03-07 2014-09-12 Baylor College Of Medicine Targeting cd138 in cancer
WO2014164544A1 (en) 2013-03-09 2014-10-09 Baylor College Of Medicine Vascular-targeted t-cell therapy
CN105452287A (zh) 2013-04-17 2016-03-30 贝勒医学院 免疫抑制性TGF-β信号转换器
CA2911185C (en) 2013-06-11 2023-09-05 Syngenta Participations Ag Methods for generating transgenic plants
US20140380524A1 (en) 2013-06-19 2014-12-25 The University Of Hong Kong Methods of using 3-hydroxy-3-methylglutaryl-coa synthase to enhance growth and/or seed yield of genetically modified plants
DK2808338T3 (da) 2013-09-16 2016-06-06 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Mutant calreticulin til diagnose af myeloide maligniteter
EP3552482B1 (de) 2013-10-29 2022-06-29 Biotech Institute, LLC Zucht, herstellung, verarbeitung und verwendung von speziellem cannabis
WO2015173398A1 (en) 2014-05-15 2015-11-19 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Antagonists of slc38a9 and their use in therapy
MA41538A (fr) 2014-10-17 2017-12-26 Baylor College Medicine Cellules immunitaires bipartites et tripartites de signalisation
WO2016094165A1 (en) 2014-12-12 2016-06-16 Syngenta Participations Ag Compositions and methods for controlling plant pests
US20170327834A1 (en) 2014-12-15 2017-11-16 Syngenta Participations Ag Pesticidal microrna carriers and use thereof
US10604757B2 (en) 2014-12-23 2020-03-31 Syngenta Participations Ag Biological control of coleopteran pests
AU2015373893B2 (en) 2014-12-31 2021-07-29 Synthetic Genomics, Inc. Compositions and methods for high efficiency in vivo genome editing
MA41433A (fr) 2015-01-26 2017-12-05 Baylor College Medicine Cellules immunitaires universelles pour l'immunothérapie anticancéreuse
JP6959869B2 (ja) 2015-02-23 2021-11-05 シーガル セラピューティクス エスアーエス 非天然セマフォリン３およびそれらの医学的使用
WO2016164810A1 (en) 2015-04-08 2016-10-13 Metabolix, Inc. Plants with enhanced yield and methods of construction
EP3280271A4 (de) 2015-04-10 2019-04-10 Syngenta Participations AG Tierfutterzusammensetzungen und verfahren zur verwendung
CN107847585B (zh) 2015-04-23 2022-09-23 贝勒医学院 用于得到体内存留性和治疗活性的nkt细胞亚群以及其繁殖
AR105155A1 (es) 2015-07-07 2017-09-13 Syngenta Participations Ag Composiciones y métodos para controlar plagas de plantas
WO2017023770A1 (en) 2015-07-31 2017-02-09 Dongfang Liu Quality of immunological synapse predicts effectiveness of chimeric antigen receptor (car) t cells
US20190338302A1 (en) 2016-02-04 2019-11-07 Yield10 Bioscience, Inc. Transgenic land plants comprising a putative transporter protein of an edible eukaryotic algae
EP3216458A1 (de) 2016-03-07 2017-09-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Modifizierter vaskulärer endothelialen wachstumsfaktor a (vegf-a) und dessen medizinische verwendung
CN109414027A (zh) 2016-04-29 2019-03-01 创新汉玛有限责任公司 用聚糖复合物制剂处理光合生物和增加品质和产量的制剂和方法
BR112018077375A2 (pt) 2016-06-30 2019-10-01 F. Hoffmann-La Roche Ag kits, moléculas de anticorpo biespecífico trivalente, composição farmacêutica, vetor de expressão, célula hospedeira e método para a produção de uma molécula de anticorpo biespecífico trivalente
AR109205A1 (es) 2016-08-05 2018-11-07 Syngenta Participations Ag Control de plagas de coleópteros utilizando moléculas de arn
AR109206A1 (es) 2016-08-05 2018-11-07 Syngenta Participations Ag Control de plagas de coleópteros utilizando moléculas de arn
US11136593B2 (en) 2016-09-09 2021-10-05 Syngenta Participations Ag Insecticidal proteins
TW201825674A (zh) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 表現雙特異性接合分子的溶瘤病毒
WO2018076335A1 (en) 2016-10-31 2018-05-03 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Compositions and methods for enhancing abiotic stress tolerance
WO2018083235A1 (en) 2016-11-03 2018-05-11 Roche Diagnostics Gmbh Novel anti-py513-ddr1 antibodies
WO2018083237A1 (en) 2016-11-03 2018-05-11 Roche Diagnostics Operations Inc. Novel anti-py520-ddr1 antibodies
WO2018083240A1 (en) 2016-11-03 2018-05-11 Roche Diagnostics Gmbh Novel anti-py796-ddr1 antibodies
WO2018083238A1 (en) 2016-11-03 2018-05-11 Roche Diagnostics Gmbh Novel anti-py792-ddr1 antibodies
CA3054060C (en) 2017-02-22 2023-09-26 Yield10 Bioscience, Inc. Transgenic land plants comprising enhanced levels of mitochondrial transporter protein
KR20190128681A (ko) 2017-03-13 2019-11-18 보너모스 엘엘씨 헥소스의 효소적 제조
EP3600408A1 (de) 2017-03-27 2020-02-05 H. Hoffnabb-La Roche Ag Verbesserte antigenbindende rezeptorformate
WO2018177966A1 (en) 2017-03-27 2018-10-04 F. Hoffmann-La Roche Ag Improved antigen binding receptors
JP7267253B2 (ja) 2017-07-13 2023-05-01 エフ． ホフマン－ラ ロシュ アーゲー Ｐｉｖｋａに対する新規結合剤およびアッセイ
AR113761A1 (es) 2017-10-18 2020-06-10 Syngenta Participations Ag Control de plagas de hemípteros utilizando moléculas de arn
CA3091431A1 (en) 2018-02-26 2019-08-29 Devgen Nv Control of insect pests using rna molecules
JP2021515567A (ja) 2018-03-14 2021-06-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規抗トロポニンｔ抗体
BR112020018235A2 (pt) 2018-03-14 2020-12-29 F. Hoffmann-La Roche Ag Métodos para gerar uma biblioteca de polinucleotídeos, bibliotecas de polinucleotídeos, uso de uma biblioteca, método para gerar uma biblioteca de anticorpos e método de seleção de um anticorpo
EP3561053A1 (de) 2018-04-26 2019-10-30 Baylor College of Medicine Immuneffektorzellen und molekulare adapter mit einem antigen-zytokin-komplex zur wirksamen krebsimmuntherapie
WO2019206780A1 (en) 2018-04-27 2019-10-31 Devgen Nv Control of insect pests using rna molecules
EP3846615A4 (de) 2018-09-04 2022-05-25 Yield10 Bioscience, Inc. Genetisch veränderte landpflanzen, die ein protein für erhöhten saatertrag und/oder eine rna für erhöhten saatertrag exprimieren
EP3867358A1 (de) 2018-10-19 2021-08-25 F. Hoffmann-La Roche AG Synergistische transkriptionsfaktoren zur induktion einer hochresistenten transendothelialen barriere
WO2020187798A1 (en) 2019-03-21 2020-09-24 Devgen Nv Control of insect pests using rna molecules
IL291089A (en) 2019-09-17 2022-07-01 Beijing Dabeinong Biotechnology Co Ltd Hydroxyphenylpyruvate mutant dioxygenase polypeptide, its encoding gene and its use
WO2022029051A1 (en) 2020-08-03 2022-02-10 F. Hoffmann-La Roche Ag Improved antigen binding receptors
CN116507640A (zh) 2020-10-28 2023-07-28 豪夫迈·罗氏有限公司 改善的抗原结合受体
WO2022093977A1 (en) 2020-10-30 2022-05-05 Fortiphyte, Inc. Pathogen resistance in plants
CN115336534A (zh) 2021-05-12 2022-11-15 北京大北农生物技术有限公司 原卟啉原氧化酶的用途
EP4373859A1 (de) 2021-07-22 2024-05-29 F. Hoffmann-La Roche AG Heterodimere fc-domänen-antikörper
AU2022397540A1 (en) 2021-11-25 2024-05-16 F. Hoffmann-La Roche Ag Improved antigen binding receptors
WO2023111168A1 (en) 2021-12-17 2023-06-22 F. Hoffmann-La Roche Ag A novel antibody for detection of amyloid beta 42 (aβ42)
WO2023154887A1 (en) 2022-02-11 2023-08-17 Northeast Agricultural University Methods and compositions for increasing protein and/or oil content and modifying oil profile in a plant
WO2023180511A1 (en) 2022-03-25 2023-09-28 F. Hoffmann-La Roche Ag Improved chimeric receptors
WO2024023578A1 (en) 2022-07-28 2024-02-01 Institut Pasteur Hsc70-4 in host-induced and spray-induced gene silencing
WO2024052856A1 (en) 2022-09-09 2024-03-14 Friedrich Alexander Universität Erlangen-Nürnberg Plant regulatory elements and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931373A (en) † 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4857467A (en) * 1986-07-23 1989-08-15 Phillips Petroleum Company Carbon and energy source markers for transformation of strains of the genes Pichia
DE3719053A1 (de) * 1987-06-06 1988-12-15 Hoechst Ag Verbesserte nutzung von pflanzenverwertbarem stickstoff durch kulturpflanzen mit ueberexpression der glutaminsynthetase
JPH02138966A (ja) * 1987-10-20 1990-05-28 Oji Paper Co Ltd 植物の形質転換体を作出する方法
AU655277B2 (en) * 1991-05-24 1994-12-15 Universidad Politecnica De Madrid Novel antipathogenic peptides and compositions containing same
DK152291D0 (da) * 1991-08-28 1991-08-28 Danisco Fremgangsmaade og kemiske forbindelser
WO2009113991A1 (en) * 2008-03-10 2009-09-17 Mobank Solutions, Llc Systems and methods for mobile device and code based money deposit, withdrawal and transfer
US8098881B2 (en) * 2008-03-11 2012-01-17 Sony Ericsson Mobile Communications Ab Advertisement insertion systems and methods for digital cameras based on object recognition

Also Published As

Publication number Publication date
JP4805309B2 (ja) 2011-11-02
DE69434744T2 (de) 2007-05-03
EP0804599A1 (de) 1997-11-05
SK285107B6 (sk) 2006-06-01
UA57696C2 (uk) 2003-07-15
CA2157470A1 (en) 1994-09-15
WO1994020627A1 (en) 1994-09-15
GB9304200D0 (en) 1993-04-21
HUT73387A (en) 1996-07-29
ES2265144T3 (es) 2007-02-01
EP0804599B1 (de) 2006-05-24
SK107095A3 (en) 1995-12-06
EP0804599B2 (de) 2012-10-10
HU225771B1 (en) 2007-08-28
AU6207794A (en) 1994-09-26
DK0804599T3 (da) 2006-09-25
AU682495B2 (en) 1997-10-09
ATE327336T1 (de) 2006-06-15
CA2157470C (en) 2012-04-17
US5767378A (en) 1998-06-16
ZA941467B (en) 1995-09-04
JP4426376B2 (ja) 2010-03-03
JP2008301827A (ja) 2008-12-18
JPH08509861A (ja) 1996-10-22
HU9502566D0 (en) 1995-10-30
DE69434744T3 (de) 2013-03-21
JP3698722B2 (ja) 2005-09-21
JP2004254705A (ja) 2004-09-16

Similar Documents

Publication Publication Date Title
ATE327336T1 (de) Positive selektion auf mannose oder xylose basierend
ZA963593B (en) IL-6 activity inhibitor
PT655890E (pt) Celulas recombinantes, construcoes de adn, vectores e metodos para expressao de enzimas degradantes de fitato em proporcoes desejadas
AU5837396A (en) Steroid sulphatase inhibitors
PT97680A (pt) Processo para preparacao de novos compostos sulfonilo e de composicoes farmaceuticas que os contem
NO960511D0 (no) Fremgangsmåte til sensilisering av kreftceller for drepercelle mediert lyse
DK0707591T3 (da) Methylphosphonsyreestere, fremgangsmåde til deres fremstilling samt deres anvendelse
EP0702694A4 (de) $i(PSEUDOMONAS SYRINGAE) pv. $i(SYRINGAE hrpY)-GEN
ES8203421A1 (es) Un procedimiento para la preparacion de acido griseolico
SE9403915D0 (sv) Process A
WO1995001439A3 (en) Plants having modified response to ethylene
AU7154096A (en) Blue copper oxidase mutants with enhanced activity
ES8707731A1 (es) Un procedimiento para la preparacion de derivados de oxindol
Rock et al. Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate: 1-alkyl-sn-glycerol phosphotransferase
DE69427857T2 (de) Markiergen
TR199901275T2 (xx) Farnezil protein transferaz inhibisyonu i�in yararl� bile�ikler.
Fernández et al. Specific ADP-ribose pyrophosphatase from Artemia cysts and rat liver: effects of nitroprusside, fluoride and ionic strength
DK0630401T3 (da) Mikroorganisme stamme W, af denne fremstillet enzympræparat, anvendelse af mikroorganismen, og fremgangsmåde til hydrolyse, især af keratin
Bild et al. Detection of β-carbanion formation during kynurenine hydrolysis catalyzed by Pseudomonas marginalis kynureninase
Makemson et al. Bovine serum albumin interacts with bacterial luciferase
Geetha et al. An in vitro protein-synthesizing system with isolated chloroplasts of Sorghum vulgare. An alternate assay system for exogenous template RNA.
Panchenko et al. Effects of inhibitors of energetic metabolism on RNA turnover in animal cells
WO1987006407A3 (en) Liquid metal ion source and alloy
NO950491L (no) Fremgangsmåte for hemming av celleproliferasjon ved bruk av apolipoprotein E
Chatterjee DNA dependent RNA polymerase from Drosophila melanogaster embryonic cells from a cell line

Legal Events

Date Code Title Description
8363 Opposition against the patent
8380 Miscellaneous part iii

Free format text: DIE VERTRETER SIND ZU BERICHTIGEN IN: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN.

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

R102 Epo decision maintaining patent in amended form now final

Ref document number: 804599

Country of ref document: EP

R102 Epo decision maintaining patent in amended form now final

Ref document number: 804599

Country of ref document: EP

Effective date: 20121010

R082 Change of representative

Ref document number: 804599

Country of ref document: EP

Representative=s name: ,