DE69232816D1 - Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen - Google Patents

Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen

Info

Publication number
DE69232816D1
DE69232816D1 DE69232816T DE69232816T DE69232816D1 DE 69232816 D1 DE69232816 D1 DE 69232816D1 DE 69232816 T DE69232816 T DE 69232816T DE 69232816 T DE69232816 T DE 69232816T DE 69232816 D1 DE69232816 D1 DE 69232816D1
Authority
DE
Germany
Prior art keywords
nucleomonomers
oligomer
helicos
oligomers
triple
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232816T
Other languages
English (en)
Other versions
DE69232816T2 (de
Inventor
Brian Froehler
Rick Wagner
Mark Matteucci
Robert J Jones
Arnold J Gutierrez
Jeff Pudlo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/799,824 external-priority patent/US5484908A/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69232816D1 publication Critical patent/DE69232816D1/de
Publication of DE69232816T2 publication Critical patent/DE69232816T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Microwave Tubes (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69232816T 1991-11-26 1992-11-24 Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen Expired - Lifetime DE69232816T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/799,824 US5484908A (en) 1991-11-26 1991-11-26 Oligonucleotides containing 5-propynyl pyrimidines
US93544492A 1992-08-25 1992-08-25
US96594192A 1992-10-23 1992-10-23
PCT/US1992/010115 WO1993010820A1 (en) 1991-11-26 1992-11-24 Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines

Publications (2)

Publication Number Publication Date
DE69232816D1 true DE69232816D1 (de) 2002-11-21
DE69232816T2 DE69232816T2 (de) 2003-06-18

Family

ID=27419954

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0637965T Pending DE637965T1 (de) 1991-11-26 1992-11-24 Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen.
DE69232816T Expired - Lifetime DE69232816T2 (de) 1991-11-26 1992-11-24 Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0637965T Pending DE637965T1 (de) 1991-11-26 1992-11-24 Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen.

Country Status (8)

Country Link
US (1) US5645985A (de)
EP (2) EP0637965B1 (de)
JP (1) JP3739785B2 (de)
AT (1) ATE226093T1 (de)
AU (2) AU3222793A (de)
CA (1) CA2122365C (de)
DE (2) DE637965T1 (de)
WO (1) WO1993010820A1 (de)

Families Citing this family (525)

* Cited by examiner, † Cited by third party
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WO1993010820A1 (en) 1993-06-10
EP0637965A1 (de) 1995-02-15
EP0637965A4 (de) 1996-01-24
EP0637965B1 (de) 2002-10-16
US5645985A (en) 1997-07-08
AU3222793A (en) 1993-06-28
CA2122365A1 (en) 1993-06-10
DE637965T1 (de) 1995-12-14
ATE226093T1 (de) 2002-11-15
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EP1256589A2 (de) 2002-11-13
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