DE69328435D1 - Neues sphingolglycolipid und verwendung davon - Google Patents

Neues sphingolglycolipid und verwendung davon

Info

Publication number
DE69328435D1
DE69328435D1 DE69328435T DE69328435T DE69328435D1 DE 69328435 D1 DE69328435 D1 DE 69328435D1 DE 69328435 T DE69328435 T DE 69328435T DE 69328435 T DE69328435 T DE 69328435T DE 69328435 D1 DE69328435 D1 DE 69328435D1
Authority
DE
Germany
Prior art keywords
galactosyl
represent
aminohexosyl
glucosyl
sphingolglycolipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69328435T
Other languages
English (en)
Other versions
DE69328435T2 (de
Inventor
Koji Akimoto
Yasuhiko Koezuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Pharma KK
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Application granted granted Critical
Publication of DE69328435D1 publication Critical patent/DE69328435D1/de
Publication of DE69328435T2 publication Critical patent/DE69328435T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69328435T 1992-10-22 1993-10-22 Neues sphingolglycolipid und verwendung davon Expired - Fee Related DE69328435T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30812492 1992-10-22
PCT/JP1993/001523 WO1994009020A1 (en) 1992-10-22 1993-10-22 Novel shingoglycolipid and use thereof

Publications (2)

Publication Number Publication Date
DE69328435D1 true DE69328435D1 (de) 2000-05-25
DE69328435T2 DE69328435T2 (de) 2000-09-14

Family

ID=17977176

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328435T Expired - Fee Related DE69328435T2 (de) 1992-10-22 1993-10-22 Neues sphingolglycolipid und verwendung davon

Country Status (10)

Country Link
US (1) US5849716A (de)
EP (1) EP0666268B1 (de)
JP (1) JP3717512B2 (de)
KR (1) KR100281264B1 (de)
AT (1) ATE191916T1 (de)
AU (1) AU683026B2 (de)
CA (1) CA2147629C (de)
DE (1) DE69328435T2 (de)
HK (1) HK1009968A1 (de)
WO (1) WO1994009020A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100527950B1 (ko) * 1997-04-10 2005-11-09 기린 비루 가부시키가이샤 알파-글리코실세라미드를 함유하는 엔케이티 세포활성화제
DE69943314D1 (de) * 1998-02-12 2011-05-12 Kapil N Bhalla Sphingolipid-derivate und verfahren zu deren verwendung
JP4099267B2 (ja) * 1998-08-07 2008-06-11 株式会社紀文フードケミファ 乳化剤および乳化組成物
IL156045A0 (en) * 2000-12-08 2003-12-23 Childrens Memorial Hospital Compositions containing gangliosides for use in the treatment of skin disorders
EP1434859A2 (de) * 2001-07-25 2004-07-07 New York University Verwendung von glycosylceramiden als adjuvantien für vakzine gegen infektionen und krebs
WO2003105769A2 (en) * 2002-06-13 2003-12-24 New York University Synthetic c-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
KR20050105215A (ko) * 2003-02-14 2005-11-03 다이이치 아스비오파마 가부시키가이샤 당지질 유도체 및 그 제조 방법 및 그 합성 중간체 및 그제조 방법
US7645873B2 (en) * 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
CN1822844B (zh) * 2003-07-17 2012-05-09 大塚制药株式会社 含配糖物的脂质体
US7771726B2 (en) * 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
AU2005235080A1 (en) * 2004-03-31 2005-11-03 New York University Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
AU2005280163B2 (en) * 2004-08-27 2011-11-24 Albert Einstein College Of Medicine, Inc. Ceramide derivatives as modulators of immunity and autoimmunity
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
CN101080487B (zh) 2004-10-07 2012-11-14 阿戈斯治疗公司 成熟树突细胞组合物及其培养方法
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
JP5090928B2 (ja) * 2004-12-28 2012-12-05 ザ ロックフェラー ユニバーシティ Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体
DK1848813T3 (da) 2005-01-28 2013-07-15 Univ Brigham Young Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler
US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
US20100256346A1 (en) * 2005-12-27 2010-10-07 Hirosuke Oku Anti-Tumor Agent and Immunostimulating Agent
US8227581B2 (en) * 2006-04-07 2012-07-24 The Scripps Research Institute Modified α-galactosyl ceramides for staining and stimulating natural killer T cells
WO2008005824A1 (en) 2006-06-30 2008-01-10 The Scripps Research Institute Adjuvants and methods of use
CA2678618C (en) 2007-02-21 2019-03-12 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cd1d molecules
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (de) * 2007-11-07 2009-05-13 Wittycell NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel
BRPI0820960B8 (pt) * 2007-12-05 2021-05-25 Abivax composição, composição farmacêutica, e uso da composição
EP2272854B1 (de) 2008-03-25 2015-08-05 Riken Neues glykolipid und anwendung davon
WO2010009271A2 (en) 2008-07-15 2010-01-21 Academia Sinica Glycan arrays on ptfe-like aluminum coated glass slides and related methods
WO2010030012A1 (ja) 2008-09-11 2010-03-18 独立行政法人理化学研究所 エステル化α－ガラクトシルセラミド類
US9220767B2 (en) * 2008-10-08 2015-12-29 Abivax Vaccine composition for use against influenza
AU2010203451B2 (en) * 2009-01-08 2016-06-30 Albert Einstein College Of Medicine, Inc. Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
EP2647384B1 (de) 2010-12-02 2018-05-23 Riken IMMUNTHERAPIE MIT ALLO-NKT-ZELLEN, ZELLEN FÜR DIE IMMUNTHERAPIE MIT UMGEORDNETER aplha KETTE DES T-ZELL REZEPTOR (TCR)-GENS IN GLEICHMÄSSIGE V alpha-J alpha-ANORDNUNG UND LAGERUNG VON NKT-ZELLEN AUS DIESEN ZELLEN
BR112013017382B1 (pt) 2011-01-05 2021-03-16 National Taiwan University método de preparação de um composto de fórmula (5)
JP6047309B2 (ja) * 2011-05-27 2016-12-21 学校法人近畿大学 抗腫瘍剤
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
WO2014021464A1 (ja) * 2012-08-03 2014-02-06 独立行政法人理化学研究所 水酸化ｋｒｎ７０００類縁体及びその用途
WO2014031498A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
EP2889039B1 (de) 2012-08-22 2017-11-08 Regimmune Corporation Präparat zur vorbeugung oder behandlung von typ-1-diabetes
AU2013339046A1 (en) 2012-11-05 2015-05-21 Regimmune Corporation Immune-tolerance inducer
PL2923208T3 (pl) 2012-11-21 2019-09-30 Institut National De La Santé Et De La Recherche Médicale (Inserm) Sposoby określania ryzyka ostrej choroby przeszczep przeciwko gospodarzowi
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
EP3013365B1 (de) 2013-06-26 2019-06-05 Academia Sinica Rm2-antigene und verwendung davon
EP3013347B1 (de) 2013-06-27 2019-12-11 Academia Sinica Glykankonjugate und verwendung davon
CN105682666B (zh) * 2013-09-06 2021-06-01 中央研究院 使用醣脂激活人类iNKT细胞
WO2015109180A2 (en) 2014-01-16 2015-07-23 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI797430B (zh) 2014-03-27 2023-04-01 中央研究院 反應性標記化合物及其用途
CA2950415A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
KR102576850B1 (ko) 2014-05-27 2023-09-11 아카데미아 시니카 박테로이드 기원의 푸코시다제 및 이의 사용 방법
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
JP7062361B2 (ja) 2014-05-27 2022-05-06 アカデミア シニカ 抗ｈｅｒ２糖操作抗体群およびその使用
KR102494193B1 (ko) 2014-05-28 2023-01-31 아카데미아 시니카 항-ｔｎｆ-알파 글리코항체 및 이의 용도
JP6899321B2 (ja) * 2014-09-08 2021-07-07 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 糖脂質を使用するヒトｉＮＫＴ細胞活性化
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI736523B (zh) 2015-01-24 2021-08-21 中央研究院 新穎聚醣結合物及其使用方法
JP2019515876A (ja) 2016-03-08 2019-06-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Ｎ−グリカンおよびそのアレイのモジュール合成のための方法
EP3500594A4 (de) 2016-08-22 2020-03-11 Cho Pharma Inc. Antikörper, bindungsfragmente und verfahren zur verwendung
WO2022118913A1 (ja) 2020-12-04 2022-06-09 株式会社レグイミューン 体内動態が改善されたＣＤ１ｄリガンド化合物含有リポソーム製剤

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4806466A (en) * 1981-10-29 1989-02-21 The Regents Of The University Of California Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes
IT1168205B (it) * 1983-07-21 1987-05-20 Wellcome Italia Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
JPS6157594A (ja) * 1984-08-30 1986-03-24 Suntory Ltd ガラクトスフインゴ脂質及びその製造法
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
ATE71104T1 (de) * 1985-08-13 1992-01-15 Solco Basel Ag Neues verfahren zur herstellung von sphingosinderivaten.
JPS6239597A (ja) * 1985-08-13 1987-02-20 ソルコ　バ−ゼル　アクチエンゲゼルシヤフト スフインゴシン誘導体の製造方法
JPH07116209B2 (ja) * 1986-04-11 1995-12-13 メクト株式会社 シアロシルセラミド類及びその製造方法
US4990603A (en) * 1986-07-04 1991-02-05 Mect Corporation Sialic acid derivatives and process therefor
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US4937232A (en) * 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
US5026557A (en) * 1987-09-09 1991-06-25 The Liposome Company, Inc. Adjuvant composition
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
US5041441A (en) * 1988-04-04 1991-08-20 The Regents Of The University Of Michigan Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US5028715A (en) * 1989-02-06 1991-07-02 Southwest Research Institute Radioprotective agents and their method of manufacture
DE69011465T2 (de) * 1989-09-29 1995-03-23 Ajinomoto Kk Verwendung von Human-ADF (=Adult T-cell leukemia-derived factor) zur Herstellung von Medikamenten.
JP3068910B2 (ja) * 1990-11-08 2000-07-24 麒麟麦酒株式会社 新規スフィンゴ糖脂質、その製造法および使用
JPH06145189A (ja) * 1991-01-23 1994-05-24 Kitasato Inst:The スフィンゴ糖脂質
JPH0559081A (ja) * 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
TW261533B (de) * 1992-07-16 1995-11-01 Kirin Brewery
JPH06239597A (ja) * 1993-02-18 1994-08-30 Hitachi Zosen Corp 箱型ブロック用作業台装置
US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives

Also Published As

Publication number Publication date
WO1994009020A1 (en) 1994-04-28
JP3717512B2 (ja) 2005-11-16
US5849716A (en) 1998-12-15
EP0666268A4 (de) 1995-06-27
AU5286093A (en) 1994-05-09
DE69328435T2 (de) 2000-09-14
KR950704341A (ko) 1995-11-20
CA2147629A1 (en) 1994-04-28
KR100281264B1 (ko) 2001-02-01
ATE191916T1 (de) 2000-05-15
EP0666268B1 (de) 2000-04-19
EP0666268A1 (de) 1995-08-09
HK1009968A1 (en) 1999-09-17
AU683026B2 (en) 1997-10-30
CA2147629C (en) 2005-03-22

Similar Documents

Publication Publication Date Title
DE69328435D1 (de) Neues sphingolglycolipid und verwendung davon
CA2146259A1 (en) Substituted benzylaminoquinuclidines
ES8608531A1 (es) Un procedimiento para preparar compuestos de tecnecio-99 deltipo de coordinacion
DE69320952D1 (de) Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
MY132263A (en) Pyridazinone derivatives and processes for preparing the same
DK0694539T3 (da) 7-O-ethere af taxanderivater
YU245589A (en) Substituted semicarbazon arthropodicids
AU3381389A (en) Derivative of caffeic acid and pharmaceutical composition containing the same
GB9320191D0 (en) Compounds
TW223016B (de)
DE69001111D1 (de) Antikrebs-zusammensetzung.
DK0424899T3 (da) Hidtil ukendte anthracyclinglycosidderivater og fremgangsmåde til fremstilling deraf
ZA891241B (en) Therapeutic agents for the treatment of peptic ulcer disease
ZA881430B (de)
HK19797A (en) Treatment of sleep apneas with azapirone derivatives
ATE176242T1 (de) Uck14-verbindungen
EP0458347A3 (en) Liquid crystal composition and display device using same
ES2068685T3 (es) Procedimiento de preparacion de nuevos derivados de 1,5-diin-cicloalquenos.
DE69532198D1 (de) Antitumor-indolopyrolocarbazolderivat
UA10018C2 (uk) 3-(2',3',4'-окси- і 4'-метоксифенілімінометил)піридини, що проявляють протипухлинну активність
IT9011709U1 (it) Quadro modulare per l'alimentazione di impianti ferroviari

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: KIRIN PHARMA KABUSHIKI KAISHA, SHIBUYA, TOKYO, JP

8339 Ceased/non-payment of the annual fee