ATE191916T1 - Neues sphingolglycolipid und verwendung davon - Google Patents
Neues sphingolglycolipid und verwendung davonInfo
- Publication number
- ATE191916T1 ATE191916T1 AT93923043T AT93923043T ATE191916T1 AT E191916 T1 ATE191916 T1 AT E191916T1 AT 93923043 T AT93923043 T AT 93923043T AT 93923043 T AT93923043 T AT 93923043T AT E191916 T1 ATE191916 T1 AT E191916T1
- Authority
- AT
- Austria
- Prior art keywords
- galactosyl
- represent
- aminohexosyl
- glucosyl
- glycolipide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30812492 | 1992-10-22 | ||
PCT/JP1993/001523 WO1994009020A1 (en) | 1992-10-22 | 1993-10-22 | Novel shingoglycolipid and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE191916T1 true ATE191916T1 (de) | 2000-05-15 |
Family
ID=17977176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93923043T ATE191916T1 (de) | 1992-10-22 | 1993-10-22 | Neues sphingolglycolipid und verwendung davon |
Country Status (10)
Country | Link |
---|---|
US (1) | US5849716A (de) |
EP (1) | EP0666268B1 (de) |
JP (1) | JP3717512B2 (de) |
KR (1) | KR100281264B1 (de) |
AT (1) | ATE191916T1 (de) |
AU (1) | AU683026B2 (de) |
CA (1) | CA2147629C (de) |
DE (1) | DE69328435T2 (de) |
HK (1) | HK1009968A1 (de) |
WO (1) | WO1994009020A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1768759A (zh) | 1997-04-10 | 2006-05-10 | 麒麟麦酒株式会社 | 神经酰胺化合物在制备细胞活化剂中的应用 |
CA2320117A1 (en) * | 1998-02-12 | 1999-08-19 | Emory University | Sphingolipid derivatives and their methods of use |
JP4099267B2 (ja) * | 1998-08-07 | 2008-06-11 | 株式会社紀文フードケミファ | 乳化剤および乳化組成物 |
JP2004531469A (ja) * | 2000-12-08 | 2004-10-14 | チルドレンズ メモリアル ホスピタル | 皮膚疾病の治療に使用するガングリオシドを含む組成物 |
AU2002327338A1 (en) * | 2001-07-25 | 2003-02-17 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
JP2005533057A (ja) * | 2002-06-13 | 2005-11-04 | ニューヨーク・ユニバーシティ | 合成c−糖脂質、ならびに癌、感染性疾患および自己免疫疾患を処置するための合成c−糖脂質の使用 |
US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
HUE037560T2 (hu) | 2003-02-14 | 2018-09-28 | Japan President Nat Ct Neurology & Psychiatry | Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására |
US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
EP1647277A4 (de) * | 2003-07-17 | 2011-09-21 | Otsuka Pharma Co Ltd | Glycosid enthaltendes liposom |
US7771726B2 (en) * | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
CA2560969A1 (en) * | 2004-03-31 | 2005-11-03 | New York University | Novel synthetic c-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases |
US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
EP1784196B1 (de) * | 2004-08-27 | 2016-12-21 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramid-derivate als modulatoren von immunität und autoimmunität |
DE602005025005D1 (de) | 2004-10-07 | 2011-01-05 | Argos Therapeutics Inc | Zusammensetzungen reifer dendritischer zellen und verfahren zu deren kultivierung |
US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
US7923013B2 (en) * | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
AU2005322027B2 (en) * | 2004-12-28 | 2013-09-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NK Tcells |
EP1848813B1 (de) | 2005-01-28 | 2013-04-10 | Brigham Young University | Aktivierung von bakteriellem glycolipid von cd1d-begrenzten nkt-zellen |
US20070231344A1 (en) * | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
WO2007074788A1 (ja) * | 2005-12-27 | 2007-07-05 | University Of The Ryukyus | 抗腫瘍剤及び免疫賦活剤 |
CA2661789C (en) * | 2006-04-07 | 2014-06-03 | The Scripps Research Institute | Modified .alpha.-galactosyl ceramides for staining and stimulating natural killer t cells |
US7794722B2 (en) * | 2006-06-30 | 2010-09-14 | The Scripps Research Institute | Adjuvants and methods of use |
CA2678618C (en) | 2007-02-21 | 2019-03-12 | Vaccinex, Inc. | Modulation of nkt cell activity with antigen-loaded cd1d molecules |
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
EP2058011A1 (de) * | 2007-11-07 | 2009-05-13 | Wittycell | NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel |
KR101566847B1 (ko) * | 2007-12-05 | 2015-11-06 | 아비박스 | 항원에 대한 면역 반응 증강을 위한 글리코실세라마이드의 용도 |
US8551959B2 (en) * | 2008-03-25 | 2013-10-08 | Riken | Glycolipid and use thereof |
US8680020B2 (en) | 2008-07-15 | 2014-03-25 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
JP5574432B2 (ja) * | 2008-09-11 | 2014-08-20 | 独立行政法人理化学研究所 | エステル化α−ガラクトシルセラミド類 |
US9220767B2 (en) * | 2008-10-08 | 2015-12-29 | Abivax | Vaccine composition for use against influenza |
AU2010203451B2 (en) * | 2009-01-08 | 2016-06-30 | Albert Einstein College Of Medicine, Inc. | Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
WO2012074116A1 (ja) | 2010-12-02 | 2012-06-07 | 独立行政法人理化学研究所 | アロNKT細胞を用いた免疫療法およびそのためのT細胞抗原受容体(TCR)遺伝子のα鎖領域が均一なVα-Jαに再構成されている細胞および該細胞由来NKT細胞のバンキング |
CA2854725C (en) | 2011-01-05 | 2019-10-22 | National Taiwan University | Methods for preparation of glycosphingolipids and uses thereof |
JP6047309B2 (ja) * | 2011-05-27 | 2016-12-21 | 学校法人近畿大学 | 抗腫瘍剤 |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
EP2881400A4 (de) * | 2012-08-03 | 2016-02-24 | Riken | Hydroxyliertes krn7000-analogon und verwendung davon |
AU2013306098A1 (en) | 2012-08-18 | 2015-02-12 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
CA2882553A1 (en) | 2012-08-22 | 2013-08-22 | Regimmune Corporation | Preparation for preventing or treating type i diabetes |
CA2889858A1 (en) | 2012-11-05 | 2014-05-08 | Regimmune Corporation | Immune-tolerance inducer |
ES2719255T3 (es) | 2012-11-21 | 2019-07-09 | Inst Nat Sante Rech Med | Métodos para determinar el riesgo de enfermedad aguda del injerto contra el hospedador |
US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
EP3041484B1 (de) | 2013-09-06 | 2021-03-03 | Academia Sinica | Humane inkt-zell-aktivierung mittels glykolipiden mit veränderten glycosylgruppen |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
AU2015206370A1 (en) | 2014-01-16 | 2016-07-07 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
TWI687428B (zh) | 2014-03-27 | 2020-03-11 | 中央研究院 | 反應性標記化合物及其用途 |
US10005847B2 (en) | 2014-05-27 | 2018-06-26 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
KR102576850B1 (ko) | 2014-05-27 | 2023-09-11 | 아카데미아 시니카 | 박테로이드 기원의 푸코시다제 및 이의 사용 방법 |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
KR20170003720A (ko) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | 항-cd20 글리코항체 및 이의 용도 |
CA2950433A1 (en) | 2014-05-28 | 2015-12-03 | Academia Sinica | Anti-tnf-alpha glycoantibodies and uses thereof |
JP6899321B2 (ja) | 2014-09-08 | 2021-07-07 | アカデミア シニカAcademia Sinica | 糖脂質を使用するヒトiNKT細胞活性化 |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
TW201808978A (zh) | 2016-03-08 | 2018-03-16 | 中央研究院 | N-聚醣及其陣列之模組化合成方法 |
CN109963868B (zh) | 2016-08-22 | 2023-11-14 | 醣基生医股份有限公司 | 抗体、结合片段及使用方法 |
AU2021392472A1 (en) | 2020-12-04 | 2023-07-06 | Osaka University | Cd1d-ligand-compound-containing liposome preparation having improved pharmacokinetics |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4598051A (en) * | 1980-03-12 | 1986-07-01 | The Regents Of The University Of California | Liposome conjugates and diagnostic methods therewith |
US4806466A (en) * | 1981-10-29 | 1989-02-21 | The Regents Of The University Of California | Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes |
IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
EP0146810A3 (de) * | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
JPS6157594A (ja) * | 1984-08-30 | 1986-03-24 | Suntory Ltd | ガラクトスフインゴ脂質及びその製造法 |
DK17885D0 (da) * | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
DD261165A5 (de) * | 1985-08-13 | 1988-10-19 | Solco Basel Ag,Ch | Neues verfahren zur herstellung von sphingosinderivaten |
EP0212400B1 (de) * | 1985-08-13 | 1992-01-02 | Solco Basel AG | Neues Verfahren zur Herstellung von Sphingosinderivaten |
JPH07116209B2 (ja) * | 1986-04-11 | 1995-12-13 | メクト株式会社 | シアロシルセラミド類及びその製造方法 |
US4990603A (en) * | 1986-07-04 | 1991-02-05 | Mect Corporation | Sialic acid derivatives and process therefor |
US4937232A (en) * | 1986-09-15 | 1990-06-26 | Duke University | Inhibition of protein kinase C by long-chain bases |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
JPS6495A (en) * | 1986-12-19 | 1989-01-05 | Tosoh Corp | Alpha-glycosyl ceramide derivative |
US5026557A (en) * | 1987-09-09 | 1991-06-25 | The Liposome Company, Inc. | Adjuvant composition |
JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
US5028715A (en) * | 1989-02-06 | 1991-07-02 | Southwest Research Institute | Radioprotective agents and their method of manufacture |
US5210073A (en) * | 1989-09-29 | 1993-05-11 | Ajinomoto Co., Inc. | Method for treating cancer therapy radiation damage or arteriosclerosis using human adf |
JP3068910B2 (ja) * | 1990-11-08 | 2000-07-24 | 麒麟麦酒株式会社 | 新規スフィンゴ糖脂質、その製造法および使用 |
JPH06145189A (ja) * | 1991-01-23 | 1994-05-24 | Kitasato Inst:The | スフィンゴ糖脂質 |
JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
TW261533B (de) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
JPH06239597A (ja) * | 1993-02-18 | 1994-08-30 | Hitachi Zosen Corp | 箱型ブロック用作業台装置 |
US5567684A (en) * | 1994-09-14 | 1996-10-22 | The Regents Of The University Of California | Synthetic ganglioside derivatives |
-
1993
- 1993-10-22 JP JP50984894A patent/JP3717512B2/ja not_active Expired - Fee Related
- 1993-10-22 DE DE69328435T patent/DE69328435T2/de not_active Expired - Fee Related
- 1993-10-22 CA CA002147629A patent/CA2147629C/en not_active Expired - Fee Related
- 1993-10-22 KR KR1019950701544A patent/KR100281264B1/ko not_active IP Right Cessation
- 1993-10-22 AU AU52860/93A patent/AU683026B2/en not_active Ceased
- 1993-10-22 WO PCT/JP1993/001523 patent/WO1994009020A1/ja active IP Right Grant
- 1993-10-22 EP EP93923043A patent/EP0666268B1/de not_active Expired - Lifetime
- 1993-10-22 US US08/416,917 patent/US5849716A/en not_active Expired - Fee Related
- 1993-10-22 AT AT93923043T patent/ATE191916T1/de not_active IP Right Cessation
-
1998
- 1998-09-22 HK HK98110813A patent/HK1009968A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100281264B1 (ko) | 2001-02-01 |
AU683026B2 (en) | 1997-10-30 |
DE69328435T2 (de) | 2000-09-14 |
CA2147629C (en) | 2005-03-22 |
DE69328435D1 (de) | 2000-05-25 |
US5849716A (en) | 1998-12-15 |
EP0666268A1 (de) | 1995-08-09 |
EP0666268A4 (de) | 1995-06-27 |
AU5286093A (en) | 1994-05-09 |
CA2147629A1 (en) | 1994-04-28 |
WO1994009020A1 (en) | 1994-04-28 |
HK1009968A1 (en) | 1999-09-17 |
EP0666268B1 (de) | 2000-04-19 |
KR950704341A (ko) | 1995-11-20 |
JP3717512B2 (ja) | 2005-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE191916T1 (de) | Neues sphingolglycolipid und verwendung davon | |
CA2146259A1 (en) | Substituted benzylaminoquinuclidines | |
DK0694539T3 (da) | 7-O-ethere af taxanderivater | |
YU245589A (en) | Substituted semicarbazon arthropodicids | |
MY132263A (en) | Pyridazinone derivatives and processes for preparing the same | |
GB9320191D0 (en) | Compounds | |
TR199902350T2 (xx) | Yeni piridin t�revleri ve onlardan olu�an farmakotik bile�imler. | |
DE69001111T2 (de) | Antikrebs-zusammensetzung. | |
DK0424899T3 (da) | Hidtil ukendte anthracyclinglycosidderivater og fremgangsmåde til fremstilling deraf | |
AU2853889A (en) | Therapeutic agents for the treatment of peptic ulcer disease | |
ZA881430B (de) | ||
HK19797A (en) | Treatment of sleep apneas with azapirone derivatives | |
ATE176242T1 (de) | Uck14-verbindungen | |
EP0458347A3 (en) | Liquid crystal composition and display device using same | |
ES2068685T3 (es) | Procedimiento de preparacion de nuevos derivados de 1,5-diin-cicloalquenos. | |
UA10018C2 (uk) | 3-(2',3',4'-окси- і 4'-метоксифенілімінометил)піридини, що проявляють протипухлинну активність | |
IT9011709V0 (it) | Quadro modulare per l'alimentazione di impianti ferroviari |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |