DE69130683T2 - PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL - Google Patents

PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL

Info

Publication number
DE69130683T2
DE69130683T2 DE69130683T DE69130683T DE69130683T2 DE 69130683 T2 DE69130683 T2 DE 69130683T2 DE 69130683 T DE69130683 T DE 69130683T DE 69130683 T DE69130683 T DE 69130683T DE 69130683 T2 DE69130683 T2 DE 69130683T2
Authority
DE
Germany
Prior art keywords
group
formula
compound
alkyl group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69130683T
Other languages
German (de)
English (en)
Other versions
DE69130683D1 (de
Inventor
Toshiaki 5-1-20 Nakamaegawa-Cho Tokushima 770 Funato
Kinji 7-8 Kitahama-Aza-Miyanohigashi Tokushima 772 Hashimoto
Makoto 122-3 Kizuno-Aza-Nogaminokoshi Tokushima 772 Inoue
Toshiko 14-21 I Tano-Gun Tokushima 771-02 Kuwahara
Yukio 79-1 Yoshinaga Otsu-Cho Tokushima 772 Sugimoto
Takuji 51-6 I Tano-Gun Tokushima 771-02 Uesako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE69130683D1 publication Critical patent/DE69130683D1/de
Application granted granted Critical
Publication of DE69130683T2 publication Critical patent/DE69130683T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69130683T 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL Expired - Fee Related DE69130683T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22
PCT/JP1991/001043 WO1992018504A1 (en) 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
DE69130683D1 DE69130683D1 (de) 1999-02-04
DE69130683T2 true DE69130683T2 (de) 1999-05-06

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130683T Expired - Fee Related DE69130683T2 (de) 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL

Country Status (12)

Country Link
US (1) US5688949A (enExample)
EP (1) EP0591528B1 (enExample)
JP (1) JPH0570353A (enExample)
KR (1) KR100191774B1 (enExample)
AT (1) ATE174917T1 (enExample)
AU (1) AU651986B2 (enExample)
CA (1) CA2107479C (enExample)
DE (1) DE69130683T2 (enExample)
DK (1) DK0591528T3 (enExample)
ES (1) ES2126573T3 (enExample)
TW (1) TW221434B (enExample)
WO (1) WO1992018504A1 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
AU680370B2 (en) * 1994-06-21 1997-07-24 Otsuka Pharmaceutical Factory, Inc. Pyrazolo(1,5-a)pyrimidine derivative
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US6664261B2 (en) * 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
JP3870298B2 (ja) * 1996-06-06 2007-01-17 株式会社大塚製薬工場 アミド誘導体
CN1104432C (zh) * 1996-07-24 2003-04-02 杜邦药品公司 吡咯并三嗪和嘧啶化合物
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
ES2294800T3 (es) * 1996-07-24 2008-04-01 Bristol-Myers Squibb Pharma Company Azolo triazinas y pirimidinas.
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
EP1392692B1 (en) 2001-03-27 2006-11-15 Neurogen Corporation (oxo-pyrazolo¬1,5a|pyrimidin-2-yl)alkyl-carboxamides
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JP4602076B2 (ja) * 2002-06-04 2010-12-22 ネオジェネシス ファーマシューティカルズ インコーポレイテッド 抗ウイルス剤としてのピラゾロ［１，５ａ］ピリミジン化合物
US7205308B2 (en) 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
JP2006501260A (ja) * 2002-09-04 2006-01-12 シェーリング　コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
TW200412966A (en) 2002-09-04 2004-08-01 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
AU2003268385B2 (en) * 2002-09-04 2006-12-21 Pharmacopeia, Inc. Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
ES2346204T3 (es) 2002-09-04 2010-10-13 Schering Corporation Pirazolopirimidinas adecuadas para el tratamiento de enfermedades cancerosas.
EP1534712B1 (en) * 2002-09-04 2007-05-16 Schering Corporation Pyrazolo[1,5-a]pyrimidine compounds as cyclin dependent kinase inhibitors
US7557110B2 (en) 2003-02-28 2009-07-07 Teijin Pharma Limited Pyrazolo[1,5-A] pyrimidine derivatives
EP1608652A1 (en) * 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
PL1889198T3 (pl) 2005-04-28 2015-04-30 Proteus Digital Health Inc System farmakologiczno-informatyczny
CN101300233A (zh) * 2005-09-09 2008-11-05 先灵公司 氮杂稠合的细胞周期蛋白依赖性激酶抑制剂
JP2009511484A (ja) * 2005-10-06 2009-03-19 シェーリング コーポレイション プロテインキナーゼインヒビターとしてのピラゾロピリミジン
CN101321760A (zh) 2005-10-06 2008-12-10 先灵公司 作为蛋白激酶抑制剂的吡唑并嘧啶
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
KR20090091315A (ko) 2006-11-29 2009-08-27 아보트 러보러터리즈 디아실글리세롤 ｏ-아실트랜스퍼라제 1형 효소의 억제제
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
CA2706571C (en) * 2007-12-19 2012-11-27 Genentech, Inc. 5-anilinoimidazopyridines and methods of use
CN102316902B (zh) 2009-02-20 2014-09-24 to-BBB控股股份有限公司 基于谷胱甘肽的药物递送系统
AU2010245823B2 (en) 2009-05-06 2016-11-24 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
MX2012007410A (es) * 2009-12-23 2012-07-17 Univ Leuven Kath Compuestos antivirales novedosos.
US8927562B2 (en) * 2010-09-28 2015-01-06 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
AU2011331301A1 (en) 2010-11-15 2013-05-23 Katholieke Universiteit Leuven Antiviral condensed heterocyclic compounds
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
EP3079693B1 (en) * 2013-12-11 2019-09-04 Nant Holdings IP, LLC Small molecule inhibitors of influenza a rna-dependent rna polymerase
JP6509238B2 (ja) * 2014-01-22 2019-05-08 キュロヴィル・アクチボラグ 治療に有用なピラゾロ［１，５−ａ］ピリミジン−７−アミン誘導体
GB201410817D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
EP3681888A4 (en) * 2017-09-15 2021-07-07 Aduro Biotech, Inc. PYRAZOLOPYRIMIDINONE COMPOUNDS AND THEIR USES
DE102018201598A1 (de) * 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
CN116348468A (zh) 2020-10-23 2023-06-27 日东制药株式会社 Cftr调节剂化合物、组合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Also Published As

Publication number Publication date
ES2126573T3 (es) 1999-04-01
DE69130683D1 (de) 1999-02-04
AU8295891A (en) 1992-11-17
CA2107479C (en) 1997-12-16
US5688949A (en) 1997-11-18
EP0591528A4 (en) 1995-02-15
CA2107479A1 (en) 1992-10-23
EP0591528B1 (en) 1998-12-23
TW221434B (enExample) 1994-03-01
ATE174917T1 (de) 1999-01-15
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
WO1992018504A1 (en) 1992-10-29
JPH0570353A (ja) 1993-03-23
KR100191774B1 (ko) 1999-06-15
AU651986B2 (en) 1994-08-11

Similar Documents

Publication Publication Date Title
DE69130683T2 (de) PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL
DE60130924T2 (de) Cyclopentaädüpyrazoloä1,5-aüpyrimidin-verbindung als crf-rezeptor antagonist
DE69603240T2 (de) Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
DE69530989T2 (de) Neue pyrimidinderivate und verfahren zu ihrer herstellung
DE3685608T2 (de) 8-phenylxanthine.
AT390732B (de) Pharmazeutika enthaltend pyrazole
DE69000467T2 (de) Bis-aza-bicyclische anxiolytica und antidepressiva.
DE69827786T2 (de) Condensierte pyridazine derivate,deren herstellung und verwendung
DE69108461T2 (de) 1-Indolylalkyl-4-(alkoxy-pyrimidinyl)piperazine.
DE3001328C2 (enExample)
CH660484A5 (de) In 1-stellung durch einen heterocyclischen rest substituierte 4-((2,5-pyrrolidindion-1-yl)alkyl)piperazin-verbindungen.
DE69813605T2 (de) Benzofuranderivate
EP0763037A1 (de) [a]-ANNELIERTE PYRROLDERIVATE UND DEREN ANWENDUNG IN DER PHARMAZIE
DE60213108T2 (de) SPIROCYCLISCHE 6,7-DIHYDRO-5H-PYRAZOLOc1,2-AÜPYRAZOL-1-ONE, DIE INFLAMMATORISCHE CYTOKINE STEUERN
DE69120899T2 (de) Neue N-Benzoylprolin-Derivate, Verfahren zur Herstellung und diese enthaltende Arzneimittel
DE69007905T2 (de) 1-Oxa-2-oxo-8-azaspiro[4,5]decan-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen daraus.
DE69116237T2 (de) Derivate von Hexahydroazepine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DD289529A5 (de) Verfahren zur herstellung heterozyklischer verbindungen
CH646972A5 (en) Process for the preparation of new 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
DE69232484T2 (de) Hydroisochinolinderivate
DE69322673T2 (de) Imidazopyridazine als Antiasthmatika
DE69406678T2 (de) Heterozyclische amine mit zns-wirksamkeit
DE3854981T2 (de) 1-Pyrrolidinacetamid-Derivate und ihre Verwendung
DE69228307T2 (de) Imidazo(1,2-c)chinazolinderivate als antihypertensive und antidysurie
DE69330283T2 (de) Neue 4-(3-benzofuranyl) piperidinyl und 4-(3-benzothienyl) piperidinyl-derivate und diese enthaltende pharmazeutische zusammenstellungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee