DE69130683T2 - PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL - Google Patents

PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL

Info

Publication number
DE69130683T2
DE69130683T2 DE69130683T DE69130683T DE69130683T2 DE 69130683 T2 DE69130683 T2 DE 69130683T2 DE 69130683 T DE69130683 T DE 69130683T DE 69130683 T DE69130683 T DE 69130683T DE 69130683 T2 DE69130683 T2 DE 69130683T2
Authority
DE
Germany
Prior art keywords
group
formula
compound
alkyl group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69130683T
Other languages
German (de)
English (en)
Other versions
DE69130683D1 (de
Inventor
Toshiaki 5-1-20 Nakamaegawa-Cho Tokushima 770 Funato
Kinji 7-8 Kitahama-Aza-Miyanohigashi Tokushima 772 Hashimoto
Makoto 122-3 Kizuno-Aza-Nogaminokoshi Tokushima 772 Inoue
Toshiko 14-21 I Tano-Gun Tokushima 771-02 Kuwahara
Yukio 79-1 Yoshinaga Otsu-Cho Tokushima 772 Sugimoto
Takuji 51-6 I Tano-Gun Tokushima 771-02 Uesako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69130683D1 publication Critical patent/DE69130683D1/de
Publication of DE69130683T2 publication Critical patent/DE69130683T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69130683T 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL Expired - Fee Related DE69130683T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22
PCT/JP1991/001043 WO1992018504A1 (en) 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
DE69130683D1 DE69130683D1 (de) 1999-02-04
DE69130683T2 true DE69130683T2 (de) 1999-05-06

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130683T Expired - Fee Related DE69130683T2 (de) 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL

Country Status (12)

Country Link
US (1) US5688949A (enExample)
EP (1) EP0591528B1 (enExample)
JP (1) JPH0570353A (enExample)
KR (1) KR100191774B1 (enExample)
AT (1) ATE174917T1 (enExample)
AU (1) AU651986B2 (enExample)
CA (1) CA2107479C (enExample)
DE (1) DE69130683T2 (enExample)
DK (1) DK0591528T3 (enExample)
ES (1) ES2126573T3 (enExample)
TW (1) TW221434B (enExample)
WO (1) WO1992018504A1 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
EP0714898B1 (en) * 1994-06-21 2001-11-14 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US6664261B2 (en) * 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
AU716633B2 (en) * 1996-06-06 2000-03-02 Otsuka Pharmaceutical Factory, Inc. Amide derivatives
SK286461B6 (sk) * 1996-07-24 2008-10-07 Bristol-Myers Squibb Pharma Company [1,5-a]-Pyrazolo-1,3,5-triazíny, ich použitie a farmaceutické kompozície na ich báze
HU229024B1 (en) * 1996-07-24 2013-07-29 Bristol Myers Squibb Pharma Co Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
MXPA03008681A (es) 2001-03-27 2004-04-02 Neurogen Corp (oxo-pirazol[1,5]pirimidin-2-il)alquil-carboxamidas.
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
AU2003240488A1 (en) * 2002-06-04 2003-12-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
CN1701073B (zh) * 2002-09-04 2011-06-22 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并[1,5-a]嘧啶
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
WO2004022559A1 (en) * 2002-09-04 2004-03-18 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
AU2003265901B2 (en) * 2002-09-04 2006-09-14 Pharmacopeia, Inc. Pyrazolopyrimidines as cyclin dependent kinase inhibitors
RU2380369C9 (ru) 2002-09-04 2011-07-10 Шеринг Корпорейшн Новые пиразолопиримидины как ингибиторы циклин-зависимой киназы
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
TWI335919B (en) * 2002-09-04 2011-01-11 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
EP1599482A4 (en) 2003-02-28 2008-10-01 Teijin Pharma Ltd PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
EP1608652A1 (en) * 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
PE20051089A1 (es) * 2004-01-22 2006-01-25 Novartis Ag Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
EP1931641B1 (en) 2005-09-09 2010-08-25 Schering Corporation NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES COMPOUNDS AS CYCLIN DEPENDENT KINASE INHI
US7776865B2 (en) 2005-10-06 2010-08-17 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
WO2007044426A2 (en) * 2005-10-06 2007-04-19 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
BRPI0719352A2 (pt) * 2006-11-29 2017-10-24 Abbott Lab inibidores de enzima diacilglicerol o-aciltransferase tipo 1
EP2690101B1 (en) * 2007-12-19 2015-06-24 Genentech, Inc. 5-Anilinoimidazopyridines and Methods of Use
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
SG181423A1 (en) * 2009-12-23 2012-07-30 Univ Leuven Kath Novel antiviral compounds
EP2621925B1 (en) * 2010-09-28 2017-06-21 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
NZ610315A (en) 2010-11-15 2015-08-28 Univ Leuven Kath Antiviral condensed heterocyclic compounds
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
EP3079693B1 (en) * 2013-12-11 2019-09-04 Nant Holdings IP, LLC Small molecule inhibitors of influenza a rna-dependent rna polymerase
CN106061975B (zh) * 2014-01-22 2019-09-24 库洛维公司 作为抗病毒化合物的吡唑并[1,5-a]嘧啶
GB201410817D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
MX2020002869A (es) * 2017-09-15 2020-07-24 Aduro Biotech Inc Compuestos de pirazolopirimidinona y usos de los mismos.
DE102018201598A1 (de) * 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
UY39482A (es) 2020-10-23 2022-05-31 Ildong Pharmaceutical Co Ltd Compuestos moduladores del cftr, composiciones y usos de estos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Also Published As

Publication number Publication date
AU651986B2 (en) 1994-08-11
TW221434B (enExample) 1994-03-01
EP0591528B1 (en) 1998-12-23
ES2126573T3 (es) 1999-04-01
KR100191774B1 (ko) 1999-06-15
EP0591528A4 (en) 1995-02-15
CA2107479A1 (en) 1992-10-23
WO1992018504A1 (en) 1992-10-29
AU8295891A (en) 1992-11-17
CA2107479C (en) 1997-12-16
DE69130683D1 (de) 1999-02-04
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
ATE174917T1 (de) 1999-01-15
JPH0570353A (ja) 1993-03-23
US5688949A (en) 1997-11-18

Similar Documents

Publication Publication Date Title
DE69130683T2 (de) PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL
DE60130924T2 (de) Cyclopentaädüpyrazoloä1,5-aüpyrimidin-verbindung als crf-rezeptor antagonist
DE69603240T2 (de) Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
EP0763037B1 (de) [a]-ANNELIERTE PYRROLDERIVATE UND DEREN ANWENDUNG IN DER PHARMAZIE
DE69530989T2 (de) Neue pyrimidinderivate und verfahren zu ihrer herstellung
DE3685608T2 (de) 8-phenylxanthine.
AT390732B (de) Pharmazeutika enthaltend pyrazole
DE69000467T2 (de) Bis-aza-bicyclische anxiolytica und antidepressiva.
DE69827786T2 (de) Condensierte pyridazine derivate,deren herstellung und verwendung
DE3001328C2 (enExample)
CH660484A5 (de) In 1-stellung durch einen heterocyclischen rest substituierte 4-((2,5-pyrrolidindion-1-yl)alkyl)piperazin-verbindungen.
DE69813605T2 (de) Benzofuranderivate
DE69713124T2 (de) 1H-PYRIDO[3,4-b]INDOLCARBOXAMIDDERIVATE, IHRE HERSTELLUNG UND THERAPEUTISCHE VERWENDUNG
DE60213108T2 (de) SPIROCYCLISCHE 6,7-DIHYDRO-5H-PYRAZOLOc1,2-AÜPYRAZOL-1-ONE, DIE INFLAMMATORISCHE CYTOKINE STEUERN
DE69120899T2 (de) Neue N-Benzoylprolin-Derivate, Verfahren zur Herstellung und diese enthaltende Arzneimittel
DE69007905T2 (de) 1-Oxa-2-oxo-8-azaspiro[4,5]decan-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen daraus.
DE69116237T2 (de) Derivate von Hexahydroazepine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DD289529A5 (de) Verfahren zur herstellung heterozyklischer verbindungen
CH646972A5 (en) Process for the preparation of new 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
DE69232484T2 (de) Hydroisochinolinderivate
DE69406678T2 (de) Heterozyclische amine mit zns-wirksamkeit
DE69232980T2 (de) Pyrroloazepinderivate
DE69330283T2 (de) Neue 4-(3-benzofuranyl) piperidinyl und 4-(3-benzothienyl) piperidinyl-derivate und diese enthaltende pharmazeutische zusammenstellungen
DE3730718A1 (de) Tetracyclische chinazolinderivate, herstellung und verwendung
DE69014930T2 (de) Aralkylamin-Verbindungen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee