TW221434B - - Google Patents

Info

Publication number
TW221434B
TW221434B TW080106516A TW80106516A TW221434B TW 221434 B TW221434 B TW 221434B TW 080106516 A TW080106516 A TW 080106516A TW 80106516 A TW80106516 A TW 80106516A TW 221434 B TW221434 B TW 221434B
Authority
TW
Taiwan
Prior art keywords
lower alkyl
substituted
hydroxy
phenyl
hydrogen
Prior art date
Application number
TW080106516A
Other languages
English (en)
Chinese (zh)
Original Assignee
Ctsuka Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctsuka Seiyaku Kk filed Critical Ctsuka Seiyaku Kk
Application granted granted Critical
Publication of TW221434B publication Critical patent/TW221434B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW080106516A 1991-04-22 1991-08-16 TW221434B (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22

Publications (1)

Publication Number Publication Date
TW221434B true TW221434B (enExample) 1994-03-01

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
TW080106516A TW221434B (enExample) 1991-04-22 1991-08-16

Country Status (12)

Country Link
US (1) US5688949A (enExample)
EP (1) EP0591528B1 (enExample)
JP (1) JPH0570353A (enExample)
KR (1) KR100191774B1 (enExample)
AT (1) ATE174917T1 (enExample)
AU (1) AU651986B2 (enExample)
CA (1) CA2107479C (enExample)
DE (1) DE69130683T2 (enExample)
DK (1) DK0591528T3 (enExample)
ES (1) ES2126573T3 (enExample)
TW (1) TW221434B (enExample)
WO (1) WO1992018504A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106232119A (zh) * 2013-12-11 2016-12-14 河谷控股Ip有限责任公司 A型流感rna‑依赖性rna聚合酶的小分子抑制剂

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
DE69523864T2 (de) * 1994-06-21 2002-06-13 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO[1,5-a] PYRIMIDIN-DERIVATE
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US6664261B2 (en) 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
CA2257222C (en) * 1996-06-06 2002-08-20 Otsuka Pharmaceutical Factory, Inc. Amide derivatives
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
EP0915880B1 (en) * 1996-07-24 2007-10-10 Bristol-Myers Squibb Pharma Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
CZ299451B6 (cs) * 1996-07-24 2008-07-30 Bristol-Myers Squibb Pharma Company [1,5-a]-Pyrazolo-1,3,5- triaziny jejich použití afarmaceutické kompozice na jejich bázi
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
CA2441926A1 (en) * 2001-03-27 2002-10-03 Neurogen Corporation (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1511751B1 (en) * 2002-06-04 2008-03-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents
US7078525B2 (en) 2002-09-04 2006-07-18 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY145332A (en) 2002-09-04 2012-01-31 Schering Corp Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7074924B2 (en) * 2002-09-04 2006-07-11 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7205308B2 (en) 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
CN1694705A (zh) * 2002-09-04 2005-11-09 先灵公司 用作依赖细胞周期蛋白激酶抑制剂的吡唑并嘧啶
PT1537116E (pt) 2002-09-04 2010-09-03 Schering Corp Pirazolopirimidinas adequadas para o tratamento de doenças cancerosas
BRPI0407834A (pt) 2003-02-28 2006-02-14 Teijin Pharma Ltd composto, processo para a manufatura do mesmo, composição, processo para a manufatura da mesma, método de tratamento ou prevenção de um distúrbio mediado por proteìna quinase em um indivìduo, uso de um composto, ensaio para determinar a atividade dos compostos, e, método de inibição da atividade ou função de uma proteìna quinase
WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
ES2349476T3 (es) * 2005-09-09 2011-01-03 Schering Corporation Nuevos derivados de 4-ciano, 4-amino y 4-aminometilo de compuestos de pirazolo[1,5-a]piridinas, pirazolo[1,5-c]pirimidinas y 2h-indazol y derivados de 5-ciano, 5-amino y 5-aminometilo de compuestos de imidazo[1,2-a]piridinas e imidazo[1,5-a]pirazinas, como inhibidores de cinasa dependiente de ciclina.
TWI333953B (en) * 2005-10-06 2010-12-01 Schering Corp Pyrazolopyrimidines as protein kinase inhibitors
US7776865B2 (en) 2005-10-06 2010-08-17 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
AU2007325350B2 (en) 2006-11-29 2012-09-20 Abbvie Inc. Inhibitors of diacylglycerol O-acylotransferase type 1 enzyme
NZ586802A (en) 2007-12-19 2012-03-30 Genentech Inc Imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives for the treatment of inflammatory diseases
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
SG10201408512RA (en) * 2009-12-23 2015-02-27 Univ Leuven Kath Novel antiviral compounds
EP2621925B1 (en) * 2010-09-28 2017-06-21 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
NZ610315A (en) 2010-11-15 2015-08-28 Univ Leuven Kath Antiviral condensed heterocyclic compounds
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
US9963455B2 (en) 2014-01-22 2018-05-08 Curovir Ab Pyrazolo[1,5-a]pyrimidines as antiviral compounds
GB201410817D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
JP2020533376A (ja) * 2017-09-15 2020-11-19 アドゥロ バイオテック，インク． ピラゾロピリミジノン化合物およびその使用
DE102018201598A1 (de) 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
US11827640B2 (en) 2020-10-23 2023-11-28 Ildong Pharmaceutical Co., Ltd. Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106232119A (zh) * 2013-12-11 2016-12-14 河谷控股Ip有限责任公司 A型流感rna‑依赖性rna聚合酶的小分子抑制剂

Also Published As

Publication number Publication date
CA2107479C (en) 1997-12-16
JPH0570353A (ja) 1993-03-23
DE69130683D1 (de) 1999-02-04
ES2126573T3 (es) 1999-04-01
KR100191774B1 (ko) 1999-06-15
ATE174917T1 (de) 1999-01-15
WO1992018504A1 (en) 1992-10-29
EP0591528B1 (en) 1998-12-23
AU651986B2 (en) 1994-08-11
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
CA2107479A1 (en) 1992-10-23
EP0591528A4 (en) 1995-02-15
US5688949A (en) 1997-11-18
DE69130683T2 (de) 1999-05-06
AU8295891A (en) 1992-11-17

Similar Documents

Publication Publication Date Title
TW221434B (enExample)
GB2230527B (en) Aminopyrimidine derivatives useful for treating cardiovascular disorders
CA2311742A1 (en) 6-amino-9-benzyl-8-hydroxypurine derivatives
ATE206412T1 (de) Heterocyclische verbindungen als bradykinin antagonisten
IL104244A (en) FUNGICIDAL COMPOSITIONS CONTAINING SUBSTITUTED 7-AMINO-1, 2, 4-TRIAZOLO £1, 5-a| PYRIMIDINE DERIVATIVES AND THEIR PREPARATION
IL99755A0 (en) Hydroxymethyl(methylenecyclopentyl)purines and pyrimidines and pharmaceutical compositions containing the same
EP0638567A4 (en) ADENOSINE INHIBITORS.
CA2111461A1 (en) 3-Aminopiperidine Derivatives and Related Nitrogen Containing Heterocycles
CA2297326A1 (en) Heterocyclic compound and antitumor agent containing the same as active component
ATE174596T1 (de) Imidazo (1,2-a)pyridine als bradykinin- antagonisten
ATE79380T1 (de) 2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
ES2168383T3 (es) Derivados de 1,2,3,4-tetrahidroquinoxalindiona y su utilizacion como antagonistas del glutamato receptor.
HUT61004A (en) Process for producing quinoxaline derivatives and pharmaceutical compositions comprising such compounds as active ingredient
IL176276A0 (en) [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINE DERIVATIVES
NZ330078A (en) Active oxygen carriers containing pterin derivatives and salts thereof for use as cosmetic agents and feed
DE69619259D1 (de) Amidin- und isothioharnstoffderivate als inhibitoren der stickstoffoxid-synthase
ZA937308B (en) Ellipticine compounds a process for their preparation and pharmaceutical compositions containing them
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
IT1147330B (it) Medicamento,o preparato farmaceutico,ad azione citostatica
NZ196018A (en) 6-(phenyl or heteroaryl)-2,3-dihydroimidazo(1,2-b)-pyridazines
IL101032A0 (en) 1,2,4-triazolo(1,5-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
JO1631B1 (en) Derivatives of permidine