NZ244892A - 6-(1h-imidazol-1-ylmethyl)-2-phenylquinoline derivatives and pharmaceutical compositions - Google Patents

6-(1h-imidazol-1-ylmethyl)-2-phenylquinoline derivatives and pharmaceutical compositions

Info

Publication number
NZ244892A
NZ244892A NZ244892A NZ24489292A NZ244892A NZ 244892 A NZ244892 A NZ 244892A NZ 244892 A NZ244892 A NZ 244892A NZ 24489292 A NZ24489292 A NZ 24489292A NZ 244892 A NZ244892 A NZ 244892A
Authority
NZ
New Zealand
Prior art keywords
group
alkoxy
imidazol
ylmethyl
aryl
Prior art date
Application number
NZ244892A
Inventor
Gerard Cremer
Pascale Goberville
Jean-Claude Muller
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9418349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ244892(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo filed Critical Synthelabo
Publication of NZ244892A publication Critical patent/NZ244892A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Communication Cables (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds corresponding to the formula (I) <IMAGE> in which, R1 represents either a 1H-tetrazol-5-yl group or a CO2H group, R2 represents either a (C1-7)alkyl group or a (C2-6)alkenyl group, R3 and R4 represent, each independently of the other, either a hydrogen atom, or a halogen atom, or a cyano group, or a (C1-7)alkyl group, or a (C3-7)cycloalkyl(C1-4)alkyl group, or an aryl group, or an aryl(C1-4)alkyl group, or an aryl(C2-4)alkenyl group, or a group -(CH2)mCOR5 in which m = 0 to 4 and R5 represents a hydrogen atom, an OH group, a (C1-6)alkoxy group or a group NR7R8, R7 and R8 representing, each independently of the other, a hydrogen atom or a (C1-4)alkyl group, or R3 and R4 represents, each independently of the other, a group -(CH2)n-R6 in which n = 1 to 4 and R6 represents an OH group, a (C1-6)alkoxy group, a (C1-4)alkoxy(C1-4)alkoxy group or a (C3-7)cycloalkyl(C1-4)alkoxy group, and their pharmaceutically acceptable organic or inorganic salts. Application in therapeutics.
NZ244892A 1991-10-28 1992-10-27 6-(1h-imidazol-1-ylmethyl)-2-phenylquinoline derivatives and pharmaceutical compositions NZ244892A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113240A FR2683819B1 (en) 1991-10-28 1991-10-28 QUINOLEIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION.

Publications (1)

Publication Number Publication Date
NZ244892A true NZ244892A (en) 1994-06-27

Family

ID=9418349

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ244892A NZ244892A (en) 1991-10-28 1992-10-27 6-(1h-imidazol-1-ylmethyl)-2-phenylquinoline derivatives and pharmaceutical compositions

Country Status (18)

Country Link
EP (1) EP0540400B1 (en)
JP (1) JPH05239053A (en)
KR (1) KR930007935A (en)
CN (1) CN1073171A (en)
AT (1) ATE126798T1 (en)
AU (1) AU651740B2 (en)
CA (1) CA2081537A1 (en)
CZ (1) CZ324292A3 (en)
DE (1) DE69204252T2 (en)
FI (1) FI924869A (en)
FR (1) FR2683819B1 (en)
HU (1) HUT62883A (en)
IL (1) IL103568A0 (en)
MX (1) MX9206169A (en)
NO (1) NO924138L (en)
NZ (1) NZ244892A (en)
PL (1) PL296369A1 (en)
ZA (1) ZA928297B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478832A (en) * 1992-05-08 1995-12-26 The Green Cross Corporation Quinoline compounds
IT1255461B (en) * 1992-07-28 1995-11-02 Luso Farmaco Inst ETHERS OF IMIDAZOLI ACTIVATED IN II ANTAGONIST
FR2699174B1 (en) * 1992-12-14 1995-01-20 Synthelabo Derivatives of 3- (quinoline-6-yl-methyl) -4H-imidazol-4-one, their preparation and their therapeutic use.
FR2710914B1 (en) * 1993-10-04 1995-11-24 Synthelabo 2- [2- (tetrazol-5-yl) phenyl] -1,2-dihydroquinoline derivatives, their preparation and their use as synthesis intermediates.
FR2716196B1 (en) * 1994-02-16 1996-04-05 Synthelabo 8- [2- (1H-tetrazol-5-yl) phenyl] quinoline derivatives, their preparation and their therapeutic use.
JPH09202774A (en) 1996-01-25 1997-08-05 Green Cross Corp:The 2-arylquinoline and its production
DE19706161A1 (en) * 1997-02-17 1998-08-20 Oswald Hartmut Prof Dr Med Use of cyanines, isocyanines and pseudoisocyanines as diuretics
KR100744826B1 (en) * 2006-04-05 2007-08-01 한국화학연구원 Quinolinone derivatives substituted with imidazole group
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103804349A (en) * 2012-11-01 2014-05-21 杨子娇 Compounds for treatment of glaucoma and their use
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (en) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc ULTRAPURE GUANYLATE CYCLASE C AGONISTS, METHOD OF MANUFACTURING AND USING THEM
CN108558750B (en) * 2018-07-11 2021-01-05 武汉工程大学 Process for synthesizing 3-nitroquinoline derivative by solvent-free method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
MX9200299A (en) * 1991-02-07 1992-12-01 Roussel Uclaf NEW NITROGENATED BICYCLE DERIVATIVES, THEIR PROCEDURE FOR PREPARING THE NEW INTERMEDIATE COMPOUNDS OBTAINED THEIR APPLICATION AS MEDICINES AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DE4117750A1 (en) * 1991-05-30 1992-12-24 Bayer Ag NEW 2-AMINO-5-CYANO-1,4-DIHYDROPYRIDINE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS
EP0528762B1 (en) * 1991-08-15 1997-05-07 Novartis AG N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists

Also Published As

Publication number Publication date
DE69204252D1 (en) 1995-09-28
MX9206169A (en) 1993-07-01
KR930007935A (en) 1993-05-20
HU9203374D0 (en) 1993-01-28
AU2734892A (en) 1993-04-29
FI924869A0 (en) 1992-10-27
DE69204252T2 (en) 1996-04-18
EP0540400B1 (en) 1995-08-23
ATE126798T1 (en) 1995-09-15
CN1073171A (en) 1993-06-16
EP0540400A1 (en) 1993-05-05
NO924138D0 (en) 1992-10-27
FI924869A (en) 1993-04-29
CZ324292A3 (en) 1993-09-15
JPH05239053A (en) 1993-09-17
ZA928297B (en) 1993-05-07
AU651740B2 (en) 1994-07-28
FR2683819B1 (en) 1994-02-11
FR2683819A1 (en) 1993-05-21
CA2081537A1 (en) 1993-04-29
NO924138L (en) 1993-04-29
PL296369A1 (en) 1993-05-31
HUT62883A (en) 1993-06-28
IL103568A0 (en) 1993-03-15

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