NZ244892A - 6-(1h-imidazol-1-ylmethyl)-2-phenylquinoline derivatives and pharmaceutical compositions - Google Patents
6-(1h-imidazol-1-ylmethyl)-2-phenylquinoline derivatives and pharmaceutical compositionsInfo
- Publication number
- NZ244892A NZ244892A NZ244892A NZ24489292A NZ244892A NZ 244892 A NZ244892 A NZ 244892A NZ 244892 A NZ244892 A NZ 244892A NZ 24489292 A NZ24489292 A NZ 24489292A NZ 244892 A NZ244892 A NZ 244892A
- Authority
- NZ
- New Zealand
- Prior art keywords
- group
- alkoxy
- imidazol
- ylmethyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Communication Cables (AREA)
- Medicinal Preparation (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds corresponding to the formula (I) <IMAGE> in which, R1 represents either a 1H-tetrazol-5-yl group or a CO2H group, R2 represents either a (C1-7)alkyl group or a (C2-6)alkenyl group, R3 and R4 represent, each independently of the other, either a hydrogen atom, or a halogen atom, or a cyano group, or a (C1-7)alkyl group, or a (C3-7)cycloalkyl(C1-4)alkyl group, or an aryl group, or an aryl(C1-4)alkyl group, or an aryl(C2-4)alkenyl group, or a group -(CH2)mCOR5 in which m = 0 to 4 and R5 represents a hydrogen atom, an OH group, a (C1-6)alkoxy group or a group NR7R8, R7 and R8 representing, each independently of the other, a hydrogen atom or a (C1-4)alkyl group, or R3 and R4 represents, each independently of the other, a group -(CH2)n-R6 in which n = 1 to 4 and R6 represents an OH group, a (C1-6)alkoxy group, a (C1-4)alkoxy(C1-4)alkoxy group or a (C3-7)cycloalkyl(C1-4)alkoxy group, and their pharmaceutically acceptable organic or inorganic salts. Application in therapeutics.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9113240A FR2683819B1 (en) | 1991-10-28 | 1991-10-28 | QUINOLEIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION. |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ244892A true NZ244892A (en) | 1994-06-27 |
Family
ID=9418349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ244892A NZ244892A (en) | 1991-10-28 | 1992-10-27 | 6-(1h-imidazol-1-ylmethyl)-2-phenylquinoline derivatives and pharmaceutical compositions |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0540400B1 (en) |
JP (1) | JPH05239053A (en) |
KR (1) | KR930007935A (en) |
CN (1) | CN1073171A (en) |
AT (1) | ATE126798T1 (en) |
AU (1) | AU651740B2 (en) |
CA (1) | CA2081537A1 (en) |
CZ (1) | CZ324292A3 (en) |
DE (1) | DE69204252T2 (en) |
FI (1) | FI924869A (en) |
FR (1) | FR2683819B1 (en) |
HU (1) | HUT62883A (en) |
IL (1) | IL103568A0 (en) |
MX (1) | MX9206169A (en) |
NO (1) | NO924138L (en) |
NZ (1) | NZ244892A (en) |
PL (1) | PL296369A1 (en) |
ZA (1) | ZA928297B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
IT1255461B (en) * | 1992-07-28 | 1995-11-02 | Luso Farmaco Inst | ETHERS OF IMIDAZOLI ACTIVATED IN II ANTAGONIST |
FR2699174B1 (en) * | 1992-12-14 | 1995-01-20 | Synthelabo | Derivatives of 3- (quinoline-6-yl-methyl) -4H-imidazol-4-one, their preparation and their therapeutic use. |
FR2710914B1 (en) * | 1993-10-04 | 1995-11-24 | Synthelabo | 2- [2- (tetrazol-5-yl) phenyl] -1,2-dihydroquinoline derivatives, their preparation and their use as synthesis intermediates. |
FR2716196B1 (en) * | 1994-02-16 | 1996-04-05 | Synthelabo | 8- [2- (1H-tetrazol-5-yl) phenyl] quinoline derivatives, their preparation and their therapeutic use. |
JPH09202774A (en) | 1996-01-25 | 1997-08-05 | Green Cross Corp:The | 2-arylquinoline and its production |
DE19706161A1 (en) * | 1997-02-17 | 1998-08-20 | Oswald Hartmut Prof Dr Med | Use of cyanines, isocyanines and pseudoisocyanines as diuretics |
KR100744826B1 (en) * | 2006-04-05 | 2007-08-01 | 한국화학연구원 | Quinolinone derivatives substituted with imidazole group |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CN103804349A (en) * | 2012-11-01 | 2014-05-21 | 杨子娇 | Compounds for treatment of glaucoma and their use |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
BR112015030326A2 (en) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | ULTRAPURE GUANYLATE CYCLASE C AGONISTS, METHOD OF MANUFACTURING AND USING THEM |
CN108558750B (en) * | 2018-07-11 | 2021-01-05 | 武汉工程大学 | Process for synthesizing 3-nitroquinoline derivative by solvent-free method |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them |
MX9200299A (en) * | 1991-02-07 | 1992-12-01 | Roussel Uclaf | NEW NITROGENATED BICYCLE DERIVATIVES, THEIR PROCEDURE FOR PREPARING THE NEW INTERMEDIATE COMPOUNDS OBTAINED THEIR APPLICATION AS MEDICINES AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
DE4117750A1 (en) * | 1991-05-30 | 1992-12-24 | Bayer Ag | NEW 2-AMINO-5-CYANO-1,4-DIHYDROPYRIDINE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS |
EP0528762B1 (en) * | 1991-08-15 | 1997-05-07 | Novartis AG | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists |
-
1991
- 1991-10-28 FR FR9113240A patent/FR2683819B1/en not_active Expired - Fee Related
-
1992
- 1992-10-22 AT AT92402879T patent/ATE126798T1/en active
- 1992-10-22 EP EP92402879A patent/EP0540400B1/en not_active Revoked
- 1992-10-22 DE DE69204252T patent/DE69204252T2/en not_active Revoked
- 1992-10-27 KR KR1019920019802A patent/KR930007935A/en not_active Application Discontinuation
- 1992-10-27 ZA ZA928297A patent/ZA928297B/en unknown
- 1992-10-27 MX MX9206169A patent/MX9206169A/en unknown
- 1992-10-27 IL IL103568A patent/IL103568A0/en unknown
- 1992-10-27 PL PL29636992A patent/PL296369A1/en unknown
- 1992-10-27 CZ CS923242A patent/CZ324292A3/en unknown
- 1992-10-27 CA CA002081537A patent/CA2081537A1/en not_active Abandoned
- 1992-10-27 NO NO92924138A patent/NO924138L/en unknown
- 1992-10-27 AU AU27348/92A patent/AU651740B2/en not_active Ceased
- 1992-10-27 JP JP4288458A patent/JPH05239053A/en active Pending
- 1992-10-27 FI FI924869A patent/FI924869A/en not_active Application Discontinuation
- 1992-10-27 NZ NZ244892A patent/NZ244892A/en unknown
- 1992-10-27 HU HU9203374A patent/HUT62883A/en unknown
- 1992-10-27 CN CN92113784A patent/CN1073171A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69204252D1 (en) | 1995-09-28 |
MX9206169A (en) | 1993-07-01 |
KR930007935A (en) | 1993-05-20 |
HU9203374D0 (en) | 1993-01-28 |
AU2734892A (en) | 1993-04-29 |
FI924869A0 (en) | 1992-10-27 |
DE69204252T2 (en) | 1996-04-18 |
EP0540400B1 (en) | 1995-08-23 |
ATE126798T1 (en) | 1995-09-15 |
CN1073171A (en) | 1993-06-16 |
EP0540400A1 (en) | 1993-05-05 |
NO924138D0 (en) | 1992-10-27 |
FI924869A (en) | 1993-04-29 |
CZ324292A3 (en) | 1993-09-15 |
JPH05239053A (en) | 1993-09-17 |
ZA928297B (en) | 1993-05-07 |
AU651740B2 (en) | 1994-07-28 |
FR2683819B1 (en) | 1994-02-11 |
FR2683819A1 (en) | 1993-05-21 |
CA2081537A1 (en) | 1993-04-29 |
NO924138L (en) | 1993-04-29 |
PL296369A1 (en) | 1993-05-31 |
HUT62883A (en) | 1993-06-28 |
IL103568A0 (en) | 1993-03-15 |
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