ZA928297B - Quinoline derivatives, process for their preparation, and their therapeutic applications. - Google Patents

Quinoline derivatives, process for their preparation, and their therapeutic applications.

Info

Publication number
ZA928297B
ZA928297B ZA928297A ZA928297A ZA928297B ZA 928297 B ZA928297 B ZA 928297B ZA 928297 A ZA928297 A ZA 928297A ZA 928297 A ZA928297 A ZA 928297A ZA 928297 B ZA928297 B ZA 928297B
Authority
ZA
South Africa
Prior art keywords
group
alkoxy
aryl
independently
preparation
Prior art date
Application number
ZA928297A
Inventor
Gerard Cremer
Pascale Goberville
Jean-Claude Muller
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9418349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA928297(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA928297B publication Critical patent/ZA928297B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Abstract

Compounds corresponding to the formula (I) <IMAGE> in which, R1 represents either a 1H-tetrazol-5-yl group or a CO2H group, R2 represents either a (C1-7)alkyl group or a (C2-6)alkenyl group, R3 and R4 represent, each independently of the other, either a hydrogen atom, or a halogen atom, or a cyano group, or a (C1-7)alkyl group, or a (C3-7)cycloalkyl(C1-4)alkyl group, or an aryl group, or an aryl(C1-4)alkyl group, or an aryl(C2-4)alkenyl group, or a group -(CH2)mCOR5 in which m = 0 to 4 and R5 represents a hydrogen atom, an OH group, a (C1-6)alkoxy group or a group NR7R8, R7 and R8 representing, each independently of the other, a hydrogen atom or a (C1-4)alkyl group, or R3 and R4 represents, each independently of the other, a group -(CH2)n-R6 in which n = 1 to 4 and R6 represents an OH group, a (C1-6)alkoxy group, a (C1-4)alkoxy(C1-4)alkoxy group or a (C3-7)cycloalkyl(C1-4)alkoxy group, and their pharmaceutically acceptable organic or inorganic salts. Application in therapeutics.
ZA928297A 1991-10-28 1992-10-27 Quinoline derivatives, process for their preparation, and their therapeutic applications. ZA928297B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113240A FR2683819B1 (en) 1991-10-28 1991-10-28 QUINOLEIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION.

Publications (1)

Publication Number Publication Date
ZA928297B true ZA928297B (en) 1993-05-07

Family

ID=9418349

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA928297A ZA928297B (en) 1991-10-28 1992-10-27 Quinoline derivatives, process for their preparation, and their therapeutic applications.

Country Status (18)

Country Link
EP (1) EP0540400B1 (en)
JP (1) JPH05239053A (en)
KR (1) KR930007935A (en)
CN (1) CN1073171A (en)
AT (1) ATE126798T1 (en)
AU (1) AU651740B2 (en)
CA (1) CA2081537A1 (en)
CZ (1) CZ324292A3 (en)
DE (1) DE69204252T2 (en)
FI (1) FI924869A (en)
FR (1) FR2683819B1 (en)
HU (1) HUT62883A (en)
IL (1) IL103568A0 (en)
MX (1) MX9206169A (en)
NO (1) NO924138L (en)
NZ (1) NZ244892A (en)
PL (1) PL296369A1 (en)
ZA (1) ZA928297B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478832A (en) * 1992-05-08 1995-12-26 The Green Cross Corporation Quinoline compounds
IT1255461B (en) * 1992-07-28 1995-11-02 Luso Farmaco Inst ETHERS OF IMIDAZOLI ACTIVATED IN II ANTAGONIST
FR2699174B1 (en) * 1992-12-14 1995-01-20 Synthelabo Derivatives of 3- (quinoline-6-yl-methyl) -4H-imidazol-4-one, their preparation and their therapeutic use.
FR2710914B1 (en) * 1993-10-04 1995-11-24 Synthelabo 2- [2- (tetrazol-5-yl) phenyl] -1,2-dihydroquinoline derivatives, their preparation and their use as synthesis intermediates.
FR2716196B1 (en) * 1994-02-16 1996-04-05 Synthelabo 8- [2- (1H-tetrazol-5-yl) phenyl] quinoline derivatives, their preparation and their therapeutic use.
JPH09202774A (en) 1996-01-25 1997-08-05 Green Cross Corp:The 2-arylquinoline and its production
DE19706161A1 (en) * 1997-02-17 1998-08-20 Oswald Hartmut Prof Dr Med Use of cyanines, isocyanines and pseudoisocyanines as diuretics
KR100744826B1 (en) * 2006-04-05 2007-08-01 한국화학연구원 Quinolinone derivatives substituted with imidazole group
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2522968T3 (en) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (en) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103804349A (en) * 2012-11-01 2014-05-21 杨子娇 Compounds for treatment of glaucoma and their use
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (en) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド Ultra high purity agonist of guanylate cyclase C, method for producing and using the same
CN108558750B (en) * 2018-07-11 2021-01-05 武汉工程大学 Process for synthesizing 3-nitroquinoline derivative by solvent-free method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
MX9200299A (en) * 1991-02-07 1992-12-01 Roussel Uclaf NEW NITROGENATED BICYCLE DERIVATIVES, THEIR PROCEDURE FOR PREPARING THE NEW INTERMEDIATE COMPOUNDS OBTAINED THEIR APPLICATION AS MEDICINES AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DE4117750A1 (en) * 1991-05-30 1992-12-24 Bayer Ag NEW 2-AMINO-5-CYANO-1,4-DIHYDROPYRIDINE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS
ATE152718T1 (en) * 1991-08-15 1997-05-15 Ciba Geigy Ag N-ACYL-N-HETEROCYCLYL OR NAPHTHYLALKYL AMINO ACIDS AS ANGIOTENSIN II ANTAGONISTS

Also Published As

Publication number Publication date
ATE126798T1 (en) 1995-09-15
CN1073171A (en) 1993-06-16
JPH05239053A (en) 1993-09-17
FI924869A0 (en) 1992-10-27
MX9206169A (en) 1993-07-01
HU9203374D0 (en) 1993-01-28
IL103568A0 (en) 1993-03-15
AU651740B2 (en) 1994-07-28
CZ324292A3 (en) 1993-09-15
NZ244892A (en) 1994-06-27
CA2081537A1 (en) 1993-04-29
KR930007935A (en) 1993-05-20
DE69204252T2 (en) 1996-04-18
AU2734892A (en) 1993-04-29
FR2683819A1 (en) 1993-05-21
EP0540400A1 (en) 1993-05-05
FR2683819B1 (en) 1994-02-11
HUT62883A (en) 1993-06-28
EP0540400B1 (en) 1995-08-23
DE69204252D1 (en) 1995-09-28
NO924138D0 (en) 1992-10-27
PL296369A1 (en) 1993-05-31
NO924138L (en) 1993-04-29
FI924869A (en) 1993-04-29

Similar Documents

Publication Publication Date Title
IL103568A0 (en) Quinoline derivatives,process for their preparation and their therapeutic applications
ES2076827T3 (en) AZAINDOLS, PREPARATION PROCEDURES AND CONTAINING MEDICINES.
DE69103206D1 (en) New derivatives of aminopiperidine, aminopyrrolidine and aminoperhydroazepine, process for their preparation and medicaments containing them.
DE69210875T2 (en) Piperidine derivatives, processes for their preparation and their therapeutic use
MX9202803A (en) NEW BENZOPYRAN COMPOUNDS AND PROCEDURE FOR THE PREPARATION.
IL103601A0 (en) Phthalazines containing an ether or thioether group in the 1-position,their preparation and pharmaceutical compositions containing them
ZA921203B (en) 4-pyrimidinone derivatives,their preparation and their application in therapy
GB2110669B (en) Imidazolidinones
GR3020292T3 (en) Use of 2-iminothiazolidin-4-one derivatives as new medicaments
GR3000488T3 (en) Novel 1,4-dihydropyridines containing fluorine, process for their preparation and their use as medicaments
GR3019362T3 (en) Tetrahydronaphtalene derivatives, their preparation and their application in therapy
GR3015212T3 (en) Ethanolaminebenzoate derivative, process for their preparation and pharmaceutical compositions containing them.
JO1825B1 (en) Therapeutic agents