KR100191774B1 - 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 - Google Patents

피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 Download PDF

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Publication number
KR100191774B1
KR100191774B1 KR1019930703210A KR930703210A KR100191774B1 KR 100191774 B1 KR100191774 B1 KR 100191774B1 KR 1019930703210 A KR1019930703210 A KR 1019930703210A KR 930703210 A KR930703210 A KR 930703210A KR 100191774 B1 KR100191774 B1 KR 100191774B1
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South Korea
Prior art keywords
group
lower alkyl
phenyl
pyrazolo
alkyl group
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Expired - Fee Related
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KR1019930703210A
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English (en)
Korean (ko)
Inventor
마꼬또 이노우에
긴지 하시모또
도시끼 구와하라
유끼오 수기모또
다꾸지 우에사꼬
도시아끼 후나또
Original Assignee
오스카 아끼히꼬
가부시끼가이샤 오스카 세이야꾸 고오죠
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019930703210A 1991-04-22 1991-08-06 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 Expired - Fee Related KR100191774B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22
JP91-90707 1991-04-22
PCT/JP1991/001043 WO1992018504A1 (en) 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME

Publications (1)

Publication Number Publication Date
KR100191774B1 true KR100191774B1 (ko) 1999-06-15

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KR1019930703210A Expired - Fee Related KR100191774B1 (ko) 1991-04-22 1991-08-06 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제

Country Status (12)

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US (1) US5688949A (enExample)
EP (1) EP0591528B1 (enExample)
JP (1) JPH0570353A (enExample)
KR (1) KR100191774B1 (enExample)
AT (1) ATE174917T1 (enExample)
AU (1) AU651986B2 (enExample)
CA (1) CA2107479C (enExample)
DE (1) DE69130683T2 (enExample)
DK (1) DK0591528T3 (enExample)
ES (1) ES2126573T3 (enExample)
TW (1) TW221434B (enExample)
WO (1) WO1992018504A1 (enExample)

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US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
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US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
PL224879B1 (pl) 2002-09-04 2017-02-28 Pharmacopeia Drug Discovery Inc Pirazolo [1,5-a] pirymidynowy związek, jego zastosowanie do wytwarzania leku oraz zawierająca go farmaceutyczna kompozycja
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
ATE364608T1 (de) * 2002-09-04 2007-07-15 Schering Corp Pyrazolopyrimidine als hemmstoffe cyclin- abhängiger kinasen
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
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US20070179161A1 (en) * 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
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AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
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WO2007032936A2 (en) * 2005-09-09 2007-03-22 Schering Corporation Azafused cyclin dependent kinase inhibitors
WO2007044426A2 (en) * 2005-10-06 2007-04-19 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
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CA2670736A1 (en) * 2006-11-29 2008-06-05 Abbott Laboratories Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme
PT2222675E (pt) 2007-12-19 2013-11-13 Genentech Inc 5-anilinoimidazopiridinas e métodos de utilização
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
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US8927562B2 (en) * 2010-09-28 2015-01-06 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
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US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
CA2939036C (en) * 2013-12-11 2020-09-22 Nant Holdings Ip, Llc Pyrazolopyrimidine derivatives useful in the treatment of influenza a and other rna viruses
BR112016016798B1 (pt) * 2014-01-22 2022-06-28 Curovir Ab Composto, composição farmacêutica, e, uso de um composto
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Also Published As

Publication number Publication date
EP0591528B1 (en) 1998-12-23
EP0591528A4 (en) 1995-02-15
TW221434B (enExample) 1994-03-01
DE69130683T2 (de) 1999-05-06
AU651986B2 (en) 1994-08-11
CA2107479C (en) 1997-12-16
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
DE69130683D1 (de) 1999-02-04
US5688949A (en) 1997-11-18
JPH0570353A (ja) 1993-03-23
AU8295891A (en) 1992-11-17
ATE174917T1 (de) 1999-01-15
CA2107479A1 (en) 1992-10-23
ES2126573T3 (es) 1999-04-01
WO1992018504A1 (en) 1992-10-29

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