DE60033859D1 - Hemmer des Respiratorischen Syncytial Virus - Google Patents

Hemmer des Respiratorischen Syncytial Virus

Info

Publication number
DE60033859D1
DE60033859D1 DE60033859T DE60033859T DE60033859D1 DE 60033859 D1 DE60033859 D1 DE 60033859D1 DE 60033859 T DE60033859 T DE 60033859T DE 60033859 T DE60033859 T DE 60033859T DE 60033859 D1 DE60033859 D1 DE 60033859D1
Authority
DE
Germany
Prior art keywords
inhibitor
respiratory syncytial
syncytial virus
virus
respiratory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60033859T
Other languages
English (en)
Other versions
DE60033859T2 (de
Inventor
Frans Eduard Janssens
Jean Fernand LACRAMPE
Jerome Emile Guillemont
Marc Gaston Venet
Koenraad Jozef Andries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE60033859D1 publication Critical patent/DE60033859D1/de
Publication of DE60033859T2 publication Critical patent/DE60033859T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60033859T 1999-06-28 2000-06-20 Hemmer des Respiratorischen Syncytial Virus Expired - Fee Related DE60033859T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202089 1999-06-28
EP99202089 1999-06-28

Publications (2)

Publication Number Publication Date
DE60033859D1 true DE60033859D1 (de) 2007-04-19
DE60033859T2 DE60033859T2 (de) 2007-11-08

Family

ID=8240374

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60008382T Expired - Fee Related DE60008382T2 (de) 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren
DE60033859T Expired - Fee Related DE60033859T2 (de) 1999-06-28 2000-06-20 Hemmer des Respiratorischen Syncytial Virus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60008382T Expired - Fee Related DE60008382T2 (de) 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren

Country Status (34)

Country Link
US (2) US7071192B1 (de)
EP (2) EP1196410B1 (de)
JP (1) JP2003503403A (de)
KR (1) KR100731273B1 (de)
CN (1) CN1171887C (de)
AR (1) AR024495A1 (de)
AT (2) ATE356121T1 (de)
AU (1) AU774829B2 (de)
BG (1) BG65373B1 (de)
BR (1) BR0011997A (de)
CA (1) CA2376785A1 (de)
CZ (1) CZ20014573A3 (de)
DE (2) DE60008382T2 (de)
DK (1) DK1196410T3 (de)
EA (1) EA004746B1 (de)
EE (1) EE04592B1 (de)
ES (2) ES2283716T3 (de)
HK (1) HK1045998B (de)
HR (2) HRP20010934A2 (de)
HU (1) HUP0201789A3 (de)
IL (2) IL147328A0 (de)
MX (1) MXPA02000117A (de)
MY (1) MY129810A (de)
NO (1) NO321599B1 (de)
NZ (1) NZ515392A (de)
PL (1) PL200694B1 (de)
PT (1) PT1196410E (de)
SI (1) SI1196410T1 (de)
SK (1) SK18952001A3 (de)
TR (2) TR200500707T2 (de)
TW (1) TWI267513B (de)
UA (1) UA75866C2 (de)
WO (1) WO2001000615A1 (de)
ZA (1) ZA200110473B (de)

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JP3923255B2 (ja) 1998-07-15 2007-05-30 帝人株式会社 チオベンズイミダゾール誘導体
DE60130865T2 (de) * 2000-01-17 2008-07-17 Teijin Pharma Ltd. Benzimidazol-derivate als menschliche chymase - inhibitoren
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
AU2002239348A1 (en) 2000-12-15 2002-06-24 Glaxo Group Limited Pyrazolopyridine derivatives
DE60112609T2 (de) 2000-12-15 2006-01-19 Glaxo Group Ltd., Greenford Pyrazolopyridine
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
EP1366048B1 (de) 2001-03-08 2004-08-25 SmithKline Beecham Corporation Pyrazolopyridinderivate
EP1372643A1 (de) 2001-03-30 2004-01-02 Smithkline Beecham Corporation Pyrazolopyridine, verfahren zu ihrer herstellung und verwendung als therapeutika
EP1377575B1 (de) 2001-04-10 2006-07-05 SmithKline Beecham Corporation Antivirale pyrazolopyridin verbindungen
JP2004527560A (ja) 2001-04-27 2004-09-09 スミスクライン ビーチャム コーポレーション ピラゾロ［１，５−α］ピリジン誘導体
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
CA2451008A1 (en) 2001-06-21 2003-01-03 Smithkline Beecham Corporation Imidazo[1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections
ES2262893T3 (es) 2001-10-05 2006-12-01 Smithkline Beecham Corporation Derivados de imidazo-piridina para su uso en el tratamiento de infeccion virica por herpes.
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
ES2292839T3 (es) 2001-12-11 2008-03-16 Smithkline Beecham Corporation Derivados de pirazolo-piridina como agentes contra el herpes.
US7244847B2 (en) * 2002-02-06 2007-07-17 Isis Pharmaceuticals, Inc. Benzimidazole compounds
CA2495266A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
CA2495245A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
EP1546148A1 (de) 2002-10-03 2005-06-29 SmithKline Beecham Corporation Auf pyrazolopyridinderivaten basierende therapeutische verbindungen
EP1682547B1 (de) * 2003-10-30 2012-10-24 Boehringer Ingelheim (Canada) Ltd. Inhibitoren der rsv-polymerase
TWI378926B (en) * 2003-12-18 2012-12-11 Tibotec Pharm Ltd Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
CA2548666C (en) * 2003-12-18 2012-08-07 Tibotec Pharmaceuticals Ltd. Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
AR046971A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Aminobenzoimidazoles y benzoimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
US7355051B2 (en) * 2003-12-18 2008-04-08 Tibotec Pharmaceuticals Piperdine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
DK1697347T3 (da) * 2003-12-18 2011-06-06 Tibotec Pharm Ltd 5- eller 6-substituerede benzimidazolderivater som inhibitorer af replikation af respiratorisk syncytial-virus
ES2574670T3 (es) * 2005-03-17 2016-06-21 Janssen Sciences Ireland Uc 1,3-Dihidro-bencimidazol-2-ilidenoaminas como inhibidores de replicación del virus sincicial respiratorio
EP1896449B1 (de) * 2005-06-20 2013-11-06 Janssen R&D Ireland Heterocyclylaminoalkylsubstituierte benzimidazole
JP5078887B2 (ja) * 2005-06-20 2012-11-21 テイボテク・フアーマシユーチカルズ 呼吸器シンシチウムウイルスに活性をもつ、１−（２−アミノ−３−（置換アルキル）−３ｈ−ベンズイミダゾイルメチル）−３−置換−１，３−ジヒドロ−ベンゾイミダゾル−２−オン
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
WO2010045276A2 (en) * 2008-10-16 2010-04-22 Cara Therapeutics, Inc. Azabenzimidazolones
JP5487692B2 (ja) 2009-04-10 2014-05-07 国立大学法人京都大学 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
BRPI1009034A2 (pt) * 2009-06-30 2019-09-24 Siga Tech Inc composição farmacêutica e método para o tratamento ou profilaxia de uma infecção viral ou doença associada a mesma
KR20140040801A (ko) * 2011-07-15 2014-04-03 시오노기세야쿠 가부시키가이샤 Ａｍｐｋ 활성화 작용을 갖는 아자벤즈이미다졸 유도체
ES2779748T3 (es) * 2012-08-23 2020-08-19 Janssen Biopharma Inc Compuestos para el tratamiento de infecciones víricas por paramixovirus
JP2016079168A (ja) 2014-10-17 2016-05-16 塩野義製薬株式会社 ９員縮合環誘導体

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Also Published As

Publication number Publication date
JP2003503403A (ja) 2003-01-28
KR100731273B1 (ko) 2007-06-21
ATE259796T1 (de) 2004-03-15
US20060058309A1 (en) 2006-03-16
AU5222200A (en) 2001-01-31
EP1400519B1 (de) 2007-03-07
EA004746B1 (ru) 2004-08-26
NO20016370D0 (no) 2001-12-27
KR20020000815A (ko) 2002-01-05
TR200500707T2 (tr) 2005-04-21
DE60033859T2 (de) 2007-11-08
CA2376785A1 (en) 2001-01-04
DE60008382D1 (en) 2004-03-25
US7071192B1 (en) 2006-07-04
SK18952001A3 (sk) 2002-11-06
WO2001000615A8 (en) 2002-01-10
ES2283716T3 (es) 2007-11-01
CZ20014573A3 (cs) 2002-05-15
HRP20080390A2 (en) 2008-12-31
DE60008382T2 (de) 2004-12-02
EE04592B1 (et) 2006-02-15
HK1045998B (zh) 2005-06-03
PL200694B1 (pl) 2009-01-30
IL147328A0 (en) 2002-08-14
AU774829B2 (en) 2004-07-08
CN1171887C (zh) 2004-10-20
HRP20010934A2 (en) 2003-06-30
NO20016370L (no) 2001-12-27
SI1196410T1 (en) 2004-08-31
PT1196410E (pt) 2004-07-30
BR0011997A (pt) 2002-03-05
EP1196410B1 (de) 2004-02-18
MXPA02000117A (es) 2002-07-02
AR024495A1 (es) 2002-10-02
HK1045998A1 (en) 2002-12-20
NZ515392A (en) 2004-03-26
NO321599B1 (no) 2006-06-06
BG65373B1 (bg) 2008-04-30
HUP0201789A3 (en) 2003-12-29
TR200103805T2 (tr) 2002-06-21
BG106288A (en) 2002-10-31
ZA200110473B (en) 2003-03-20
CN1358182A (zh) 2002-07-10
EP1196410A1 (de) 2002-04-17
MY129810A (en) 2007-05-31
ES2215670T3 (es) 2004-10-16
UA75866C2 (en) 2006-06-15
US7407969B2 (en) 2008-08-05
EE200100694A (et) 2003-02-17
HUP0201789A2 (hu) 2002-11-28
EA200200086A1 (ru) 2002-06-27
WO2001000615A1 (en) 2001-01-04
IL147328A (en) 2007-06-03
DK1196410T3 (da) 2004-06-28
TWI267513B (en) 2006-12-01
ATE356121T1 (de) 2007-03-15
EP1400519A1 (de) 2004-03-24
PL352385A1 (en) 2003-08-25

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