AR046971A1 - Aminobenzoimidazoles y benzoimidazoles como inhibidores de la replicacion del virus sincitial respiratorio - Google Patents
Aminobenzoimidazoles y benzoimidazoles como inhibidores de la replicacion del virus sincitial respiratorioInfo
- Publication number
- AR046971A1 AR046971A1 ARP040104806A ARP040104806A AR046971A1 AR 046971 A1 AR046971 A1 AR 046971A1 AR P040104806 A ARP040104806 A AR P040104806A AR P040104806 A ARP040104806 A AR P040104806A AR 046971 A1 AR046971 A1 AR 046971A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyloxy
- alkyl
- r4ar4b
- aminobenzoimidazoles
- benzoimidazoles
- Prior art date
Links
- 230000010076 replication Effects 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- JWYUFVNJZUSCSM-UHFFFAOYSA-N 2-aminobenzimidazole Chemical class C1=CC=C2NC(N)=NC2=C1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- -1 nitro, hydroxy Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Aminobenzoimidazoles y benzoimidazoles que tiene actividad inhibidora de la replicacion del VSR y que tienen la formula (1) sus profármacos, N-oxidos, sales de adicion, aminas cuaternarias, complejos metálicos y formas estereoquímicamente isoméricas, en los que G es un enlace directo o alcandiilo C1-10 sustituido de manera opcional con uno o más hidroxi, alquiloxi C1-6, Ar1-alquiloxi C1-6, alquiltio C1-6, Ar1-alquiltio C1-6, HO(-CH2-CH2-O)n-, alquiloxi C1-6(-CH2-CH2-O)n- o Ar1- alquiloxi C1-6(-CH2-CH2-O)n-; R1 es Ar1 o un heterociclo monocíclico o bicíclico; Q es H, amino o mono- o di(alquil C1-4)amino; uno de R2a y R3a se selecciona de halo, alquilo C1-6 opcionalmente mono- o polisustituido, alquenilo C2-6 opcionalmente mono- o polisustituido, nitro, hidroxi, Ar2, N(R4aR4b), N(R4aR4b)sulfonilo; N(R4aR4b)carbonilo, alquiloxi C1-6, Ar2oxi, Ar2 alquiloxi C1-6, carboxilo, alquiloxicarbonilo C1-6 o -C(=Z)Ar2; y el otro de R2a y R3a es H; en el caso que R2a sea diferente de H entonces R2b es H, alquilo C1-6 o halogeno y R3b es H; en el caso que R3a sea diferente de H entonces R3b es H, alquilo C1-6 o halogeno y R2b es H. Composiciones que contienen estos compuestos como componente activo y procesos para preparar estos compuestos y composiciones.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03104797 | 2003-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR046971A1 true AR046971A1 (es) | 2006-01-04 |
Family
ID=34924148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040104806A AR046971A1 (es) | 2003-12-18 | 2004-12-20 | Aminobenzoimidazoles y benzoimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
Country Status (19)
Country | Link |
---|---|
US (1) | US8044073B2 (es) |
EP (1) | EP1697343B1 (es) |
JP (1) | JP4915734B2 (es) |
CN (1) | CN1918146B (es) |
AR (1) | AR046971A1 (es) |
AT (1) | ATE435222T1 (es) |
AU (1) | AU2004298457B2 (es) |
BR (1) | BRPI0417811A (es) |
CA (1) | CA2548657A1 (es) |
DK (1) | DK1697343T3 (es) |
ES (1) | ES2328700T3 (es) |
MY (1) | MY141292A (es) |
NZ (1) | NZ547796A (es) |
PL (1) | PL1697343T3 (es) |
PT (1) | PT1697343E (es) |
RU (1) | RU2379302C2 (es) |
TW (1) | TWI356055B (es) |
WO (1) | WO2005058869A1 (es) |
ZA (1) | ZA200605893B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
JP5078887B2 (ja) * | 2005-06-20 | 2012-11-21 | テイボテク・フアーマシユーチカルズ | 呼吸器シンシチウムウイルスに活性をもつ、1−(2−アミノ−3−(置換アルキル)−3h−ベンズイミダゾイルメチル)−3−置換−1,3−ジヒドロ−ベンゾイミダゾル−2−オン |
BRPI0722411A2 (pt) | 2006-12-22 | 2012-06-05 | Avexa Ltd | pirimidinonas bicìclicas e seus usos |
CA2864825C (en) * | 2012-02-17 | 2021-01-26 | Abbvie Inc. | Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv) |
EA038819B1 (ru) | 2013-08-21 | 2021-10-25 | Алиос Биофарма, Инк. | Противовирусные соединения |
MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
NZ748072A (en) | 2017-03-20 | 2020-06-26 | Forma Therapeutics Inc | Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators |
KR102645995B1 (ko) | 2017-09-29 | 2024-03-11 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 병용 약학 제제 |
EP3594206A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-quinoline derivatives for treating a rna virus infection |
EP3594205A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-aryl derivatives for treating a rna virus infection |
CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
US12053458B2 (en) | 2018-09-19 | 2024-08-06 | Novo Nordisk Health Care Ag | Treating sickle cell disease with a pyruvate kinase R activating compound |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179505A (en) * | 1977-03-30 | 1979-12-18 | Janssen Pharmaceutica N.V. | 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives |
CA1140119A (en) | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
US4492708A (en) | 1982-09-27 | 1985-01-08 | Eli Lilly And Company | Antiviral benzimidazoles |
KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
JPH09505029A (ja) | 1993-07-19 | 1997-05-20 | 藤沢薬品工業株式会社 | ドパミン受容体作動薬、5−HT受容体拮抗薬あるいはα▲下1▼受容体拮抗薬として有用なベンズイミダゾール誘導体 |
US5545653A (en) * | 1995-06-07 | 1996-08-13 | Eli Lilly And Company | Anti-viral compounds |
CA2227688C (en) * | 1998-01-16 | 2007-07-31 | James W. Critchfield | Methods and compositions for inhibition of viral replication |
DE60033859T2 (de) * | 1999-06-28 | 2007-11-08 | Janssen Pharmaceutica N.V. | Hemmer des Respiratorischen Syncytial Virus |
CN1210275C (zh) * | 1999-06-28 | 2005-07-13 | 詹森药业有限公司 | 呼吸道合胞病毒复制抑制剂 |
CA2376781A1 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors |
US20040157866A1 (en) | 2001-04-30 | 2004-08-12 | Hisashi Takasugi | Amide compounds |
US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
-
2004
- 2004-12-20 CA CA002548657A patent/CA2548657A1/en not_active Abandoned
- 2004-12-20 RU RU2006125726/04A patent/RU2379302C2/ru not_active IP Right Cessation
- 2004-12-20 AR ARP040104806A patent/AR046971A1/es not_active Application Discontinuation
- 2004-12-20 BR BRPI0417811-4A patent/BRPI0417811A/pt not_active IP Right Cessation
- 2004-12-20 TW TW093139737A patent/TWI356055B/zh not_active IP Right Cessation
- 2004-12-20 EP EP04804949A patent/EP1697343B1/en active Active
- 2004-12-20 AU AU2004298457A patent/AU2004298457B2/en not_active Ceased
- 2004-12-20 MY MYPI20045261A patent/MY141292A/en unknown
- 2004-12-20 US US10/596,514 patent/US8044073B2/en active Active
- 2004-12-20 ES ES04804949T patent/ES2328700T3/es active Active
- 2004-12-20 AT AT04804949T patent/ATE435222T1/de active
- 2004-12-20 PT PT04804949T patent/PT1697343E/pt unknown
- 2004-12-20 CN CN2004800416897A patent/CN1918146B/zh active Active
- 2004-12-20 PL PL04804949T patent/PL1697343T3/pl unknown
- 2004-12-20 DK DK04804949T patent/DK1697343T3/da active
- 2004-12-20 JP JP2006544463A patent/JP4915734B2/ja active Active
- 2004-12-20 WO PCT/EP2004/053613 patent/WO2005058869A1/en active Application Filing
- 2004-12-20 NZ NZ547796A patent/NZ547796A/en not_active IP Right Cessation
-
2006
- 2006-07-17 ZA ZA200605893A patent/ZA200605893B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200605893B (en) | 2007-11-28 |
PL1697343T3 (pl) | 2009-12-31 |
TW200602327A (en) | 2006-01-16 |
US20070099924A1 (en) | 2007-05-03 |
CA2548657A1 (en) | 2005-06-30 |
EP1697343B1 (en) | 2009-07-01 |
ATE435222T1 (de) | 2009-07-15 |
CN1918146B (zh) | 2011-09-14 |
JP4915734B2 (ja) | 2012-04-11 |
CN1918146A (zh) | 2007-02-21 |
MY141292A (en) | 2010-04-16 |
JP2007514717A (ja) | 2007-06-07 |
AU2004298457A1 (en) | 2005-06-30 |
NZ547796A (en) | 2009-04-30 |
DK1697343T3 (da) | 2009-10-05 |
BRPI0417811A (pt) | 2007-03-27 |
AU2004298457B2 (en) | 2010-05-27 |
RU2379302C2 (ru) | 2010-01-20 |
PT1697343E (pt) | 2009-09-16 |
WO2005058869A1 (en) | 2005-06-30 |
ES2328700T3 (es) | 2009-11-17 |
TWI356055B (en) | 2012-01-11 |
RU2006125726A (ru) | 2008-01-27 |
EP1697343A1 (en) | 2006-09-06 |
US8044073B2 (en) | 2011-10-25 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |