PL1697343T3 - Aminobenzimidazole i benzimidazole jako inhibitory replikacji wirusa oddechowego - Google Patents
Aminobenzimidazole i benzimidazole jako inhibitory replikacji wirusa oddechowegoInfo
- Publication number
- PL1697343T3 PL1697343T3 PL04804949T PL04804949T PL1697343T3 PL 1697343 T3 PL1697343 T3 PL 1697343T3 PL 04804949 T PL04804949 T PL 04804949T PL 04804949 T PL04804949 T PL 04804949T PL 1697343 T3 PL1697343 T3 PL 1697343T3
- Authority
- PL
- Poland
- Prior art keywords
- aminobenzimidazoles
- benzimidazoles
- inhibitors
- respiratory syncytial
- syncytial virus
- Prior art date
Links
- JWYUFVNJZUSCSM-UHFFFAOYSA-N 2-aminobenzimidazole Chemical class C1=CC=C2NC(N)=NC2=C1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03104797 | 2003-12-18 | ||
US56683404P | 2004-04-30 | 2004-04-30 | |
PCT/EP2004/053613 WO2005058869A1 (en) | 2003-12-18 | 2004-12-20 | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
EP04804949A EP1697343B1 (en) | 2003-12-18 | 2004-12-20 | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1697343T3 true PL1697343T3 (pl) | 2009-12-31 |
Family
ID=34924148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL04804949T PL1697343T3 (pl) | 2003-12-18 | 2004-12-20 | Aminobenzimidazole i benzimidazole jako inhibitory replikacji wirusa oddechowego |
Country Status (19)
Country | Link |
---|---|
US (1) | US8044073B2 (pl) |
EP (1) | EP1697343B1 (pl) |
JP (1) | JP4915734B2 (pl) |
CN (1) | CN1918146B (pl) |
AR (1) | AR046971A1 (pl) |
AT (1) | ATE435222T1 (pl) |
AU (1) | AU2004298457B2 (pl) |
BR (1) | BRPI0417811A (pl) |
CA (1) | CA2548657A1 (pl) |
DK (1) | DK1697343T3 (pl) |
ES (1) | ES2328700T3 (pl) |
MY (1) | MY141292A (pl) |
NZ (1) | NZ547796A (pl) |
PL (1) | PL1697343T3 (pl) |
PT (1) | PT1697343E (pl) |
RU (1) | RU2379302C2 (pl) |
TW (1) | TWI356055B (pl) |
WO (1) | WO2005058869A1 (pl) |
ZA (1) | ZA200605893B (pl) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
JP5078887B2 (ja) * | 2005-06-20 | 2012-11-21 | テイボテク・フアーマシユーチカルズ | 呼吸器シンシチウムウイルスに活性をもつ、1−(2−アミノ−3−(置換アルキル)−3h−ベンズイミダゾイルメチル)−3−置換−1,3−ジヒドロ−ベンゾイミダゾル−2−オン |
NZ577491A (en) | 2006-12-22 | 2011-06-30 | Avexa Ltd | 2-heteroaryl-3-hydroxy-4-oxo-pyrido[1,2-a]pyrimidines and uses thereof |
US9447051B2 (en) * | 2012-02-17 | 2016-09-20 | Abbvie Inc. | Diaminopyrimidines and uses thereof |
CN105636936B (zh) | 2013-08-21 | 2022-04-05 | 詹森生物制药有限公司 | 抗病毒化合物 |
MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
MX2018014032A (es) | 2017-03-20 | 2019-08-21 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato cinasa (pkr). |
BR112020006334A2 (pt) | 2017-09-29 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | combinação de agentes farmacêuticos como inibidores de rsv |
EP3594205A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-aryl derivatives for treating a rna virus infection |
US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179505A (en) | 1977-03-30 | 1979-12-18 | Janssen Pharmaceutica N.V. | 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives |
CA1140119A (en) | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
US4492708A (en) * | 1982-09-27 | 1985-01-08 | Eli Lilly And Company | Antiviral benzimidazoles |
KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
AU7195694A (en) * | 1993-07-19 | 1995-02-20 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives useful as dopamine receptor antagonist, 5-ht receptor agonist or alpha1 receptor antagonist |
US5545653A (en) * | 1995-06-07 | 1996-08-13 | Eli Lilly And Company | Anti-viral compounds |
CA2227688C (en) * | 1998-01-16 | 2007-07-31 | James W. Critchfield | Methods and compositions for inhibition of viral replication |
DE60033859T2 (de) * | 1999-06-28 | 2007-11-08 | Janssen Pharmaceutica N.V. | Hemmer des Respiratorischen Syncytial Virus |
CZ20014574A3 (cs) * | 1999-06-28 | 2002-05-15 | Janssen Pharmaceutica N. V. | Inhibitory replikace respiračně syncyciálního viru |
CA2376676C (en) * | 1999-06-28 | 2009-01-20 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
WO2002090347A1 (en) * | 2001-04-30 | 2002-11-14 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds |
US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
FR2833948B1 (fr) | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
-
2004
- 2004-12-20 DK DK04804949T patent/DK1697343T3/da active
- 2004-12-20 JP JP2006544463A patent/JP4915734B2/ja active Active
- 2004-12-20 RU RU2006125726/04A patent/RU2379302C2/ru not_active IP Right Cessation
- 2004-12-20 EP EP04804949A patent/EP1697343B1/en active Active
- 2004-12-20 PL PL04804949T patent/PL1697343T3/pl unknown
- 2004-12-20 NZ NZ547796A patent/NZ547796A/en not_active IP Right Cessation
- 2004-12-20 WO PCT/EP2004/053613 patent/WO2005058869A1/en active Application Filing
- 2004-12-20 ES ES04804949T patent/ES2328700T3/es active Active
- 2004-12-20 AT AT04804949T patent/ATE435222T1/de active
- 2004-12-20 AR ARP040104806A patent/AR046971A1/es not_active Application Discontinuation
- 2004-12-20 AU AU2004298457A patent/AU2004298457B2/en not_active Ceased
- 2004-12-20 BR BRPI0417811-4A patent/BRPI0417811A/pt not_active IP Right Cessation
- 2004-12-20 MY MYPI20045261A patent/MY141292A/en unknown
- 2004-12-20 TW TW093139737A patent/TWI356055B/zh not_active IP Right Cessation
- 2004-12-20 PT PT04804949T patent/PT1697343E/pt unknown
- 2004-12-20 CN CN2004800416897A patent/CN1918146B/zh active Active
- 2004-12-20 CA CA002548657A patent/CA2548657A1/en not_active Abandoned
- 2004-12-20 US US10/596,514 patent/US8044073B2/en active Active
-
2006
- 2006-07-17 ZA ZA200605893A patent/ZA200605893B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AR046971A1 (es) | 2006-01-04 |
AU2004298457B2 (en) | 2010-05-27 |
ATE435222T1 (de) | 2009-07-15 |
TWI356055B (en) | 2012-01-11 |
TW200602327A (en) | 2006-01-16 |
EP1697343B1 (en) | 2009-07-01 |
EP1697343A1 (en) | 2006-09-06 |
ZA200605893B (en) | 2007-11-28 |
JP2007514717A (ja) | 2007-06-07 |
ES2328700T3 (es) | 2009-11-17 |
MY141292A (en) | 2010-04-16 |
PT1697343E (pt) | 2009-09-16 |
WO2005058869A1 (en) | 2005-06-30 |
RU2006125726A (ru) | 2008-01-27 |
CN1918146A (zh) | 2007-02-21 |
RU2379302C2 (ru) | 2010-01-20 |
NZ547796A (en) | 2009-04-30 |
CA2548657A1 (en) | 2005-06-30 |
US20070099924A1 (en) | 2007-05-03 |
JP4915734B2 (ja) | 2012-04-11 |
BRPI0417811A (pt) | 2007-03-27 |
AU2004298457A1 (en) | 2005-06-30 |
US8044073B2 (en) | 2011-10-25 |
CN1918146B (zh) | 2011-09-14 |
DK1697343T3 (da) | 2009-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200605893B (en) | Aminobenzimidazones and benzimidazoles as inhibitors of respiratory syncytial virus replication | |
TWI349007B (en) | Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication | |
EG25799A (en) | Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication | |
ZA200705402B (en) | Respiratory devices and methods of use | |
EP1827391A4 (en) | DOSAGE FORMS AND METHODS OF USE THEREOF | |
IL198397A0 (en) | Anilinopiperazine derivatives and methods of use thereof | |
IL189080A0 (en) | Substituted benzimidazoles and methods of preparation | |
IL180488A0 (en) | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof of kinase inhibitors | |
EP2021455A4 (en) | SYSTEM FOR PREPARING CYTOBLOCS AND METHODS OF USE THEREOF | |
IL192053A (en) | 2-Admentiluria derivatives as selective inhibitors of 1hsd-β11 and their use in drug preparation | |
EP1951379A4 (en) | NOSE OR MOUTH KIT MT THREE OR MORE SKILLS AND MANUFACTURING METHOD THEREFOR | |
EP1766094A4 (en) | INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE | |
EP2046413A4 (en) | MEDICAL SYSTEMS AND APPLICATION METHOD | |
EP2023718A4 (en) | CREATINLIGATE COMPOUNDS AND APPLICATION METHOD THEREFOR | |
EP1797186A4 (en) | EXPRESSION SYSTEM, ITS COMPONENTS AND USE METHOD | |
EP1817277A4 (en) | PHENYL DERIVATIVES AND METHOD OF USE | |
EP1812451A4 (en) | COMPOUNDS AND METHODS OF USE THEREOF | |
EP1946007A4 (en) | ANDROSTERONE DERIVATIVES AND METHODS OF USE | |
EP1883404A4 (en) | P38 INHIBITORS AND METHODS OF USE | |
MY142783A (en) | 5-or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication | |
EP1768993A4 (en) | CYSTEINE-RICH REGION OF SYNCYTIAL RESPIRATORY VIRUS AND METHODS OF USE THEREOF | |
IL176063A0 (en) | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication | |
SI1723136T1 (sl) | Piperidin-amino-benzimidazolni derivati kot inhibitorji replikacije respiratornega sincicijskega virusa | |
ZA200800536B (en) | Substituted benzimidazoles and methods of preparation | |
EP2076280A4 (en) | FELINE INFLUENZA VACCINE AND METHOD OF USE |