CO2019002246A2 - Compuesto heterocíclico nitrogenado bicíclico - Google Patents

Compuesto heterocíclico nitrogenado bicíclico

Info

Publication number
CO2019002246A2
CO2019002246A2 CONC2019/0002246A CO2019002246A CO2019002246A2 CO 2019002246 A2 CO2019002246 A2 CO 2019002246A2 CO 2019002246 A CO2019002246 A CO 2019002246A CO 2019002246 A2 CO2019002246 A2 CO 2019002246A2
Authority
CO
Colombia
Prior art keywords
compound
heterocyclic compound
pde7
nitrogenous heterocyclic
pde7 inhibitor
Prior art date
Application number
CONC2019/0002246A
Other languages
English (en)
Inventor
Tatsuo Nakajima
Norimitsu Hayashi
Kouhei Ishizawa
Yasunori Tsuzaki
Ryo Iwamura
Kazunari Tsuboike
Original Assignee
Mitsubishi Tanabe Pharma Corp
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Ube Industries filed Critical Mitsubishi Tanabe Pharma Corp
Publication of CO2019002246A2 publication Critical patent/CO2019002246A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención proporciona: un nuevo uso de un compuesto heterocíclico específico que contiene nitrógeno bicíclico como un inhibidor de PDE7; un nuevo compuesto heterocíclico que contiene nitrógeno bicíclico que tiene un efecto inhibitorio de PDE7, un método para producir el compuesto, un uso del compuesto, y una composición farmacéutica que contiene el inhibidor de PDE7 o el compuesto; y otros; más específicamente, la presente invención proporciona un inhibidor de PDE7 que contiene el compuesto representado por la fórmula (I): [en donde los símbolos tienen los mismos significados que los descritos en la descripción] o una sal farmacéuticamente aceptable del mismo como un ingrediente activo.
CONC2019/0002246A 2016-08-26 2019-03-12 Compuesto heterocíclico nitrogenado bicíclico CO2019002246A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016166277 2016-08-26
PCT/JP2017/030609 WO2018038265A1 (ja) 2016-08-26 2017-08-25 二環式含窒素複素環化合物

Publications (1)

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CO2019002246A2 true CO2019002246A2 (es) 2019-06-28

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US (1) US20190185479A1 (es)
EP (1) EP3505171A4 (es)
JP (1) JPWO2018038265A1 (es)
KR (1) KR20190040054A (es)
CN (1) CN109937038A (es)
AU (1) AU2017316965B2 (es)
BR (1) BR112019003710A2 (es)
CA (1) CA3034802A1 (es)
CO (1) CO2019002246A2 (es)
MX (1) MX2019002281A (es)
PH (1) PH12019500394A1 (es)
RU (1) RU2019108464A (es)
SG (1) SG11201901619WA (es)
TW (1) TW201811782A (es)
WO (1) WO2018038265A1 (es)

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LT3697789T (lt) 2017-10-18 2021-12-10 Incyte Corporation Kondensuoti imidazolo dariniai, pakeisti tretinėmis hidroksigrupėmis, kaip pi3k-gama inhibitoriai
MA53561A (fr) 2018-09-05 2022-05-11 Incyte Corp Formes cristallines d'un inhibiteur de phosphoinositide 3-kinase (pi3k)
CN110078736B (zh) * 2019-06-05 2021-08-03 广州白云山医药集团股份有限公司白云山制药总厂 吡唑并嘧啶衍生物、其制备方法及其应用
CN116867762A (zh) 2021-02-19 2023-10-10 株式会社Api 环己烯酮化合物的制造方法
CN112979659B (zh) * 2021-02-22 2022-07-08 中国医科大学 一类HIF-2α小分子抑制剂的制备及用途
WO2023220439A1 (en) * 2022-05-12 2023-11-16 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2024038089A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

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Publication number Priority date Publication date Assignee Title
US4076711A (en) 1976-04-05 1978-02-28 Schering Corporation Triazolo [4,5-d]-pyrimidines
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
JP2006219373A (ja) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
AU2008230710B2 (en) * 2007-03-27 2014-04-10 Omeros Corporation The use of PDE7 inhibitors for the treatment of movement disorders
US20120149902A1 (en) * 2009-07-28 2012-06-14 Ube Industries, Ltd. Pyrrolo[2,3-d]pyrimidine derivative
WO2013176877A2 (en) 2012-05-07 2013-11-28 Omeros Corporation Treatment of addiction and impulse-control disorders using pde7 inhibitors
MA39986A (fr) * 2014-04-25 2017-03-01 Vitae Pharmaceuticals Inc Dérivés de purine en tant qu'inhibiteurs de cd73 pour le traitement du cancer

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US20190185479A1 (en) 2019-06-20
EP3505171A4 (en) 2020-08-26
WO2018038265A1 (ja) 2018-03-01
CA3034802A1 (en) 2018-03-01
TW201811782A (zh) 2018-04-01
BR112019003710A2 (pt) 2019-05-28
EP3505171A1 (en) 2019-07-03
RU2019108464A3 (es) 2020-09-28
AU2017316965B2 (en) 2020-09-10
NZ751261A (en) 2021-03-26
RU2019108464A (ru) 2020-09-28
SG11201901619WA (en) 2019-03-28
KR20190040054A (ko) 2019-04-16
AU2017316965A1 (en) 2019-04-11
JPWO2018038265A1 (ja) 2019-06-24
PH12019500394A1 (en) 2020-01-20
MX2019002281A (es) 2019-06-20
CN109937038A (zh) 2019-06-25

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