BR112019003710A2 - inibidor de pde7, composto, composição farmacêutica, uso de um inibidor de pde7 ou de um composto, e, método para tratar ou prevenir uma doença que é melhorada pela inibição de pde7. - Google Patents

inibidor de pde7, composto, composição farmacêutica, uso de um inibidor de pde7 ou de um composto, e, método para tratar ou prevenir uma doença que é melhorada pela inibição de pde7.

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Publication number
BR112019003710A2
BR112019003710A2 BR112019003710A BR112019003710A BR112019003710A2 BR 112019003710 A2 BR112019003710 A2 BR 112019003710A2 BR 112019003710 A BR112019003710 A BR 112019003710A BR 112019003710 A BR112019003710 A BR 112019003710A BR 112019003710 A2 BR112019003710 A2 BR 112019003710A2
Authority
BR
Brazil
Prior art keywords
compound
pde7
pde7 inhibitor
inhibitor
pharmaceutical composition
Prior art date
Application number
BR112019003710A
Other languages
English (en)
Inventor
Tsuboike Kazunari
Ishizawa Kouhei
Hayashi Norimitsu
Iwamura Ryo
Nakajima Tatsuo
Tsuzaki Yasunori
Original Assignee
Mitsubishi Tanabe Pharma Corp
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Ube Industries filed Critical Mitsubishi Tanabe Pharma Corp
Publication of BR112019003710A2 publication Critical patent/BR112019003710A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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Abstract

a presente invenção provê: um novo uso de um composto heterocíclico bicíclico específico nitrogenado como um inibidor de pde7; um novo composto heterocíclico bicíclico nitrogenado com um efeito inibidor de pde7, um método para produzir o composto, um uso do composto e uma composição farmacêutica contendo o inibidor de pde7 ou o composto; e outros. mais especificamente, a presente invenção provê um inibidor de pde7 contendo o composto representado pela fórmula (i): [em que os símbolos têm os mesmos significados que os descritos na descrição] ou um sal farmaceuticamente aceitável do mesmo.
BR112019003710A 2016-08-26 2017-08-25 inibidor de pde7, composto, composição farmacêutica, uso de um inibidor de pde7 ou de um composto, e, método para tratar ou prevenir uma doença que é melhorada pela inibição de pde7. BR112019003710A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016166277 2016-08-26
PCT/JP2017/030609 WO2018038265A1 (ja) 2016-08-26 2017-08-25 二環式含窒素複素環化合物

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BR112019003710A2 true BR112019003710A2 (pt) 2019-05-28

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BR112019003710A BR112019003710A2 (pt) 2016-08-26 2017-08-25 inibidor de pde7, composto, composição farmacêutica, uso de um inibidor de pde7 ou de um composto, e, método para tratar ou prevenir uma doença que é melhorada pela inibição de pde7.

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US (1) US20190185479A1 (pt)
EP (1) EP3505171A4 (pt)
JP (1) JPWO2018038265A1 (pt)
KR (1) KR20190040054A (pt)
CN (1) CN109937038A (pt)
AU (1) AU2017316965B2 (pt)
BR (1) BR112019003710A2 (pt)
CA (1) CA3034802A1 (pt)
CO (1) CO2019002246A2 (pt)
MX (1) MX2019002281A (pt)
PH (1) PH12019500394A1 (pt)
RU (1) RU2019108464A (pt)
SG (1) SG11201901619WA (pt)
TW (1) TW201811782A (pt)
WO (1) WO2018038265A1 (pt)

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MD3697789T2 (ro) 2017-10-18 2022-02-28 Incyte Corp Derivați imidazol condensați substituiți cu grupări hidroxi terțiare ca inhibitori PI3K-GAMA
JP2021535182A (ja) 2018-09-05 2021-12-16 インサイト・コーポレイションIncyte Corporation ホスホイノシチド３−キナーゼ（ｐｉ３ｋ）阻害剤の結晶形態
CN110078736B (zh) * 2019-06-05 2021-08-03 广州白云山医药集团股份有限公司白云山制药总厂 吡唑并嘧啶衍生物、其制备方法及其应用
JPWO2022176837A1 (pt) 2021-02-19 2022-08-25
CN112979659B (zh) * 2021-02-22 2022-07-08 中国医科大学 一类HIF-2α小分子抑制剂的制备及用途
WO2023220439A1 (en) * 2022-05-12 2023-11-16 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2024038089A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

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PH12019500394A1 (en) 2020-01-20
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