ATE356121T1 - Hemmer des respiratorischen syncytial virus - Google Patents

Hemmer des respiratorischen syncytial virus

Info

Publication number
ATE356121T1
ATE356121T1 AT03102464T AT03102464T ATE356121T1 AT E356121 T1 ATE356121 T1 AT E356121T1 AT 03102464 T AT03102464 T AT 03102464T AT 03102464 T AT03102464 T AT 03102464T AT E356121 T1 ATE356121 T1 AT E356121T1
Authority
AT
Austria
Prior art keywords
respiratory syncytial
syncytial virus
virus inhibitors
inhibitors
respiratory
Prior art date
Application number
AT03102464T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Jean Fernand Armand Lacrampe
Desmoulins Camille
Jerome Emile George Guillemont
Camille Desmoulins Rue
Marc Gaston Venet
Koenraad Jozef Lodewij Andries
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE356121T1 publication Critical patent/ATE356121T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT03102464T 1999-06-28 2000-06-20 Hemmer des respiratorischen syncytial virus ATE356121T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202089 1999-06-28

Publications (1)

Publication Number Publication Date
ATE356121T1 true ATE356121T1 (de) 2007-03-15

Family

ID=8240374

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00936899T ATE259796T1 (de) 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren
AT03102464T ATE356121T1 (de) 1999-06-28 2000-06-20 Hemmer des respiratorischen syncytial virus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00936899T ATE259796T1 (de) 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren

Country Status (34)

Country Link
US (2) US7071192B1 (de)
EP (2) EP1400519B1 (de)
JP (1) JP2003503403A (de)
KR (1) KR100731273B1 (de)
CN (1) CN1171887C (de)
AR (1) AR024495A1 (de)
AT (2) ATE259796T1 (de)
AU (1) AU774829B2 (de)
BG (1) BG65373B1 (de)
BR (1) BR0011997A (de)
CA (1) CA2376785A1 (de)
CZ (1) CZ20014573A3 (de)
DE (2) DE60008382T2 (de)
DK (1) DK1196410T3 (de)
EA (1) EA004746B1 (de)
EE (1) EE04592B1 (de)
ES (2) ES2215670T3 (de)
HK (1) HK1045998B (de)
HR (2) HRP20010934A2 (de)
HU (1) HUP0201789A3 (de)
IL (2) IL147328A0 (de)
MX (1) MXPA02000117A (de)
MY (1) MY129810A (de)
NO (1) NO321599B1 (de)
NZ (1) NZ515392A (de)
PL (1) PL200694B1 (de)
PT (1) PT1196410E (de)
SI (1) SI1196410T1 (de)
SK (1) SK18952001A3 (de)
TR (2) TR200103805T2 (de)
TW (1) TWI267513B (de)
UA (1) UA75866C2 (de)
WO (1) WO2001000615A1 (de)
ZA (1) ZA200110473B (de)

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US20040010004A1 (en) 2000-01-17 2004-01-15 Naoki Tsuchiya Benzimidazole derivatives
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US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
DE60112609T2 (de) 2000-12-15 2006-01-19 Glaxo Group Ltd., Greenford Pyrazolopyridine
US7163940B2 (en) 2000-12-15 2007-01-16 Smithkline Beecham Corporation Pyrazolopyridinyl pyrimidine therapeutic compounds
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
ES2227451T3 (es) 2001-03-08 2005-04-01 Smithkline Beecham Corporation Derivados de pirazolopiridina.
JP4237497B2 (ja) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用
WO2002083672A1 (en) 2001-04-10 2002-10-24 Smithkline Beecham Corporation Antiviral pyrazolopyridine compounds
EP1385847B1 (de) 2001-04-27 2005-06-01 SmithKline Beecham Corporation Pyrazolo[1,5]pyridinderivate
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
IL158667A0 (en) 2001-06-21 2004-05-12 Smithkline Beecham Corp Imidazo [1,2-a] pyridine derivatives for the prophylaxis and treatment of herpes viral infections
ES2262893T3 (es) 2001-10-05 2006-12-01 Smithkline Beecham Corporation Derivados de imidazo-piridina para su uso en el tratamiento de infeccion virica por herpes.
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
US7199120B2 (en) 2001-12-11 2007-04-03 Smithkline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
US7244847B2 (en) * 2002-02-06 2007-07-17 Isis Pharmaceuticals, Inc. Benzimidazole compounds
CA2495245A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
CA2495266A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US7153863B2 (en) 2002-10-03 2006-12-26 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridline derivatives
JP4537407B2 (ja) * 2003-10-30 2010-09-01 ベーリンガー インゲルハイム （カナダ） リミテッド Ｒｓｖポリメラーゼインヒビター
DK1723136T3 (da) * 2003-12-18 2011-06-27 Tibotec Pharm Ltd Piperidinamino-benzimidazol-derivat som inhibitorer af replikation af respiratorisk syncytial virus
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
AR046770A1 (es) * 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio
ATE435222T1 (de) * 2003-12-18 2009-07-15 Tibotec Pharm Ltd Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
CN1894236B (zh) * 2003-12-18 2011-08-17 泰博特克药品有限公司 作为呼吸道合胞病毒复制抑制剂的氨基-苯并咪唑类衍生物
PL1711485T3 (pl) * 2003-12-18 2009-11-30 Tibotec Pharm Ltd Pochodne aminobenzoimidazoli jako inhibitory replikacji wirusa zespólni układu oddechowego
RU2410382C2 (ru) * 2005-03-17 2011-01-27 Тиботек Фармасьютикалз Лтд 1, 3-дигидробензимидазол-2-илиденовые амины в качестве ингибиторов репликации респираторного синцитиального вируса
CA2612263C (en) 2005-06-20 2015-04-14 Tibotec Pharmaceuticals Ltd. 1-(2-amino-3-(substituted alkyl)-3h-benzimidazolylmethyl)-3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
US7884215B2 (en) * 2005-06-20 2011-02-08 Bonfanti Jean-Francois 2-substituted benzimidazoles
JP5094716B2 (ja) * 2005-06-20 2012-12-12 テイボテク・フアーマシユーチカルズ ヘテロシクリルアミノアルキル置換ベンズイミダゾール
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
WO2010045276A2 (en) * 2008-10-16 2010-04-22 Cara Therapeutics, Inc. Azabenzimidazolones
JP5487692B2 (ja) 2009-04-10 2014-05-07 国立大学法人京都大学 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
MX336687B (es) * 2009-06-30 2016-01-28 Siga Technologies Inc Tratamiento y prevencion de infecciones del virus del dengue.
EP3495366A1 (de) * 2011-07-15 2019-06-12 Shionogi & Co., Ltd Azabenzimidazolderivat mit ampk-aktivierender wirkung
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Also Published As

Publication number Publication date
HUP0201789A2 (hu) 2002-11-28
HUP0201789A3 (en) 2003-12-29
IL147328A0 (en) 2002-08-14
EE200100694A (et) 2003-02-17
HRP20010934A2 (en) 2003-06-30
EA200200086A1 (ru) 2002-06-27
IL147328A (en) 2007-06-03
CZ20014573A3 (cs) 2002-05-15
SI1196410T1 (en) 2004-08-31
TR200103805T2 (tr) 2002-06-21
HK1045998B (zh) 2005-06-03
MXPA02000117A (es) 2002-07-02
DE60008382T2 (de) 2004-12-02
ES2215670T3 (es) 2004-10-16
NO20016370D0 (no) 2001-12-27
HRP20080390A2 (en) 2008-12-31
EA004746B1 (ru) 2004-08-26
EP1196410B1 (de) 2004-02-18
DE60033859D1 (de) 2007-04-19
WO2001000615A1 (en) 2001-01-04
US7071192B1 (en) 2006-07-04
EP1400519A1 (de) 2004-03-24
US20060058309A1 (en) 2006-03-16
BG106288A (en) 2002-10-31
KR20020000815A (ko) 2002-01-05
ZA200110473B (en) 2003-03-20
WO2001000615A8 (en) 2002-01-10
AU774829B2 (en) 2004-07-08
DK1196410T3 (da) 2004-06-28
SK18952001A3 (sk) 2002-11-06
EE04592B1 (et) 2006-02-15
HK1045998A1 (en) 2002-12-20
CN1171887C (zh) 2004-10-20
BG65373B1 (bg) 2008-04-30
BR0011997A (pt) 2002-03-05
AR024495A1 (es) 2002-10-02
PT1196410E (pt) 2004-07-30
ATE259796T1 (de) 2004-03-15
TR200500707T2 (tr) 2005-04-21
UA75866C2 (en) 2006-06-15
US7407969B2 (en) 2008-08-05
EP1196410A1 (de) 2002-04-17
JP2003503403A (ja) 2003-01-28
ES2283716T3 (es) 2007-11-01
PL200694B1 (pl) 2009-01-30
DE60033859T2 (de) 2007-11-08
PL352385A1 (en) 2003-08-25
CN1358182A (zh) 2002-07-10
DE60008382D1 (en) 2004-03-25
NO20016370L (no) 2001-12-27
AU5222200A (en) 2001-01-31
TWI267513B (en) 2006-12-01
KR100731273B1 (ko) 2007-06-21
MY129810A (en) 2007-05-31
NO321599B1 (no) 2006-06-06
CA2376785A1 (en) 2001-01-04
NZ515392A (en) 2004-03-26
EP1400519B1 (de) 2007-03-07

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