TR200103805T2 - Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler - Google Patents

Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler

Info

Publication number
TR200103805T2
TR200103805T2 TR2001/03805T TR200103805T TR200103805T2 TR 200103805 T2 TR200103805 T2 TR 200103805T2 TR 2001/03805 T TR2001/03805 T TR 2001/03805T TR 200103805 T TR200103805 T TR 200103805T TR 200103805 T2 TR200103805 T2 TR 200103805T2
Authority
TR
Turkey
Prior art keywords
replication
respiratory syncytial
syncytial virus
inhibit
substances
Prior art date
Application number
TR2001/03805T
Other languages
English (en)
Inventor
Eduard Janssens Frans
Fernand Armand Lacrampe Jean
Emile Georges Guillemont Jerome
Gaston Venet Marc
Jozef Lodenwijk Marcel Andries Koenraad
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR200103805T2 publication Critical patent/TR200103805T2/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Bu bulus, solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler olarak formül (I) e sahip bilesikler, bunlarin ön ilaçlari, N-oksitler, katilma tuzlari, kuaterner aminleri, metal kompleksleri ve streokimyasal izomerik sekiller; bunlarin hazirlanmasi, bunlari ihtiva eden terkipler ve bunlarin ilaç olarak kullanimi ile ilgili olup; burada -a1=a2-a3=a4, formül -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- veya -CH=CH-CH=N- ye sahip bir radikaldir; Q, (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) ve (b-8) formülüne sahip bir radikaldir; G, bir dogrudan bag veya istege bagli olarak sübstitüe edilmis bir C1-10alkandiildir; R1, istege bagli olarak sübstitüe edilmis bir bisiklik heterolhalkadir; ve diger degiskenler tarifnamede tarif edildigi gibidir.
TR2001/03805T 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler TR200103805T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202089 1999-06-28

Publications (1)

Publication Number Publication Date
TR200103805T2 true TR200103805T2 (tr) 2002-06-21

Family

ID=8240374

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2005/00707T TR200500707T2 (tr) 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.
TR2001/03805T TR200103805T2 (tr) 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2005/00707T TR200500707T2 (tr) 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.

Country Status (34)

Country Link
US (2) US7071192B1 (tr)
EP (2) EP1196410B1 (tr)
JP (1) JP2003503403A (tr)
KR (1) KR100731273B1 (tr)
CN (1) CN1171887C (tr)
AR (1) AR024495A1 (tr)
AT (2) ATE259796T1 (tr)
AU (1) AU774829B2 (tr)
BG (1) BG65373B1 (tr)
BR (1) BR0011997A (tr)
CA (1) CA2376785A1 (tr)
CZ (1) CZ20014573A3 (tr)
DE (2) DE60008382T2 (tr)
DK (1) DK1196410T3 (tr)
EA (1) EA004746B1 (tr)
EE (1) EE04592B1 (tr)
ES (2) ES2215670T3 (tr)
HK (1) HK1045998B (tr)
HR (2) HRP20010934A2 (tr)
HU (1) HUP0201789A3 (tr)
IL (2) IL147328A0 (tr)
MX (1) MXPA02000117A (tr)
MY (1) MY129810A (tr)
NO (1) NO321599B1 (tr)
NZ (1) NZ515392A (tr)
PL (1) PL200694B1 (tr)
PT (1) PT1196410E (tr)
SI (1) SI1196410T1 (tr)
SK (1) SK18952001A3 (tr)
TR (2) TR200500707T2 (tr)
TW (1) TWI267513B (tr)
UA (1) UA75866C2 (tr)
WO (1) WO2001000615A1 (tr)
ZA (1) ZA200110473B (tr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495580B1 (en) 1998-01-29 2002-12-17 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US20040010004A1 (en) 2000-01-17 2004-01-15 Naoki Tsuchiya Benzimidazole derivatives
WO2000003997A1 (fr) 1998-07-15 2000-01-27 Teijin Limited Derives de thiobenzimidazole
DK1249450T3 (da) * 2000-01-17 2008-02-11 Teijin Pharma Ltd Benzimidazolderivater som human chymase-inhibitorer
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
DE60112330T2 (de) 2000-12-15 2006-04-13 Glaxo Group Ltd., Greenford Pyrazolopyridinderivate
US6919352B2 (en) 2000-12-15 2005-07-19 Smithkline Beecham Corporation Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
WO2002072581A2 (en) 2001-03-08 2002-09-19 Smithkline Beecham Corporation Pyrazolopyriadine derivatives
US7034030B2 (en) 2001-03-30 2006-04-25 Smithkline Beecham Corporation Pyralopyridines, process for their preparation and use as therapeutic compounds
DE60212949T2 (de) 2001-04-10 2007-01-04 Smithkline Beecham Corp. Antivirale pyrazolopyridin verbindungen
ES2242028T3 (es) 2001-04-27 2005-11-01 Smithkline Beecham Corporation Derivados de pirazolo(1,5-a)piridina.
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
CN1518550A (zh) 2001-06-21 2004-08-04 ʷ��˿�������ȳ�ķ���޹�˾ 用于预防和治疗疱疹病毒感染的咪唑并[1,2-a]吡啶衍生物
ATE326466T1 (de) 2001-10-05 2006-06-15 Smithkline Beecham Corp Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
JP2005516916A (ja) 2001-12-11 2005-06-09 スミスクライン ビーチャム コーポレーション 抗ヘルペス薬としてのピラゾロ−ピリジン誘導体
US7244847B2 (en) * 2002-02-06 2007-07-17 Isis Pharmaceuticals, Inc. Benzimidazole compounds
CA2495245A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
EP1545513A2 (en) 2002-08-09 2005-06-29 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US7153863B2 (en) 2002-10-03 2006-12-26 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridline derivatives
EP1682547B1 (en) * 2003-10-30 2012-10-24 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
RU2369606C2 (ru) * 2003-12-18 2009-10-10 Тиботек Фармасьютикалз Лтд. Производные 5- или 6-замещенных бензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса
DE602004031776D1 (de) 2003-12-18 2011-04-21 Tibotec Pharm Ltd Piperidinamino-benzimidazol-derivate al respiratorisches syncytialvirus replikation inhibitoren
MY140893A (en) * 2003-12-18 2010-01-29 Tibotec Pharm Ltd Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
PL1711485T3 (pl) * 2003-12-18 2009-11-30 Tibotec Pharm Ltd Pochodne aminobenzoimidazoli jako inhibitory replikacji wirusa zespólni układu oddechowego
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
CA2548657A1 (en) * 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
BRPI0606278B8 (pt) * 2005-03-17 2021-05-25 Janssen R & D Ireland aminas de 1,3-diidro-benzimidazol-2-ilideno como inibidores de replicação de vírus sincicial respiratório, seu processo de preparação e composição farmacêutica
RU2419613C2 (ru) * 2005-06-20 2011-05-27 Тиботек Фармасьютикалз Лтд Гетероциклиламиноалкилзамещенные бензимидазолы
US8034835B2 (en) 2005-06-20 2011-10-11 Tibotec Pharmaceuticals Ltd. 1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
US20110190336A1 (en) * 2008-10-16 2011-08-04 Cara Therapeutics, Inc. Azabenzimidazolones
JP5487692B2 (ja) 2009-04-10 2014-05-07 国立大学法人京都大学 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
JP2012532102A (ja) * 2009-06-30 2012-12-13 シガ・テクノロジーズ・インコーポレーテッド デングウイルス感染の治療法および予防法
US9567330B2 (en) * 2011-07-15 2017-02-14 Shionogi & Co., Ltd. Azabenzimidazole derivative having AMPK-activating activity
BR112015003376A8 (pt) * 2012-08-23 2018-01-23 Alios Biopharma Inc composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e usos de quantidade eficiente de composto ou sal farmaceuticamente aceitável do mesmo ou composição farmacêutica
JP2016079168A (ja) 2014-10-17 2016-05-16 塩野義製薬株式会社 ９員縮合環誘導体

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4556660A (en) 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
EP0144101B1 (en) 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
EG17993A (en) 1986-02-03 1991-08-30 Janssen Pharmaceutica Nv Anti-histaminic compositions containing n-heterocyclyl-4-piperidinanines
US4897401A (en) 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
GB8716313D0 (en) 1987-07-10 1987-08-19 Janssen Pharmaceutica Nv 2-(heterocyclylalkyl)imidazopyridines
US5597824A (en) 1987-11-03 1997-01-28 Abbott Laboratories Analogs of oxetanyl purines and pyrimidines
IE904378A1 (en) 1989-12-20 1991-07-03 Abbott Lab Analogs of oxetanyl purines and pyrimidines
KR100190299B1 (ko) 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
US5567824A (en) 1994-05-24 1996-10-22 Merck & Co., Inc. Palladium catalyzed ring closure of triazolyltryptamine
US5693661A (en) * 1995-06-07 1997-12-02 Eli Lilly And Company Anti-viral compounds
PE107598A1 (es) * 1996-09-11 1999-01-29 Ucb Sa Cetirizina util para el tratamiento de enfermedades de tipo virico
AU6031898A (en) 1997-01-22 1998-08-07 Eli Lilly And Company Anti-viral compounds
CA2293508A1 (en) * 1997-06-04 1998-12-10 Louis Nickolaus Jungheim Anti-viral compounds
CN1292698A (zh) * 1998-03-06 2001-04-25 詹森药业有限公司 甘氨酸传递抑制剂
JP2002521334A (ja) * 1998-07-20 2002-07-16 ブリストルーマイヤーズ スクイブ カンパニー 置換ベンズイミダゾール抗ウィルス剤

Also Published As

Publication number Publication date
JP2003503403A (ja) 2003-01-28
DE60008382D1 (en) 2004-03-25
EE200100694A (et) 2003-02-17
PL200694B1 (pl) 2009-01-30
ATE356121T1 (de) 2007-03-15
HK1045998A1 (en) 2002-12-20
AU774829B2 (en) 2004-07-08
EP1196410A1 (en) 2002-04-17
NZ515392A (en) 2004-03-26
CN1358182A (zh) 2002-07-10
MY129810A (en) 2007-05-31
BG65373B1 (bg) 2008-04-30
DE60033859D1 (de) 2007-04-19
IL147328A0 (en) 2002-08-14
HRP20010934A2 (en) 2003-06-30
HRP20080390A2 (en) 2008-12-31
SK18952001A3 (sk) 2002-11-06
EE04592B1 (et) 2006-02-15
KR100731273B1 (ko) 2007-06-21
EP1400519B1 (en) 2007-03-07
UA75866C2 (en) 2006-06-15
CZ20014573A3 (cs) 2002-05-15
EP1196410B1 (en) 2004-02-18
KR20020000815A (ko) 2002-01-05
BG106288A (en) 2002-10-31
DE60008382T2 (de) 2004-12-02
ZA200110473B (en) 2003-03-20
ES2215670T3 (es) 2004-10-16
ES2283716T3 (es) 2007-11-01
NO20016370L (no) 2001-12-27
US20060058309A1 (en) 2006-03-16
CN1171887C (zh) 2004-10-20
DK1196410T3 (da) 2004-06-28
EA200200086A1 (ru) 2002-06-27
TR200500707T2 (tr) 2005-04-21
CA2376785A1 (en) 2001-01-04
DE60033859T2 (de) 2007-11-08
AR024495A1 (es) 2002-10-02
US7071192B1 (en) 2006-07-04
AU5222200A (en) 2001-01-31
US7407969B2 (en) 2008-08-05
NO20016370D0 (no) 2001-12-27
NO321599B1 (no) 2006-06-06
BR0011997A (pt) 2002-03-05
MXPA02000117A (es) 2002-07-02
IL147328A (en) 2007-06-03
HUP0201789A2 (hu) 2002-11-28
PT1196410E (pt) 2004-07-30
WO2001000615A8 (en) 2002-01-10
HK1045998B (zh) 2005-06-03
ATE259796T1 (de) 2004-03-15
PL352385A1 (en) 2003-08-25
SI1196410T1 (en) 2004-08-31
EP1400519A1 (en) 2004-03-24
TWI267513B (en) 2006-12-01
HUP0201789A3 (en) 2003-12-29
WO2001000615A1 (en) 2001-01-04
EA004746B1 (ru) 2004-08-26

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