HUP0301377A2 - Tiotropiumsót tartalmazó inhalációs oldatformájú kombinációs gyógyszerkészítmény - Google Patents

Tiotropiumsót tartalmazó inhalációs oldatformájú kombinációs gyógyszerkészítmény

Info

Publication number
HUP0301377A2
HUP0301377A2 HU0301377A HUP0301377A HUP0301377A2 HU P0301377 A2 HUP0301377 A2 HU P0301377A2 HU 0301377 A HU0301377 A HU 0301377A HU P0301377 A HUP0301377 A HU P0301377A HU P0301377 A2 HUP0301377 A2 HU P0301377A2
Authority
HU
Hungary
Prior art keywords
pharmacologically acceptable
tiotropium salt
tiotropium
pharmaceutical composition
solution containing
Prior art date
Application number
HU0301377A
Other languages
English (en)
Inventor
Petra Barth
Karin Drechsel
Barbara Niklaus-Humke
Christel Schmelzer
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7661727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0301377(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of HUP0301377A2 publication Critical patent/HUP0301377A2/hu
Publication of HUP0301377A3 publication Critical patent/HUP0301377A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgyát az alábbi összetevőkből álló, legalább kéthatóanyag kombinációját tartalmazó folyékony, hajtógázmentesgyógyszerkészítmény: - egy tiotropiumsó, mint az egyik hatóanyag,aminek a tiotropiumban kifejezett koncentrációja 0,0005 és 5 tömeg%között van, - egy, az antiallergikumok, antihisztaminikumok,szteroidok és/vagy a leukotrién-antagonisták csoportjába tartozótovábbi hatóanyag, - víz vagy vizes etanol, mint oldószer, amelybenlegalább a tiotropiumsó oldott állapotban van, - sav, a pH értékének2,0 és 4,5 közé való beállítására, - egy farmakológiailag elfogadhatókonzerválószer, - adott esetben egy farmakológiailag elfogadhatókomplexképző és/vagy stabilizátor és/vagy egy farmakológiailagelfogadható koszolvens és/vagy más farmakológiailag elfogadható segéd-és adalékanyagok, a konzerválószeren kívül; és főleg az asztma és/vagya COPD kezelésére való inhalációs alkalmazása képezi. Ó
HU0301377A 2000-10-31 2001-10-24 Combination pharmaceutical composition in form of inhalative solution containing a tiotropium salt HUP0301377A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10054042 2000-10-31
PCT/EP2001/012296 WO2002036591A2 (de) 2000-10-31 2001-10-24 Inhalative lösungsformulierung mit einem tiotropiumsalz

Publications (2)

Publication Number Publication Date
HUP0301377A2 true HUP0301377A2 (hu) 2003-10-28
HUP0301377A3 HUP0301377A3 (en) 2005-12-28

Family

ID=7661727

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301377A HUP0301377A3 (en) 2000-10-31 2001-10-24 Combination pharmaceutical composition in form of inhalative solution containing a tiotropium salt

Country Status (33)

Country Link
EP (1) EP1335729A2 (hu)
JP (1) JP4559703B2 (hu)
KR (1) KR100983208B1 (hu)
CN (1) CN1237970C (hu)
AR (1) AR038765A1 (hu)
AU (2) AU2002221741B2 (hu)
BG (1) BG66425B1 (hu)
BR (1) BR0115016A (hu)
CA (1) CA2427583C (hu)
CZ (1) CZ305033B6 (hu)
DE (1) DE10152369A1 (hu)
EA (1) EA009068B1 (hu)
EC (1) ECSP034570A (hu)
EE (1) EE05343B1 (hu)
HK (1) HK1060569A1 (hu)
HR (1) HRP20030337A2 (hu)
HU (1) HUP0301377A3 (hu)
IL (2) IL155676A0 (hu)
ME (1) ME00242B (hu)
MX (1) MXPA03003750A (hu)
MY (1) MY132777A (hu)
NO (1) NO332524B1 (hu)
NZ (1) NZ526024A (hu)
PE (1) PE20020518A1 (hu)
PL (1) PL361001A1 (hu)
SA (1) SA01220503B1 (hu)
SK (1) SK288031B6 (hu)
TW (1) TWI296934B (hu)
UA (1) UA76435C2 (hu)
UY (1) UY26991A1 (hu)
WO (1) WO2002036591A2 (hu)
YU (1) YU33103A (hu)
ZA (1) ZA200303045B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070092334A (ko) 2000-04-28 2007-09-12 코산 바이오사이언시즈, 인코포레이티드 폴리케타이드의 제조방법
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
CA2544733A1 (en) * 2003-10-09 2005-04-21 Inverseon, Inc. Methods for treating diseases and conditions with inverse agonists and for screening for agents acting as inverse agonists
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
SI1863476T1 (sl) * 2005-03-16 2016-05-31 Meda Pharma Gmbh & Co. Kg Kombinacija antiholinergikov in antagonistov receptorja levkotriena za zdravljenje respiratornih bolezni
CA2653744C (en) * 2006-05-26 2018-01-16 Dey, L.P. Nebulizable compositions of quaternary ammonium muscarinic receptor antagonists
CN100446770C (zh) * 2007-01-10 2008-12-31 上海现代药物制剂工程研究中心有限公司 丙酸培氯米松水雾剂
TR200907237A2 (tr) * 2009-09-23 2011-04-21 Bi̇lgi̇ç Mahmut Tiotropyum kuru toz kombinasyonu
CN116196298A (zh) * 2018-07-26 2023-06-02 四川海思科制药有限公司 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用
CN111936124A (zh) * 2018-07-26 2020-11-13 四川海思科制药有限公司 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0504112A3 (en) * 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations
DE4203306A1 (de) * 1992-02-06 1993-08-12 Ig Spruehtechnik Gmbh Asthma oder pulmonal-aerosolzubereitungen mit lecithin
ES2183001T3 (es) * 1995-06-27 2003-03-16 Boehringer Ingelheim Pharma Nuevo preparado medicamentoso estable para la produccion de aerosoles exentos de gas propulsor.
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
JPH11511758A (ja) * 1996-06-04 1999-10-12 ザ、プロクター、エンド、ギャンブル、カンパニー 鼻腔用ステロイドと抗ヒスタミン剤を含む鼻腔内噴霧薬
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
JPH10298107A (ja) * 1997-04-25 1998-11-10 Taisho Pharmaceut Co Ltd 医薬組成物
WO2000007567A1 (de) * 1998-08-04 2000-02-17 Jago Research Ag Medizinische aerosolformulierungen
DE19847968A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen

Also Published As

Publication number Publication date
AR038765A1 (es) 2005-01-26
CZ20031487A3 (cs) 2003-09-17
EA200300483A1 (ru) 2003-12-25
SK288031B6 (sk) 2012-12-03
KR20040010552A (ko) 2004-01-31
PE20020518A1 (es) 2002-07-12
WO2002036591A2 (de) 2002-05-10
EA009068B1 (ru) 2007-10-26
KR100983208B1 (ko) 2010-09-20
NO332524B1 (no) 2012-10-08
HUP0301377A3 (en) 2005-12-28
EE200300202A (et) 2003-10-15
CA2427583A1 (en) 2002-05-10
SK5262003A3 (en) 2003-10-07
AU2002221741B2 (en) 2007-04-05
CZ305033B6 (cs) 2015-04-08
ME00242B (me) 2011-05-10
EP1335729A2 (de) 2003-08-20
NO20031914D0 (no) 2003-04-29
AU2174102A (en) 2002-05-15
YU33103A (sh) 2006-05-25
DE10152369A1 (de) 2002-05-08
CA2427583C (en) 2008-02-12
TWI296934B (en) 2008-05-21
CN1237970C (zh) 2006-01-25
JP4559703B2 (ja) 2010-10-13
JP2004523482A (ja) 2004-08-05
ZA200303045B (en) 2004-04-22
EE05343B1 (et) 2010-10-15
IL155676A (en) 2012-05-31
SA01220503B1 (ar) 2007-03-10
BR0115016A (pt) 2005-05-03
PL361001A1 (en) 2004-09-20
BG66425B1 (bg) 2014-04-30
UA76435C2 (en) 2006-08-15
HK1060569A1 (en) 2004-08-13
BG107726A (bg) 2004-11-30
WO2002036591A3 (de) 2002-07-25
IL155676A0 (en) 2003-11-23
NZ526024A (en) 2005-10-28
CN1473044A (zh) 2004-02-04
HRP20030337A2 (en) 2005-04-30
MXPA03003750A (es) 2004-10-15
MY132777A (en) 2007-10-31
ECSP034570A (es) 2003-06-25
UY26991A1 (es) 2002-06-20
MEP40708A (en) 2011-02-10
NO20031914L (no) 2003-06-23

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