ATE259796T1 - Respiratorisches syncytialvirus replikation inhibitoren - Google Patents

Respiratorisches syncytialvirus replikation inhibitoren

Info

Publication number
ATE259796T1
ATE259796T1 AT00936899T AT00936899T ATE259796T1 AT E259796 T1 ATE259796 T1 AT E259796T1 AT 00936899 T AT00936899 T AT 00936899T AT 00936899 T AT00936899 T AT 00936899T AT E259796 T1 ATE259796 T1 AT E259796T1
Authority
AT
Austria
Prior art keywords
replication inhibitors
syncytialvirus
respiratory
respiratory syncytialvirus
replication
Prior art date
Application number
AT00936899T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Jean Fernand Armand Lacrampe
Jerome Emile G Jans Guillemont
Marc Gaston Venet
Koenraad Jozef Lodewij Andries
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE259796T1 publication Critical patent/ATE259796T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00936899T 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren ATE259796T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202089 1999-06-28
PCT/EP2000/005677 WO2001000615A1 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (1)

Publication Number Publication Date
ATE259796T1 true ATE259796T1 (de) 2004-03-15

Family

ID=8240374

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00936899T ATE259796T1 (de) 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren
AT03102464T ATE356121T1 (de) 1999-06-28 2000-06-20 Hemmer des respiratorischen syncytial virus

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03102464T ATE356121T1 (de) 1999-06-28 2000-06-20 Hemmer des respiratorischen syncytial virus

Country Status (34)

Country Link
US (2) US7071192B1 (de)
EP (2) EP1400519B1 (de)
JP (1) JP2003503403A (de)
KR (1) KR100731273B1 (de)
CN (1) CN1171887C (de)
AR (1) AR024495A1 (de)
AT (2) ATE259796T1 (de)
AU (1) AU774829B2 (de)
BG (1) BG65373B1 (de)
BR (1) BR0011997A (de)
CA (1) CA2376785A1 (de)
CZ (1) CZ20014573A3 (de)
DE (2) DE60033859T2 (de)
DK (1) DK1196410T3 (de)
EA (1) EA004746B1 (de)
EE (1) EE04592B1 (de)
ES (2) ES2283716T3 (de)
HK (1) HK1045998B (de)
HR (2) HRP20010934A2 (de)
HU (1) HUP0201789A3 (de)
IL (2) IL147328A0 (de)
MX (1) MXPA02000117A (de)
MY (1) MY129810A (de)
NO (1) NO321599B1 (de)
NZ (1) NZ515392A (de)
PL (1) PL200694B1 (de)
PT (1) PT1196410E (de)
SI (1) SI1196410T1 (de)
SK (1) SK18952001A3 (de)
TR (2) TR200103805T2 (de)
TW (1) TWI267513B (de)
UA (1) UA75866C2 (de)
WO (1) WO2001000615A1 (de)
ZA (1) ZA200110473B (de)

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US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
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US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
ATE301653T1 (de) 2000-12-15 2005-08-15 Glaxo Group Ltd Pyrazolopyridine
ATE300541T1 (de) 2000-12-15 2005-08-15 Glaxo Group Ltd Pyrazolopyridinderivate
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
EP1366048B1 (de) 2001-03-08 2004-08-25 SmithKline Beecham Corporation Pyrazolopyridinderivate
JP4237497B2 (ja) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用
WO2002083672A1 (en) 2001-04-10 2002-10-24 Smithkline Beecham Corporation Antiviral pyrazolopyridine compounds
JP2004527560A (ja) 2001-04-27 2004-09-09 スミスクライン ビーチャム コーポレーション ピラゾロ[1,5−α]ピリジン誘導体
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
CN1518550A (zh) 2001-06-21 2004-08-04 ʷ��˿�������ȳ�ķ���޹�˾ 用于预防和治疗疱疹病毒感染的咪唑并[1,2-a]吡啶衍生物
ATE326466T1 (de) * 2001-10-05 2006-06-15 Smithkline Beecham Corp Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
JP2005516916A (ja) 2001-12-11 2005-06-09 スミスクライン ビーチャム コーポレーション 抗ヘルペス薬としてのピラゾロ−ピリジン誘導体
US7244847B2 (en) * 2002-02-06 2007-07-17 Isis Pharmaceuticals, Inc. Benzimidazole compounds
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AU2003258176A1 (en) 2002-08-09 2004-02-25 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
AU2003275266A1 (en) 2002-10-03 2004-05-04 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
JP4537407B2 (ja) * 2003-10-30 2010-09-01 ベーリンガー インゲルハイム (カナダ) リミテッド Rsvポリメラーゼインヒビター
CN1918146B (zh) * 2003-12-18 2011-09-14 泰博特克药品有限公司 作为呼吸道合胞病毒复制抑制剂的氨基苯并咪唑和苯并咪唑
RU2332414C2 (ru) * 2003-12-18 2008-08-27 Тиботек Фармасьютикалз Лтд. Производные аминобензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса
CN1894236B (zh) * 2003-12-18 2011-08-17 泰博特克药品有限公司 作为呼吸道合胞病毒复制抑制剂的氨基-苯并咪唑类衍生物
AR046771A1 (es) * 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados piperidina-amino-bencimidazol como inhibidores de la replicacion del virus sincitial respiratorio
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EP1951704B1 (de) * 2005-03-17 2016-03-16 Janssen Sciences Ireland UC Zur vorbeugung oder behandlung viraler infekte geeignete 1,3-dihydrobenzimidazol-2-ylidenamine
JP5078887B2 (ja) * 2005-06-20 2012-11-21 テイボテク・フアーマシユーチカルズ 呼吸器シンシチウムウイルスに活性をもつ、1−(2−アミノ−3−(置換アルキル)−3h−ベンズイミダゾイルメチル)−3−置換−1,3−ジヒドロ−ベンゾイミダゾル−2−オン
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Also Published As

Publication number Publication date
EE200100694A (et) 2003-02-17
NO20016370L (no) 2001-12-27
ZA200110473B (en) 2003-03-20
EP1400519A1 (de) 2004-03-24
HUP0201789A2 (hu) 2002-11-28
BR0011997A (pt) 2002-03-05
EP1400519B1 (de) 2007-03-07
US7071192B1 (en) 2006-07-04
PT1196410E (pt) 2004-07-30
IL147328A0 (en) 2002-08-14
TR200103805T2 (tr) 2002-06-21
ES2283716T3 (es) 2007-11-01
US7407969B2 (en) 2008-08-05
PL200694B1 (pl) 2009-01-30
DE60033859T2 (de) 2007-11-08
NO20016370D0 (no) 2001-12-27
TWI267513B (en) 2006-12-01
CN1358182A (zh) 2002-07-10
EA004746B1 (ru) 2004-08-26
HK1045998A1 (en) 2002-12-20
WO2001000615A1 (en) 2001-01-04
KR100731273B1 (ko) 2007-06-21
UA75866C2 (en) 2006-06-15
DE60008382T2 (de) 2004-12-02
WO2001000615A8 (en) 2002-01-10
EP1196410B1 (de) 2004-02-18
ES2215670T3 (es) 2004-10-16
JP2003503403A (ja) 2003-01-28
DK1196410T3 (da) 2004-06-28
SK18952001A3 (sk) 2002-11-06
EP1196410A1 (de) 2002-04-17
AR024495A1 (es) 2002-10-02
TR200500707T2 (tr) 2005-04-21
HRP20080390A2 (en) 2008-12-31
KR20020000815A (ko) 2002-01-05
IL147328A (en) 2007-06-03
NZ515392A (en) 2004-03-26
PL352385A1 (en) 2003-08-25
EE04592B1 (et) 2006-02-15
EA200200086A1 (ru) 2002-06-27
DE60008382D1 (en) 2004-03-25
SI1196410T1 (en) 2004-08-31
AU774829B2 (en) 2004-07-08
BG106288A (en) 2002-10-31
DE60033859D1 (de) 2007-04-19
AU5222200A (en) 2001-01-31
CA2376785A1 (en) 2001-01-04
BG65373B1 (bg) 2008-04-30
HUP0201789A3 (en) 2003-12-29
US20060058309A1 (en) 2006-03-16
MY129810A (en) 2007-05-31
NO321599B1 (no) 2006-06-06
HK1045998B (zh) 2005-06-03
HRP20010934A2 (en) 2003-06-30
CN1171887C (zh) 2004-10-20
CZ20014573A3 (cs) 2002-05-15
MXPA02000117A (es) 2002-07-02
ATE356121T1 (de) 2007-03-15

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