DE3588090D1 - Durch Säuren spaltbare Verbindungen - Google Patents

Durch Säuren spaltbare Verbindungen

Info

Publication number
DE3588090D1
DE3588090D1 DE3588090T DE3588090T DE3588090D1 DE 3588090 D1 DE3588090 D1 DE 3588090D1 DE 3588090 T DE3588090 T DE 3588090T DE 3588090 T DE3588090 T DE 3588090T DE 3588090 D1 DE3588090 D1 DE 3588090D1
Authority
DE
Germany
Prior art keywords
cross
linkers
disclosed
active substance
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3588090T
Other languages
English (en)
Other versions
DE3588090T2 (de
Inventor
Walter A Blattler
John M Lambert
Peter D Senter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Application granted granted Critical
Publication of DE3588090D1 publication Critical patent/DE3588090D1/de
Publication of DE3588090T2 publication Critical patent/DE3588090T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DE3588090T 1984-08-29 1985-05-23 Durch Säuren spaltbare Verbindungen Expired - Fee Related DE3588090T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/645,614 US4542225A (en) 1984-08-29 1984-08-29 Acid-cleavable compound

Publications (2)

Publication Number Publication Date
DE3588090D1 true DE3588090D1 (de) 1996-04-11
DE3588090T2 DE3588090T2 (de) 1996-07-18

Family

ID=24589735

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3588090T Expired - Fee Related DE3588090T2 (de) 1984-08-29 1985-05-23 Durch Säuren spaltbare Verbindungen
DE8585902881T Expired - Fee Related DE3585369D1 (de) 1984-08-29 1985-05-23 Von saeure gespaltete verbindung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585902881T Expired - Fee Related DE3585369D1 (de) 1984-08-29 1985-05-23 Von saeure gespaltete verbindung.

Country Status (7)

Country Link
US (3) US4542225A (de)
EP (2) EP0408157B1 (de)
JP (2) JPH06102679B2 (de)
AT (2) ATE135003T1 (de)
CA (1) CA1241949A (de)
DE (2) DE3588090T2 (de)
WO (1) WO1986001409A1 (de)

Families Citing this family (263)

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US4618492A (en) 1986-10-21
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US4542225A (en) 1985-09-17
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