AR020318A1 - Una molecula polinucleotidica aislada, un polipeptido aislado codificado por dicha molecula, un vector de expresion, una celula huesped transformada, unaproteina de fusion, una composicion farmaceutica y una vacuna que comprenden dicho polipeptido o proteina; metodos para el tratamiento, deteccion, - Google Patents

Una molecula polinucleotidica aislada, un polipeptido aislado codificado por dicha molecula, un vector de expresion, una celula huesped transformada, unaproteina de fusion, una composicion farmaceutica y una vacuna que comprenden dicho polipeptido o proteina; metodos para el tratamiento, deteccion,

Info

Publication number
AR020318A1
AR020318A1 ARP990101169A ARP990101169A AR020318A1 AR 020318 A1 AR020318 A1 AR 020318A1 AR P990101169 A ARP990101169 A AR P990101169A AR P990101169 A ARP990101169 A AR P990101169A AR 020318 A1 AR020318 A1 AR 020318A1
Authority
AR
Argentina
Prior art keywords
molecula
isolated
pharmaceutical composition
expression vector
fusion protein
Prior art date
Application number
ARP990101169A
Other languages
English (en)
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/040,984 external-priority patent/US6210883B1/en
Priority claimed from US09/123,912 external-priority patent/US6312695B1/en
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of AR020318A1 publication Critical patent/AR020318A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Una molécula polinucleotídica aislada, caracterizada porque comprende una secunecia de nucleotidos seleccionada del grupo consistente en: a) secuenciasprovistas en las SEQ.ID. NO: 1-3, 6-8, 10-13, 15-27, 29, 30, 32,34-49, 51, 52, 54, 55, 57-59, 61-69, 71, 73, 74, 77, 78, 80-82, 84, 86-96, 107-109, 111, 113,125, 127, 128, 129, 131-133, 142, 144, 148-151, 153, 154, 157, 158, 160, 167, 168 y 171; (b)los complementos de secuencias provistas en SEQ. ID, NO. 1-3, 6-8,10-13, 15-27, 29, 30, 32, 34-49, 51, 52, 54, 55, 57-59, 61-69, 71, 73,74,78,80-82, 84,86-96, 107-109, 111, 113, 125, 127, 128, 129, 131-133, 142, 144, 148-151,153, 154, 157, 158, 160, 167, 168 y 171; (c) secuencias que se hibridizan en una secuencia de (a) y (b) bajo condiciones moderadamente rigurosas. Unpolipéptido aislado, que comprende una porcion inmunogénica de una proteína de tumor pulmonar,ouna de sus variantes, comprende una secuencia de aminoácidos codificada por la molécula polinucleotídica. Un vector de expresion comprende la moléculapolinucleotídica; una célula huésped transformada con el vector de expresion; una proteína de fusion que comprende el polipéptido, una composicion farmacéuticay una vacuna que comprenden dicho polipéptido que comprende una porcion inmunogénica de una proteína de tumor pulmonar, o una de sus variantes y que comprendeuna secuencia de aminoácidos codificada por una molécula polinucleotídica que consiste en una secuencia seleccionada del grupo consistente en: (a)secuenciasprovistasen SEQ. ID. NO: 4, 5, 9, 14,28, 31, 33, 50, 53, 56, 60, 70, 72, 75, 76, 79, 83, 85, 97-106, 115-124, 126, 130, 134-141, 143, 145-147 y 162-164; (b)secuencias complementarias de las secuencias de SEQ. ID. NO:4, 5, 9, 14, 28, 31, 33, 50, 53, 56, 60, 70, 72, 75, 76, 79, 83, 85, 97-106, 115-124, 126, 130,134-141, 143, 145-147 y 162-164; (c)secunecias que se hibridizan en una secuencia de (a) y (b) bajo condiciones moderadamente rigurosas. Una composicionfarmacéutica y vacuna que comprenden la proteína de fusion. Métodos para el tratamiento, deteccion, monitoreo de la progresion e inhibicion del desarrollo de
ARP990101169A 1998-03-18 1999-03-17 Una molecula polinucleotidica aislada, un polipeptido aislado codificado por dicha molecula, un vector de expresion, una celula huesped transformada, unaproteina de fusion, una composicion farmaceutica y una vacuna que comprenden dicho polipeptido o proteina; metodos para el tratamiento, deteccion, AR020318A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4080298A 1998-03-18 1998-03-18
US09/040,984 US6210883B1 (en) 1998-03-18 1998-03-18 Compounds and methods for diagnosis of lung cancer
US12393398A 1998-07-27 1998-07-27
US09/123,912 US6312695B1 (en) 1998-03-18 1998-07-27 Compounds and methods for therapy of lung cancer

Publications (1)

Publication Number Publication Date
AR020318A1 true AR020318A1 (es) 2002-05-08

Family

ID=45569967

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101169A AR020318A1 (es) 1998-03-18 1999-03-17 Una molecula polinucleotidica aislada, un polipeptido aislado codificado por dicha molecula, un vector de expresion, una celula huesped transformada, unaproteina de fusion, una composicion farmaceutica y una vacuna que comprenden dicho polipeptido o proteina; metodos para el tratamiento, deteccion,

Country Status (3)

Country Link
EP (2) EP2003201A3 (es)
KR (1) KR20010041992A (es)
AR (1) AR020318A1 (es)

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489710A (en) 1981-06-23 1984-12-25 Xoma Corporation Composition and method for transplantation therapy
US4429008B1 (en) 1981-12-10 1995-05-16 Univ California Thiol reactive liposomes
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
JPS59116229A (ja) 1982-12-24 1984-07-05 Teijin Ltd 細胞毒性複合体を活性成分とする癌治療用剤およびその製造法
US4673562A (en) 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4873088A (en) 1983-09-06 1989-10-10 Liposome Technology, Inc. Liposome drug delivery method and composition
US4625014A (en) 1984-07-10 1986-11-25 Dana-Farber Cancer Institute, Inc. Cell-delivery agent
US4542225A (en) 1984-08-29 1985-09-17 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
US4918164A (en) 1987-09-10 1990-04-17 Oncogen Tumor immunotherapy using anti-idiotypic antibodies
US4638045A (en) 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4699784A (en) 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US4735792A (en) 1987-04-28 1988-04-05 The United States Of America As Represented By The United States Department Of Energy Radioiodinated maleimides and use as agents for radiolabeling antibodies
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
WO1989001973A2 (en) 1987-09-02 1989-03-09 Applied Biotechnology, Inc. Recombinant pox virus for immunization against tumor-associated antigens
EP0398880A4 (en) 1988-01-04 1990-12-27 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
US5215926A (en) 1988-06-03 1993-06-01 Cellpro, Inc. Procedure for designing efficient affinity cell separation processes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
DE69032284T2 (de) 1989-03-21 1998-10-08 Vical, Inc., San Diego, Calif. Expression von exogenen polynukleotidsequenzen in wirbeltieren
WO1991002805A2 (en) 1989-08-18 1991-03-07 Viagene, Inc. Recombinant retroviruses delivering vector constructs to target cells
WO1991016116A1 (en) 1990-04-23 1991-10-31 Cellpro Incorporated Immunoselection device and method
DK0553288T3 (da) 1990-10-18 1997-12-29 Cellpro Inc Apparat og fremgangsmåde til udskillelse af partikler ved brug af en eftergivende beholder
WO1992020068A1 (en) 1991-05-07 1992-11-12 Sophos Technologic Fast memory system employing mostly good memories
US5240856A (en) 1991-10-23 1993-08-31 Cellpro Incorporated Apparatus for cell separation
US5359681A (en) 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
US5589579A (en) * 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
US5633161A (en) * 1995-03-29 1997-05-27 Millennium Pharmaceuticals, Inc. Murine gene fomy030 coding for tumor progression inhibitor
JPH11506332A (ja) 1995-06-02 1999-06-08 インサイト・ファーマスーティカルズ・インコーポレイテッド 全長ｃＤＮＡ配列を獲得する改良された方法
WO1999044620A1 (en) * 1998-03-03 1999-09-10 Magainin Pharmaceuticals, Inc. Asthma associated factors as targets for treating atopic allergies including asthma and related disorders

Also Published As

Publication number Publication date
EP2003201A2 (en) 2008-12-17
KR20010041992A (ko) 2001-05-25
EP1792988A2 (en) 2007-06-06
EP1792988A3 (en) 2007-08-22
EP2003201A3 (en) 2008-12-31

Similar Documents

Publication Publication Date Title
Gitt et al. Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes.
WO2000003685A3 (en) Nitrilase homologs
DK2014678T3 (da) KDR-peptider og vacciner indeholdende disse
MX9708427A (es) Serpina derivada de pancreas.
Lother et al. Promoters in the E. coli replication origin
MY120693A (en) Human bikunin
DK0550687T3 (da) 5' til 3'-exonukleasemutationer af termostabile DNA-polymeraser
CA2901545A1 (en) Use of spacer elements in a nucleic acid to control movement of a helicase
ES2054878T3 (es) Expresion de la proapolipoproteina a-i humana.
DE69838334D1 (de) Kdr, ein menschlicher tyrosin kinase rezeptor
BR9811592A (pt) Oxidase de citocinina
WO1998006841A3 (en) Two human nsp-like proteins
BR0004643A (pt) Sequências de nucleotìdeos que codificam para o eno gene
AR010337A1 (es) Acido nucleico aislado, molecula de acido nucleico, sonda, vector de expresion recombinante, celula, metodo para producir un polipeptido de h.pylori, metodo para detectar la presencia de un acido nucleico helicobacter, polipeptido de h.pylori aislado, proteina de fusion, formulacion para vacuna
DK0811071T3 (da) Amplifikeringssekvenser hidrørende fra desmin-genet, vektorer indeholdende disse sekvenser og anvendelse heraf til fremstilling af proteiner
CO5280153A1 (es) Antigeno asociados con tumores (r11)
ES2111536T3 (es) Metodos y secuencias de acidos nucleicos para la expresion del operon de la sintasa de celulosa.
AR020318A1 (es) Una molecula polinucleotidica aislada, un polipeptido aislado codificado por dicha molecula, un vector de expresion, una celula huesped transformada, unaproteina de fusion, una composicion farmaceutica y una vacuna que comprenden dicho polipeptido o proteina; metodos para el tratamiento, deteccion,
Edens et al. Physical mapping of the central terminator for transcription on the bacteriophage M13 genome
ATE377087T1 (de) Verfahren zur herstellung eines rekombinanten rinderadenovirus-vektors
Sanger et al. Selected Papers of Frederick Sanger: With Commentaries
US9783800B2 (en) Method for producing peptides having azole-derived skeleton
Lewis et al. Homologous plasminogen N‐terminal and plasminogen‐related gene A and B peptides: Characterization of cDNAs and recombinant fusion proteins
MX9701596A (es) Un homologo de quinasa de proteina activada por mitogeno humana.
ES2552598T3 (es) Hemocianina y secuencia de ácido nucleico que codifica para la misma