ATE536550T1 - Halbleiter nanokristalle enthaltende transfektibare mizellen - Google Patents
Halbleiter nanokristalle enthaltende transfektibare mizellenInfo
- Publication number
- ATE536550T1 ATE536550T1 AT09154683T AT09154683T ATE536550T1 AT E536550 T1 ATE536550 T1 AT E536550T1 AT 09154683 T AT09154683 T AT 09154683T AT 09154683 T AT09154683 T AT 09154683T AT E536550 T1 ATE536550 T1 AT E536550T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- semiconductor nanocrystals
- gpcrs
- micellars
- transfectable
- Prior art date
Links
- 239000004054 semiconductor nanocrystal Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 5
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 3
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 3
- 238000012216 screening Methods 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000002825 functional assay Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108091008880 orphan GPCRs Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5097—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving plant cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Botany (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23867700P | 2000-10-06 | 2000-10-06 | |
| US31255801P | 2001-08-15 | 2001-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE536550T1 true ATE536550T1 (de) | 2011-12-15 |
Family
ID=26931860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01986346T ATE425457T1 (de) | 2000-10-06 | 2001-10-05 | Zellen mit spektraler signatur sowie verfahren zu ihrer herstellung und nutzung |
| AT09154683T ATE536550T1 (de) | 2000-10-06 | 2001-10-05 | Halbleiter nanokristalle enthaltende transfektibare mizellen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01986346T ATE425457T1 (de) | 2000-10-06 | 2001-10-05 | Zellen mit spektraler signatur sowie verfahren zu ihrer herstellung und nutzung |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20020155507A1 (de) |
| EP (2) | EP2085781B2 (de) |
| AT (2) | ATE425457T1 (de) |
| AU (1) | AU2002226876A1 (de) |
| CA (1) | CA2424817A1 (de) |
| DE (1) | DE60137953D1 (de) |
| WO (1) | WO2002029410A2 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050059031A1 (en) | 2000-10-06 | 2005-03-17 | Quantum Dot Corporation | Method for enhancing transport of semiconductor nanocrystals across biological membranes |
| EP1414989A1 (de) * | 2001-07-12 | 2004-05-06 | Berlock APS | Organometallische sonde |
| JP3683265B2 (ja) * | 2002-05-28 | 2005-08-17 | 松下電器産業株式会社 | ナノ粒子の製造方法及び該製造方法によって製造されたナノ粒子 |
| US20040132173A1 (en) * | 2002-08-28 | 2004-07-08 | Kimon Angelides | Optical fiber array device capable of simultaneously performing multiple functional assays |
| US7176036B2 (en) | 2002-09-20 | 2007-02-13 | Arrowhead Center, Inc. | Electroactive microspheres and methods |
| EP1590656A1 (de) * | 2003-01-24 | 2005-11-02 | Plant Research International B.V. | Identifikationsetikett bei pflanzen oder pflanzenteilen |
| US7723394B2 (en) * | 2003-11-17 | 2010-05-25 | Los Alamos National Security, Llc | Nanocrystal/sol-gel nanocomposites |
| US7226953B1 (en) * | 2003-11-17 | 2007-06-05 | Los Alamos National Security, Llc | Nanocrystal/sol-gel nanocomposites |
| US7846412B2 (en) * | 2003-12-22 | 2010-12-07 | Emory University | Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof |
| US20050148100A1 (en) * | 2003-12-30 | 2005-07-07 | Intel Corporation | Methods and devices for using Raman-active probe constructs to assay biological samples |
| US7226794B2 (en) * | 2004-04-14 | 2007-06-05 | Agilent Technologies, Inc. | Surface-enhanced Raman spectroscopy for biosensor systems and methods for determining the presence of biomolecules |
| EP2400030B1 (de) * | 2004-05-18 | 2016-01-20 | The Board of Trustees of the Leland Stanford Junior University | Detektion von Proteintranslokation durch Beta-Galactosidase-Reporter-Fragmentkomplementierung |
| CA2568168C (en) | 2004-05-25 | 2016-07-05 | Carlsberg A/S | Identification of compounds modifying a cellular response |
| US7618778B2 (en) | 2004-06-02 | 2009-11-17 | Kaufman Joseph C | Producing, cataloging and classifying sequence tags |
| JP4040610B2 (ja) * | 2004-07-23 | 2008-01-30 | キヤノン株式会社 | 物体の標識方法、該方法により標識を付された物体、ならびに付された標識の検出による物体の判別方法 |
| JP2008514737A (ja) * | 2004-09-09 | 2008-05-08 | アプレーラ コーポレイション | エネルギー移動検出系のためのジオキセタンナノ粒子アセンブリ、そのアセンブリを作製する方法、およびバイオアッセイにおいてそのアセンブリを使用する方法 |
| FR2877571B1 (fr) * | 2004-11-05 | 2007-04-13 | Nanobiotix Sarl | Nanoparticules pourvues d'un element de ciblage intracellulaire, preparation et utilisations |
| WO2006055736A1 (en) * | 2004-11-16 | 2006-05-26 | Illumina, Inc. | And methods and apparatus for reading coded microbeads |
| US20060148103A1 (en) * | 2004-12-30 | 2006-07-06 | Yin-Peng Chen | Highly sensitive biological assays |
| US7397558B2 (en) * | 2005-03-17 | 2008-07-08 | Hewlett-Packard Development Company, L.P. | Ordered array of nanoparticles for efficient nanoenhanced Raman scattering detection and methods of forming the same |
| US8845927B2 (en) * | 2006-06-02 | 2014-09-30 | Qd Vision, Inc. | Functionalized nanoparticles and method |
| US9297092B2 (en) * | 2005-06-05 | 2016-03-29 | Qd Vision, Inc. | Compositions, optical component, system including an optical component, devices, and other products |
| US8263417B2 (en) * | 2006-01-04 | 2012-09-11 | The Board Of Trustees Of The Leland Stanford Junior University | Self-illuminating dot systems and methods of use thereof |
| US7226752B1 (en) * | 2006-01-19 | 2007-06-05 | Avago Technologies General Ip (Singapore) Pte. Ltd. | Methods for detecting an analyte in a sample |
| US8849087B2 (en) * | 2006-03-07 | 2014-09-30 | Qd Vision, Inc. | Compositions, optical component, system including an optical component, devices, and other products |
| WO2007120762A2 (en) * | 2006-04-14 | 2007-10-25 | Cambrios Technologies Corporation | Fluorescent particles bound to multifunctional scaffolds and their uses |
| US9212056B2 (en) * | 2006-06-02 | 2015-12-15 | Qd Vision, Inc. | Nanoparticle including multi-functional ligand and method |
| US20080003576A1 (en) * | 2006-06-30 | 2008-01-03 | Jingwu Zhang | Assay platforms and detection methodology using surface enhanced Raman scattering (SERS) upon specific biochemical interactions |
| WO2008049034A1 (en) * | 2006-10-17 | 2008-04-24 | Zymera, Inc. | System for assays of aminotranferase |
| US20100056391A1 (en) * | 2006-12-22 | 2010-03-04 | Trustees Of Princeton University | Integrated screening assays and methods of use |
| US9557217B2 (en) * | 2007-02-13 | 2017-01-31 | Bti Holdings, Inc. | Universal multidetection system for microplates |
| EP2126581B1 (de) * | 2007-03-20 | 2014-07-09 | Becton Dickinson and Company | Assays unter verwendung von wirkstoffen für oberflächenverstärkte raman-spektroskopie |
| EP2207789B1 (de) * | 2007-09-12 | 2014-06-11 | QD Vision, Inc. | Funktionalisierte nanopartikel und verfahren |
| CA2734895C (en) | 2008-08-18 | 2014-06-17 | Discoverx Corporation | Receptor tyrosine kinase assays |
| US20100136551A1 (en) * | 2008-10-10 | 2010-06-03 | Hansang Cho | Microfluidic platform and related methods and systems |
| US7879625B1 (en) | 2008-12-03 | 2011-02-01 | The United States Of America As Represented By The Secretary Of The Navy | Preparation of SERS substrates on silica-coated magnetic microspheres |
| WO2010104600A1 (en) * | 2009-03-13 | 2010-09-16 | Oxazogen, Inc. | Optical power limiting polymeric matrix |
| CA2777841C (en) | 2009-11-02 | 2017-01-17 | Francis M. Creighton | Magnetomotive stator system and methods for wireless control of magnetic rotors |
| GB201005601D0 (en) | 2010-04-01 | 2010-05-19 | Nanoco Technologies Ltd | Ecapsulated nanoparticles |
| US20130273561A1 (en) * | 2010-10-29 | 2013-10-17 | The Governing Council Of The University Of Toronto | Lipid encapsulation of surface enhanced raman scattering (sers) nanoparticles |
| WO2012158832A2 (en) | 2011-05-16 | 2012-11-22 | Qd Vision, Inc. | Method for preparing semiconductor nanocrystals |
| WO2013028253A1 (en) | 2011-08-19 | 2013-02-28 | Qd Vision, Inc. | Semiconductor nanocrystals and methods |
| MY181697A (en) * | 2012-03-30 | 2021-01-04 | Johnson Matthey Plc | Tracer and method of identifying tracer in product |
| US9883878B2 (en) | 2012-05-15 | 2018-02-06 | Pulse Therapeutics, Inc. | Magnetic-based systems and methods for manipulation of magnetic particles |
| US10067149B2 (en) | 2012-12-12 | 2018-09-04 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| BR112015013710B1 (pt) | 2012-12-12 | 2022-08-09 | Promega Corporation | Métodos in vitro para detectar uma interação entre um agente bioativo e um alvo celular |
| HK1246160A1 (zh) | 2015-05-28 | 2018-09-07 | Nanobiotix | 用作治疗性疫苗的纳米粒子 |
| WO2017147407A1 (en) * | 2016-02-25 | 2017-08-31 | Board Of Regents, The University Of Texas System | Compositions comprising composite nanocarriers and methods of making and uses thereof |
| US11918315B2 (en) | 2018-05-03 | 2024-03-05 | Pulse Therapeutics, Inc. | Determination of structure and traversal of occlusions using magnetic particles |
| US20220057405A1 (en) * | 2019-02-25 | 2022-02-24 | Absorption Systems Llc | Cells and methods for evaluating the activity of organic anion transporting polypeptide 2a1 (oatp2a1) |
| US12171443B1 (en) | 2021-03-09 | 2024-12-24 | Pulse Therapeutics, Inc. | Magnetically controlled flow generation |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3770380A (en) | 1971-04-19 | 1973-11-06 | Us Army | Article and method for multiple immune adherence assay |
| US4011308A (en) | 1974-01-04 | 1977-03-08 | General Electric Company | Method for surface immunological detection of biological particles by the use of tagged antibodies |
| US3876504A (en) | 1974-06-10 | 1975-04-08 | Early Warning Co | Procedure for determination of antigens and antibodies and articles for use therewith |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4372745A (en) | 1979-12-19 | 1983-02-08 | Electro-Nucleonics, Inc. | Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer |
| FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| EP0092227B1 (de) | 1982-04-19 | 1988-07-27 | Nissan Motor Co., Ltd. | Verfahren zum Verstellen des Übersetzungsverhältnisses eines stufenlosen Getriebes unter Anpassung der Beschleunigung |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4743548A (en) | 1984-09-25 | 1988-05-10 | Calgene, Inc. | Plant cell microinjection technique |
| US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| EP0188256B1 (de) | 1985-01-14 | 1991-08-21 | NeoRx | Metall-Radionuklid markiertes Protein für Diagnose und Therapie |
| US4722890A (en) | 1985-08-27 | 1988-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Quantitative assay for human terminal complement cascade activation |
| US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
| US5068193A (en) | 1985-11-06 | 1991-11-26 | Calgene, Inc. | Novel method and compositions for introducing alien DNA in vivo |
| US4795855A (en) | 1985-11-14 | 1989-01-03 | Joanne Fillatti | Transformation and foreign gene expression with woody species |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5565347A (en) | 1986-06-10 | 1996-10-15 | Calgene, Inc. | Transformation and foreign gene expression with plant species |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5141648A (en) | 1987-12-02 | 1992-08-25 | Neorx Corporation | Methods for isolating compounds using cleavable linker bound matrices |
| US5218112A (en) | 1988-02-03 | 1993-06-08 | Xoma Corporation | Linking agents and methods |
| US5090914A (en) | 1988-03-04 | 1992-02-25 | Xoma Corporation | Activated polymers and conjugates thereof |
| US5330746A (en) * | 1988-05-03 | 1994-07-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dental varnish composition, and method of use |
| US5565346A (en) | 1988-07-27 | 1996-10-15 | Calgene, Inc. | Transformation and regeneration system for legumes |
| US5670617A (en) * | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| CA2084987C (en) | 1990-06-11 | 2007-02-13 | Gilead Sciences, Inc. | Nucleic acid ligands |
| GB2276169A (en) | 1990-07-05 | 1994-09-21 | Celltech Ltd | Antibodies specific for carcinoembryonic antigen |
| US5462856A (en) * | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
| EP0549692A4 (en) | 1990-09-21 | 1993-08-25 | Fred Hutchinson Cancer Research Center | Protein sequence-specific oligonucleotide sequences |
| EP0555333B1 (de) | 1990-10-19 | 1995-12-27 | University Of Florida | Künstliche virushüllen |
| US5252348A (en) | 1990-10-19 | 1993-10-12 | Univ. Of Florida Research Foundation, Inc. | Artificial viral envelopes |
| EP0572529A4 (de) | 1991-02-21 | 1994-11-02 | Gilead Sciences Inc | Spezifisches aptamer für biomolekülen und verfahren zu dessen produktion. |
| US5505928A (en) | 1991-11-22 | 1996-04-09 | The Regents Of University Of California | Preparation of III-V semiconductor nanocrystals |
| US5262357A (en) | 1991-11-22 | 1993-11-16 | The Regents Of The University Of California | Low temperature thin films formed from nanocrystal precursors |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| US5534416A (en) * | 1993-04-13 | 1996-07-09 | Molecular Probes, Inc. | Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes |
| DE69530553T2 (de) * | 1994-05-13 | 2004-03-25 | KURARAY CO., LTD, Kurashiki | Medizinisches polymergel |
| US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| JP2740153B2 (ja) * | 1995-03-07 | 1998-04-15 | エフ・ホフマン−ラ ロシユ アーゲー | 混合ミセル |
| US6069296A (en) | 1995-06-02 | 2000-05-30 | Massachusetts Institute Of Technology | Regulators of G-protein signalling |
| US5643599A (en) * | 1995-06-07 | 1997-07-01 | President And Fellows Of Harvard College | Intracellular delivery of macromolecules |
| US5690807A (en) | 1995-08-03 | 1997-11-25 | Massachusetts Institute Of Technology | Method for producing semiconductor particles |
| AU726749B2 (en) * | 1995-08-10 | 2000-11-16 | Kazunori Kataoka | Block polymer having functional groups on its both ends |
| GB9609793D0 (en) | 1996-05-10 | 1996-07-17 | Ciba Geigy Ag | Pigment compositions |
| US5874245A (en) | 1996-05-16 | 1999-02-23 | Takeda Chemical Industries, Ltd. | Human G-protein coupled receptor (HIBCD07) |
| IL132941A0 (en) * | 1997-05-21 | 2001-03-19 | Univ Leland Stanford Junior | Composition and method for enhancing transport across biological membranes |
| US20030004123A1 (en) * | 1997-06-26 | 2003-01-02 | Boucher Richard C. | Targeted gene transfer using G protein coupled receptors |
| US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
| US5990479A (en) * | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6048615A (en) | 1998-01-30 | 2000-04-11 | E. I. Du Pont De Nemours And Company | Filament having a trilobal cross-section and a trilobal void |
| US6210910B1 (en) * | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
| US6280934B1 (en) | 1998-05-13 | 2001-08-28 | Millennium Pharmaceuticals, Inc. | Assay for agents which alter G-protein coupled receptor activity |
| US6036886A (en) * | 1998-07-29 | 2000-03-14 | Nanocrystals Technology L.P. | Microemulsion method for producing activated metal oxide nanocrystals |
| EP1271154A3 (de) * | 1998-09-18 | 2005-08-17 | Massachusetts Institute Of Technology | Biologische Verwendung von Halbleiter-Nanokristallen |
| CA2344478C (en) | 1998-09-18 | 2010-03-30 | Massachusetts Institute Of Technology | Biological applications of semiconductor nanocrystals |
| US6617583B1 (en) * | 1998-09-18 | 2003-09-09 | Massachusetts Institute Of Technology | Inventory control |
| US6251303B1 (en) * | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
| US6306610B1 (en) * | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
| US6114038A (en) * | 1998-11-10 | 2000-09-05 | Biocrystal Ltd. | Functionalized nanocrystals and their use in detection systems |
| US6261779B1 (en) * | 1998-11-10 | 2001-07-17 | Bio-Pixels Ltd. | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
| US6235540B1 (en) * | 1999-03-30 | 2001-05-22 | Coulter International Corp. | Semiconductor nanoparticles for analysis of blood cell populations and methods of making same |
| AU4701200A (en) * | 1999-05-07 | 2000-11-21 | Quantum Dot Corporation | A method of detecting an analyte using semiconductor nanocrystals |
| MXPA02003284A (es) | 1999-10-01 | 2002-10-04 | Surromed Inc | Metodo de manufactura de particulas coloidales cilindricas como codigos de nanobarras. |
| US7225082B1 (en) | 1999-10-01 | 2007-05-29 | Oxonica, Inc. | Colloidal rod particles as nanobar codes |
| US6194213B1 (en) * | 1999-12-10 | 2001-02-27 | Bio-Pixels Ltd. | Lipophilic, functionalized nanocrystals and their use for fluorescence labeling of membranes |
| EP1246607B1 (de) * | 1999-12-30 | 2007-06-27 | Dana-Farber Cancer Institute, Inc. | Proteoliposomen, die ein integral membranprotein mit einer oder memhreren transmembrandomänen enthalten |
| US20030099940A1 (en) | 2000-02-16 | 2003-05-29 | Empedocles Stephen A. | Single target counting assays using semiconductor nanocrystals |
| US6761877B2 (en) * | 2000-02-18 | 2004-07-13 | Biocrystal, Ltd. | Functionalized encapsulated fluorescent nanocrystals |
| US6734420B2 (en) | 2000-04-06 | 2004-05-11 | Quantum Dot Corporation | Differentiable spectral bar code methods and systems |
| US6838243B2 (en) * | 2000-04-28 | 2005-01-04 | Quantum Dot Corporation | Methods and compositions for polynucleotide analysis using generic capture sequences |
| US6548264B1 (en) * | 2000-05-17 | 2003-04-15 | University Of Florida | Coated nanoparticles |
| AU2002306500C1 (en) * | 2001-02-16 | 2006-09-28 | Cellgate, Inc. | Transporters comprising spaced arginine moieties |
-
2001
- 2001-10-05 EP EP09154683.8A patent/EP2085781B2/de not_active Expired - Lifetime
- 2001-10-05 AT AT01986346T patent/ATE425457T1/de not_active IP Right Cessation
- 2001-10-05 AU AU2002226876A patent/AU2002226876A1/en not_active Abandoned
- 2001-10-05 EP EP01986346A patent/EP1327145B1/de not_active Expired - Lifetime
- 2001-10-05 CA CA002424817A patent/CA2424817A1/en not_active Abandoned
- 2001-10-05 US US09/972,744 patent/US20020155507A1/en not_active Abandoned
- 2001-10-05 WO PCT/US2001/031410 patent/WO2002029410A2/en not_active Ceased
- 2001-10-05 AT AT09154683T patent/ATE536550T1/de active
- 2001-10-05 DE DE60137953T patent/DE60137953D1/de not_active Expired - Lifetime
-
2003
- 2003-02-26 US US10/374,652 patent/US20040023261A1/en not_active Abandoned
-
2007
- 2007-03-05 US US11/682,063 patent/US20070148634A1/en not_active Abandoned
-
2015
- 2015-12-09 US US14/964,275 patent/US20160161496A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1327145A2 (de) | 2003-07-16 |
| EP2085781A1 (de) | 2009-08-05 |
| ATE425457T1 (de) | 2009-03-15 |
| WO2002029410A3 (en) | 2003-01-30 |
| EP2085781B2 (de) | 2020-03-11 |
| CA2424817A1 (en) | 2002-04-11 |
| DE60137953D1 (de) | 2009-04-23 |
| US20070148634A1 (en) | 2007-06-28 |
| US20040023261A1 (en) | 2004-02-05 |
| US20020155507A1 (en) | 2002-10-24 |
| WO2002029410A2 (en) | 2002-04-11 |
| EP2085781B1 (de) | 2011-12-07 |
| AU2002226876A1 (en) | 2002-04-15 |
| EP1327145B1 (de) | 2009-03-11 |
| US20160161496A1 (en) | 2016-06-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE536550T1 (de) | Halbleiter nanokristalle enthaltende transfektibare mizellen | |
| DE69939945D1 (de) | Verfahren zur isolierung von stammzellen | |
| ATE408455T1 (de) | Arrayplatten und verfahren zur herstellung von arrayplatten | |
| ES2088470T3 (es) | Ensayo de una etapa para recuento absoluto. | |
| ATE490466T1 (de) | Als interne funktionskontrolle in tests zum nachweis von seltenen zellen verwendete markierte zellen | |
| CA2374735A1 (en) | Encoding and decoding of array sensors utilizing nanocrystals | |
| EP1399547A4 (de) | VERFAHREN UND ZUSAMMENSETZUNGEN MIT i RENILLA /iGFP | |
| DE60210406D1 (de) | Erhöhung des durchsatzes in einem automatischen klinischen analysierer durch aufteilen von assays nach typ | |
| WO2004012658A3 (en) | Method and device for protein delivery into cells | |
| DE60230672D1 (de) | Nukleinsäureanreicherung | |
| WO2005063817A3 (en) | Methods for identifying functional antibodies | |
| WO2002079490A3 (en) | Bio-barcodes based on oligonucleotide-modified particles | |
| WO2005021728A3 (en) | Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations | |
| ATE266204T1 (de) | ßFLOW-ZYTOMETRISCHERß VOLLBLUT- DENDRITZELLE- IMMUNFUNCTIONTEST | |
| WO2002061387A3 (en) | Open substrate platforms suitable for analysis of biomolecules | |
| ATE421697T1 (de) | Verfahren zur identifizierung von verbindungen, die transmembran-proteine beeinflussen | |
| DE69622696D1 (de) | Zellzählung durch einen immunoassay | |
| DE60110407D1 (de) | Reagenz zur bestimmung von blutplättchen-mikroteilchen | |
| WO2004020597A3 (en) | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations | |
| DE60037007D1 (de) | Angereicherte zentralnervensystem-zellpopulationen | |
| IL162568A0 (en) | fluorescent protein from aequorea coerulscens and uses thereof | |
| DE69629976D1 (de) | Typ I Prokollagen aminoterminales Propeptid, dessen Antikörper und Testverfahren unter Verwendung davon | |
| ZA9710964B (en) | Synthetic biepitope compounds which can be used as standards in the biological assays of troponin I | |
| ATE323285T1 (de) | Nicht-enzymatische methoden zur erzeugung von chemilumineszenz bei acridan-alkenen | |
| DK1057021T3 (da) | Fremgangsmåde til måling af totalanalyt |