MXPA03007358A - Transportadores que contienen porciones de arginina separadas. - Google Patents

Transportadores que contienen porciones de arginina separadas.

Info

Publication number
MXPA03007358A
MXPA03007358A MXPA03007358A MXPA03007358A MXPA03007358A MX PA03007358 A MXPA03007358 A MX PA03007358A MX PA03007358 A MXPA03007358 A MX PA03007358A MX PA03007358 A MXPA03007358 A MX PA03007358A MX PA03007358 A MXPA03007358 A MX PA03007358A
Authority
MX
Mexico
Prior art keywords
transport
transporters
moiety
subunit
arginine
Prior art date
Application number
MXPA03007358A
Other languages
English (en)
Inventor
L Vandeusen Christopher
Original Assignee
Cellgate Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellgate Inc filed Critical Cellgate Inc
Publication of MXPA03007358A publication Critical patent/MXPA03007358A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invencion provee composiciones y metodos para incrementar el transporte de compuestos biologicamente activos a traves de membranas biologicas y a traves y hacia los tejidos epitelial o endotelial de origen animal. La composicion incluye un agente biologicamente activo y una porcion para transporte. La porcion para transporte incluye una estructura que se selecciona del grupo que consiste de (ZYZ)nZ, (ZY)nZ, (ZYY)nZ y (ZYYY)nZ. La subunidad "Z" es L-arginina o D-arginina, y la subunidad "Y" es un aminoacido que no contiene una porcion amidino o guanidino. El subindice "n" es un numero entero que varia desde 2 hasta 10. El metodo para incrementar el transporte implica la administracion de la composicion antes mencionada.
MXPA03007358A 2001-02-16 2002-02-14 Transportadores que contienen porciones de arginina separadas. MXPA03007358A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26962701P 2001-02-16 2001-02-16
PCT/US2002/004491 WO2002065986A2 (en) 2001-02-16 2002-02-14 Transporters comprising spaced arginine moieties

Publications (1)

Publication Number Publication Date
MXPA03007358A true MXPA03007358A (es) 2004-12-13

Family

ID=23028023

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007358A MXPA03007358A (es) 2001-02-16 2002-02-14 Transportadores que contienen porciones de arginina separadas.

Country Status (9)

Country Link
US (3) US7585834B2 (es)
EP (1) EP1401473B1 (es)
JP (1) JP2005508832A (es)
AT (1) ATE437647T1 (es)
AU (1) AU2002306500C1 (es)
CA (1) CA2437983C (es)
DE (1) DE60233137D1 (es)
MX (1) MXPA03007358A (es)
WO (1) WO2002065986A2 (es)

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US20030032593A1 (en) 2003-02-13
DE60233137D1 (de) 2009-09-10
WO2002065986A9 (en) 2003-03-13
ATE437647T1 (de) 2009-08-15
US20100081618A1 (en) 2010-04-01
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