ATE260658T1 - Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen - Google Patents

Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen

Info

Publication number
ATE260658T1
ATE260658T1 AT97925749T AT97925749T ATE260658T1 AT E260658 T1 ATE260658 T1 AT E260658T1 AT 97925749 T AT97925749 T AT 97925749T AT 97925749 T AT97925749 T AT 97925749T AT E260658 T1 ATE260658 T1 AT E260658T1
Authority
AT
Austria
Prior art keywords
respiratory depression
pharmaceutical preparations
reducing respiratory
reducing
animal
Prior art date
Application number
AT97925749T
Other languages
English (en)
Inventor
Kwen-Jen Chang
Robert W Mcnutt Jr
Hugh O Pettit
Michael J Bishop
Original Assignee
Ardent Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardent Pharmaceuticals Inc filed Critical Ardent Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE260658T1 publication Critical patent/ATE260658T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
AT97925749T 1996-06-05 1997-05-28 Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen ATE260658T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/658,726 US5807858A (en) 1996-06-05 1996-06-05 Compositions and methods for reducing respiratory depression
PCT/US1997/009123 WO1997046240A1 (en) 1996-06-05 1997-05-28 Compositions and methods for reducing respiratory depression

Publications (1)

Publication Number Publication Date
ATE260658T1 true ATE260658T1 (de) 2004-03-15

Family

ID=24642427

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97925749T ATE260658T1 (de) 1996-06-05 1997-05-28 Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen

Country Status (7)

Country Link
US (1) US5807858A (de)
EP (1) EP0938317B1 (de)
AT (1) ATE260658T1 (de)
AU (1) AU714472B2 (de)
CA (1) CA2257393C (de)
DE (1) DE69727956D1 (de)
WO (1) WO1997046240A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles
US6548637B1 (en) 1998-06-18 2003-04-15 Sepracor, Inc. Ligands for opioid receptors
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
AU2001239896A1 (en) 2000-03-16 2001-10-03 Sepracor, Inc. Peptidomimetic ligands for cellular receptors and ion channels
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
NZ539828A (en) * 2001-05-18 2007-01-26 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
US7189725B2 (en) * 2001-09-25 2007-03-13 Mount Cook Biosciences, Inc. Enantiomerically pure opioid diarylmethylpiperazine as a cardioprotection agent
NZ531875A (en) * 2001-09-25 2006-10-27 Ardent Pharmaceuticals Inc An enantiomerically pure diarylmethylpiperazine and methods for use in the treatment for conditions such as drug addiction, mental disorders, arthritis and asthma
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
JP4892654B2 (ja) * 2001-10-29 2012-03-07 マウント クック ファーマ，インコーポレーテッド デルタレセプターアゴニスト化合物によるうつ病の治療方法
PL372096A1 (en) 2002-01-02 2005-07-11 Ardent Pharmaceuticals, Inc. Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203302D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7314880B2 (en) * 2003-01-02 2008-01-01 Mount Cook Biosciences, Inc. Cardioprotective delta opioid receptor agonists and methods of using same
RU2005136524A (ru) * 2003-05-16 2006-06-27 Астразенека Аб (Se) Производные диарилметилиденпиперидина, способы их получения и их применение
SE0400027D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
KR101234421B1 (ko) * 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
CN101198330A (zh) * 2005-04-14 2008-06-11 蒙特库克生物科学公司 新阿片类化合物的组合物及其使用方法
US20070197786A1 (en) * 2005-07-22 2007-08-23 Kwen-Jen Chang Enantiomerically pure opioid diarylmethylpiperazine
SG172685A1 (en) 2006-06-28 2011-07-28 Amgen Inc Glycine transporter-1 inhibitors
EA201001644A1 (ru) * 2008-05-20 2011-06-30 Астразенека Аб Способ лечения тревожного большого депрессивного расстройства
CA3061323C (en) * 2017-04-30 2023-09-26 Versi Group, Llc An opioid for use to reduce and/or treat drug addiction

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2630435A (en) * 1948-09-09 1953-03-03 Burroughs Wellcome Co N-benzohydryl-n-methyl piperazines and process of preparing same
US4518711A (en) * 1983-05-16 1985-05-21 Gibson-Stephens Institute Conformationally constrained cyclic enkephalin analogs with delta receptor specificity
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
IN163948B (de) * 1986-01-17 1988-12-10 Robins Co Inc A H
NZ224236A (en) * 1987-04-16 1990-08-28 Lilly Co Eli Trans 3,4 pyridine derivatives and pharmaceutical compositions
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
AU650421B2 (en) * 1989-06-19 1994-06-23 Wellcome Foundation Limited, The Medicaments useful in cancer therapy and having antihistaminic properties
EP0458160A3 (en) * 1990-05-25 1992-03-18 Sociedad Espanola De Especialidades Farmaco-Terapeuticas, S.A. Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
WO1995004051A1 (en) * 1993-07-30 1995-02-09 The Wellcome Foundation Limited Piperazine compounds used in therapy

Also Published As

Publication number Publication date
DE69727956D1 (de) 2004-04-08
AU714472B2 (en) 2000-01-06
EP0938317A4 (de) 2000-08-23
CA2257393A1 (en) 1997-12-11
EP0938317B1 (de) 2004-03-03
EP0938317A1 (de) 1999-09-01
WO1997046240A1 (en) 1997-12-11
CA2257393C (en) 2010-08-24
AU3079897A (en) 1998-01-05
US5807858A (en) 1998-09-15

Similar Documents

Publication Publication Date Title
DE69727956D1 (de) Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen
SE9504661D0 (sv) New compounds
NO971889L (no) Forbindelser og sammensetninger for levering av aktive midler
DE69705300D1 (de) Cyclopropylalkansäurederivate
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
DE122011100032I1 (de) Verwendung von n-substituierten pyridonen als tumornekrose-faktor alpha hemmer.
MY123354A (en) 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
EA200400432A1 (ru) Производные мочевины
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
EP1140900A4 (de) Pyrazol verbindungen und ihre verwendung
FI972434A0 (fi) Lamotrigiiniä sisältävä farmaseuttinen koostumus
UA42819C2 (uk) Ін`єкційний та інфузійний розчин, що містить енрофлокcацин
KR960703863A (ko) 암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer)
FI934680A0 (fi) Arylmorfolin, framstaellning och anvaending
ATE246515T1 (de) Verfahren zur herstellung von oralen dosierungsformulierungen enthaltend diclofenac
DE69330601D1 (de) Serotoninergische ergolin derivate
DK0823909T3 (da) Hidtil ukendte heterocykliske forbindelser
SE9504662D0 (sv) New compounds
AU1998995A (en) Substituted fused and bridged bicyclic compounds as therapeutic agents
DK0625153T3 (da) Nyt isoindolinonderivat, dets fremstilling og farmaceutiske præparater med et indhold deraf
NO950177L (no) Farmakologisk aktive erivater
AP9801235A0 (en) Erythromycin derivatives.
GEP20032975B (en) Echinocandin Derivatives, Preparation Method and Pharmaceutical Composition
DK0802920T3 (da) Fusacandin-antisvampemidler
ATE228359T1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties