PT3149025T - Peptídeos penetrantes de células e métodos de fabrico e utilização dos mesmos - Google Patents
Peptídeos penetrantes de células e métodos de fabrico e utilização dos mesmosInfo
- Publication number
- PT3149025T PT3149025T PT15796259T PT15796259T PT3149025T PT 3149025 T PT3149025 T PT 3149025T PT 15796259 T PT15796259 T PT 15796259T PT 15796259 T PT15796259 T PT 15796259T PT 3149025 T PT3149025 T PT 3149025T
- Authority
- PT
- Portugal
- Prior art keywords
- making
- methods
- cell penetrating
- penetrating peptides
- peptides
- Prior art date
Links
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 title 1
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0039—Coumarin dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
- A61K49/0047—Green fluorescent protein [GFP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462001535P | 2014-05-21 | 2014-05-21 | |
| US201562158351P | 2015-05-07 | 2015-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3149025T true PT3149025T (pt) | 2019-08-01 |
Family
ID=54554977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT15796259T PT3149025T (pt) | 2014-05-21 | 2015-05-21 | Peptídeos penetrantes de células e métodos de fabrico e utilização dos mesmos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10626147B2 (pt) |
| EP (2) | EP3613426A1 (pt) |
| JP (2) | JP6807831B2 (pt) |
| CN (2) | CN106852146B (pt) |
| CA (1) | CA2949705A1 (pt) |
| CY (1) | CY1121953T1 (pt) |
| DK (1) | DK3149025T3 (pt) |
| ES (1) | ES2739613T3 (pt) |
| HK (1) | HK1232239A1 (pt) |
| HR (1) | HRP20191254T1 (pt) |
| HU (1) | HUE045872T2 (pt) |
| LT (1) | LT3149025T (pt) |
| PL (1) | PL3149025T3 (pt) |
| PT (1) | PT3149025T (pt) |
| RS (1) | RS59119B1 (pt) |
| SI (1) | SI3149025T1 (pt) |
| WO (1) | WO2015179691A2 (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106852146B (zh) | 2014-05-21 | 2021-08-13 | 恩特拉达治疗学股份有限公司 | 细胞穿透肽及其制备和使用方法 |
| US10815276B2 (en) * | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| EP3185880B1 (en) * | 2014-08-27 | 2020-02-12 | Ohio State Innovation Foundation | Improved peptidyl calcineurin inhibitors |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| WO2018089648A2 (en) | 2016-11-09 | 2018-05-17 | Ohio State Innovation Foundation | Di-sulfide containing cell penetrating peptides and methods of making and using thereof |
| TW201825510A (zh) * | 2016-11-22 | 2018-07-16 | 俄亥俄州立創新基金會 | 細胞穿透肽序列 |
| US11352394B2 (en) | 2016-11-22 | 2022-06-07 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
| WO2018098226A1 (en) | 2016-11-22 | 2018-05-31 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
| MX2019007367A (es) * | 2016-12-23 | 2020-01-27 | Bicycletx Ltd | Ligandos de peptido para enlace a mt1-mmp. |
| US11730819B2 (en) * | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| JP7301757B2 (ja) | 2017-06-26 | 2023-07-03 | バイスクルアールディー・リミテッド | 検出可能部分を持つ二環式ペプチドリガンドおよびその使用 |
| US11339192B2 (en) | 2017-10-04 | 2022-05-24 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| CN108070025B (zh) * | 2017-10-24 | 2019-11-19 | 中山大学附属口腔医院 | 一种细胞穿透肽和细胞穿透肽复合物及二者的应用 |
| US11510991B2 (en) | 2017-10-27 | 2022-11-29 | Ohio State Innovation Foundation | Polypeptide conjugates for intracellular delivery of stapled peptides |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| EP3749365A4 (en) | 2018-01-29 | 2022-01-12 | Ohio State Innovation Foundation | PEPTIDY INHIBITORS OF THE CALCINEURIN-NFAT INTERACTION |
| WO2019148195A2 (en) * | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Cyclic peptidyl inhibitors of cal-pdz binding domain |
| EP3755351A4 (en) | 2018-02-22 | 2021-11-24 | Entrada Therapeutics, Inc. | COMPOSITIONS AND TREATMENT METHODS FOR MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY |
| EP3790890A4 (en) * | 2018-05-09 | 2022-03-02 | Ohio State Innovation Foundation | CYCLIC PEPTIDES OF CELL PENETRATION WITH ONE OR MORE HYDROPHOBIC RESIDUES |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| GB201810329D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to integrin avB3 |
| GB201810325D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to PSMA |
| GB201810320D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to CD38 |
| GB201810316D0 (en) * | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| GB201810327D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to IL-17 |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| EP3817776A4 (en) * | 2018-07-02 | 2022-11-30 | Ohio State Innovation Foundation | POLYPEPTIDE CONJUGATES FOR INTRACELLULAR RELEASE OF NUCLEIC ACIDS |
| US20210386788A1 (en) | 2018-10-24 | 2021-12-16 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| GB201900530D0 (en) * | 2019-01-15 | 2019-03-06 | Bicyclerd Ltd | Bicyclic peptide ligands specific for CD38 |
| SG11202111606TA (en) | 2019-05-09 | 2021-11-29 | Bicycletx Ltd | Bicyclic peptide ligands specific for ox40 |
| TW202110485A (zh) | 2019-07-30 | 2021-03-16 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| CN113105554B (zh) * | 2020-01-13 | 2022-07-26 | 广东泰禾医药科技有限公司 | 一种抗肿瘤融合蛋白及其制法和应用 |
| KR20230135586A (ko) | 2021-01-24 | 2023-09-25 | 마이클 데이비드 포레스트 | Atp 합성효소 억제제 - 미용 및 치료 용도 |
| JP2024519601A (ja) * | 2021-03-31 | 2024-05-20 | エントラーダ セラピューティクス，インコーポレイティド | 環状細胞透過性ペプチド |
| WO2022240758A1 (en) * | 2021-05-10 | 2022-11-17 | Entrada Therapeutics, Inc. | Compositions and methods for modulating gene expression |
| AU2022271873A1 (en) | 2021-05-10 | 2024-01-04 | Entrada Therapeutics, Inc. | Compositions and methods for intracellular therapeutics |
| US20230027739A1 (en) * | 2021-05-10 | 2023-01-26 | Entrada Therapeutics, Inc. | Antigen-binding and antigen degradation constructs |
| CA3230279A1 (en) * | 2021-09-01 | 2023-03-09 | Xiang Li | Compositions and methods for skipping exon 45 in duchenne muscular dystrophy |
| AU2022339769A1 (en) * | 2021-09-01 | 2024-03-28 | Entrada Therapeutics, Inc. | Compounds and methods for skipping exon 44 in duchenne muscular dystrophy |
| WO2023081893A1 (en) * | 2021-11-08 | 2023-05-11 | Entrada Therapeutics, Inc. | Intracellular targeting of oligonucleotides |
| WO2023178327A1 (en) * | 2022-03-17 | 2023-09-21 | Ohio State Innovation Foundation | Membrane translocation domains and uses thereof |
| WO2023205451A1 (en) * | 2022-04-22 | 2023-10-26 | Entrada Therapeutics, Inc. | Cyclic peptides for delivering therapeutics |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965536A (en) | 1993-12-15 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods of inhibiting CXC intercrine molecules |
| US6110889A (en) | 1996-06-14 | 2000-08-29 | Board Of Regents, The University Of Texas System | Peptide tumor cell growth inhibitors |
| JP3791981B2 (ja) | 1996-10-15 | 2006-06-28 | 森永乳業株式会社 | ペプチド誘導体及び抗真菌剤 |
| WO1998041223A1 (en) | 1997-03-20 | 1998-09-24 | The Regents Of The University Of California | N-methyl-d-aspartate receptor channel blockers and method for identifying such |
| CA2224066A1 (en) | 1997-10-24 | 1999-04-24 | Universite D'ottawa/ University Of Ottawa | Peptides as analgesics |
| US6388054B1 (en) | 1998-08-20 | 2002-05-14 | John M. Stewart | Anti-cancer compounds |
| AU758903B2 (en) | 1998-11-26 | 2003-04-03 | Pentapharm Ag | Transport system conjugate |
| WO2000066175A2 (en) | 1999-04-30 | 2000-11-09 | Slil Biomedical Corporation | Conjugates as therapies for cancer and prostate diseases |
| US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| WO2000066528A2 (en) | 1999-04-30 | 2000-11-09 | Slil Biomedical Corporation | Quinones for treatment of diseases |
| EP1574507A3 (en) | 1999-04-30 | 2005-10-26 | SLIL Biomedical Corporation | Furo- and pyrano-naphthoquinones and their use in the treatment of cancer |
| ATE335719T1 (de) | 1999-04-30 | 2006-09-15 | Cellgate Inc | Polyamine und ihre therapeutische verwendung |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| JP2003501393A (ja) | 1999-06-05 | 2003-01-14 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ | 心臓血管細胞増殖を阻害するための方法および組成物 |
| EP1210121A2 (en) | 1999-08-24 | 2002-06-05 | Cellgate Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| US6730293B1 (en) | 1999-08-24 | 2004-05-04 | Cellgate, Inc. | Compositions and methods for treating inflammatory diseases of the skin |
| US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
| US20020009491A1 (en) | 2000-02-14 | 2002-01-24 | Rothbard Jonathan B. | Compositions and methods for enhancing drug delivery across biological membranes and tissues |
| WO2002010142A1 (en) | 2000-08-02 | 2002-02-07 | Slil Biomedical Corporation | Cyclic polyamine compounds for cancer therapy |
| US20030072715A1 (en) | 2000-08-02 | 2003-04-17 | Benjamin Frydman | Cyclic polyamine compounds for cancer therapy |
| EP1345956A2 (en) | 2000-10-13 | 2003-09-24 | University of Lausanne | Intracellular delivery of biological effectors by novel transporter peptide sequences |
| US7033597B2 (en) | 2000-10-13 | 2006-04-25 | Université de Lausanne | Intracellular delivery of biological effectors |
| WO2002057313A2 (en) | 2000-10-27 | 2002-07-25 | Consensus Pharmaceuticals, Inc. | Receptor-binding compounds and methods for identifying them |
| US20030167129A1 (en) | 2000-10-27 | 2003-09-04 | Nestor John J. | Binding compounds and methods for identifying binding compounds |
| EP1337504A4 (en) | 2000-11-08 | 2005-10-05 | Cellgate Inc | NOVEL AMINO ACID CONJUGATES AND POLYAMINE ANALOGUES USEFUL AS ANTICANCING AGENTS |
| AU2002238106A1 (en) | 2001-02-13 | 2002-08-28 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
| JP2005508832A (ja) | 2001-02-16 | 2005-04-07 | セルゲイト， インコーポレイテッド | 間隔を開けてアルギニン部分を含むトランスポーター |
| WO2002090503A2 (en) | 2001-05-04 | 2002-11-14 | The Scripps Research Institute | Anti-microbial peptides and compositions |
| CA2455951A1 (en) | 2001-08-03 | 2003-02-20 | The Board Of Trustees Of The Leland Stanford Junior University | Bi-directional synthesis of oligoguanidine transport agents |
| US20030130356A1 (en) | 2001-10-16 | 2003-07-10 | Slil Biomedical Corporation | Oligoamine compounds and derivatives thereof for cancer therapy |
| AU2002346498A1 (en) * | 2001-11-30 | 2003-06-17 | Applera Corporation | Thermus brockianus nucleic acid polymerases |
| EP1453787A1 (en) | 2001-12-07 | 2004-09-08 | SLIL Biomedical Corporation | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
| JP2005538035A (ja) | 2001-12-11 | 2005-12-15 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | グアニジニウム輸送試薬および結合体 |
| KR100863090B1 (ko) | 2002-01-17 | 2008-10-13 | 다케다 파머수티컬 컴패니 리미티드 | 항증식 활성을 지니고／지니거나 핵산 손상제 또는 처리제를 증강시키는 펩티드 및 펩티드모방체 |
| FR2836474B1 (fr) | 2002-02-22 | 2004-12-24 | Synt Em | Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique |
| AU2003232077A1 (en) | 2002-05-06 | 2003-11-17 | The Scripps Research Institute | Cyclic peptide anti-cancer agents and methods |
| AU2003241384A1 (en) | 2002-05-06 | 2003-11-17 | The Scripps Research Institute | Cyclic peptide anti-viral agents and methods |
| EP1515973A1 (en) | 2002-06-26 | 2005-03-23 | Cellgate Inc. | Porphyrin-polyamine conjugates for cancer therapy |
| US20040192665A1 (en) | 2002-08-02 | 2004-09-30 | Slil Biomedical Corporation | Conjugates of porphyrin compounds with chemotherapeutic agents |
| US20060128614A1 (en) | 2002-09-20 | 2006-06-15 | Jya-Wei Cheng | Antimicrobial peptides with reduced hemolysis and methods of their use |
| AU2003297657A1 (en) | 2002-11-29 | 2004-06-23 | Adaptive Therapeutics, Inc. | Antifungal therapeutic agents |
| US20090123468A1 (en) * | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| JP2007526316A (ja) | 2004-03-01 | 2007-09-13 | ルーメン セラピューティックス リミテッド ライアビリティ カンパニー | 疾患を処置するための組成物および方法 |
| EP1799200A1 (en) | 2004-10-04 | 2007-06-27 | Cellgate, Inc. | Polyamine analogs as therapeutic agents for ocular diseases |
| WO2006086773A2 (en) | 2005-02-11 | 2006-08-17 | Cellgate, Inc. | Polyamine analogs as modulators of cell migration and cell motility |
| WO2007040535A1 (en) | 2005-10-03 | 2007-04-12 | Cellgate, Inc. | Use of polyamine analogs for treatment and prevention of intestinal polyps |
| WO2007055578A1 (en) | 2005-11-11 | 2007-05-18 | Leids Universitair Medisch Centrum | Cyclic antimicrobial peptides derived from lactoferrin |
| WO2007070372A2 (en) | 2005-12-09 | 2007-06-21 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
| NO346186B1 (no) | 2005-12-22 | 2022-04-11 | Novabiotics Ltd | Anvendelse av et syklisk peptid for fremstilling av et medikament for behandling eller forebyggelse av en soppinfeksjon. |
| US9181303B2 (en) | 2005-12-22 | 2015-11-10 | Novabiotics Limited | Treatment of bacterial infections with cyclic antimicrobial peptides |
| WO2007097561A1 (en) * | 2006-02-20 | 2007-08-30 | Ewha University - Industry Collaboration Foundation | Peptide having cell membrane penetrating activity |
| US8628750B2 (en) | 2006-02-27 | 2014-01-14 | Technische Universitat Munchen | Cancer imaging and treatment |
| US20070232677A1 (en) | 2006-03-14 | 2007-10-04 | Marton Laurence J | Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds |
| DE602007011901D1 (de) | 2006-03-20 | 2011-02-24 | Cepep Iii Ab Stockholm | Ptiden und zellpenetrierenden peptiden gekoppelt a |
| WO2007111993A2 (en) | 2006-03-22 | 2007-10-04 | Cellgate, Inc. | Polyamine analogs as therapeutic agents for skin diseases |
| WO2008077194A1 (en) | 2006-12-22 | 2008-07-03 | Xenome Ltd | Receptor agonists |
| GB0702020D0 (en) | 2007-02-02 | 2007-03-14 | Novabiotics Ltd | Peptides and their use |
| GB0716897D0 (en) | 2007-08-30 | 2007-10-10 | Univ Muenchen Tech | Cancer imaging and treatment |
| DK2244741T3 (en) | 2008-01-18 | 2015-05-26 | Visen Medical Inc | Fluorescent imaging agents |
| US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
| WO2011095218A1 (en) | 2010-02-05 | 2011-08-11 | Polyphor Ag | Template-fixed pep tidomime tics with cxcr7 modulating activity |
| EP2531204B1 (en) | 2010-02-05 | 2016-02-03 | Polyphor AG | Template - fixed peptidomimetics with cxcr7 modulating activity |
| JP5909611B2 (ja) * | 2010-04-06 | 2016-04-27 | 愛知県 | 癌細胞選択的膜透過性ペプチドおよびその利用 |
| JP2012131743A (ja) * | 2010-12-22 | 2012-07-12 | Kyoto Univ | 腫瘍集積型抗癌剤 |
| US9744191B2 (en) | 2012-03-19 | 2017-08-29 | Yale University | Antimicrobial compositions and methods |
| WO2014053882A1 (en) * | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| US20150038671A1 (en) | 2013-05-30 | 2015-02-05 | Keykavous Parang | Efficient Synthesis of CN2097 and RC7 and Their Analogs |
| US10736932B2 (en) | 2014-05-20 | 2020-08-11 | Ohio State Innovation Foundation | Small molecule Ras inhibitors |
| CN106852146B (zh) | 2014-05-21 | 2021-08-13 | 恩特拉达治疗学股份有限公司 | 细胞穿透肽及其制备和使用方法 |
| US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| CA2955057A1 (en) | 2014-07-11 | 2016-01-14 | C3 Jian, Inc. | Targeting peptides that bind s. mutans, constructs comprising such peptides and uses thereof |
| EP3185880B1 (en) | 2014-08-27 | 2020-02-12 | Ohio State Innovation Foundation | Improved peptidyl calcineurin inhibitors |
| US10351599B2 (en) | 2014-09-19 | 2019-07-16 | Tensive Controls, Inc. | Anti-microbial peptides |
| JP2016065018A (ja) | 2014-09-25 | 2016-04-28 | 国立大学法人京都大学 | Ｃｘｃｒ７結合剤およびｃｘｃｒ７結合剤を含有する医薬組成物 |
| CN105440105B (zh) | 2015-12-17 | 2018-11-27 | 倪京满 | 一种具有高稳定性及抗耐药活性的组合抗菌肽的制备和应用 |
-
2015
- 2015-05-21 CN CN201580034608.9A patent/CN106852146B/zh active Active
- 2015-05-21 JP JP2017513613A patent/JP6807831B2/ja active Active
- 2015-05-21 US US15/312,878 patent/US10626147B2/en active Active
- 2015-05-21 WO PCT/US2015/032043 patent/WO2015179691A2/en active Application Filing
- 2015-05-21 EP EP19182012.5A patent/EP3613426A1/en active Pending
- 2015-05-21 SI SI201530819T patent/SI3149025T1/sl unknown
- 2015-05-21 CA CA2949705A patent/CA2949705A1/en active Pending
- 2015-05-21 EP EP15796259.8A patent/EP3149025B1/en active Active
- 2015-05-21 CN CN202110807512.9A patent/CN113861268A/zh active Pending
- 2015-05-21 PT PT15796259T patent/PT3149025T/pt unknown
- 2015-05-21 LT LTEP15796259.8T patent/LT3149025T/lt unknown
- 2015-05-21 PL PL15796259T patent/PL3149025T3/pl unknown
- 2015-05-21 ES ES15796259T patent/ES2739613T3/es active Active
- 2015-05-21 HU HUE15796259A patent/HUE045872T2/hu unknown
- 2015-05-21 DK DK15796259.8T patent/DK3149025T3/da active
- 2015-05-21 RS RS20190977A patent/RS59119B1/sr unknown
-
2017
- 2017-06-14 HK HK17105886.7A patent/HK1232239A1/zh unknown
-
2019
- 2019-07-12 HR HRP20191254TT patent/HRP20191254T1/hr unknown
- 2019-07-30 CY CY20191100816T patent/CY1121953T1/el unknown
-
2020
- 2020-04-14 JP JP2020072542A patent/JP2020169170A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10626147B2 (en) | 2020-04-21 |
| EP3149025A4 (en) | 2018-02-21 |
| HK1232239A1 (zh) | 2018-01-05 |
| DK3149025T3 (da) | 2019-07-22 |
| EP3149025B1 (en) | 2019-06-26 |
| PL3149025T3 (pl) | 2019-11-29 |
| CN113861268A (zh) | 2021-12-31 |
| WO2015179691A3 (en) | 2016-02-25 |
| SI3149025T1 (sl) | 2019-09-30 |
| JP2020169170A (ja) | 2020-10-15 |
| LT3149025T (lt) | 2019-09-25 |
| EP3149025A2 (en) | 2017-04-05 |
| JP6807831B2 (ja) | 2021-01-06 |
| WO2015179691A9 (en) | 2016-03-31 |
| EP3613426A9 (en) | 2023-05-24 |
| EP3613426A1 (en) | 2020-02-26 |
| HUE045872T2 (hu) | 2020-01-28 |
| US20170190743A1 (en) | 2017-07-06 |
| CN106852146B (zh) | 2021-08-13 |
| HRP20191254T1 (hr) | 2019-10-18 |
| CN106852146A (zh) | 2017-06-13 |
| ES2739613T3 (es) | 2020-02-03 |
| JP2017519041A (ja) | 2017-07-13 |
| CA2949705A1 (en) | 2015-11-26 |
| CY1121953T1 (el) | 2020-10-14 |
| RS59119B1 (sr) | 2019-09-30 |
| WO2015179691A2 (en) | 2015-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1232239A1 (zh) | 細胞穿透肽及其製造和使用方法 | |
| HK1250481A1 (zh) | 經過修飾的t細胞及其製備和使用方法 | |
| HK1243102A1 (zh) | 抗cd79b抗體和使用方法 | |
| HRP20181359T1 (hr) | Anti-jagged1 protutijela i postupci uporabe | |
| IL251868A0 (en) | Anti-tim3 antibodies and methods of use | |
| IL250415B (en) | Antibodies against pd-l and methods of using them | |
| IL251165A0 (en) | Anti-il-1beta antibodies and methods of their use | |
| IL251286A0 (en) | Anti-pdgf-b antibodies and methods of use | |
| GB201419472D0 (en) | Method of using and electrochemical device | |
| IL247448A0 (en) | Peptides and methods of use | |
| GB201403107D0 (en) | Permeability and transformation of cells | |
| AU2014901577A0 (en) | Thermo-Electrochemical Cell and Method of Use |