JP2017519041A - 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法 - Google Patents
細胞膜透過性ペプチド、並びにこの作製方法及び使用方法 Download PDFInfo
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Abstract
Description
本発明は、アメリカ国立衛生研究所により認可された補助金番号GM062820、GM110208、及びCA132855の下での政府援助と共に行われた。政府は本発明に特定の権利を有する。
I
式中、AA1、AA2、AA3、AA4、AA5、AA6、AA7、AA8、及びAA9(即ち、AA1〜AA9)は、それぞれ独立してアミノ酸であり、かつm、n及びpは0〜1から独立して選択される。式Iのその他の実施例では、m及びpが1である時に、nが2以上となるように、9個を超えるアミノ酸が存在することができる。これらのより大きなペプチドは、本明細書のそれぞれの式、例えばIA、II、IIa、IIb、及びIIcと共に開示されている。いくつかの実施例では、3つ以上のアミノ酸はアルギニンであり、1つ以上のアミノ酸はフェニルアラニンである。更にその他の実施例では、1つ以上のアミノ酸はナフチルアラニンまたはトリプトファンである。
Ia
式中、AA1〜AA9、m、n、及びpは式Iで規定した通りであり、曲線は共有結合を示す。
II
式中、カーゴ部位は検出可能部位、治療用部位、標的部位、またはこれらの組み合わせを含むことができ、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIa
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIb
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIc
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
また、本明細書を通して、種々の広報が参照される。これらの広報の開示は、開示された主題に関係する現況技術をより完全に記載するために、それら全体が本出願に参照として組み込まれる。開示された参照はまた、参考文献を頼りにする文章において論じられる、参考文献に含まれる物質のために、本明細書に参照として個々に、及び特異的に組み込まれる。
一般的な定義
化合物
I
式中、AA1、AA2、AA3、AA4、AA5、AA6、AA7、AA8、及びAA9(即ち、AA1〜AA9)は、それぞれ独立してアミノ酸であり、かつm、n及びpは0〜1から独立して選択される。9個を超えるアミノ酸が存在する場合、式Iは、m及びpがそれぞれ1であることができ、nは2以上、例えば2〜10、または2〜5であることができる。いくつかの実施例では、3つ以上のアミノ酸はアルギニンであり、1つ以上のアミノ酸はフェニルアラニンである。更にその他の実施例では、1つ以上のアミノ酸はナフチルアラニンまたはトリプトファンである。
I
式中、AA1、AA2、AA3、AA4、AA5、AA6、AA7、AA8、及びAA9(即ち、AA1〜AA9)は、それぞれ独立してアミノ酸であり、かつm、n及びpは0〜1から独立して選択される。
Ia
式中、AA1〜AA9、m、n、及びpは式Iで規定した通りであり、曲線は共有結合を示す。曲線は、ペプチド骨格(即ち、別のAAのαアミンとアミン結合を形成する、あるAAのカルボン酸)における共有結合、2つのAAの側鎖間の結合、AAのある側鎖からの、別のAAの骨格カルボン酸もしくはαアミンのいずれかへの結合、または2つのAA間のジスルフィド結合であることができる。
II
式中、カーゴ部位は検出可能部位、治療用部位、標的部位、またはこれらの組み合わせを含むことができ、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIa
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIb
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIc
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
細胞膜透過性ペプチド
*1文字での略称:本明細書で大文字で表す場合、Lアミノ酸の形態を示し、本明細書で小文字で表す場合、Dアミノ酸の形態を示す。
Φ=L−ナフチルアラニン、φ=D−ナフチルアラニン;Ω=L−ノルロイシン
カーゴ部位
検出可能部位は、任意の検出可能な標識を含むことができる。好適な検出可能な標識の例としては、UV−Vis標識、近赤外標識、発光基、燐光基、磁気スピン共鳴標識、光増感剤、光開裂部位、キレート化中心(chelating center)、重原子、放射性同位体、同位体で検出可能なスピン共鳴標識、常磁性部位、発色団、またはこれらの任意の組み合わせが挙げられるが、これらに限定されない。いくつかの実施形態において、標識は更なる試薬を添加することなく検出可能である。
治療用部位
*Fpa,Σ:L−4−フルオロフェニルアラニン;Pip,Θ:L−ホモプロリン;Nle,Ω:L−ノルロイシン;Phg,Ψ L−フェニルグリシン;F2Pmp,Λ:L−4−(ホスホノジフルオロメチル)フェニルアラニン;Dap,L−2,3−ジアミノプロピオン酸;Nal,Φ’:L−β−ナフチルアラニン;Pp,θ:L−ピペコリン酸;Sar,Ξ:サルコシン;Tm,トリメシン酸。
具体例
I
式中、AA1、AA2、AA3、AA4、AA5、AA6、AA7、AA8、及びAA9(即ち、AA1〜AA9)は、それぞれ独立してアミノ酸であり、かつm、n及びpは0〜1から独立して選択される。
I−1
式中、AA1〜AA6は式Iで規定した通りである。
I−2
式中、AA1〜AA7は式Iで規定した通りである。
I−3
式中、AA1〜AA8は式Iで規定した通りである。
I−4
式中、AA1〜AA9は式Iで規定した通りである。
Ia
式中、AA1〜AA9、m、n、及びpは式Iで規定した通りであり、曲線は共有結合を示す。
Ia−1
式中、AA1〜AA6は式Iで規定した通りである。
Ia−2
式中、AA1〜AA7は式Iで規定した通りである。
Ia−3
式中、AA1〜AA8は式Iで規定した通りである。
Ia−4
式中、AA1〜AA9は式Iで規定した通りである。
II
式中、カーゴ部位は検出可能部位、治療用部位、標的部位、またはこれらの組み合わせを含むことができ、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
II−1
式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
II−2
式中、AA1〜AA7は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
II−3
式中、AA1〜AA8は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
II−4
式中、AA1〜AA9は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIa
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIa−1
式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである。本明細書ではまた、式IIa−1もまた開示され、式中、AA1〜AA6の1つは存在しない(即ち、環内構造に5つのアミノ酸がある)。
IIa−2
式中、AA1〜AA7は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIa−3
式中、AA1〜AA8は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIa−4
式中、AA1〜AA9は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIb
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIb−1
式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIb−2
式中、AA1〜AA7は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIb−3
式中、AA1〜AA8は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIb−4
式中、AA1〜AA9は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIc
式中、カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである。
IIc−1
式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIc−2
式中、AA1〜AA7は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIc−3
式中、AA1〜AA8は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
IIc−4
式中、AA1〜AA9は式Iで規定した通りであり、カーゴは式IIで規定した通りである。
*Fpa,Σ:L−4−フルオロフェニルアラニン;Pip,Θ:L−ホモプロリン;Nle,Ω:L−ノルロイシン;Phg,Ψ L−フェニルグリシン;F2Pmp,Λ:L−4−(ホスホノジフルオロメチル)フェニルアラニン;Dap,J:L−2,3−ジアミノプロピオン酸;Nal,Φ’:L−β−ナフチルアラニン;Pp,θ:L−ピペコリン酸;Sar,Ξ:サルコシン;Tm=トリメシン酸;Φ=L−2−ナフチルアラニン;Rho=ローダミンB;Dex=デキサメタゾン;FITC=フルオレセインイソチオシアネート;miniPEG=8−アミノ−3,6−ジオキサオクタン酸;pCAP=ホスホクマリンアミノプロピオン酸;Amc=7−アミノ−4−メチルクマリン;FITC=フルオレセインイソチオシアネート;U=2−アミノ酪酸。
作製方法
使用方法
投与組成物、投与配合物、及び投与方法
実施例1
導入
aKcat/KMを前述の通りに測定した(Ren,L et al.Biochemistry,2011,50,2339−2356)。
apNPP=p−ニトロフェニルホスフェート;kcat/KMは上述の通りに測定した(Ren,L et al.Biochemistry,2011,50,2339−2356)。
実施例2
aAmc=7−アミノ−4−メチルクマリン;FITC=フルオレセインイソチオシアネート;Φ=L−2−ナフチルアラニン;Ω=ノルロイシン;U=2−アミノ酪酸。
実施例3
に当てはめることで入手した。式中、V0は、阻害剤の不存在下における酵素反応速度である。阻害定数(Ki)は、固定した酵素濃度(15nM)、かつ種々のpNPPの濃度(0〜24mM)及び阻害剤濃度(0〜112nM)にて、初期速度を測ることにより測定した。反応速度(V)を、pNPP濃度([S])に対してプロットし、等式
に当てはめ、ミカエリス定数Kを得た。Ki値は、K値を阻害濃度[I]に対してプロットし、等式
に当てはめることにより得た。式中、K0は阻害剤の不存在下([I]=0)における、ミカエリス定数である。
に当てはめることにより、平衡解離定数(KD)を測定した。式中、Yは所与のタンパク質濃度xにおけるFA値であり、Lはペプチドの濃度であり、Qb/Qfはフルオロフォアタンパク質の相互作用に対する補正係数であり、Amaxは、ペプチド全てタンパク質に結合した場合の最大のFA値であり、一方で、Aminはペプチド全てが遊離した場合のFA値である。100nMのFITC標識Pin1阻害剤5を1μMのPin1でインキュベーションし、続いて0〜5μMの非標識阻害剤を添加することによりFA競合アッセイを実施した。FA値をプレートリーダーで同様に測定した。4つのパラメーターの用量応答阻害式(Prism 6,GraphPad)を使用して、競合濃度に対してFA値をプロットし、曲線に当てはめることによりIC50値を得た。
aFpa=L−4−フルオロフェニルアラニン;Pip=L−ホモプロリン;Nle=L−ノルロイシン;Phg=L−フェニルグリシン;F2Pmp=L−4−(ホスホノジフルオロメチル)フェニルアラニン。
*配列を更に分析に通した。
阻害剤2の細胞膜透過性を向上させるために、CPPモチーフが一方の環内に配置されながら、標的結合配列が別の環を構成する二環式環(図23)を調査した。二環式環はCPP環を最少の大きさにとどめ、以前に観察した動向(Qian,Z et al.ACS Chem.Biol.2013,8,423−431)によると、より効率的な細胞内取り込みをもたらすことができる。後者の組み込みはCPP環のサイズを変化させず、それ故に環状CPPの送達効率に影響を与えるはずはないため、二環式環は任意のサイズのカーゴを収容することができなければならない。硬いスキャフォールド(例えばトリメシン酸)の使用はまた、CPP及びカーゴモチーフを互いに離したまま保持し、いかなる相互干渉をも最小限に抑え得る。単環式ペプチドと比較して、二環式ペプチドのより小さな環は、構造的により強い硬さ、及び改善された代謝安定性をもたらすことができる。
aNAは、1μMの阻害剤で目立った阻害がなかった。
aDap=L−2,3−ジアミノプロピオン酸;Nal=L−β−ナフチルアラニン;Pip=L−ピペコリン酸;Sar=サルコシン;Tm=トリメシン酸。FA分析に関して、全てのペプチドについて、C末端リジン側鎖をFITCで標識した。
実施例4
Φ=L−ナフチルアラニン;φ=D−ナフチルアラニン;f=D−フェニルアラニン;r=D−アルギニン;q=D−グルタミン
実施例5
実施例6
aヒット1〜3は第1ラウンドのスクリーニングから選択したが、ヒット4〜7は第2ラウンドのスクリーニングから選択した。
ライブラリー(100mgの樹脂)を、欠陥WWドメインを有するS16A/Y23A変異体Pin1に対してスクリーニングした。変異体Pin1を、N末端にてマルトース結合タンパク質(MBP)融合として作製した。スクリーニングの第1ラウンドの間、Texas−Redで標識したMBP−Pin1をペプチドライブラリーでインキュベーションし、蛍光ビーズを顕微鏡下にてライブラリーから取り除いた。3つの陽性ビーズが、残りのヒットよりも著しく大きい蛍光強度を有し、これらを部分Edman分解および質量分析(PED−MS)によるペプチド配列決定に直接通した(表17)。他の13個の蛍光ビーズをスクリーニングの第2ラウンドに通し、この間に、各ビーズ上の二環式ペプチドをテトラメチルローダミン(TMR)アジドで、Pra残基を標識し、NaOH溶液による処理でビーズから外した。
Claims (61)
- 式Iの細胞膜透過性ペプチド化合物。
I
(式中、AA1、AA2、AA3、AA4、AA5、AA6、AA7、AA8、及びAA9はそれぞれ独立してアミノ酸であり、m、n、及びpは0及び1から独立して選択され、式中、3つ以上のアミノ酸はアルギニンである) - m、n、及びpは0であり、前記化合物は式I−1である、請求項1に記載の細胞膜透過性ペプチド化合物。
I−1
(式中、AA1〜AA6は式Iで規定した通りである) - mは1、n及びpは0であり、前記化合物は式I−2である、請求項1に記載の細胞膜透過性ペプチド化合物。
I−2
(式中、AA1〜AA7は式Iで規定した通りである) - m及びnは1、pは0であり、前記化合物は式I−3である、請求項1に記載の細胞膜透過性ペプチド化合物。
I−3
(式中、AA1〜AA8は式Iで規定した通りである) - m、n、及びpは1であり、前記化合物は式I−4である、請求項1に記載の細胞膜透過性ペプチド化合物。
I−4
(式中、AA1〜AA9は式Iで規定した通りである) - 前記細胞膜透過性ペプチド化合物は環状である、請求項1〜5のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記細胞膜透過性ペプチド化合物は環状であり、前記化合物は式Iaである、請求項1に記載の細胞膜透過性ペプチド化合物。
Ia
(式中、AA1〜AA9、m、n、及びpは式Iで規定した通りであり、曲線は共有結合を示す) - m、n、及びpは0であり、前記化合物は式Ia−1である、請求項7に記載の細胞膜透過性ペプチド化合物。
Ia−1
(式中、AA1〜AA6は式Iで規定した通りである) - mは1、n及びpは0であり、前記化合物は式Ia−2である、請求項7に記載の細胞膜透過性ペプチド化合物。
Ia−2
(式中、AA1〜AA7は式Iで規定した通りである) - m及びnは1、pは0であり、前記化合物は式Ia−3である、請求項7に記載の細胞膜透過性ペプチド化合物。
Ia−3
(式中、AA1〜AA8は式Iで規定した通りである) - m、n、及びpは1であり、前記化合物は式Ia−4である、請求項7に記載の細胞膜透過性ペプチド化合物。
Ia−4
(式中、AA1〜AA9は式Iで規定した通りである) - 前記細胞膜透過性ペプチド化合物は更にカーゴ部位を含み、前記カーゴ部位は検出可能部位、治療用部位、標的部位、またはこれらの組み合わせを含むことができる、請求項1〜11のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記細胞膜透過性ペプチド化合物は、式IIである、請求項1に記載の細胞膜透過性ペプチド化合物。
II
(式中、前記カーゴ部位は検出可能部位、治療用部位、標的部位、またはこれらの組み合わせを含むことができ、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである) - m、n、及びpは0であり、前記化合物は式II−1である、請求項13に記載の細胞膜透過性ペプチド化合物。
II−1
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - mは1、n及びpは0であり、前記化合物は式II−2である、請求項13に記載の細胞膜透過性ペプチド化合物。
II−2
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m及びnは1、pは0であり、前記化合物は式II−3である、請求項13に記載の細胞膜透過性ペプチド化合物。
II−3
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m、n、及びpは1であり、前記化合物は式II−4である、請求項13に記載の細胞膜透過性ペプチド化合物。
II−4
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - 前記細胞膜透過性ペプチド部位及びカーゴ部位は共に環状である、請求項12〜16のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記細胞膜透過性ペプチド化合物は式IIaである、請求項13に記載の細胞膜透過性ペプチド化合物。
IIa
(式中、前記カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである) - m、n、及びpは0であり、前記化合物は式IIa−1である、請求項19に記載の細胞膜透過性ペプチド化合物。
IIa−1
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - mは1、n及びpは0であり、前記化合物は式IIa−2である、請求項19に記載の細胞膜透過性ペプチド化合物。
IIa−2
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m及びnは1、pは0であり、前記化合物は式IIa−3である、請求項19に記載の細胞膜透過性ペプチド化合物。
IIa−3
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m、n、及びpは1であり、前記化合物は式IIa−4である、請求項19に記載の細胞膜透過性ペプチド化合物。
IIa−4
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - 前記細胞膜透過性ペプチド部位は環状であり、前記カーゴ部位は前記環状細胞膜透過性ペプチド部位に結合している、請求項12〜16のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記化合物は式IIbである、請求項13に記載の細胞膜透過性ペプチド化合物。
IIb
(式中、前記カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである) - m、n、及びpは0であり、前記化合物は式IIb−1である、請求項25に記載の細胞膜透過性ペプチド化合物。
IIb−1
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - mは1、n及びpは0であり、前記化合物は式IIb−2である、請求項25に記載の細胞膜透過性ペプチド化合物。
IIb−2
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m及びnは1、pは0であり、前記化合物は式IIb−3である、請求項25に記載の細胞膜透過性ペプチド化合物。
IIb−3
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m、n、及びpは1であり、前記化合物は式IIb−4である、請求項25に記載の細胞膜透過性ペプチド化合物。
IIb−4
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - 前記カーゴ部位は環状であり、前記細胞膜透過性ペプチド部位は環状であり、これらは共に縮合二環式環を形成する、請求項12〜16のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記化合物は式式IIcである、請求項13に記載の細胞膜透過性化合物。
IIc
(式中、前記カーゴ部位は式IIで規定した通りであり、かつAA1〜AA9、m、n、及びpは式Iで規定した通りである) - m、n、及びpは0であり、前記化合物は式IIc−1である、請求項31に記載の細胞膜透過性化合物。
IIc−1
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - mは1、n及びpは0であり、前記化合物は式IIc−2である、請求項31に記載の細胞膜透過性化合物。
IIc−2
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m及びnは1であり、pは0であり、前記化合物は式IIc−3である、請求項31に記載の細胞膜透過性化合物。
IIc−3
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - m、n、及びpは1であり、前記化合物は式IIc−4である、請求項31に記載の細胞膜透過性化合物。
IIc−4
(式中、AA1〜AA6は式Iで規定した通りであり、カーゴは式IIで規定した通りである) - 少なくとも1つのアミノ酸がナフチルアラニン、トリプトファン、もしくはフェニルアラニン、またはこれらの誘導体もしくは類似体である、請求項1〜35のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記アミノ酸の少なくとも3つはアルギニンである、請求項1〜36のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記アミノ酸の少なくとも1つはフェニルアラニンである、請求項1〜37のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記カーゴ部位は治療用部位を含む、請求項12〜38のいずれか一項に記載の細胞膜透過性ペプチド化合物。
- 前記治療用部位は、Ras、PTP1B、Pin1、Grb2 SH2、CAL PDZ等、またはこれらの組み合わせに対して阻害剤として機能することができる標的部位を含むことができる、請求項39に記載の細胞膜透過性ペプチド化合物。
- 請求項1〜40のいずれか一項に記載の化合物を含む組成物。
- 請求項1〜41のいずれか一項に記載の化合物を含む医薬組成物。
- 必要な対象における疾病または病状の治療方法であって、前記対象に、請求項1〜42のいずれか一項に記載の有効量の化合物または組成物を投与することを含む、前記方法。
- 対象における癌の治療または予防方法であって、前記対象に、請求項1〜43のいずれか一項に記載の有効量の化合物または組成物を投与することを含む、前記方法。
- 第2の化合物または組成物を投与することを更に含み、前記第2の化合物または組成物は抗癌剤を含む請求項44のいずれか一項に記載の方法。
- 前記対象に有効量の電離放射線を投与することを更に含む、請求項44〜45のいずれか一項に記載の方法。
- 前記対象に投与される前記化合物または組成物は、Ras、PTP1B、Pin1、Grb2 SH2、またはこれらの組み合わせに対して阻害剤として機能することができる標的部位を含むことができる治療用部位を含むことができる、請求項44〜46のいずれか一項に記載の方法。
- 前記腫瘍細胞を、請求項1〜42のいずれか一項に記載の有効量の化合物または組成物と接触させることを含む、対象における腫瘍細胞の殺傷方法。
- 前記腫瘍細胞を第2の化合物または組成物と接触させることを更に含み、前記第2の化合物または組成物は抗癌剤を含む、請求項48に記載の方法。
- 前記腫瘍細胞を有効量の電離放射線で照射することを更に含む、請求項48〜49のいずれか一項に記載の方法。
- 前記対象に投与される前記化合物または組成物は、Ras、PTP1B、Pin1、Grb2 SH2、またはこれらの組み合わせに対して阻害剤として機能することができる標的部位を含むことができる治療用部位を含むことができる、請求項49〜50のいずれか一項に記載の方法。
- 請求項1〜42のいずれか一項に記載の有効量の化合物または組成物を投与することを含む、代謝異常または状態を有する対象の治療方法。
- 前記代謝異常は2型糖尿病である、請求項52に記載の方法。
- 前記対象に投与される前記化合物または組成物は、PTP1Bに対する阻害剤として機能することができる標的部位を含むことができる治療用部位を含むことができる、請求項52〜53のいずれか一項に記載の方法。
- 請求項1〜42のいずれか一項に記載の有効量の化合物または組成物を投与することを含む、免疫不全または状態を有する対象の治療方法。
- 前記対象に投与される前記化合物または組成物は、Pin1に対する阻害剤として機能することができる標的部位を含むことができる治療用部位を含むことができる、請求項55に記載の方法。
- 請求項1〜42のいずれか一項に記載の有効量の化合物または組成物を投与することを含む、嚢胞性線維症を有する対象の治療方法。
- 前記対象に投与される前記化合物または組成物は、CAL PDZに対する阻害剤として機能することができる標的部位を含むことができる治療用部位を含むことができる、請求項57に記載の方法。
- 前記CFTR機能を修正する分子もまた、前記化合物または組成物と共に投与される、請求項57に記載の方法。
- 心筋細胞に化合物を送達する方法であって、前記心筋細胞を、請求項1〜42のいずれか一項に記載の有効量の化合物または組成物と接触させることを含む、前記方法。
- 表1、6、または18のいずれかに示す化合物。
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Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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US10815276B2 (en) * | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
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GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
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US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
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WO2020086742A1 (en) | 2018-10-24 | 2020-04-30 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
CA3137095A1 (en) | 2019-05-09 | 2020-11-12 | Bicycletx Limited | Bicyclic peptide ligands specific for ox40 |
TW202118770A (zh) | 2019-07-30 | 2021-05-16 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
US20220348937A1 (en) | 2019-09-06 | 2022-11-03 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
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BR112023012422A2 (pt) | 2021-01-24 | 2023-12-12 | Michael David Forrest | Inibidores da atp sintase - usos cosmético e terapêutico |
WO2022213118A1 (en) * | 2021-03-31 | 2022-10-06 | Entrada Therapeutics, Inc. | Cyclic cell penetrating peptides |
EP4337264A1 (en) | 2021-05-10 | 2024-03-20 | Entrada Therapeutics, Inc. | Compositions and methods for modulating tissue distribution of intracellular therapeutics |
WO2022240758A1 (en) * | 2021-05-10 | 2022-11-17 | Entrada Therapeutics, Inc. | Compositions and methods for modulating gene expression |
WO2022240757A1 (en) * | 2021-05-10 | 2022-11-17 | Entrada Therapeutics, Inc. | Antigen-binding and antigen degradation constructs |
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WO2023081893A1 (en) * | 2021-11-08 | 2023-05-11 | Entrada Therapeutics, Inc. | Intracellular targeting of oligonucleotides |
WO2023178327A1 (en) * | 2022-03-17 | 2023-09-21 | Ohio State Innovation Foundation | Membrane translocation domains and uses thereof |
WO2023205451A1 (en) * | 2022-04-22 | 2023-10-26 | Entrada Therapeutics, Inc. | Cyclic peptides for delivering therapeutics |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009527251A (ja) * | 2006-02-20 | 2009-07-30 | エファ・ユニバーシティ・インダストリー・コラボレイション・ファウンデイション | 細胞膜透過性ペプチド |
WO2011126010A1 (ja) * | 2010-04-06 | 2011-10-13 | 三菱化学株式会社 | 癌細胞選択的膜透過性ペプチドおよびその利用 |
JP2012131743A (ja) * | 2010-12-22 | 2012-07-12 | Kyoto Univ | 腫瘍集積型抗癌剤 |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965536A (en) | 1993-12-15 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods of inhibiting CXC intercrine molecules |
WO2002064091A2 (en) | 2001-02-13 | 2002-08-22 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
US6110889A (en) | 1996-06-14 | 2000-08-29 | Board Of Regents, The University Of Texas System | Peptide tumor cell growth inhibitors |
JP3791981B2 (ja) | 1996-10-15 | 2006-06-28 | 森永乳業株式会社 | ペプチド誘導体及び抗真菌剤 |
WO1998041223A1 (en) | 1997-03-20 | 1998-09-24 | The Regents Of The University Of California | N-methyl-d-aspartate receptor channel blockers and method for identifying such |
CA2224066A1 (en) | 1997-10-24 | 1999-04-24 | Universite D'ottawa/ University Of Ottawa | Peptides as analgesics |
US6388054B1 (en) | 1998-08-20 | 2002-05-14 | John M. Stewart | Anti-cancer compounds |
WO2000032235A1 (de) | 1998-11-26 | 2000-06-08 | Pentapharm Ag | Transportsystemkonjugate |
US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
EP1574507A3 (en) | 1999-04-30 | 2005-10-26 | SLIL Biomedical Corporation | Furo- and pyrano-naphthoquinones and their use in the treatment of cancer |
US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
BR0010702A (pt) | 1999-04-30 | 2002-02-13 | Slil Biomedical Corp | Novas quinonas como terapias de doenças |
NZ515140A (en) | 1999-04-30 | 2003-07-25 | Slil Biomedical Corp | Conformationally restricted polyamine analogs as disease therapies for cancer, epilepsy, alzheimers, infections, grafts and others |
CA2368801A1 (en) | 1999-04-30 | 2000-11-09 | Slil Biomedical Corporation | Conjugates as therapies for cancer and prostate diseases |
IL141250A0 (en) | 1999-06-05 | 2002-03-10 | Univ Leland Stanford Junior | Method and composition for inhibiting cardiovascular cell proliferation |
US6730293B1 (en) | 1999-08-24 | 2004-05-04 | Cellgate, Inc. | Compositions and methods for treating inflammatory diseases of the skin |
US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
EP1210121A2 (en) | 1999-08-24 | 2002-06-05 | Cellgate Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
US20020009491A1 (en) | 2000-02-14 | 2002-01-24 | Rothbard Jonathan B. | Compositions and methods for enhancing drug delivery across biological membranes and tissues |
WO2002010142A1 (en) | 2000-08-02 | 2002-02-07 | Slil Biomedical Corporation | Cyclic polyamine compounds for cancer therapy |
US20030072715A1 (en) | 2000-08-02 | 2003-04-17 | Benjamin Frydman | Cyclic polyamine compounds for cancer therapy |
US7033597B2 (en) | 2000-10-13 | 2006-04-25 | Université de Lausanne | Intracellular delivery of biological effectors |
JP4387669B2 (ja) | 2000-10-13 | 2009-12-16 | ザイジェン エス.アー. | 新規なトランスポーターペプチド配列による生物学的エフェクターの細胞内送達 |
WO2002057313A2 (en) | 2000-10-27 | 2002-07-25 | Consensus Pharmaceuticals, Inc. | Receptor-binding compounds and methods for identifying them |
US20030167129A1 (en) | 2000-10-27 | 2003-09-04 | Nestor John J. | Binding compounds and methods for identifying binding compounds |
WO2002091989A2 (en) | 2000-11-08 | 2002-11-21 | Slil Biomedical Corporation | Antiviral therapies using polyamine or polyamine analog-amino acid conjugates |
DE60233137D1 (de) | 2001-02-16 | 2009-09-10 | Univ R | Transporter mit beabstandeten arginin-teilchen |
WO2002090503A2 (en) | 2001-05-04 | 2002-11-14 | The Scripps Research Institute | Anti-microbial peptides and compositions |
JP2004537596A (ja) | 2001-08-03 | 2004-12-16 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | オリゴグアニジン輸送因子の二方向合成 |
CA2463771A1 (en) | 2001-10-16 | 2003-04-24 | Slil Biomedical Corporation | Oligoamine compounds and derivatives thereof for cancer therapy |
AU2002346498A1 (en) | 2001-11-30 | 2003-06-17 | Applera Corporation | Thermus brockianus nucleic acid polymerases |
AU2002364539A1 (en) | 2001-12-07 | 2003-06-23 | Cellgate, Inc. | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
EP1461084A2 (en) | 2001-12-11 | 2004-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Guanidinium transport reagents and conjugates |
CA2471192C (en) * | 2002-01-17 | 2014-05-20 | Canbas Co., Ltd. | Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments |
FR2836474B1 (fr) | 2002-02-22 | 2004-12-24 | Synt Em | Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique |
AU2003241384A1 (en) | 2002-05-06 | 2003-11-17 | The Scripps Research Institute | Cyclic peptide anti-viral agents and methods |
AU2003232077A1 (en) | 2002-05-06 | 2003-11-17 | The Scripps Research Institute | Cyclic peptide anti-cancer agents and methods |
JP2005533820A (ja) | 2002-06-26 | 2005-11-10 | セルゲイト, インコーポレイテッド | 癌治療のためのポルフィリン−ポリアミン結合体 |
US20040192665A1 (en) | 2002-08-02 | 2004-09-30 | Slil Biomedical Corporation | Conjugates of porphyrin compounds with chemotherapeutic agents |
US20060128614A1 (en) | 2002-09-20 | 2006-06-15 | Jya-Wei Cheng | Antimicrobial peptides with reduced hemolysis and methods of their use |
AU2003297657A1 (en) | 2002-11-29 | 2004-06-23 | Adaptive Therapeutics, Inc. | Antifungal therapeutic agents |
US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
CA2557814A1 (en) | 2004-03-01 | 2005-09-15 | Lumen Therapeutics, Llc | Compositions and methods for treating diseases |
WO2006041805A1 (en) | 2004-10-04 | 2006-04-20 | Cellgate, Inc. | Polyamine analogs as therapeutic agents for ocular diseases |
WO2006086773A2 (en) | 2005-02-11 | 2006-08-17 | Cellgate, Inc. | Polyamine analogs as modulators of cell migration and cell motility |
WO2007040535A1 (en) | 2005-10-03 | 2007-04-12 | Cellgate, Inc. | Use of polyamine analogs for treatment and prevention of intestinal polyps |
WO2007055578A1 (en) | 2005-11-11 | 2007-05-18 | Leids Universitair Medisch Centrum | Cyclic antimicrobial peptides derived from lactoferrin |
WO2007070372A2 (en) | 2005-12-09 | 2007-06-21 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
CA2655448C (en) | 2005-12-22 | 2016-09-06 | Novabiotics Limited | Cyclic antimicrobial peptides |
US9181303B2 (en) | 2005-12-22 | 2015-11-10 | Novabiotics Limited | Treatment of bacterial infections with cyclic antimicrobial peptides |
EP1991562A2 (en) | 2006-02-27 | 2008-11-19 | Technische Universität München | Cancer imaging and treatment |
WO2007106554A2 (en) | 2006-03-14 | 2007-09-20 | Progen Pharmaceuticals, Inc. | Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds |
US20100279918A1 (en) * | 2006-03-20 | 2010-11-04 | Burnham Institute For Medical Research | Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents |
WO2007111993A2 (en) | 2006-03-22 | 2007-10-04 | Cellgate, Inc. | Polyamine analogs as therapeutic agents for skin diseases |
WO2008077194A1 (en) | 2006-12-22 | 2008-07-03 | Xenome Ltd | Receptor agonists |
GB0702020D0 (en) | 2007-02-02 | 2007-03-14 | Novabiotics Ltd | Peptides and their use |
GB0716897D0 (en) | 2007-08-30 | 2007-10-10 | Univ Muenchen Tech | Cancer imaging and treatment |
CA2749108C (en) | 2008-01-18 | 2017-06-27 | Visen Medical, Inc. | Intramolecularly-quenched fluorescent imaging agents |
WO2010107832A1 (en) | 2009-03-17 | 2010-09-23 | Bracco Imaging Spa | Lhrh-ii peptide analogs |
WO2011095218A1 (en) | 2010-02-05 | 2011-08-11 | Polyphor Ag | Template-fixed pep tidomime tics with cxcr7 modulating activity |
AU2010344997B2 (en) | 2010-02-05 | 2015-09-10 | Polyphor Ag | Template - fixed peptidomimetics with CXCR7 modulating activity |
US9744191B2 (en) | 2012-03-19 | 2017-08-29 | Yale University | Antimicrobial compositions and methods |
WO2014053882A1 (en) | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
US20150038671A1 (en) | 2013-05-30 | 2015-02-05 | Keykavous Parang | Efficient Synthesis of CN2097 and RC7 and Their Analogs |
WO2015179438A1 (en) | 2014-05-20 | 2015-11-26 | Ohio State Innovation Foundation | Small molecule rac or rho inhibitors |
US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
ES2739613T3 (es) * | 2014-05-21 | 2020-02-03 | Entrada Therapeutics Inc | Péptidos que penetran en las células y sus métodos de preparación y su uso |
EP3166959A4 (en) | 2014-07-11 | 2017-12-13 | C3 Jian, Inc. | Targeting peptides that bind s. mutans, constructs comprising such peptides and uses thereof |
US10456443B2 (en) | 2014-08-27 | 2019-10-29 | Ohio State Innovation Foundation | Peptidyl calcineurin inhibitors |
WO2016044683A1 (en) | 2014-09-19 | 2016-03-24 | Tensive Controls, Inc. | Anti-microbial peptides |
JP2016065018A (ja) | 2014-09-25 | 2016-04-28 | 国立大学法人京都大学 | Cxcr7結合剤およびcxcr7結合剤を含有する医薬組成物 |
CN105440105B (zh) | 2015-12-17 | 2018-11-27 | 倪京满 | 一种具有高稳定性及抗耐药活性的组合抗菌肽的制备和应用 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009527251A (ja) * | 2006-02-20 | 2009-07-30 | エファ・ユニバーシティ・インダストリー・コラボレイション・ファウンデイション | 細胞膜透過性ペプチド |
WO2011126010A1 (ja) * | 2010-04-06 | 2011-10-13 | 三菱化学株式会社 | 癌細胞選択的膜透過性ペプチドおよびその利用 |
JP2012131743A (ja) * | 2010-12-22 | 2012-07-12 | Kyoto Univ | 腫瘍集積型抗癌剤 |
Non-Patent Citations (2)
Title |
---|
ACS CHEM. BIOL., PUBLISHED: NOVEMBER 6, 2012, vol. 8, JPN6019014121, pages 423 - 431, ISSN: 0004183802 * |
CHEMISTRY & BIOLOGY, 2011年, vol. 18, JPN6019014123, pages 1000 - 1010, ISSN: 0004019924 * |
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US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
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EP3613426A1 (en) | 2020-02-26 |
CN113861268A (zh) | 2021-12-31 |
PT3149025T (pt) | 2019-08-01 |
WO2015179691A3 (en) | 2016-02-25 |
CA2949705A1 (en) | 2015-11-26 |
EP3149025B1 (en) | 2019-06-26 |
US20170190743A1 (en) | 2017-07-06 |
WO2015179691A9 (en) | 2016-03-31 |
HUE045872T2 (hu) | 2020-01-28 |
HK1232239A1 (zh) | 2018-01-05 |
EP3149025A2 (en) | 2017-04-05 |
HRP20191254T1 (hr) | 2019-10-18 |
SI3149025T1 (sl) | 2019-09-30 |
JP6807831B2 (ja) | 2021-01-06 |
CN106852146A (zh) | 2017-06-13 |
LT3149025T (lt) | 2019-09-25 |
RS59119B1 (sr) | 2019-09-30 |
DK3149025T3 (da) | 2019-07-22 |
EP3613426A9 (en) | 2023-05-24 |
EP3149025A4 (en) | 2018-02-21 |
ES2739613T3 (es) | 2020-02-03 |
PL3149025T3 (pl) | 2019-11-29 |
CY1121953T1 (el) | 2020-10-14 |
US10626147B2 (en) | 2020-04-21 |
WO2015179691A2 (en) | 2015-11-26 |
JP2020169170A (ja) | 2020-10-15 |
CN106852146B (zh) | 2021-08-13 |
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