FR2836474B1 - Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique - Google Patents

Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique

Info

Publication number
FR2836474B1
FR2836474B1 FR0202299A FR0202299A FR2836474B1 FR 2836474 B1 FR2836474 B1 FR 2836474B1 FR 0202299 A FR0202299 A FR 0202299A FR 0202299 A FR0202299 A FR 0202299A FR 2836474 B1 FR2836474 B1 FR 2836474B1
Authority
FR
France
Prior art keywords
transporting
compositions
compounds
hematoencephalic barrier
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0202299A
Other languages
English (en)
Other versions
FR2836474A1 (fr
Inventor
Patrick Mouchet
Anthony R Rees
Eskil Elmer
Marcus F Keep
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synt EM SA
Maas Biolab LLC
Original Assignee
Synt EM SA
Maas Biolab LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synt EM SA, Maas Biolab LLC filed Critical Synt EM SA
Priority to FR0202299A priority Critical patent/FR2836474B1/fr
Priority to AU2003229835A priority patent/AU2003229835A1/en
Priority to PCT/FR2003/000591 priority patent/WO2003070755A2/fr
Publication of FR2836474A1 publication Critical patent/FR2836474A1/fr
Application granted granted Critical
Publication of FR2836474B1 publication Critical patent/FR2836474B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0202299A 2002-02-22 2002-02-22 Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique Expired - Fee Related FR2836474B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0202299A FR2836474B1 (fr) 2002-02-22 2002-02-22 Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique
AU2003229835A AU2003229835A1 (en) 2002-02-22 2003-02-24 Compounds, compositions and method for transporting cyclosporin molecules through the blood brain barrier
PCT/FR2003/000591 WO2003070755A2 (fr) 2002-02-22 2003-02-24 Composes et compositions pour le transport de la cyclosporine a travers la barriere hemato-encephalique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202299A FR2836474B1 (fr) 2002-02-22 2002-02-22 Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique

Publications (2)

Publication Number Publication Date
FR2836474A1 FR2836474A1 (fr) 2003-08-29
FR2836474B1 true FR2836474B1 (fr) 2004-12-24

Family

ID=27676020

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0202299A Expired - Fee Related FR2836474B1 (fr) 2002-02-22 2002-02-22 Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique

Country Status (3)

Country Link
AU (1) AU2003229835A1 (fr)
FR (1) FR2836474B1 (fr)
WO (1) WO2003070755A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2851471B1 (fr) * 2003-02-24 2006-07-28 Synt Em Composes comprenant au moins une substance active et au moins un vecteur relies par un agent de liaison, leurs utilisations et lesdits agents de liaison
AU2004287434B2 (en) 2003-10-27 2011-04-07 City Of Hope Methods of lowering lipid levels in a mammal
EP1957093B1 (fr) * 2005-08-29 2017-04-12 SHASHOUA, Victor E. Procedes et compositions de neuroprotection et de neurorestauration
EP1810675A1 (fr) * 2006-01-18 2007-07-25 Institut Curie Methode de traitement de la maladie de Huntington par l'inhibition de la dephosphorylation de la S421
WO2007094026A1 (fr) * 2006-02-17 2007-08-23 Paolo La Colla Traitement prophylactique et/ou thérapeutique de maladies prolifératives et conformationnelles
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
DE102008060549A1 (de) * 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
FR2968662B1 (fr) 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation
HUE045872T2 (hu) 2014-05-21 2020-01-28 Entrada Therapeutics Inc Sejteket penetráló peptidek és ezek elõállítására és alkalmazására szolgáló eljárások
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
EP3185880B1 (fr) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Inhibiteurs améliorés de la peptidyl-calcineurine
US11576946B2 (en) 2018-01-29 2023-02-14 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction
TW201945014A (zh) 2018-02-22 2019-12-01 美商安卓達治療股份有限公司 用於治療粒線體性神經胃腸腦病變之組合物及方法
WO2019217682A1 (fr) 2018-05-09 2019-11-14 Ohio State Innovation Foundation Peptides cycliques de pénétration cellulaire avec un ou plusieurs résidus hydrophobes
CN113952468B (zh) * 2021-09-26 2023-07-07 中国人民解放军空军军医大学 一种治疗心肌缺血再灌注损伤的环孢菌素a纳米药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001667A1 (fr) * 1990-07-25 1992-02-06 G.D. Searle & Co. Promedicaments nephroselectifs de regulation de l'activite du systeme nerveux sympathique du rein, utilises dans le traitement de l'hypertension
FR2767323B1 (fr) * 1997-08-12 2001-01-05 Synt Em Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives
US6593292B1 (en) * 1999-08-24 2003-07-15 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
US6669951B2 (en) * 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues

Also Published As

Publication number Publication date
AU2003229835A8 (en) 2003-09-09
WO2003070755A3 (fr) 2004-03-04
WO2003070755A2 (fr) 2003-08-28
FR2836474A1 (fr) 2003-08-29
AU2003229835A1 (en) 2003-09-09

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20101029