BRPI0514420A - peptìdeo, variante do mesmo, ou um sal farmaceuticamente aceitável do mesmo, composição, uso de um peptìdeo ou de uma variante de peptìdeo, substrato, e, métodos de tratamento ou prevenção de um infecção microbiana, e de tratamento de uma ferida em um indivìduo - Google Patents

peptìdeo, variante do mesmo, ou um sal farmaceuticamente aceitável do mesmo, composição, uso de um peptìdeo ou de uma variante de peptìdeo, substrato, e, métodos de tratamento ou prevenção de um infecção microbiana, e de tratamento de uma ferida em um indivìduo

Info

Publication number
BRPI0514420A
BRPI0514420A BRPI0514420-5A BRPI0514420A BRPI0514420A BR PI0514420 A BRPI0514420 A BR PI0514420A BR PI0514420 A BRPI0514420 A BR PI0514420A BR PI0514420 A BRPI0514420 A BR PI0514420A
Authority
BR
Brazil
Prior art keywords
peptide
variant
treating
substrate
pharmaceutically acceptable
Prior art date
Application number
BRPI0514420-5A
Other languages
English (en)
Inventor
Deborah O'neil
Original Assignee
Novabiotics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0418414.9A external-priority patent/GB0418414D0/en
Application filed by Novabiotics Ltd filed Critical Novabiotics Ltd
Publication of BRPI0514420A publication Critical patent/BRPI0514420A/pt
Publication of BRPI0514420B1 publication Critical patent/BRPI0514420B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PEPTìDEO, VARIANTE DO MESMO, OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO, USO DE UM PEPTìDEO OU DE UMA VARIANTE DE PEPTìDEO, SUBSTRATO, E, MéTODOS DE TRATAMENTO OU PREVENçãO DE UMA INFECçãO MICROBIANA, E DE TRATAMENTO DE UMA FERIDA EM UM INDIVìDUO A invenção refere-se a um peptídeo que compreende aminoácidos de acordo com a Fórmula (I):((X)~ 1~(Y)~ m~)~ n~ em que 1 e m s~o números inteiros de 0 a 10; X e Y, que podem ser iguais ou diferentes, são um aminoácido selecionado do grupo que consiste de aminoácidos hidrofóbicos e/ou aminoácidos catiónicos, para uso como um medicamento.
BRPI0514420-5A 2004-08-18 2005-08-18 Peptídeo, ou um sal farmaceuticamente aceitável do mesmo, e, uso de um peptídeo BRPI0514420B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0418414.9A GB0418414D0 (en) 2004-08-18 2004-08-18 Peptide
GB0418414.9 2004-08-18
US7979505A 2005-03-14 2005-03-14
US11/079,795 2005-03-14
PCT/GB2005/003245 WO2006018652A2 (en) 2004-08-18 2005-08-18 Antimicrobial peptides comprising an arginine- and/or lysine-containing motif

Publications (2)

Publication Number Publication Date
BRPI0514420A true BRPI0514420A (pt) 2008-06-10
BRPI0514420B1 BRPI0514420B1 (pt) 2022-05-17

Family

ID=35907779

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514420-5A BRPI0514420B1 (pt) 2004-08-18 2005-08-18 Peptídeo, ou um sal farmaceuticamente aceitável do mesmo, e, uso de um peptídeo

Country Status (25)

Country Link
US (4) US7847059B2 (pt)
EP (5) EP1927597B1 (pt)
JP (1) JP5020078B2 (pt)
KR (1) KR101234780B1 (pt)
CN (3) CN103360485A (pt)
AT (1) ATE479704T1 (pt)
AU (1) AU2005273638B2 (pt)
BR (1) BRPI0514420B1 (pt)
CA (2) CA2575058C (pt)
CY (1) CY1113684T1 (pt)
DE (1) DE602005023315D1 (pt)
DK (2) DK1927597T3 (pt)
ES (1) ES2613027T3 (pt)
GB (1) GB2431404A (pt)
HK (1) HK1105982A1 (pt)
IL (2) IL180727A (pt)
MX (1) MX2007002057A (pt)
NO (1) NO342832B1 (pt)
NZ (2) NZ584340A (pt)
PL (1) PL1778720T3 (pt)
PT (2) PT1778720E (pt)
RU (1) RU2396273C2 (pt)
SG (3) SG155211A1 (pt)
SI (1) SI1778720T1 (pt)
WO (1) WO2006018652A2 (pt)

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Also Published As

Publication number Publication date
US20070244044A1 (en) 2007-10-18
CN103360485A (zh) 2013-10-23
CN101031583A (zh) 2007-09-05
CA2974538A1 (en) 2006-02-23
RU2396273C2 (ru) 2010-08-10
EP3147293A1 (en) 2017-03-29
PL1778720T3 (pl) 2011-03-31
DK1927597T3 (en) 2017-02-13
AU2005273638B2 (en) 2011-09-29
JP2008509980A (ja) 2008-04-03
EP2096118A1 (en) 2009-09-02
US20110269673A1 (en) 2011-11-03
US8088888B2 (en) 2012-01-03
SI1778720T1 (sl) 2011-04-29
RU2007109518A (ru) 2008-09-27
IL180727A (en) 2015-06-30
US20110021415A1 (en) 2011-01-27
NZ553494A (en) 2010-07-30
EP1778720A2 (en) 2007-05-02
DK1778720T3 (da) 2010-11-29
BRPI0514420B1 (pt) 2022-05-17
ATE479704T1 (de) 2010-09-15
CA2575058C (en) 2017-09-12
SG155211A1 (en) 2009-09-30
PT1778720E (pt) 2010-11-29
US7847059B2 (en) 2010-12-07
US8350003B2 (en) 2013-01-08
US20120071398A1 (en) 2012-03-22
CY1113684T1 (el) 2016-06-22
NO342832B1 (no) 2018-08-13
IL213319A (en) 2017-07-31
EP3147293B1 (en) 2022-05-04
JP5020078B2 (ja) 2012-09-05
KR20070083486A (ko) 2007-08-24
EP3141559A1 (en) 2017-03-15
ES2613027T3 (es) 2017-05-22
SG188092A1 (en) 2013-03-28
EP1927597B1 (en) 2016-11-02
SG10201606278UA (en) 2016-09-29
MX2007002057A (es) 2007-07-19
AU2005273638A1 (en) 2006-02-23
CN103360486A (zh) 2013-10-23
DE602005023315D1 (de) 2010-10-14
GB2431404A (en) 2007-04-25
EP1778720B1 (en) 2010-09-01
KR101234780B1 (ko) 2013-02-20
GB0703060D0 (en) 2007-03-28
US8470769B2 (en) 2013-06-25
PT1927597T (pt) 2017-02-10
WO2006018652A3 (en) 2006-07-13
NO20071369L (no) 2007-05-04
CN101031583B (zh) 2013-06-05
NZ584340A (en) 2010-09-30
HK1105982A1 (en) 2008-02-29
IL213319A0 (en) 2011-07-31
WO2006018652A2 (en) 2006-02-23
EP1927597A1 (en) 2008-06-04
CA2575058A1 (en) 2006-02-23
IL180727A0 (en) 2007-06-03

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