EP1042360A2 - Zusammensetzungen für immunotherapie und diagnose von brustkrebs und verfahren für ihre verwendung - Google Patents
Zusammensetzungen für immunotherapie und diagnose von brustkrebs und verfahren für ihre verwendungInfo
- Publication number
- EP1042360A2 EP1042360A2 EP98964884A EP98964884A EP1042360A2 EP 1042360 A2 EP1042360 A2 EP 1042360A2 EP 98964884 A EP98964884 A EP 98964884A EP 98964884 A EP98964884 A EP 98964884A EP 1042360 A2 EP1042360 A2 EP 1042360A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- polypeptide
- protein
- seq
- breast cancer
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/49—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Definitions
- the polypeptides disclosed herein may also be employed to generate and/or isolate tumor-reactive T-cells, which can then be administered to the patient.
- antigen-specific T-cell lines may be generated by in vivo immunization with short peptides corresponding to immunogenic portions ofthe disclosed polypeptides.
- the resulting antigen specific CD8+ CTL clones may be isolated from the patient, expanded using standard tissue culture techniques, and returned to the patient.
- Suitable portions of such breast tumor proteins are portions that are able to generate a binding agent that indicates the presence of primary or metastatic breast cancer in substantially all (i.e., at least about 80%, and preferably at least about 90%) of the patients for which breast cancer would be indicated using the full length protein, and that indicate the absence of breast cancer in substantially all of those samples that would be negative when tested with full length protein.
- the representative assays described below, such as the two-antibody sandwich assay may generally be employed for evaluating the ability of a binding agent to detect metastatic human breast tumors.
- the signal detected from the reporter group that remains bound to the solid support is generally compared to a signal that corresponds to a predetermined cut-off value.
- the cut-off value is the average mean signal obtained when the immobilized antibody is incubated with samples from patients without breast cancer.
- a sample generating a signal that is three standard deviations above the predetermined cut-off value is considered positive for breast cancer.
- the cut-off value is determined using a Receiver Operator Curve, according to the method of Sackett et al., Clinical Epidemiology: A Basic Science for Clinical Medicine, Little Brown and Co., 1985, p. 106-7.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08012753A EP1992640A1 (de) | 1997-12-24 | 1998-12-22 | Verbindungen für die Immuntherapie und Diagnose von Brustkrebs und Verfahren zu ihrer Verwendung |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US118554 | 1980-02-04 | ||
| US99825597A | 1997-12-24 | 1997-12-24 | |
| US99825397A | 1997-12-24 | 1997-12-24 | |
| US998255 | 1997-12-24 | ||
| US998253 | 1997-12-24 | ||
| US09/118,554 US6365348B1 (en) | 1997-12-24 | 1998-07-17 | Compounds for diagnosis of Breast cancer and methods for their use |
| US118627 | 1998-07-17 | ||
| US09/118,627 US6379951B1 (en) | 1997-12-24 | 1998-07-17 | Compounds for immunotherapy of breast cancer and methods for their use |
| PCT/US1998/027416 WO1999033869A2 (en) | 1997-12-24 | 1998-12-22 | Compounds for immunotherapy and diagnosis of breast cancer and methods for their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP08012753A Division EP1992640A1 (de) | 1997-12-24 | 1998-12-22 | Verbindungen für die Immuntherapie und Diagnose von Brustkrebs und Verfahren zu ihrer Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1042360A2 true EP1042360A2 (de) | 2000-10-11 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98964884A Withdrawn EP1042360A2 (de) | 1997-12-24 | 1998-12-22 | Zusammensetzungen für immunotherapie und diagnose von brustkrebs und verfahren für ihre verwendung |
| EP08012753A Withdrawn EP1992640A1 (de) | 1997-12-24 | 1998-12-22 | Verbindungen für die Immuntherapie und Diagnose von Brustkrebs und Verfahren zu ihrer Verwendung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP08012753A Withdrawn EP1992640A1 (de) | 1997-12-24 | 1998-12-22 | Verbindungen für die Immuntherapie und Diagnose von Brustkrebs und Verfahren zu ihrer Verwendung |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1042360A2 (de) |
| JP (1) | JP2002507387A (de) |
| AU (1) | AU2010699A (de) |
| CA (1) | CA2316397A1 (de) |
| WO (1) | WO1999033869A2 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6379951B1 (en) | 1997-12-24 | 2002-04-30 | Corixa Corporation | Compounds for immunotherapy of breast cancer and methods for their use |
| US6410507B1 (en) * | 1997-12-24 | 2002-06-25 | Corixa Corporation | Compounds for immunotherapy and diagnosis of breast cancer and methods for their use |
| US6432707B1 (en) | 1997-12-24 | 2002-08-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| WO1999055859A2 (en) * | 1998-04-29 | 1999-11-04 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Cd40-interacting and traf-interacting proteins |
| US20030003507A1 (en) | 1999-06-02 | 2003-01-02 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US6528054B1 (en) * | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| US6762020B1 (en) | 1999-03-15 | 2004-07-13 | Protein Design Labs, Inc. | Methods of diagnosing breast cancer |
| US6316272B1 (en) | 1999-03-15 | 2001-11-13 | Eos Biotechnology, Inc. | Methods of diagnosis of colorectal cancer and methods of screening for colorectal cancer modulators |
| US6649342B1 (en) | 1999-03-15 | 2003-11-18 | Eos Biotechnology, Inc. | Methods of diagnosing breast cancer, compositions, and methods of screening for breast cancer modulators |
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- 1998-12-22 JP JP2000526543A patent/JP2002507387A/ja active Pending
- 1998-12-22 WO PCT/US1998/027416 patent/WO1999033869A2/en active Application Filing
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- 1998-12-22 EP EP08012753A patent/EP1992640A1/de not_active Withdrawn
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| EP1992640A1 (de) | 2008-11-19 |
| WO1999033869A3 (en) | 1999-12-23 |
| WO1999033869A2 (en) | 1999-07-08 |
| AU2010699A (en) | 1999-07-19 |
| CA2316397A1 (en) | 1999-07-08 |
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