AU2001269690A1 - Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth - Google Patents
Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growthInfo
- Publication number
- AU2001269690A1 AU2001269690A1 AU2001269690A AU6969001A AU2001269690A1 AU 2001269690 A1 AU2001269690 A1 AU 2001269690A1 AU 2001269690 A AU2001269690 A AU 2001269690A AU 6969001 A AU6969001 A AU 6969001A AU 2001269690 A1 AU2001269690 A1 AU 2001269690A1
- Authority
- AU
- Australia
- Prior art keywords
- compositions
- methods
- immune system
- steroid hormone
- hormone responsive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
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- A—HUMAN NECESSITIES
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- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
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- C12N5/0693—Tumour cells; Cancer cells
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- G—PHYSICS
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- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
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- C07K2317/52—Constant or Fc region; Isotype
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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Abstract
Compositions and methods that use the body's natural secretory immune system in a new way against steroid hormone responsive tumors of the breast and prostate, as well as other glandular/mucus epithelial tissues such as colon, ovary, endometrium, kidney, bladder, stomach, pancreas and secretory pituitary gland are provided. Also provided are new ways of identifying carcinogenic, or potentially carcinogenic, bacteria in a tissue or body fluid to provide better anti-cancer therapies and preventatives than have been available previously.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20331400P | 2000-05-10 | 2000-05-10 | |
US60/203,314 | 2000-05-10 | ||
US20834800P | 2000-05-31 | 2000-05-31 | |
US20811100P | 2000-05-31 | 2000-05-31 | |
US60/208,111 | 2000-05-31 | ||
US60/208,348 | 2000-05-31 | ||
US22907100P | 2000-08-30 | 2000-08-30 | |
US60/229,071 | 2000-08-30 | ||
US23127300P | 2000-09-08 | 2000-09-08 | |
US60/231,273 | 2000-09-08 | ||
PCT/US2001/015183 WO2001085210A2 (en) | 2000-05-10 | 2001-05-10 | Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001269690A1 true AU2001269690A1 (en) | 2001-11-20 |
Family
ID=27539481
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001269690A Abandoned AU2001269690A1 (en) | 2000-05-10 | 2001-05-10 | Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth |
AU2001272908A Abandoned AU2001272908A1 (en) | 2000-05-10 | 2001-05-10 | Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001272908A Abandoned AU2001272908A1 (en) | 2000-05-10 | 2001-05-10 | Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers |
Country Status (8)
Country | Link |
---|---|
US (4) | US7947275B2 (en) |
EP (5) | EP2394660A1 (en) |
AT (2) | ATE485520T1 (en) |
AU (2) | AU2001269690A1 (en) |
CA (2) | CA2409765A1 (en) |
DE (1) | DE60143320D1 (en) |
MX (2) | MXPA02011093A (en) |
WO (2) | WO2001086307A2 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7863011B2 (en) * | 2000-05-10 | 2011-01-04 | Signe Biopharma, Inc. | Screening method for predicting susceptibility to breast cancer |
US20030072812A1 (en) * | 2001-05-10 | 2003-04-17 | Sirbasku David A | Breast cancer eradication program |
US8119138B2 (en) * | 2000-05-10 | 2012-02-21 | Signe Biopharma Inc. | Anti-estrogen and immune modulator combinations for treating breast cancer |
MXPA02011093A (en) | 2000-05-10 | 2004-08-19 | David A Sirbasku | Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers. |
CA2451770A1 (en) * | 2001-06-28 | 2003-01-09 | Entelos, Inc. | Method and apparatus for computer modeling of an adaptive immune response |
AU2002343714A1 (en) | 2001-11-13 | 2003-05-26 | David A. Sirbasku | Breast cancer eradication program |
EP1515748A4 (en) * | 2001-11-14 | 2006-04-12 | David A Sirbasku | Anti-estrogen and immune modulator combinations for treating breast cancer |
EP1490502B1 (en) * | 2001-11-14 | 2013-01-09 | Signe BioPharma Inc. | Screening method for predicting susceptibility to breast cancer |
US7364846B2 (en) * | 2002-10-11 | 2008-04-29 | Molecular Devices Corporation | Gene expression profiling from FFPE samples |
EP2471924A1 (en) * | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
EP2302055B1 (en) | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
WO2008073922A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
ATE552334T1 (en) * | 2005-09-13 | 2012-04-15 | Takara Bio Inc | SERUM-FREE MEDIUM FOR PRODUCING RETROVIRAL VECTORS |
AU2007299748A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention |
EP2487240B1 (en) * | 2006-09-19 | 2016-11-16 | Interpace Diagnostics, LLC | Micrornas differentially expressed in pancreatic diseases and uses thereof |
WO2008073915A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Micrornas differentially expressed in leukemia and uses thereof |
EP2104735A2 (en) * | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
US8709413B2 (en) * | 2006-12-13 | 2014-04-29 | Michael R. Simon | Treatment of celiac disease with IgA |
CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
US8015145B2 (en) * | 2007-06-05 | 2011-09-06 | Siemens Medical Solutions Usa, Inc. | System for providing healthcare operation specific user interface display images |
WO2008154333A2 (en) * | 2007-06-08 | 2008-12-18 | Asuragen, Inc. | Mir-34 regulated genes and pathways as targets for therapeutic intervention |
EP2198050A1 (en) | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Micrornas differentially expressed in cervical cancer and uses thereof |
WO2009052386A1 (en) * | 2007-10-18 | 2009-04-23 | Asuragen, Inc. | Micrornas differentially expressed in lung diseases and uses thereof |
WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
US20090192114A1 (en) * | 2007-12-21 | 2009-07-30 | Dmitriy Ovcharenko | miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
US20090193338A1 (en) * | 2008-01-28 | 2009-07-30 | Trevor Fiatal | Reducing network and battery consumption during content delivery and playback |
EP2260110B1 (en) * | 2008-02-08 | 2014-11-12 | Asuragen, INC. | miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS |
EP2268832A2 (en) * | 2008-03-06 | 2011-01-05 | Asuragen, INC. | Microrna markers for recurrence of colorectal cancer |
WO2009154835A2 (en) * | 2008-03-26 | 2009-12-23 | Asuragen, Inc. | Compositions and methods related to mir-16 and therapy of prostate cancer |
US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
US20100179213A1 (en) * | 2008-11-11 | 2010-07-15 | Mirna Therapeutics, Inc. | Methods and Compositions Involving miRNAs In Cancer Stem Cells |
JP2012530133A (en) * | 2009-06-16 | 2012-11-29 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | Methods for improving side effects associated with transfusion of red blood cells over time |
US8993347B2 (en) | 2009-12-17 | 2015-03-31 | Cornell University | Methods for detecting antibodies in mucosal samples and device for sampling mucosal material |
WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
EP3049514B1 (en) * | 2013-09-24 | 2019-11-20 | University Of Miami | Cell culture media |
DK3126383T3 (en) | 2014-04-03 | 2019-04-01 | Igm Biosciences Inc | MODIFIED J-CHAIN |
DK3265575T3 (en) | 2015-03-04 | 2021-05-31 | Igm Biosciences Inc | CD20 BINDING MOLECULES AND USES THEREOF |
DK3356401T3 (en) * | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | BINDING MOLECULES WITH MODIFIED J-CHAIN |
AU2016329197B2 (en) | 2015-09-30 | 2021-01-21 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4393071A (en) | 1975-03-17 | 1983-07-12 | Naoharu Fujii | Method of treating gastric, mammary, lung and uterus tumors |
FR2558373B1 (en) | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | ANTI-ESTROGEN MEDICINAL PRODUCT BASED ON 4-HYDROXYTAMOXIFENE FOR PERCUTANEOUS ADMINISTRATION |
US4683200A (en) | 1984-05-17 | 1987-07-28 | Setsuo Hirohashi | Monoclonal antibody to human cancer antigen and method for producing same |
GB8607137D0 (en) | 1986-03-21 | 1986-04-30 | Efamol Ltd | Compositions |
US5135849A (en) | 1986-04-17 | 1992-08-04 | Trustees Of Tufts College | In-vitro methods for identifying compositions which are agonists and antagonists of androgens |
US4859585A (en) * | 1986-04-17 | 1989-08-22 | Trustees Of Tufts College | In-vitro methods for identifying compositions which are agonists and antagonists of estrogens |
GB8628104D0 (en) | 1986-11-25 | 1986-12-31 | Connaught Lab | Pasteurization of immunoglobin solutions |
US5980896A (en) | 1989-06-30 | 1999-11-09 | Bristol-Myers Squibb Company | Antibodies reactive with human carcinomas |
DE3927112C1 (en) * | 1989-08-17 | 1990-10-25 | Biotest Pharma Gmbh, 6072 Dreieich, De | |
CN1057785A (en) * | 1990-04-16 | 1992-01-15 | 哈佛大学校长及研究员协会 | The synthetic poly-ig receptor, receptor-antibody complex is produced and is used |
RU1837891C (en) | 1991-01-31 | 1993-08-30 | Keshelava Viktor V | Method for preparation antitumor agent |
WO1992013500A1 (en) | 1991-02-08 | 1992-08-20 | Surgical Innovations, Inc. | Method and apparatus for repair of inguinal hernias |
US6200547B1 (en) | 1994-01-26 | 2001-03-13 | Ferx Incorporated | Magnetically responsive compositions for carrying biologically active substances and methods of production and use |
US5405772A (en) * | 1993-06-18 | 1995-04-11 | Amgen Inc. | Medium for long-term proliferation and development of cells |
US5641863A (en) | 1993-09-30 | 1997-06-24 | University Of Pennsylvania | Chimeric IgG Fc receptors |
GB9320820D0 (en) * | 1993-10-08 | 1993-12-01 | Biokine Tech Ltd | Compounds for medicinal use |
JPH07238036A (en) * | 1994-02-28 | 1995-09-12 | Green Cross Corp:The | Method for suppressing increase in globulin dimer of globulin liquid composition for intravenous injection |
US5772995A (en) | 1994-07-18 | 1998-06-30 | Sidney Kimmel Cancer Center | Compositions and methods for enhanced tumor cell immunity in vivo |
US5866323A (en) * | 1995-04-07 | 1999-02-02 | Case Western Reserve University | Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors |
US6902743B1 (en) | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
CA2224115A1 (en) | 1995-06-07 | 1996-12-19 | Washington University | Multidentate metal complexes and methods of making and using thereof |
WO1997046715A1 (en) * | 1996-06-03 | 1997-12-11 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Fc receptor polymorphism |
EP0920490A2 (en) | 1996-07-25 | 1999-06-09 | Genzyme Corporation | Chondrocyte media formulations and culture procedures |
EP2221361A3 (en) * | 1996-08-30 | 2011-02-09 | Life Technologies Corporation | Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium |
JP2001510690A (en) * | 1997-07-28 | 2001-08-07 | エール ユニヴァーシティ | Human estrogen receptor beta |
US6020161A (en) | 1997-08-19 | 2000-02-01 | Smithkline Beecham Corporation | PIGR-1, a member of immunoglobulin gene superfamily |
JP2002507387A (en) | 1997-12-24 | 2002-03-12 | コリクサ コーポレイション | Compounds for immunotherapy and diagnosis of breast cancer and methods for their use |
WO2000005403A1 (en) * | 1998-07-24 | 2000-02-03 | Uab Research Foundation | GENETIC POLYMORPHISM IN THE RECEPTOR FOR IgA |
IL125608A0 (en) * | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
US6844189B1 (en) | 1998-11-06 | 2005-01-18 | Myriad Genetics, Inc. | Chromosome 17P-linked prostate cancer susceptibility gene |
JP2003532378A (en) | 1999-11-29 | 2003-11-05 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | Isolation of five novel genes encoding novel Fc receptor-type melanomas involved in the development of lymphoma / melanoma |
EP1261371A4 (en) | 2000-02-25 | 2005-04-13 | Univ California | Membrane estrogen receptor-directed therapy in breast cancer |
US6763307B2 (en) | 2000-03-06 | 2004-07-13 | Bioseek, Inc. | Patient classification |
EP1268555A2 (en) | 2000-03-27 | 2003-01-02 | The Regents of The University of California | Ligands directed to the non-secretory component, non-stalk region of pigr and methods of use thereof |
MXPA02011093A (en) | 2000-05-10 | 2004-08-19 | David A Sirbasku | Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers. |
US8119138B2 (en) | 2000-05-10 | 2012-02-21 | Signe Biopharma Inc. | Anti-estrogen and immune modulator combinations for treating breast cancer |
AU2002343714A1 (en) | 2001-11-13 | 2003-05-26 | David A. Sirbasku | Breast cancer eradication program |
EP1490502B1 (en) | 2001-11-14 | 2013-01-09 | Signe BioPharma Inc. | Screening method for predicting susceptibility to breast cancer |
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AU2001272908A1 (en) | 2001-11-20 |
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US20120115161A1 (en) | 2012-05-10 |
US8563249B2 (en) | 2013-10-22 |
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WO2001086307A3 (en) | 2003-10-02 |
US7947275B2 (en) | 2011-05-24 |
US20020006630A1 (en) | 2002-01-17 |
EP2394659A1 (en) | 2011-12-14 |
WO2001085210A2 (en) | 2001-11-15 |
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