WO1999043812A3 - Dlc-1 gene, a putative tumors suppressor gene - Google Patents

Dlc-1 gene, a putative tumors suppressor gene Download PDF

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Publication number
WO1999043812A3
WO1999043812A3 PCT/US1999/004164 US9904164W WO9943812A3 WO 1999043812 A3 WO1999043812 A3 WO 1999043812A3 US 9904164 W US9904164 W US 9904164W WO 9943812 A3 WO9943812 A3 WO 9943812A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
dlc
cancer
putative
frequently deleted
Prior art date
Application number
PCT/US1999/004164
Other languages
French (fr)
Other versions
WO1999043812A2 (en
Inventor
Bao-Zhu Yuan
Nicholas C Popescu
Snorri S Thorgeirsson
Original Assignee
Us Health
Yuan Bao Zhu
Nicholas C Popescu
Snorri S Thorgeirsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Yuan Bao Zhu, Nicholas C Popescu, Snorri S Thorgeirsson filed Critical Us Health
Priority to AU28791/99A priority Critical patent/AU2879199A/en
Publication of WO1999043812A2 publication Critical patent/WO1999043812A2/en
Publication of WO1999043812A3 publication Critical patent/WO1999043812A3/en
Priority to US10/995,914 priority patent/US7534565B2/en
Priority to US12/239,581 priority patent/US20090239220A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

A cDNA molecule corresponding to a human gene is disclosed. The gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
PCT/US1999/004164 1998-02-25 1999-02-25 Dlc-1 gene, a putative tumors suppressor gene WO1999043812A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU28791/99A AU2879199A (en) 1998-02-25 1999-02-25 Dlc-1 gene, a putative tumors suppressor gene
US10/995,914 US7534565B2 (en) 1998-02-25 2004-11-24 DLC-1 gene deleted in cancers
US12/239,581 US20090239220A1 (en) 1998-02-25 2008-09-26 Dlc-1 gene deleted in cancers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7595298P 1998-02-25 1998-02-25
US60/075,952 1998-02-25

Publications (2)

Publication Number Publication Date
WO1999043812A2 WO1999043812A2 (en) 1999-09-02
WO1999043812A3 true WO1999043812A3 (en) 1999-10-28

Family

ID=22128974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004164 WO1999043812A2 (en) 1998-02-25 1999-02-25 Dlc-1 gene, a putative tumors suppressor gene

Country Status (2)

Country Link
AU (1) AU2879199A (en)
WO (1) WO1999043812A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2687609B1 (en) 2008-11-10 2017-01-04 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for treating solid tumor
CN104436162A (en) * 2013-09-24 2015-03-25 中国科学院上海生命科学研究院 Method and preparation for inhibiting bone metastasis due to breast cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHINEN K. ET AL.: "Isolation of 45 exon-like fragments from 8p22-p21.3, a region that is commonly deleted in hepatocellular, colorectal, and non-small cell lung carcinomas", CYTOGENETICS AND CELL GENETICS, vol. 75, 1 January 1996 (1996-01-01), pages 190 - 196, XP002084550, ISSN: 0301-0171 *
HOMMA Y. AND EMORI Y.: "A dual function signal mediator showing RhoGAP and phospholipase C-delta stimulating activities.", EMBO JOURNAL, vol. 14, no. 2, 1995, pages 286 - 291, XP002113384 *
SYMONS M.: "RHO FAMILY GTPASES: THE CYTOSKELETON AND BEYOND", TIBS TRENDS IN BIOCHEMICAL SCIENCES, vol. 21, 1 May 1996 (1996-05-01), pages 178 - 181, XP002074622, ISSN: 0968-0004 *
WEI M.-H. ET AL.: "Cloning and molecular characterization of the human ortholog of the rat dual regulator p122RhoGAP.", EMBL DATABASE ENTRY AF026219; ACCESSION NUMBER AF026219, 1 November 1997 (1997-11-01), XP002113383 *
YUAN B. Z. ET AL.: "Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.", CANCER RESEARCH, vol. 58, no. 10, 15 May 1998 (1998-05-15), pages 2196 - 2199, XP002113386 *
YUAN B.Z. ET AL.: "Homo sapiens deleted in liver cancer-1 (DCL-1) mRNA, complete cds.", EMBL DATABASE ENTRY AF035119; ACCESSION NUMBER AF035119, 2 December 1997 (1997-12-02), XP002113385 *

Also Published As

Publication number Publication date
AU2879199A (en) 1999-09-15
WO1999043812A2 (en) 1999-09-02

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