WO2000012702A3 - Human genes differentially expressed in colorectal cancer - Google Patents

Human genes differentially expressed in colorectal cancer Download PDF

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Publication number
WO2000012702A3
WO2000012702A3 PCT/US1999/019424 US9919424W WO0012702A3 WO 2000012702 A3 WO2000012702 A3 WO 2000012702A3 US 9919424 W US9919424 W US 9919424W WO 0012702 A3 WO0012702 A3 WO 0012702A3
Authority
WO
WIPO (PCT)
Prior art keywords
human genes
colorectal cancer
differentially expressed
genes differentially
genes
Prior art date
Application number
PCT/US1999/019424
Other languages
French (fr)
Other versions
WO2000012702A2 (en
Inventor
Wilson O Endege
Kathleen E Steinmann
Jon H Astle
Christopher C Burgess
Eddie Carroll Iii
Theodore J Catino
Poornima Dwivedi
Donna M Ford
Marcia E Lewis
Gary A Molino
John E Monahan
Robert Schlegel
Original Assignee
Bayer Ag
Wilson O Endege
Kathleen E Steinmann
Jon H Astle
Christopher C Burgess
Eddie Carroll Iii
Theodore J Catino
Poornima Dwivedi
Donna M Ford
Marcia E Lewis
Gary A Molino
John E Monahan
Robert Schlegel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Wilson O Endege, Kathleen E Steinmann, Jon H Astle, Christopher C Burgess, Eddie Carroll Iii, Theodore J Catino, Poornima Dwivedi, Donna M Ford, Marcia E Lewis, Gary A Molino, John E Monahan, Robert Schlegel filed Critical Bayer Ag
Priority to AU56916/99A priority Critical patent/AU5691699A/en
Priority to EP99943918A priority patent/EP1108021A2/en
Priority to JP2000567689A priority patent/JP2002523088A/en
Publication of WO2000012702A2 publication Critical patent/WO2000012702A2/en
Publication of WO2000012702A3 publication Critical patent/WO2000012702A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Abstract

This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
PCT/US1999/019424 1998-08-31 1999-08-30 Human genes differentially expressed in colorectal cancer WO2000012702A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU56916/99A AU5691699A (en) 1998-08-31 1999-08-30 Human genes differentially expressed in colorectal cancer
EP99943918A EP1108021A2 (en) 1998-08-31 1999-08-30 Human genes differentially expressed in colorectal cancer
JP2000567689A JP2002523088A (en) 1998-08-31 1999-08-30 Human genes differentially expressed in colon cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9863998P 1998-08-31 1998-08-31
US60/098,639 1998-08-31
US11739399P 1999-01-27 1999-01-27
US60/117,393 1999-01-27

Publications (2)

Publication Number Publication Date
WO2000012702A2 WO2000012702A2 (en) 2000-03-09
WO2000012702A3 true WO2000012702A3 (en) 2000-09-08

Family

ID=26794949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019424 WO2000012702A2 (en) 1998-08-31 1999-08-30 Human genes differentially expressed in colorectal cancer

Country Status (4)

Country Link
EP (1) EP1108021A2 (en)
JP (1) JP2002523088A (en)
AU (1) AU5691699A (en)
WO (1) WO2000012702A2 (en)

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Publication number Priority date Publication date Assignee Title
EP1621620A3 (en) * 1999-09-01 2006-05-10 Genetech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6953658B2 (en) 2000-03-09 2005-10-11 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating gastrointestinal cancer
WO2001073027A2 (en) * 2000-03-24 2001-10-04 Corixa Corporation Compositions and methods for therapy and diagnosis of colon cancer
AU2001263810A1 (en) * 2000-03-27 2001-10-08 Bayer Aktiengesellschaft Regulation of human c-myb-related genes
AU2001262133A1 (en) * 2000-03-27 2001-10-08 Bayer Aktiengesellschaft Regulation of human nedd1-related protein
AU2001250405A1 (en) * 2000-03-27 2001-10-08 Bayer Aktiengesellschaft Regulation of human adp-ribosylation factor-related protein
EP1272521A2 (en) * 2000-03-27 2003-01-08 Bayer Aktiengesellschaft Regulation of human oatp2-related protein
ATE287951T1 (en) * 2000-03-29 2005-02-15 Max Planck Gesellschaft SPATIAL SHAPE OF POLYPEPTIDES CONTAINING TPR STRUCTURAL MOTIF WITH CHAPERONE BINDING FUNCTION, THEIR CRYSTALS AND COMPOUNDS FOR INHIBITING SUCH POLYPEPTIDES
EP1666594A3 (en) * 2000-06-02 2006-06-21 Genentech, Inc. Polypeptide, nucleic acid encoding it, and their use for the diagnosis of cancer
WO2002012280A2 (en) * 2000-08-03 2002-02-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
AU2001294999A1 (en) * 2000-08-07 2002-02-18 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
AU2001294943A1 (en) * 2000-10-02 2002-04-15 Bayer Corporation Nucleic acid sequences differentially expressed in cancer tissue
US20020137038A1 (en) * 2000-12-04 2002-09-26 Lasek Amy W. Intestinal proteins
US20050272120A1 (en) 2001-06-20 2005-12-08 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1992643A3 (en) 2001-06-20 2008-12-10 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20030186302A1 (en) * 2002-03-29 2003-10-02 Yixin Wang Colorectal cancer diagnostics
ATE370414T1 (en) 2002-12-20 2007-09-15 Hoffmann La Roche USE OF NICOTINAMIDE N-METHYLTRANSFERASE FOR DIAGNOSING COLORECTAL CANCER
EP1572118A4 (en) * 2002-12-20 2010-07-14 Millennium Pharm Inc Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 216
EP2311468B1 (en) 2003-08-08 2014-01-15 Perseus Proteomics Inc. Gene overexpressed in cancer
DE10341812A1 (en) * 2003-09-10 2005-04-07 Ganymed Pharmaceuticals Ag Differentially expressed in tumors gene products and their use

Citations (2)

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EP0284362A2 (en) * 1987-03-23 1988-09-28 Imperial Chemical Industries Plc Molecular markers
WO1995011923A1 (en) * 1993-10-29 1995-05-04 Dana-Farber Cancer Institute, Inc. A novel tumor marker and novel method of isolating same

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0284362A2 (en) * 1987-03-23 1988-09-28 Imperial Chemical Industries Plc Molecular markers
WO1995011923A1 (en) * 1993-10-29 1995-05-04 Dana-Farber Cancer Institute, Inc. A novel tumor marker and novel method of isolating same

Non-Patent Citations (7)

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Title
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DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002126134, Database accession no. Z94055 *
JAU MIN WONG ET AL: "UBIQUITIN-RIBOSOMAL PROTEIN S27A GENE OVEREXPRESSES IN HUMAN COLORECTAL CARCINOMA IS AN EARLY GROWTH RESPONSE GENE", CANCER RESEARCH, vol. 53, no. 8, 15 April 1993 (1993-04-15), pages 1916 - 1920, XP002024627, ISSN: 0008-5472 *
KONDOH N ET AL.: "Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class-I messenger RNAs associated with colon-carcinoma progression and differentiation", CANCER RESEARCH., vol. 52, no. 4, 15 February 1992 (1992-02-15), BALTIMORE, US, pages 791 - 796, XP002119317, ISSN: 0008-5472 *
SCHWEINFEST C W ET AL: "Subtraction hybridization cDNA libraries from colon carcinoma and hepatic cancer", GENE ANALYSIS TECHNIQUES, vol. 7, 1 January 1990 (1990-01-01), pages 64 - 70, XP002089887, ISSN: 0735-0651 *
VAN BELZEN N ET AL: "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms", LABORATORY INVESTIGATION, vol. 77, no. 1, 1 July 1997 (1997-07-01), pages 85 - 92, XP002089891, ISSN: 0023-6837 *
VIDER B ET AL: "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 232, no. 3, March 1997 (1997-03-01), pages 742 - 748, XP002104685, ISSN: 0006-291X *

Also Published As

Publication number Publication date
EP1108021A2 (en) 2001-06-20
JP2002523088A (en) 2002-07-30
WO2000012702A2 (en) 2000-03-09
AU5691699A (en) 2000-03-21

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